iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033581

Ensembl Protein ID

ENSECAP00000005837.1

UniProt Accession

F7CK20; F7CK20_HORSE

Protein Name

Tyrosine-protein kinase

Gene Name

FGR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000007837.1	ENSECAT00000007886.1	ENSECAP00000005837.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.50e-16	59.1	79	135

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++lydyea ++d+Lt++kG++ +++  ++++++W+++ +  +g+ G +P+n+v+ ++
   Q: 79   LFIALYDYEARTEDDLTFTKGEKFHIL--NNTEGDWWEARSLSSGQTGYIPSNYVAPVD 135
           5789***********************..8999**********************9987 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MGCVFCKKLE PGPKEDAGLE GDLRGYGAAD HYGPDPTQGR PSSSFAHIPN YNNFSPQPAS 60
SAFLDAGTIR GISGTGVTLF IALYDYEART EDDLTFTKGE KFHILNNTEG DWWEARSLSS 120

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Nucleotide Sequence
(Fasta)

GCTCATTTAG AGGGGCTCCC CAAGGGACCC TGGTGGCCTC GGCTTCTGAC CTGGGGCCTT 60
TCCCTGATAT GGGGATAGGA GCAAGCTCTG TGATGTGTAA GTGTTCACTT TGCTCTGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0016235--C:aggresome
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0050830--P:defense response to Gram-positive bacterium
GO:0045087--P:innate immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0030335--P:positive regulation of cell migration
GO:0050715--P:positive regulation of cytokine secretion
GO:0043306--P:positive regulation of mast cell degranulation
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0042127--P:regulation of cell proliferation
GO:0008360--P:regulation of cell shape
GO:0045088--P:regulation of innate immune response
GO:0050764--P:regulation of phagocytosis
GO:0045859--P:regulation of protein kinase activity
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

ecb:100056804

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001938	Ailuropoda melanoleuca	93.36	0.00e+00	1028.00
IUUC-Aca-004483	Anolis carolinensis	73.03	0.00e+00	803.00
IUUC-Bta-012607	Bos taurus	92.79	0.00e+00	1030.00
IUUC-Cja-018914	Callithrix jacchus	87.85	0.00e+00	972.00
IUUC-Cfa-020165	Canis familiaris	91.84	0.00e+00	1016.00
IUUC-Cpo-021476	Cavia porcellus	90.89	0.00e+00	990.00
IUUC-Csa-023692	Chlorocebus sabaeus	91.30	0.00e+00	1017.00
IUUC-Dno-028920	Dasypus novemcinctus	91.46	0.00e+00	1013.00
IUUC-Dme-031976	Drosophila melanogaster	60.83	1.00e-162	566.00
IUUC-Fca-036499	Felis catus	92.98	0.00e+00	1037.00
IUUC-Ggo-044640	Gorilla gorilla	90.93	0.00e+00	1012.00
IUUC-Hsa-046751	Homo sapiens	90.74	0.00e+00	1010.00
IUUC-Itr-048218	Ictidomys tridecemlineatus	92.22	0.00e+00	1015.00
IUUC-Loc-052620	Lepisosteus oculatus	72.83	0.00e+00	804.00
IUUC-Laf-054128	Loxodonta africana	90.89	0.00e+00	1018.00
IUUC-Mcc-054715	Macaca mulatta	90.93	0.00e+00	1014.00
IUUC-Meu-056155	Macropus eugenii	83.63	0.00e+00	793.00
IUUC-Mmr-060615	Microcebus murinus	92.84	0.00e+00	1016.00
IUUC-Mmu-063286	Mus musculus	85.96	0.00e+00	954.00
IUUC-Mpu-066641	Mustela putorius furo	93.36	0.00e+00	1032.00
IUUC-Oan-073486	Ornithorhynchus anatinus	80.53	0.00e+00	888.00
IUUC-Ocu-074552	Oryctolagus cuniculus	92.21	0.00e+00	1006.00
IUUC-Oga-088731	Otolemur garnettii	92.22	0.00e+00	1026.00
IUUC-Oar-090207	Ovis aries	92.79	0.00e+00	1026.00
IUUC-Ptr-090979	Pan troglodytes	90.93	0.00e+00	1013.00
IUUC-Pan-092188	Papio anubis	91.30	0.00e+00	1017.00
IUUC-Pab-098617	Pongo abelii	90.55	0.00e+00	1011.00
IUUC-Pca-100834	Procavia capensis	80.46	0.00e+00	862.00
IUUC-Rno-104945	Rattus norvegicus	85.39	0.00e+00	940.00
IUUC-Sha-107103	Sarcophilus harrisii	76.84	0.00e+00	827.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence