iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004309

UUCD1 version

UUC-AnC-00013

Ensembl Protein ID

ENSACAP00000004180.3

UniProt Accession

G1KCQ3; G1KCQ3_ANOCA

Protein Name

Uncharacterized protein

Gene Name

CUL3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000004212.3	ENSACAT00000004279.3	ENSACAP00000004180.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	1.60e-230	766.9	37	665

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeqlLktynreWekfreqlkvlrkifay 89
           l++a+++i+r++++  ++eely+++y+++l+k+g+klY+ l+ev++e++ ++v+++v +s ++++L+t+n++W++++++++++r+i++y
   Q: 37   LKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLiNKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMY 125
           799*********************************************99*************************************** PP
   S: 90   ldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleat 176
           +dr+yv++ ++v++v++L+l ++r+++v++  i+++l ++ll++i++eRkge+vdr  +++++++l+ L+l+ +++y+e+FEa+fle++
   Q: 126  MDRVYVQQ-NNVENVYNLGLIIFRDQVVRYgcIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMS 213
           ********.******************************************************************************** PP
   S: 177  qefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll....aelvallrdkktedlsrmykL 261
           +ef+++es++fl+en+ + Y+kkvear+nee er++++l++ste+++++vve+eli+kh+++++    ++lv++l++ ktedl++mykL
   Q: 214  AEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVemenSGLVHMLKNGKTEDLACMYKL 302
           ****************************************************************99999******************** PP
   S: 262  lsrvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaakspE 350
           +srv+ngl++++++++s+++eqgka++++e + k+p++y++ ll+lk++++++++e+Fnnd+ F ++++ +fe+f+n n     ++spE
   Q: 303  FSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLN-----SRSPE 386
           *******************************************************************************.....***** PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           +l+ +iD++L+k++kglte+e+e++ldk++++f++++ekdvFe+yYk+hLa+RLl++ks+s+++E+++i+kLk+ecg++ftskLe+Mf+
   Q: 387  YLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFR 475
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFkeekentees.esvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkael. 526
           d+++S++++++F+++ + t  s  +v+l+v+vL++g+Wpt+s+t+k+++P+  ++++e+f++fYl khsgR+L++qh++g+a+l+a++ 
   Q: 476  DMSISNTTMDEFRQHLQTTGVSlGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFy 564
           ********************99889**************************************************************** PP
   S: 527  .....................kkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqvlkkepeskei 592
                                +++k++lqVstfQm++L++fnn+ek+++ee++++t++pe+eL r+lqsL+++k  ++vl+kep+skei
   Q: 565  gpvkkedgsevgvggaqvtgsNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKptQRVLTKEPKSKEI 653
           *********999999998888888***************************************************************** PP
   S: 593  eeedlfsvNqef 604
           e++++f+vN++f
   Q: 654  ENGHIFTVNDQF 665
           **********99 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MSNLSKGTGS RKDTKMRIRA FPMTMDEKYV NSIWDLLKNA IQEIQRKNNS GLSFEELYRN 60
AYTMVLHKHG EKLYTGLREV VTEHLINKVR EDVLNSLNNN FLQTLNQAWN DHQTAMVMIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGAACC TGAGCAAAGG CACGGGCAGC CGGAAGGATA CCAAGATGCG GATCCGAGCC 60
TTCCCGGTGA GTGAGGGAAG GAAGGAAGGG AGTTGGGAGA GTTGGCTACG ACGACGCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0005634--C:nucleus
GO:0005827--C:polar microtubule
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0016477--P:cell migration
GO:0000902--P:cell morphogenesis
GO:0048208--P:COPII vesicle coating
GO:0040016--P:embryonic cleavage
GO:0044346--P:fibroblast apoptotic process
GO:0007369--P:gastrulation
GO:0007229--P:integrin-mediated signaling pathway
GO:0072576--P:liver morphogenesis
GO:0007080--P:mitotic metaphase plate congression
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032467--P:positive regulation of cytokinesis
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0017145--P:stem cell division
GO:0043149--P:stress fiber assembly
GO:0071630--P:ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome
GO:0016055--P:Wnt signaling pathway

KEGG

acs:100559387

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000335	Aegilops tauschii	47.32	0.00e+00	685.00
IUUC-Aml-002278	Ailuropoda melanoleuca	98.97	0.00e+00	1554.00
IUUC-Atr-002616	Amborella trichopoda	52.36	0.00e+00	774.00
IUUC-Apl-004172	Anas platyrhynchos	100.00	0.00e+00	1522.00
IUUC-Aly-005566	Arabidopsis lyrata	51.64	0.00e+00	769.00
IUUC-Ath-007587	Arabidopsis thaliana	52.03	0.00e+00	774.00
IUUC-Ago-007795	Ashbya gossypii	25.29	1.00e-48	188.00
IUUC-Acl-008317	Aspergillus clavatus	36.48	3.00e-145	508.00
IUUC-Afl-008727	Aspergillus flavus	36.53	2.00e-144	506.00
IUUC-Afu-008879	Aspergillus fumigatus	37.96	5.00e-133	468.00
IUUC-Ani-009393	Aspergillus nidulans	35.55	4.00e-136	478.00
IUUC-Ang-009626	Aspergillus niger	36.44	1.00e-141	496.00
IUUC-Aor-010207	Aspergillus oryzae	36.53	2.00e-144	506.00
IUUC-Ate-010305	Aspergillus terreus	37.16	1.00e-140	493.00
IUUC-Ame-011805	Astyanax mexicanus	96.88	0.00e+00	1517.00
IUUC-Bgr-012098	Blumeria graminis	36.02	4.00e-121	428.00
IUUC-Bta-013445	Bos taurus	99.87	0.00e+00	1567.00
IUUC-Bci-013612	Botrytis cinerea	36.61	2.00e-139	489.00
IUUC-Bdi-014269	Brachypodium distachyon	52.55	0.00e+00	749.00
IUUC-Bol-015350	Brassica oleracea	52.16	0.00e+00	772.00
IUUC-Bra-016763	Brassica rapa	52.29	0.00e+00	775.00
IUUC-Cel-018641	Caenorhabditis elegans	48.66	0.00e+00	729.00
IUUC-Cja-019175	Callithrix jacchus	99.74	0.00e+00	1565.00
IUUC-Cfa-020905	Canis familiaris	99.47	0.00e+00	1523.00
IUUC-Cpo-021293	Cavia porcellus	97.78	0.00e+00	1528.00
IUUC-Cre-022776	Chlamydomonas reinhardtii	48.30	0.00e+00	700.00
IUUC-Csa-023800	Chlorocebus sabaeus	99.61	0.00e+00	1563.00
IUUC-Cho-024839	Choloepus hoffmanni	98.82	0.00e+00	1355.00
IUUC-Cin-025201	Ciona intestinalis	71.63	0.00e+00	1030.00
IUUC-Csv-026107	Ciona savignyi	71.24	0.00e+00	1096.00
IUUC-Cgl-026630	Colletotrichum gloeosporioides	35.43	1.00e-124	440.00
IUUC-Cne-027048	Cryptococcus neoformans	34.80	1.00e-117	417.00
IUUC-Cme-027254	Cyanidioschyzon merolae	31.00	2.00e-88	319.00
IUUC-Dre-028488	Danio rerio	97.53	0.00e+00	1531.00
IUUC-Dno-029784	Dasypus novemcinctus	99.74	0.00e+00	1565.00
IUUC-Dor-030682	Dipodomys ordii	92.49	0.00e+00	1367.00
IUUC-Dse-031326	Dothistroma septosporum	35.74	3.00e-128	452.00
IUUC-Dme-032112	Drosophila melanogaster	69.57	0.00e+00	1082.00
IUUC-Ete-032347	Echinops telfairi	81.33	0.00e+00	1196.00
IUUC-Eca-033560	Equus caballus	99.73	0.00e+00	1520.00
IUUC-Eeu-034502	Erinaceus europaeus	97.79	0.00e+00	1345.00
IUUC-Fca-035544	Felis catus	99.87	0.00e+00	1520.00
IUUC-Fal-036751	Ficedula albicollis	99.87	0.00e+00	1522.00
IUUC-Fox-037857	Fusarium oxysporum	36.92	1.00e-137	483.00
IUUC-Fso-038163	Fusarium solani	36.73	2.00e-141	496.00
IUUC-Gmo-039270	Gadus morhua	97.02	0.00e+00	1531.00
IUUC-Ggr-039999	Gaeumannomyces graminis	33.88	5.00e-128	451.00
IUUC-Gga-040329	Gallus gallus	99.87	0.00e+00	1568.00
IUUC-Gac-041510	Gasterosteus aculeatus	96.90	0.00e+00	1527.00
IUUC-Gma-043182	Glycine max	52.34	0.00e+00	748.00
IUUC-Ggo-044903	Gorilla gorilla	99.46	0.00e+00	1511.00
IUUC-Hsa-046000	Homo sapiens	99.61	0.00e+00	1563.00
IUUC-Hvu-047831	Hordeum vulgare	52.46	0.00e+00	701.00
IUUC-Itr-049067	Ictidomys tridecemlineatus	99.78	0.00e+00	940.00
IUUC-Kpa-049372	Komagataella pastoris	35.07	2.00e-115	410.00
IUUC-Lch-050458	Latimeria chalumnae	97.52	0.00e+00	1521.00
IUUC-Lpe-051396	Leersia perrieri	51.76	0.00e+00	758.00
IUUC-Loc-052186	Lepisosteus oculatus	98.83	0.00e+00	1554.00
IUUC-Lma-053030	Leptosphaeria maculans	38.55	7.00e-144	504.00
IUUC-Laf-053684	Loxodonta africana	99.87	0.00e+00	1520.00
IUUC-Mcc-055770	Macaca mulatta	99.61	0.00e+00	1563.00
IUUC-Meu-056852	Macropus eugenii	99.73	0.00e+00	762.00
IUUC-Mor-057273	Magnaporthe oryzae	34.76	3.00e-133	469.00
IUUC-Mpo-057403	Magnaporthe poae	34.00	7.00e-130	457.00
IUUC-Mtr-058317	Medicago truncatula	51.51	0.00e+00	751.00
IUUC-Mla-059055	Melampsora laricipopulina	37.40	2.00e-133	469.00
IUUC-Mga-060076	Meleagris gallopavo	98.26	0.00e+00	1490.00
IUUC-Mvi-060470	Microbotryum violaceum	33.52	2.00e-135	476.00
IUUC-Mmr-060976	Microcebus murinus	99.87	0.00e+00	1567.00
IUUC-Mdo-062741	Monodelphis domestica	99.87	0.00e+00	1567.00
IUUC-Mmu-063905	Mus musculus	99.61	0.00e+00	1563.00
IUUC-Mac-064718	Musa acuminata	50.79	0.00e+00	731.00
IUUC-Mpu-066356	Mustela putorius furo	99.87	0.00e+00	1520.00
IUUC-Mlu-067768	Myotis lucifugus	99.33	0.00e+00	1516.00
IUUC-Nfi-068285	Neosartorya fischeri	37.20	2.00e-146	512.00
IUUC-Ncr-068883	Neurospora crassa	36.28	2.00e-138	486.00
IUUC-Nle-069638	Nomascus leucogenys	99.60	0.00e+00	1514.00
IUUC-Opr-070333	Ochotona princeps	90.75	0.00e+00	1270.00
IUUC-Ont-071601	Oreochromis niloticus	98.18	0.00e+00	1576.00
IUUC-Oan-073281	Ornithorhynchus anatinus	99.84	0.00e+00	1303.00
IUUC-Ocu-074504	Oryctolagus cuniculus	99.73	0.00e+00	1522.00
IUUC-Oba-075332	Oryza barthii	52.31	0.00e+00	749.00
IUUC-Obr-076435	Oryza brachyantha	53.12	0.00e+00	715.00
IUUC-Ogl-077655	Oryza glaberrima	52.29	0.00e+00	761.00
IUUC-Ogu-078458	Oryza glumaepatula	52.31	0.00e+00	751.00
IUUC-Oin-079567	Oryza indica	52.16	0.00e+00	758.00
IUUC-Olo-080930	Oryza longistaminata	53.02	0.00e+00	758.00
IUUC-Ome-081353	Oryza meridionalis	52.29	0.00e+00	759.00
IUUC-Oni-082378	Oryza nivara	52.29	0.00e+00	761.00
IUUC-Opu-084055	Oryza punctata	52.16	0.00e+00	760.00
IUUC-Oru-084202	Oryza rufipogon	52.31	0.00e+00	751.00
IUUC-Osa-085290	Oryza sativa	52.29	0.00e+00	761.00
IUUC-Ola-087562	Oryzias latipes	97.92	0.00e+00	1541.00
IUUC-Olu-087866	Ostreococcus lucimarinus	37.79	1.00e-139	490.00
IUUC-Oga-088833	Otolemur garnettii	99.87	0.00e+00	1520.00
IUUC-Oar-089958	Ovis aries	99.87	0.00e+00	1520.00
IUUC-Ptr-091013	Pan troglodytes	99.61	0.00e+00	1563.00
IUUC-Pan-091796	Papio anubis	98.93	0.00e+00	1507.00
IUUC-Psi-093564	Pelodiscus sinensis	98.12	0.00e+00	1486.00
IUUC-Pno-094939	Phaeosphaeria nodorum	38.22	2.00e-138	486.00
IUUC-Ppa-095920	Physcomitrella patens	51.84	0.00e+00	765.00
IUUC-Pfo-097498	Poecilia formosa	93.77	0.00e+00	1523.00
IUUC-Pab-098164	Pongo abelii	99.61	0.00e+00	1563.00
IUUC-Pop-099497	Populus trichocarpa	53.08	0.00e+00	787.00
IUUC-Pca-100702	Procavia capensis	91.67	0.00e+00	1393.00
IUUC-Ppe-101971	Prunus persica	51.70	0.00e+00	735.00
IUUC-Pva-103129	Pteropus vampyrus	99.74	0.00e+00	1567.00
IUUC-Pgr-103684	Puccinia graminis	36.44	2.00e-110	393.00
IUUC-Ptt-103961	Puccinia triticina	36.62	2.00e-109	390.00
IUUC-Pte-104325	Pyrenophora teres	38.06	1.00e-135	477.00
IUUC-Pyt-104746	Pyrenophora triticirepentis	37.09	1.00e-133	470.00
IUUC-Rno-105935	Rattus norvegicus	99.73	0.00e+00	1519.00
IUUC-Sce-106354	Saccharomyces cerevisiae	26.88	6.00e-53	202.00
IUUC-Sha-106569	Sarcophilus harrisii	99.27	0.00e+00	1384.00
IUUC-Sja-107676	Schizosaccharomyces japonicus	38.51	2.00e-154	539.00
IUUC-Spo-108135	Schizosaccharomyces pombe	37.52	3.00e-138	485.00
IUUC-Smo-109555	Selaginella moellendorffii	53.49	0.00e+00	790.00
IUUC-Sit-110763	Setaria italica	52.94	0.00e+00	764.00
IUUC-Sly-111090	Solanum lycopersicum	51.84	0.00e+00	763.00
IUUC-Stu-112351	Solanum tuberosum	51.97	0.00e+00	765.00
IUUC-Sar-113144	Sorex araneus	99.82	0.00e+00	1117.00
IUUC-Sbi-114690	Sorghum bicolor	52.16	0.00e+00	764.00
IUUC-Sre-115005	Sporisorium reilianum	38.04	2.00e-135	476.00
IUUC-Ssc-116053	Sus scrofa	99.64	0.00e+00	1141.00
IUUC-Tgu-116523	Taeniopygia guttata	99.87	0.00e+00	1520.00
IUUC-Tru-118189	Takifugu rubripes	94.01	0.00e+00	1445.00
IUUC-Tsy-118962	Tarsius syrichta	93.54	0.00e+00	1388.00
IUUC-Tni-120614	Tetraodon nigroviridis	57.35	0.00e+00	880.00
IUUC-Tca-121282	Theobroma cacao	52.68	0.00e+00	769.00
IUUC-Tre-122201	Trichoderma reesei	35.88	3.00e-134	472.00
IUUC-Tvi-122321	Trichoderma virens	36.36	6.00e-135	474.00
IUUC-Tae-124292	Triticum aestivum	51.90	0.00e+00	744.00
IUUC-Tur-126800	Triticum urartu	51.63	0.00e+00	741.00
IUUC-Tme-127053	Tuber melanosporum	40.48	1.00e-156	546.00
IUUC-Tbe-127427	Tupaia belangeri	85.06	0.00e+00	1164.00
IUUC-Ttr-128662	Tursiops truncatus	97.99	0.00e+00	1480.00
IUUC-Uma-129597	Ustilago maydis	38.40	1.00e-134	474.00
IUUC-Vda-129726	Verticillium dahliae	35.26	7.00e-134	471.00
IUUC-Vpa-130809	Vicugna pacos	100.00	0.00e+00	746.00
IUUC-Vvi-131630	Vitis vinifera	52.42	0.00e+00	757.00
IUUC-Xtr-131887	Xenopus tropicalis	98.83	0.00e+00	1551.00
IUUC-Xma-133517	Xiphophorus maculatus	98.05	0.00e+00	1544.00
IUUC-Yli-134576	Yarrowia lipolytica	33.46	3.00e-111	395.00
IUUC-Zma-135030	Zea mays	52.60	0.00e+00	771.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence