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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063726
UUCD1 version UUC-MuM-01211
Ensembl Protein ID ENSMUSP00000147619.1
UniProt Accession Q8BY87; Q32NY0; Q5EBP2; Q6KAR9; Q80V06; Q8BHU1; Q8BI15; Q8BI16; Q8BUW4; Q91X25; UBP47_MOUSE
Genbank Protein ID BAC27179.1; BAC27195.1; BAC30979.1; BAC38411.1; BAC40073.1; BAD21388.1; AAH12722.1; AAH24117.1; AAH89364.1; AAI08426.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 47; Deubiquitinating enzyme 47; Ubiquitin thioesterase 47; Ubiquitin-specific-processing protease 47
Genbank Nucleotide ID AK030909; AK030963; AK041541; AK082114; AK087981; AK131138; BC012722; BC024117; BC089364; BC108425
Gene Name Usp47
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000059263.9 ENSMUST00000106653.3 ENSMUSP00000102264.2
ENSMUSG00000059263.9 ENSMUST00000215510.1 ENSMUSP00000151051.1
ENSMUSG00000059263.9 ENSMUST00000210309.1 ENSMUSP00000147619.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 3.50e-75 254.4 188 562
Active Site
Position(s) Description Evidence
197 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
503 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl N+  tCY+NS+LQ+L+++pe+r++l +    ++++++ ++p +++  +lq+lf  l++skk+a++++++++++++ ++e    +q
   Q: 188  VGLVNQAMTCYLNSLLQTLFMTPEFRNALYK---WEFEDSE-EDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSE--AWQQ 270
           6******************************...5555554.6899*********************************9998..9*** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +D+qE++++++d+le++                           k++++ +li++l+qg+lk+ ++clec+ +  r ++ ld++l ++ 
   Q: 271  HDVQELCRVMFDALEQKW--------------------------KQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRP 333
           ******************..........................678999*************************************95 PP
   S: 179  ke.etkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
              +++  s++++L++f ++e l+g n+y+ce+ckkk++a+k l++ ++P  L+l+LkRf f+ ++++r+k+n++++fp+eLd+s f  
   Q: 334  YGsSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMSFPEELDMSTFID 422
           54045678******************************************************************************998 PP
   S: 267  speekqke.....................................................kkkYeLiavvvHsGslssGHYvayvkn. 301
            ++ek+ +                                                     +  YeL++v+vHsGs+ +GHY+a++k+ 
   Q: 423  IEDEKSPQtesctdsgaenegschsdqmsndfstddavdegiclesssgsekiskpgleknSLMYELFSVMVHSGSAAGGHYYACIKSf 511
           86666666788888888889999999999999999999999999999999999999999999**************************5 PP
   S: 302  ekgkWllfdDskVtevkeeevleetg................staYvlfYk 336
           ++++W+ f+D++V+ +++e++++++g                ++aY+l+Y+
   Q: 512  SDDQWYSFNDQHVSRITQEDIKKTHGgssgsrgyyssafassTNAYMLIYR 562
           5666*******************888************************8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER) (By similarity). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.
 Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER) (By similarity). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.
Protein Sequence
(Fasta)
MVPGEENQLV PKEDVFWRCR QNIFDEMKKK FLQIENAAEE PRVLCIIQDT TNSKTVSERI 60
TLNLPASTPV RKLFEDVANK VGYINGTFDL TRENGVTTAD MAPLDHTSDK SLLDANFEPG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063726|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGCAGCAG CGGCGACGGC GGCGGCGCCC TGGGTCGGTG TCTGCGCGCT GGTGTCTAAG 60
GCCTGAGCGG AGGCCTCCTC AGTTGCTGGA GCGCAGGCGG CTGGGAGGAT GACTGTCGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063726|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF14560--Ubiquitin_2
PF00443--UCH
Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071987--F:WD40-repeat domain binding
GO:0006284--P:base-excision repair
GO:0006974--P:cellular response to DNA damage stimulus
GO:0034644--P:cellular response to UV
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0043066--P:negative regulation of apoptotic process
