iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000000335.3	ENSMMUT00000000490.3	ENSMMUP00000000454.2
ENSMMUG00000000335.3	ENSMMUT00000009250.3	ENSMMUP00000008691.3
ENSMMUG00000000335.3	ENSMMUT00000000487.3	ENSMMUP00000000451.3
ENSMMUG00000000335.3	ENSMMUT00000018932.3	ENSMMUP00000017729.3
ENSMMUG00000000335.3	ENSMMUT00000065274.1	ENSMMUP00000050746.1
ENSMMUG00000000335.3	ENSMMUT00000075068.1	ENSMMUP00000057309.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.40e-08	34.3	15	60
E3 activity/RING/U-box	2.10e-06	28.8	9	80

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl..qkwpglknssskefrCPlCr 46
           C+iCle + + pl+l CgH f++ C+  ++   ++  + +e +CP+Cr
   Q: 15   CPICLELLTE-PLSLHCGHSFCQACItaNHK-KSMLYKEGERSCPVCR 60
           ********99.***************86444.5666789999*****8 PP

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwl......asggktcPvtrqplteedlvPnltlrrliqa 67
           v ee  CpI lel ++P  l +G+++ +++I          ++g+++cPv+r + ++e++ Pn  + +++++
   Q: 9    VKEEVTCPICLELLTEPLSLHCGHSFCQACITANHkksmlyKEGERSCPVCRISYQPENIQPNRHVANIVEK 80
           78999**************************874433334455555*****************998887776 PP

Organism

Macaca mulatta

Functional Description
(View)

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV-agm). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).

Protein Sequence
(Fasta)

MASGILLNVK EEVTCPICLE LLTEPLSLHC GHSFCQACIT ANHKKSMLYK EGERSCPVCR 60
ISYQPENIQP NRHVANIVEK LREVKLSPEE GQKVDHCARH GEKLLLFCQE DSKVICWLCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCACTTTC CTGCCCCGAT GTGAGCAAGA ATTTCCTGCA CTTCCTCTAG GAAAATTCCT 60
TTGCGCAGAT CAGGCCCCTG GATTGGTGAC TGAATCCTAA CCGTGTCTTT CCTGGCCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0051--Antiviral defense
KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR032917--TRIM5
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:1990462--C:omegasome
GO:0000932--C:P-body
GO:0042802--F:identical protein binding
GO:0008329--F:signaling pattern recognition receptor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0002218--P:activation of innate immune response
GO:0006914--P:autophagy
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:0045071--P:negative regulation of viral genome replication
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410--P:positive regulation of MAPK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070534--P:protein K63-linked ubiquitination
GO:0031664--P:regulation of lipopolysaccharide-mediated signaling pathway
GO:0032880--P:regulation of protein localization

KEGG

mcc:574288

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013110	Bos taurus	57.37	1.00e-157	549.00
IUUC-Cja-019944	Callithrix jacchus	68.01	0.00e+00	652.00
IUUC-Csa-023609	Chlorocebus sabaeus	92.65	0.00e+00	988.00
IUUC-Cho-024416	Choloepus hoffmanni	61.87	3.00e-92	332.00
IUUC-Dor-030700	Dipodomys ordii	52.01	3.00e-144	504.00
IUUC-Ete-033021	Echinops telfairi	52.42	1.00e-122	432.00
IUUC-Ggo-044783	Gorilla gorilla	84.54	0.00e+00	824.00
IUUC-Hsa-046573	Homo sapiens	86.92	0.00e+00	865.00
IUUC-Kpa-049392	Komagataella pastoris	33.91	1.00e-09	57.00
IUUC-Mmr-061336	Microcebus murinus	60.84	4.00e-152	531.00
IUUC-Mlu-067695	Myotis lucifugus	59.57	2.00e-154	539.00
IUUC-Nle-069081	Nomascus leucogenys	82.49	0.00e+00	816.00
IUUC-Opr-071057	Ochotona princeps	52.23	2.00e-133	469.00
IUUC-Oar-090073	Ovis aries	56.20	4.00e-143	501.00
IUUC-Ptr-090927	Pan troglodytes	85.71	0.00e+00	843.00
IUUC-Pan-092730	Papio anubis	97.38	0.00e+00	1015.00
IUUC-Pab-098782	Pongo abelii	85.92	0.00e+00	859.00
IUUC-Sar-113094	Sorex araneus	48.70	5.00e-115	407.00
IUUC-Tsy-119055	Tarsius syrichta	60.83	1.00e-165	575.00
IUUC-Tbe-127426	Tupaia belangeri	52.60	1.00e-132	466.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence