iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tgu-116469

Ensembl Protein ID

ENSTGUP00000011589.1

UniProt Accession

H0ZLW6; H0ZLW6_TAEGU

Genbank Protein ID

ENSTGUP00000011589

Protein Name

Presenilin

Genbank Nucleotide ID

ABQF01002509

Gene Name

PSEN1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000011237.1	ENSTGUT00000011714.1	ENSTGUP00000011589.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	7.70e-08	32.1	144	179

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavn 37
           +eta+e+++++FP+l+ys+++ +L++++  +++a+ 
   Q: 144  VETAQERNETLFPALIYSSTMIWLVNMAEEDPEAQR 179
           89*************************998888876 PP

Organism

Taeniopygia guttata

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

ALNSILNAAI MISVIIVMTI LLVVLYKYRC YKVIHGWLII SSLLLLFFFS FIYLGEVFKT 60
YNVAMDYITV ALMIWNFGVV GMICIHWKGP LRLQQAYLIM ISALMALVFI KYLPEWTAWL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGAGGAGC GGTGGCGGAG CGCGGGCAGC GCTGCCGTGC AGGTCCGTCT GTCGGCGGGG 60
CGGGCGAGGG CGCCGGGCCG CGCTGGGGGC CGGGCGCGCT GTGCCACCGG GGGCGGCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	34.21	1.00e-24	108.00
IUUC-Aml-001648	Ailuropoda melanoleuca	86.29	9.00e-141	492.00
IUUC-Atr-003039	Amborella trichopoda	33.42	1.00e-35	144.00
IUUC-Apl-003727	Anas platyrhynchos	96.47	3.00e-158	551.00
IUUC-Aca-004582	Anolis carolinensis	91.74	3.00e-152	530.00
IUUC-Bta-013026	Bos taurus	84.53	2.00e-139	488.00
IUUC-Bdi-014196	Brachypodium distachyon	32.69	5.00e-28	118.00
IUUC-Cja-019994	Callithrix jacchus	87.32	2.00e-138	485.00
IUUC-Cfa-020074	Canis familiaris	88.79	1.00e-142	498.00
IUUC-Cpo-022237	Cavia porcellus	87.32	9.00e-141	493.00
IUUC-Csa-023537	Chlorocebus sabaeus	87.32	6.00e-140	489.00
IUUC-Cho-024735	Choloepus hoffmanni	74.04	6.00e-123	433.00
IUUC-Dno-029758	Dasypus novemcinctus	87.61	3.00e-140	491.00
IUUC-Dor-030609	Dipodomys ordii	71.01	4.00e-107	381.00
IUUC-Ete-032487	Echinops telfairi	74.76	4.00e-71	261.00
IUUC-Eca-033391	Equus caballus	68.42	1.00e-114	405.00
IUUC-Eeu-035134	Erinaceus europaeus	85.02	4.00e-129	453.00
IUUC-Fca-036243	Felis catus	88.50	5.00e-142	496.00
IUUC-Fal-036600	Ficedula albicollis	99.41	4.00e-165	573.00
IUUC-Gmo-039665	Gadus morhua	71.47	2.00e-108	385.00
IUUC-Gga-040993	Gallus gallus	97.35	2.00e-161	561.00
IUUC-Ggo-044859	Gorilla gorilla	83.47	9.00e-101	359.00
IUUC-Hsa-046822	Homo sapiens	87.32	9.00e-140	489.00
IUUC-Hvu-047141	Hordeum vulgare	35.41	2.00e-26	113.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	86.96	1.00e-140	491.00
IUUC-Lpe-051132	Leersia perrieri	31.88	3.00e-28	119.00
IUUC-Loc-052469	Lepisosteus oculatus	67.83	3.00e-112	398.00
IUUC-Laf-053979	Loxodonta africana	83.53	1.00e-126	446.00
IUUC-Mcc-055682	Macaca mulatta	87.32	9.00e-140	489.00
IUUC-Meu-056004	Macropus eugenii	68.44	9.00e-107	379.00
IUUC-Mga-059466	Meleagris gallopavo	96.76	5.00e-160	556.00
IUUC-Mdo-062122	Monodelphis domestica	86.47	6.00e-140	490.00
IUUC-Mmu-063176	Mus musculus	86.43	2.00e-133	468.00
IUUC-Mac-064858	Musa acuminata	38.14	2.00e-21	95.90
IUUC-Mpu-065927	Mustela putorius furo	88.50	3.00e-142	498.00
IUUC-Mlu-067079	Myotis lucifugus	87.02	2.00e-149	521.00
IUUC-Nle-070180	Nomascus leucogenys	87.32	9.00e-140	489.00
IUUC-Opr-070847	Ochotona princeps	80.52	6.00e-125	440.00
IUUC-Oan-072783	Ornithorhynchus anatinus	84.59	5.00e-137	479.00
IUUC-Ocu-074527	Oryctolagus cuniculus	86.76	2.00e-138	485.00
IUUC-Oba-075256	Oryza barthii	32.42	2.00e-25	109.00
IUUC-Obr-076302	Oryza brachyantha	31.28	2.00e-29	122.00
IUUC-Ogl-077097	Oryza glaberrima	31.84	2.00e-27	116.00
IUUC-Ogu-078570	Oryza glumaepatula	31.56	4.00e-26	112.00
IUUC-Oin-079244	Oryza indica	31.84	2.00e-27	116.00
IUUC-Olo-080484	Oryza longistaminata	36.79	1.00e-22	100.00
IUUC-Ome-081814	Oryza meridionalis	32.40	7.00e-28	118.00
IUUC-Oni-082057	Oryza nivara	31.84	2.00e-27	116.00
IUUC-Opu-084176	Oryza punctata	32.77	8.00e-28	117.00
IUUC-Oru-084618	Oryza rufipogon	31.56	5.00e-26	111.00
IUUC-Osa-085602	Oryza sativa	31.56	4.00e-26	112.00
IUUC-Olu-087811	Ostreococcus lucimarinus	36.39	3.00e-43	168.00
IUUC-Oar-090348	Ovis aries	86.14	7.00e-143	499.00
IUUC-Ptr-091060	Pan troglodytes	87.32	9.00e-140	489.00
IUUC-Psi-093505	Pelodiscus sinensis	93.81	3.00e-155	541.00
IUUC-Pab-098591	Pongo abelii	87.32	8.00e-140	489.00
IUUC-Pop-099661	Populus trichocarpa	34.01	1.00e-31	130.00
IUUC-Pca-101029	Procavia capensis	84.39	2.00e-131	461.00
IUUC-Ppe-101495	Prunus persica	31.31	3.00e-28	119.00
IUUC-Pva-102244	Pteropus vampyrus	80.83	2.00e-129	454.00
IUUC-Rno-105861	Rattus norvegicus	86.18	3.00e-129	454.00
IUUC-Sha-107045	Sarcophilus harrisii	85.88	1.00e-138	486.00
IUUC-Ssl-108517	Sclerotinia sclerotiorum	21.26	3.10e+00	26.90
IUUC-Smo-109325	Selaginella moellendorffii	34.53	7.00e-37	147.00
IUUC-Sit-110624	Setaria italica	33.02	3.00e-26	112.00
IUUC-Sar-113169	Sorex araneus	82.89	3.00e-124	438.00
IUUC-Sbi-114305	Sorghum bicolor	33.12	7.00e-27	114.00
IUUC-Ssc-115766	Sus scrofa	86.73	3.00e-138	484.00
IUUC-Tae-123984	Triticum aestivum	34.54	4.00e-26	112.00
IUUC-Tur-126237	Triticum urartu	34.54	5.00e-26	111.00
IUUC-Tbe-128148	Tupaia belangeri	74.60	7.00e-94	337.00
IUUC-Ttr-128793	Tursiops truncatus	87.24	3.00e-138	484.00
IUUC-Vpa-130625	Vicugna pacos	79.15	1.00e-114	406.00
IUUC-Vvi-131312	Vitis vinifera	33.78	4.00e-33	135.00
IUUC-Xtr-131790	Xenopus tropicalis	86.43	9.00e-129	452.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence