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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105291
UUCD1 version UUC-RaN-00954
Ensembl Protein ID ENSRNOP00000009112.4
UniProt Accession Q9WUC8; PLRG1_RAT
Genbank Protein ID AAD24799.1; AAH87742.1
Protein Name Pleiotropic regulator 1
Genbank Nucleotide ID AF128241; BC087742
Gene Name Plrg1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000006655.7 ENSRNOT00000009113.7 ENSRNOP00000009112.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.10e-44 148.8 202 238
UBD/Beta-Prp 2.60e-63 214.3 297 490
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH ++v+c+a  ++   +v+Gs D tik+WDl +g+l
   Q: 202  GHLGWVRCIAVePGnQWFVTGSADRTIKIWDLASGKL 238
           8***********77799***************99987 PP
   

   UBD/Beta-Prp
   S: 19   spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgd 107
           +p  ++l+t srd+t ++wdv+t+  +++lsgh+++v++v+++  ++ ++tgs D ti++wdl +gk+ +tl++h++sv+++ ++p  +
   Q: 297  HPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPLHY 385
           67778899999999999999999999999999999999999999999999999999999999999999999999999999999999999 PP
   S: 108  klvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.......tgghtdsvyslsfd 189
           +++sGs d+ i+ w+ + g  ++  lsgh++++n+++v+  + +lvsG++++t+ lWd +tg   ++        + + ++ +   +fd
   Q: 386  TFASGSPDN-IKQWKFPDGGFIQ-NLSGHNAIINTLAVNT-DGVLVSGADNGTMHLWDWRTGYNFQRVhaavqpgSLDSESGIFACAFD 471
           999999665.8999999999999.9999999999999998.678899999999999999999888888765555533355555555599 PP
   S: 190  sngkelvsgsldgtvklwd 208
           ++  +l+++  d+t+k++ 
   Q: 472  RSESRLLTAEADKTIKVYR 490
           9999999999999999986 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.
 Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.
Protein Sequence
(Fasta)
MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN EYGPVLHMPT 60
SKENLKEKGP QNAPDSYPHK QYPANQGQDV EYLVTGTHPY PPGPGVALTA DTKIQRMPSE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105291|E3,WD_repeat;UBD,Beta-Prp|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCCGGCGAC AGGCCCCAAT CTCCGGAAGG AGCGGCAGAA TAGTGGCGGC GATTTCTGCG 60
TCGAGCATTT GGAGTTTCTT CGCTGCTGAA CGGGTAGACT AAACGGCGGC GACATGGTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105291|E3,WD_repeat;UBD,Beta-Prp|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005662--C:DNA replication factor A complex
GO:0001650--C:fibrillar center
GO:0031965--C:nuclear membrane
GO:0016607--C:nuclear speck
GO:0071011--C:precatalytic spliceosome
GO:0000974--C:Prp19 complex
GO:0000398--P:mRNA splicing, via spliceosome
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0034504--P:protein localization to nucleus
KEGG rno:60376
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000084 Aegilops tauschii 46.99 5.00e-129 454.00
IUUC-Aml-001605 Ailuropoda melanoleuca 95.71 0.00e+00 1025.00
IUUC-Atr-002757 Amborella trichopoda 49.59 4.00e-130 458.00
IUUC-Apl-003198 Anas platyrhynchos 88.95 0.00e+00 959.00
IUUC-Aca-004683 Anolis carolinensis 88.37 0.00e+00 944.00
IUUC-Aly-005775 Arabidopsis lyrata 60.53 2.00e-125 442.00
IUUC-Ath-007460 Arabidopsis thaliana 54.05 3.00e-126 445.00
IUUC-Ago-007884 Ashbya gossypii 47.31 3.00e-106 378.00
IUUC-Acl-008153 Aspergillus clavatus 64.02 1.00e-127 449.00
IUUC-Afl-008384 Aspergillus flavus 64.63 1.00e-128 452.00
IUUC-Afu-009045 Aspergillus fumigatus 64.63 2.00e-128 452.00
IUUC-Ani-009229 Aspergillus nidulans 62.03 7.00e-128 450.00
IUUC-Ang-009812 Aspergillus niger 64.98 2.00e-122 431.00
IUUC-Aor-010059 Aspergillus oryzae 64.63 1.00e-128 452.00
IUUC-Ate-010351 Aspergillus terreus 63.37 1.00e-135 476.00
IUUC-Ame-011613 Astyanax mexicanus 58.76 7.00e-154 536.00
IUUC-Bgr-012042 Blumeria graminis 63.72 1.00e-134 473.00
IUUC-Bta-012406 Bos taurus 94.56 0.00e+00 1012.00
IUUC-Bci-013760 Botrytis cinerea 63.04 6.00e-134 470.00
IUUC-Bdi-014776 Brachypodium distachyon 51.58 3.00e-130 458.00
IUUC-Bol-016189 Brassica oleracea 53.17 8.00e-126 443.00
IUUC-Bra-018044 Brassica rapa 53.17 1.00e-125 443.00
IUUC-Cel-018651 Caenorhabditis elegans 53.03 4.00e-155 541.00
IUUC-Cja-019974 Callithrix jacchus 95.72 0.00e+00 1034.00
IUUC-Cfa-021085 Canis familiaris 95.34 0.00e+00 1026.00
IUUC-Cpo-021458 Cavia porcellus 94.76 0.00e+00 1021.00
IUUC-Cre-022880 Chlamydomonas reinhardtii 60.18 5.00e-124 437.00
IUUC-Csa-023883 Chlorocebus sabaeus 96.30 0.00e+00 1039.00
IUUC-Cho-024623 Choloepus hoffmanni 93.92 0.00e+00 989.00
IUUC-Cin-025190 Ciona intestinalis 59.96 0.00e+00 644.00
IUUC-Csv-026367 Ciona savignyi 59.32 0.00e+00 654.00
IUUC-Cgl-026499 Colletotrichum gloeosporioides 64.69 6.00e-140 490.00
IUUC-Cne-027069 Cryptococcus neoformans 63.12 2.00e-126 446.00
IUUC-Cme-027233 Cyanidioschyzon merolae 31.08 4.00e-35 142.00
IUUC-Dre-028260 Danio rerio 77.91 0.00e+00 831.00
IUUC-Dno-029112 Dasypus novemcinctus 96.11 0.00e+00 1036.00
IUUC-Dor-031118 Dipodomys ordii 94.63 0.00e+00 798.00
IUUC-Dse-031493 Dothistroma septosporum 46.29 9.00e-126 443.00
IUUC-Dme-032138 Drosophila melanogaster 59.53 4.00e-171 593.00
IUUC-Ete-032411 Echinops telfairi 83.17 0.00e+00 828.00
IUUC-Eca-033521 Equus caballus 94.76 0.00e+00 1022.00
IUUC-Eeu-035249 Erinaceus europaeus 80.73 0.00e+00 655.00
IUUC-Fca-036358 Felis catus 94.95 0.00e+00 1022.00
IUUC-Fal-036933 Ficedula albicollis 89.53 0.00e+00 959.00
IUUC-Fox-037713 Fusarium oxysporum 56.93 5.00e-140 491.00
IUUC-Fso-038380 Fusarium solani 64.04 6.00e-139 487.00
IUUC-Gmo-039133 Gadus morhua 78.56 0.00e+00 832.00
IUUC-Ggr-039915 Gaeumannomyces graminis 66.36 3.00e-132 465.00
IUUC-Gga-041176 Gallus gallus 87.60 0.00e+00 948.00
IUUC-Gac-042344 Gasterosteus aculeatus 76.74 0.00e+00 829.00
IUUC-Gma-043328 Glycine max 50.40 1.00e-133 469.00
IUUC-Ggo-044478 Gorilla gorilla 96.11 0.00e+00 1037.00
IUUC-Hsa-046037 Homo sapiens 96.30 0.00e+00 1038.00
IUUC-Hvu-047349 Hordeum vulgare 50.51 2.00e-132 466.00
IUUC-Itr-048390 Ictidomys tridecemlineatus 96.31 0.00e+00 1038.00
IUUC-Kpa-049343 Komagataella pastoris 58.77 2.00e-118 419.00
IUUC-Lch-049830 Latimeria chalumnae 82.95 0.00e+00 891.00
IUUC-Lpe-051442 Leersia perrieri 48.97 2.00e-129 456.00
IUUC-Loc-051794 Lepisosteus oculatus 81.89 0.00e+00 852.00
IUUC-Lma-053137 Leptosphaeria maculans 45.03 9.00e-127 447.00
IUUC-Laf-053471 Loxodonta africana 95.13 0.00e+00 1018.00
IUUC-Mcc-055627 Macaca mulatta 96.11 0.00e+00 1036.00
IUUC-Meu-056148 Macropus eugenii 81.02 0.00e+00 862.00
IUUC-Mor-056960 Magnaporthe oryzae 61.28 7.00e-137 480.00
IUUC-Mtr-057816 Medicago truncatula 47.55 1.00e-126 446.00
IUUC-Mla-059031 Melampsora laricipopulina 60.39 2.00e-127 449.00
IUUC-Mga-059337 Meleagris gallopavo 87.94 0.00e+00 948.00
IUUC-Mvi-060217 Microbotryum violaceum 63.58 4.00e-129 454.00
IUUC-Mmr-061018 Microcebus murinus 96.12 0.00e+00 1034.00
IUUC-Mdo-062863 Monodelphis domestica 90.31 0.00e+00 942.00
IUUC-Mmu-063988 Mus musculus 98.44 0.00e+00 1050.00
IUUC-Mac-064459 Musa acuminata 48.33 8.00e-122 430.00
IUUC-Mpu-066559 Mustela putorius furo 95.53 0.00e+00 1027.00
IUUC-Mlu-067361 Myotis lucifugus 91.98 0.00e+00 973.00
IUUC-Nfi-068492 Neosartorya fischeri 64.94 1.00e-128 453.00
IUUC-Ncr-068808 Neurospora crassa 59.63 4.00e-137 481.00
IUUC-Nle-069875 Nomascus leucogenys 96.50 0.00e+00 1041.00
IUUC-Opr-070462 Ochotona princeps 96.24 3.00e-155 541.00
IUUC-Ont-071365 Oreochromis niloticus 76.94 0.00e+00 830.00
IUUC-Oan-072708 Ornithorhynchus anatinus 90.08 0.00e+00 969.00
IUUC-Ocu-074594 Oryctolagus cuniculus 95.73 0.00e+00 1027.00
IUUC-Oba-075570 Oryza barthii 59.61 1.00e-127 449.00
IUUC-Obr-076366 Oryza brachyantha 64.83 1.00e-91 329.00
IUUC-Ogl-077153 Oryza glaberrima 59.61 7.00e-127 447.00
IUUC-Ogu-078540 Oryza glumaepatula 59.61 2.00e-127 449.00
IUUC-Oin-079612 Oryza indica 57.29 1.00e-125 442.00
IUUC-Olo-081077 Oryza longistaminata 57.29 1.00e-125 442.00
IUUC-Ome-081236 Oryza meridionalis 57.03 1.00e-125 442.00
IUUC-Oni-082499 Oryza nivara 59.61 2.00e-127 449.00
IUUC-Opu-083499 Oryza punctata 57.29 2.00e-125 442.00
IUUC-Oru-084276 Oryza rufipogon 59.61 2.00e-127 449.00
IUUC-Osa-085849 Oryza sativa 59.61 2.00e-127 449.00
IUUC-Ola-086655 Oryzias latipes 76.21 0.00e+00 819.00
IUUC-Olu-087637 Ostreococcus lucimarinus 57.77 4.00e-119 421.00
IUUC-Oga-087934 Otolemur garnettii 95.74 0.00e+00 1028.00
IUUC-Oar-090185 Ovis aries 93.22 0.00e+00 998.00
IUUC-Ptr-091198 Pan troglodytes 96.50 0.00e+00 1041.00
