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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031616
UUCD1 version UUC-DrM-00040
Ensembl Protein ID FBpp0075275
UniProt Accession Q9VUX2; Q8MSR3; MIB_DROME
Genbank Protein ID AAF49551.3; AAM50016.1
Protein Name E3 ubiquitin-protein ligase mind-bomb; Mind bomb homolog; RING-type E3 ubiquitin transferase mind-bomb
Genbank Nucleotide ID AE014296; AY118647
Gene Name mib1; mind-bomb; CG5841
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0263601 FBtr0075520 FBpp0075275
FBgn0263601 FBtr0333578 FBpp0305755
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20176925; 19686683
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 60.46 0.00e+00 1208.00 IUUC-Hsa-046439
E3 activity/RING/RING 65.05 0.00e+00 1284.00 IUUC-Mmu-063520
E3 activity/RING/RING 48.89 3.00e-10 60.10 IUUC-Ots-000026
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination of Delta (Dl) and Serrate (Ser) receptors, which act as ligands of Notch proteins. Positively regulates the Notch signaling by ubiquitinating the intracellular domain of Dl and Ser, leading to endocytosis of Dl and Ser receptors. Regulates a subset of Notch signaling events, including wing margin specification, leg segmentation and vein determination, that are distinct from those events requiring neuralize (neur) activity. Also modulates lateral inhibition, a neur- and Dl-dependent signaling event, suggesting a distinct but partially complementary function with neur.
 E3 ubiquitin-protein ligase that mediates ubiquitination of Delta (Dl) and Serrate (Ser) receptors, which act as ligands of Notch proteins. Positively regulates the Notch signaling by ubiquitinating the intracellular domain of Dl and Ser, leading to endocytosis of Dl and Ser receptors. Regulates a subset of Notch signaling events, including wing margin specification, leg segmentation and vein determination, that are distinct from those events requiring neuralize (neur) activity. Also modulates lateral inhibition, a neur- and Dl-dependent signaling event, suggesting a distinct but partially complementary function with neur.
Protein Sequence
(Fasta)
MSCAATLSSA KDSTNANASG GGGGGGGGGA PTNSNTNTNT NTQSTAVGVV VSSAAGTGVG 60
VGGGGGGGGS LPGGTTSSSS ASAAGGVAAG GGGNSAAALV RRFSMEGVGA RVIRGPDWKW 120
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Protein Fasta Sequence


>IUUC-Dme-031616|E3,RING|Drosophila melanogaster
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Nucleotide Sequence
(Fasta)
AGATCTATCG CTTGCGCGAC TACGGTCACA TTCTTCGGTG GTTGTAAAAA TTCCGTGAGT 60
GTTTAGCAGC GACTCCGATT TTAAACGTGA ATTACCCAAC GAAAGAGTGC AGTATACCGT 120
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Nucleotide Fasta Sequence


>IUUC-Dme-031616|E3,RING|Drosophila melanogaster
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Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001370--BIR_rpt
IPR010606--Mib_Herc2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR000433--Znf_ZZ
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS51416--MIB_HERC2
PS50089--ZF_RING_2
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2
Pfam

PF12796--Ank_2
PF06701--MIB_HERC2
PF00569--ZZ
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00184--RING
SM00291--ZnF_ZZ
Gene Ontology

GO:0045179--C:apical cortex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0046331--P:lateral inhibition
GO:0007219--P:Notch signaling pathway
GO:0045747--P:positive regulation of Notch signaling pathway
GO:0008104--P:protein localization
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0008593--P:regulation of Notch signaling pathway
GO:0007423--P:sensory organ development
KEGG dme:Dmel_CG5841
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001993 Ailuropoda melanoleuca 66.19 0.00e+00 1285.00
IUUC-Apl-003867 Anas platyrhynchos 66.26 0.00e+00 1305.00
IUUC-Aca-004471 Anolis carolinensis 66.13 0.00e+00 1316.00
IUUC-Ame-011923 Astyanax mexicanus 63.25 0.00e+00 1207.00
IUUC-Bta-012972 Bos taurus 66.36 0.00e+00 1312.00
IUUC-Cel-018156 Caenorhabditis elegans 25.00 9.00e-13 68.20
IUUC-Cja-019044 Callithrix jacchus 62.35 0.00e+00 1127.00
IUUC-Cfa-020049 Canis familiaris 64.51 0.00e+00 1259.00
IUUC-Cpo-022228 Cavia porcellus 64.93 0.00e+00 1183.00
IUUC-Csa-023228 Chlorocebus sabaeus 66.57 0.00e+00 1315.00
IUUC-Cho-024456 Choloepus hoffmanni 64.55 4.00e-132 465.00
IUUC-Cin-025506 Ciona intestinalis 65.97 0.00e+00 840.00
IUUC-Csv-026037 Ciona savignyi 57.40 0.00e+00 1248.00
IUUC-Dre-028261 Danio rerio 61.20 0.00e+00 1375.00
IUUC-Dno-029816 Dasypus novemcinctus 66.57 0.00e+00 1316.00
IUUC-Dor-030678 Dipodomys ordii 57.40 0.00e+00 729.00
IUUC-Eca-033837 Equus caballus 64.81 0.00e+00 1180.00
IUUC-Eeu-034896 Erinaceus europaeus 58.24 8.00e-132 463.00
IUUC-Fca-036568 Felis catus 64.76 0.00e+00 1169.00
IUUC-Fal-037586 Ficedula albicollis 66.23 0.00e+00 1315.00
IUUC-Gmo-038802 Gadus morhua 60.96 0.00e+00 1390.00
IUUC-Gga-040131 Gallus gallus 66.23 0.00e+00 1315.00
IUUC-Gac-042052 Gasterosteus aculeatus 60.00 0.00e+00 1341.00
IUUC-Ggo-044970 Gorilla gorilla 66.57 0.00e+00 1315.00
IUUC-Hsa-046439 Homo sapiens 66.57 0.00e+00 1315.00
IUUC-Lch-049434 Latimeria chalumnae 62.36 0.00e+00 1221.00
IUUC-Loc-052278 Lepisosteus oculatus 62.50 0.00e+00 1236.00
IUUC-Lma-053158 Leptosphaeria maculans 31.48 2.00e-05 43.50
IUUC-Laf-054292 Loxodonta africana 64.16 0.00e+00 1167.00
IUUC-Meu-056752 Macropus eugenii 77.07 3.00e-96 345.00
IUUC-Mga-059408 Meleagris gallopavo 64.40 0.00e+00 1191.00
IUUC-Mmr-061628 Microcebus murinus 66.46 0.00e+00 1314.00
IUUC-Mdo-062055 Monodelphis domestica 66.43 0.00e+00 1315.00
IUUC-Mmu-063520 Mus musculus 66.36 0.00e+00 1326.00
IUUC-Mpu-065864 Mustela putorius furo 66.46 0.00e+00 1314.00
IUUC-Mlu-067802 Myotis lucifugus 64.81 0.00e+00 1180.00
IUUC-Ncr-068640 Neurospora crassa 41.67 6.00e-05 42.40
IUUC-Nle-069568 Nomascus leucogenys 65.45 0.00e+00 1271.00
IUUC-Opr-071018 Ochotona princeps 53.76 3.00e-116 412.00
IUUC-Ont-072079 Oreochromis niloticus 62.60 0.00e+00 1419.00
IUUC-Oan-073346 Ornithorhynchus anatinus 73.08 0.00e+00 998.00
IUUC-Ocu-073932 Oryctolagus cuniculus 66.46 0.00e+00 1314.00
IUUC-Ola-087184 Oryzias latipes 66.09 0.00e+00 1333.00
IUUC-Oga-089002 Otolemur garnettii 65.96 0.00e+00 1319.00
IUUC-Oar-089440 Ovis aries 64.71 0.00e+00 1183.00
IUUC-Ptr-090690 Pan troglodytes 66.06 0.00e+00 1296.00
IUUC-Pan-092295 Papio anubis 66.57 0.00e+00 1315.00
IUUC-Psi-093118 Pelodiscus sinensis 66.53 0.00e+00 1317.00
IUUC-Pma-094438 Petromyzon marinus 74.73 1.00e-168 584.00
IUUC-Pfo-096302 Poecilia formosa 62.59 0.00e+00 1246.00
IUUC-Pab-097804 Pongo abelii 61.81 2.00e-179 621.00
IUUC-Pca-101028 Procavia capensis 61.15 2.00e-147 516.00
IUUC-Pva-102890 Pteropus vampyrus 65.15 0.00e+00 651.00
IUUC-Pte-104190 Pyrenophora teres 41.38 2.00e-05 44.30
IUUC-Pyt-104763 Pyrenophora triticirepentis 41.38 2.00e-05 44.30
IUUC-Rno-105470 Rattus norvegicus 66.30 0.00e+00 1294.00
IUUC-Sha-106650 Sarcophilus harrisii 65.91 0.00e+00 1261.00
IUUC-Sja-108012 Schizosaccharomyces japonicus 44.68 2.00e-07 49.70
IUUC-Spo-108198 Schizosaccharomyces pombe 44.44 2.00e-07 49.30
IUUC-Smo-109365 Selaginella moellendorffii 32.54 8.00e-10 57.80
IUUC-Sar-113247 Sorex araneus 60.81 5.00e-167 580.00
IUUC-Ssc-115706 Sus scrofa 66.46 0.00e+00 1314.00
IUUC-Tgu-116863 Taeniopygia guttata 66.03 0.00e+00 1308.00
IUUC-Tru-117733 Takifugu rubripes 65.79 0.00e+00 1326.00
IUUC-Tsy-119313 Tarsius syrichta 60.06 0.00e+00 779.00
IUUC-Tni-120601 Tetraodon nigroviridis 65.07 0.00e+00 1320.00
IUUC-Tbe-127979 Tupaia belangeri 62.44 0.00e+00 928.00
IUUC-Ttr-128673 Tursiops truncatus 66.57 0.00e+00 1316.00
IUUC-Vpa-130332 Vicugna pacos 63.93 0.00e+00 1228.00
IUUC-Xtr-132423 Xenopus tropicalis 65.59 0.00e+00 1314.00
Created Date 25-Jun-2017

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