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010972--P:negative regulation of G2/M transition of mitotic cell cycle
GO:1902230--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0030307--P:positive regulation of cell growth
GO:0042493--P:response to drug
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:74996
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002228 Ailuropoda melanoleuca 93.46 0.00e+00 2498.00
IUUC-Apl-003486 Anas platyrhynchos 88.04 0.00e+00 2313.00
IUUC-Aca-005061 Anolis carolinensis 86.77 0.00e+00 2378.00
IUUC-Ame-011206 Astyanax mexicanus 79.44 0.00e+00 2083.00
IUUC-Bta-012942 Bos taurus 94.03 0.00e+00 2513.00
IUUC-Cel-018600 Caenorhabditis elegans 37.45 2.00e-121 431.00
IUUC-Cja-018950 Callithrix jacchus 95.06 0.00e+00 2328.00
IUUC-Cfa-020299 Canis familiaris 95.19 0.00e+00 2512.00
IUUC-Cpo-021943 Cavia porcellus 94.79 0.00e+00 2500.00
IUUC-Csa-023285 Chlorocebus sabaeus 93.39 0.00e+00 2465.00
IUUC-Cho-025006 Choloepus hoffmanni 86.67 0.00e+00 2135.00
IUUC-Cin-025145 Ciona intestinalis 41.69 0.00e+00 724.00
IUUC-Csv-025839 Ciona savignyi 50.38 9.00e-167 581.00
IUUC-Dre-027959 Danio rerio 80.20 0.00e+00 2065.00
IUUC-Dno-030023 Dasypus novemcinctus 91.64 0.00e+00 2377.00
IUUC-Dor-030994 Dipodomys ordii 94.69 0.00e+00 944.00
IUUC-Dme-031604 Drosophila melanogaster 49.39 7.00e-147 515.00
IUUC-Ete-032596 Echinops telfairi 78.52 0.00e+00 1273.00
IUUC-Eca-033913 Equus caballus 93.84 0.00e+00 2508.00
IUUC-Eeu-034518 Erinaceus europaeus 87.61 0.00e+00 2118.00
IUUC-Fca-035997 Felis catus 94.47 0.00e+00 2532.00
IUUC-Fal-037088 Ficedula albicollis 88.76 0.00e+00 2080.00
IUUC-Gmo-038920 Gadus morhua 76.92 0.00e+00 2008.00
IUUC-Gga-040953 Gallus gallus 88.15 0.00e+00 2338.00
IUUC-Gac-042400 Gasterosteus aculeatus 78.36 0.00e+00 2040.00
IUUC-Ggo-044820 Gorilla gorilla 92.20 0.00e+00 2412.00
IUUC-Hsa-046634 Homo sapiens 94.69 0.00e+00 2514.00
IUUC-Lch-050440 Latimeria chalumnae 84.31 0.00e+00 2272.00
IUUC-Loc-051904 Lepisosteus oculatus 83.07 0.00e+00 2216.00
IUUC-Laf-053760 Loxodonta africana 93.75 0.00e+00 2519.00
IUUC-Mcc-054637 Macaca mulatta 94.84 0.00e+00 2522.00
IUUC-Meu-056904 Macropus eugenii 92.76 0.00e+00 1641.00
IUUC-Mga-059556 Meleagris gallopavo 87.60 0.00e+00 2303.00
IUUC-Mmr-061192 Microcebus murinus 95.20 0.00e+00 2531.00
IUUC-Mdo-061929 Monodelphis domestica 93.10 0.00e+00 2511.00
IUUC-Mpu-066014 Mustela putorius furo 94.94 0.00e+00 2496.00
IUUC-Mlu-067232 Myotis lucifugus 94.29 0.00e+00 2487.00
IUUC-Nle-069619 Nomascus leucogenys 93.24 0.00e+00 2461.00
IUUC-Opr-070224 Ochotona princeps 90.69 0.00e+00 1126.00
IUUC-Ont-071384 Oreochromis niloticus 79.67 0.00e+00 2081.00
IUUC-Oan-073208 Ornithorhynchus anatinus 86.91 0.00e+00 2353.00
IUUC-Ocu-074285 Oryctolagus cuniculus 94.91 0.00e+00 2526.00
IUUC-Ola-087051 Oryzias latipes 78.74 0.00e+00 2006.00
IUUC-Oga-088928 Otolemur garnettii 94.72 0.00e+00 2498.00
IUUC-Oar-090215 Ovis aries 94.45 0.00e+00 2514.00
IUUC-Ptr-091035 Pan troglodytes 94.69 0.00e+00 2518.00
IUUC-Pan-092377 Papio anubis 94.28 0.00e+00 2471.00
IUUC-Pfo-096722 Poecilia formosa 79.11 0.00e+00 2057.00
IUUC-Pab-098723 Pongo abelii 94.69 0.00e+00 2516.00
IUUC-Pca-100105 Procavia capensis 89.29 0.00e+00 2291.00
IUUC-Pva-102514 Pteropus vampyrus 94.79 0.00e+00 927.00
IUUC-Rno-105384 Rattus norvegicus 97.97 0.00e+00 2570.00
IUUC-Sha-106982 Sarcophilus harrisii 89.24 0.00e+00 2434.00
IUUC-Sar-113723 Sorex araneus 84.96 0.00e+00 920.00
IUUC-Ssc-115671 Sus scrofa 95.12 0.00e+00 2004.00
IUUC-Tgu-116722 Taeniopygia guttata 86.58 0.00e+00 2308.00
IUUC-Tru-118380 Takifugu rubripes 76.88 0.00e+00 2056.00
IUUC-Tsy-119646 Tarsius syrichta 88.55 0.00e+00 2286.00
IUUC-Tni-120762 Tetraodon nigroviridis 77.36 0.00e+00 2085.00
IUUC-Tbe-127861 Tupaia belangeri 92.67 0.00e+00 2311.00
IUUC-Ttr-129254 Tursiops truncatus 89.25 0.00e+00 1419.00
IUUC-Vpa-130141 Vicugna pacos 95.40 0.00e+00 1158.00
IUUC-Xtr-132700 Xenopus tropicalis 80.51 0.00e+00 2174.00
Created Date 25-Jun-2017

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