IUUC-Pan-092622 Papio anubis 96.30 0.00e+00 1039.00
IUUC-Psi-093320 Pelodiscus sinensis 88.78 0.00e+00 952.00
IUUC-Pma-094638 Petromyzon marinus 76.50 0.00e+00 833.00
IUUC-Pno-094826 Phaeosphaeria nodorum 46.90 1.00e-106 379.00
IUUC-Ppa-095576 Physcomitrella patens 63.99 3.00e-124 438.00
IUUC-Pfo-096894 Poecilia formosa 77.22 0.00e+00 834.00
IUUC-Pab-098020 Pongo abelii 96.50 0.00e+00 1041.00
IUUC-Pop-099180 Populus trichocarpa 48.62 1.00e-127 449.00
IUUC-Pca-100909 Procavia capensis 89.59 0.00e+00 810.00
IUUC-Ppe-101346 Prunus persica 47.44 1.00e-126 446.00
IUUC-Pva-102167 Pteropus vampyrus 77.67 0.00e+00 785.00
IUUC-Pgr-103516 Puccinia graminis 50.10 7.00e-131 460.00
IUUC-Ptt-103738 Puccinia triticina 50.83 2.00e-131 462.00
IUUC-Pte-104352 Pyrenophora teres 58.19 3.00e-131 461.00
IUUC-Pyt-104632 Pyrenophora triticirepentis 58.77 3.00e-132 465.00
IUUC-Sce-106204 Saccharomyces cerevisiae 50.15 3.00e-103 368.00
IUUC-Sha-106943 Sarcophilus harrisii 89.36 0.00e+00 931.00
IUUC-Sja-107659 Schizosaccharomyces japonicus 65.08 1.00e-129 456.00
IUUC-Spo-108049 Schizosaccharomyces pombe 63.72 8.00e-134 470.00
IUUC-Smo-109043 Selaginella moellendorffii 61.38 1.00e-126 446.00
IUUC-Sit-110431 Setaria italica 58.12 1.00e-130 459.00
IUUC-Sly-111391 Solanum lycopersicum 48.74 2.00e-121 429.00
IUUC-Stu-112364 Solanum tuberosum 55.59 1.00e-95 342.00
IUUC-Sar-113450 Sorex araneus 97.13 0.00e+00 714.00
IUUC-Sbi-113829 Sorghum bicolor 50.31 2.00e-130 458.00
IUUC-Sre-115153 Sporisorium reilianum 61.16 4.00e-121 428.00
IUUC-Ssc-115798 Sus scrofa 94.57 0.00e+00 1013.00
IUUC-Tgu-117417 Taeniopygia guttata 89.67 0.00e+00 958.00
IUUC-Tru-117615 Takifugu rubripes 75.83 0.00e+00 783.00
IUUC-Tsy-119480 Tarsius syrichta 96.67 0.00e+00 1035.00
IUUC-Tni-119847 Tetraodon nigroviridis 75.39 0.00e+00 811.00
IUUC-Tca-121287 Theobroma cacao 47.75 2.00e-127 449.00
IUUC-Tre-122010 Trichoderma reesei 65.20 3.00e-143 501.00
IUUC-Tvi-122475 Trichoderma virens 61.46 5.00e-142 497.00
IUUC-Tae-124397 Triticum aestivum 50.31 3.00e-134 471.00
IUUC-Tur-126116 Triticum urartu 42.15 6.00e-101 361.00
IUUC-Tme-126992 Tuber melanosporum 65.55 5.00e-136 478.00
IUUC-Tbe-127803 Tupaia belangeri 84.81 0.00e+00 736.00
IUUC-Ttr-128933 Tursiops truncatus 95.15 0.00e+00 1019.00
IUUC-Uma-129447 Ustilago maydis 59.38 1.00e-116 413.00
IUUC-Vda-129780 Verticillium dahliae 63.82 4.00e-138 484.00
IUUC-Vpa-130557 Vicugna pacos 89.13 2.00e-118 419.00
IUUC-Vvi-130918 Vitis vinifera 47.13 1.00e-122 432.00
IUUC-Xtr-132409 Xenopus tropicalis 84.53 0.00e+00 877.00
IUUC-Xma-133420 Xiphophorus maculatus 77.33 0.00e+00 837.00
IUUC-Yli-134362 Yarrowia lipolytica 47.51 4.00e-121 428.00
IUUC-Zma-135804 Zea mays 56.88 1.00e-125 442.00
Created Date 25-Jun-2017

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