iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012825

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

DNA excision repair protein ERCC-8

Genbank Nucleotide ID

BT021196

Gene Name

ERCC8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000021606.5	ENSBTAT00000028792.5	ENSBTAP00000028792.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.50e-29	100.2	98	130

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           H+ sv  +++  +d +++ s+s D+t+kvWD+ 
   Q: 98   HKYSVETVQWypHDtGMFTSSSFDKTLKVWDTN 130
           8999*******9778****************75 PP

Organism

Bos taurus

Functional Description
(View)

Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (By similarity).

Protein Sequence
(Fasta)

MLGFLSARQA GLEDPLRLRR AESTRRVLGL ELNKDRDVER IHCSGVNTLD IEPVEGRYML 60
SGGSDGVIVL YDLENSSRQP YYTCKAVCSV GRSHPDVHKY SVETVQWYPH DTGMFTSSSF 120

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Nucleotide Sequence
(Fasta)

CAGTTCACAA GCCAATGTGA AAGAACGGGA TGCTAGGGTT CTTGTCGGCT CGACAAGCGG 60
GTTTAGAAGA CCCTCTTCGC CTCCGGAGAG CAGAGTCCAC ACGGAGGTAA AGAGAGCCTT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0016363--C:nuclear matrix
GO:0000109--C:nucleotide-excision repair complex
GO:0043234--C:protein complex
GO:0032403--F:protein complex binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006289--P:nucleotide-excision repair
GO:0045739--P:positive regulation of DNA repair
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006979--P:response to oxidative stress
GO:0009411--P:response to UV
GO:0010165--P:response to X-ray
GO:0006283--P:transcription-coupled nucleotide-excision repair

KEGG

bta:518857

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001170	Aegilops tauschii	32.10	1.00e-37	152.00
IUUC-Aml-002201	Ailuropoda melanoleuca	94.46	0.00e+00	780.00
IUUC-Atr-002784	Amborella trichopoda	37.02	2.00e-40	159.00
IUUC-Apl-003202	Anas platyrhynchos	81.32	0.00e+00	658.00
IUUC-Aca-004708	Anolis carolinensis	82.76	6.00e-179	619.00
IUUC-Aly-006144	Arabidopsis lyrata	33.50	3.00e-64	239.00
IUUC-Ath-006673	Arabidopsis thaliana	40.67	8.00e-45	174.00
IUUC-Acl-008195	Aspergillus clavatus	39.39	1.00e-42	167.00
IUUC-Afl-008406	Aspergillus flavus	37.65	2.00e-38	153.00
IUUC-Afu-008759	Aspergillus fumigatus	36.23	1.00e-39	157.00
IUUC-Ani-009380	Aspergillus nidulans	36.42	4.00e-41	162.00
IUUC-Ang-009820	Aspergillus niger	38.34	1.00e-38	154.00
IUUC-Aor-010092	Aspergillus oryzae	38.26	1.00e-43	170.00
IUUC-Ate-010491	Aspergillus terreus	37.72	2.00e-44	173.00
IUUC-Bci-013856	Botrytis cinerea	32.69	7.00e-54	204.00
IUUC-Bdi-014899	Brachypodium distachyon	34.41	2.00e-65	243.00
IUUC-Bol-015337	Brassica oleracea	38.36	2.00e-43	170.00
IUUC-Bra-018089	Brassica rapa	32.36	3.00e-65	242.00
IUUC-Cja-018725	Callithrix jacchus	93.20	0.00e+00	771.00
IUUC-Cfa-021162	Canis familiaris	94.96	0.00e+00	780.00
IUUC-Cpo-022190	Cavia porcellus	93.45	0.00e+00	776.00
IUUC-Cre-022960	Chlamydomonas reinhardtii	35.91	1.00e-39	157.00
IUUC-Csa-023610	Chlorocebus sabaeus	93.95	0.00e+00	780.00
IUUC-Cho-024689	Choloepus hoffmanni	92.45	0.00e+00	709.00
IUUC-Cin-025324	Ciona intestinalis	39.62	3.00e-80	291.00
IUUC-Csv-026059	Ciona savignyi	38.27	2.00e-74	272.00
IUUC-Cgl-026384	Colletotrichum gloeosporioides	34.81	2.00e-40	160.00
IUUC-Cme-027182	Cyanidioschyzon merolae	28.66	1.00e-12	68.20
IUUC-Dre-028696	Danio rerio	72.64	8.00e-177	612.00
IUUC-Dno-029102	Dasypus novemcinctus	94.71	0.00e+00	781.00
IUUC-Dor-030361	Dipodomys ordii	76.07	2.00e-174	604.00
IUUC-Dse-031167	Dothistroma septosporum	29.98	6.00e-45	174.00
IUUC-Ete-032856	Echinops telfairi	76.32	2.00e-175	607.00
IUUC-Eca-033611	Equus caballus	95.58	0.00e+00	672.00
IUUC-Eeu-034583	Erinaceus europaeus	72.54	4.00e-161	560.00
IUUC-Fca-036481	Felis catus	94.46	0.00e+00	778.00
IUUC-Fal-037327	Ficedula albicollis	80.00	1.00e-166	578.00
IUUC-Fox-037684	Fusarium oxysporum	33.78	3.00e-44	172.00
IUUC-Fso-038306	Fusarium solani	34.84	1.00e-54	207.00
IUUC-Gmo-039043	Gadus morhua	69.70	7.00e-167	579.00
IUUC-Ggr-039783	Gaeumannomyces graminis	32.28	1.00e-38	154.00
IUUC-Gga-041085	Gallus gallus	86.49	0.00e+00	638.00
IUUC-Gac-042328	Gasterosteus aculeatus	68.24	5.00e-160	556.00
IUUC-Gma-043004	Glycine max	32.48	4.00e-55	208.00
IUUC-Ggo-045627	Gorilla gorilla	85.57	0.00e+00	705.00
IUUC-Hsa-046028	Homo sapiens	93.95	0.00e+00	780.00
IUUC-Hvu-047678	Hordeum vulgare	29.25	4.00e-31	128.00
IUUC-Itr-048648	Ictidomys tridecemlineatus	94.46	0.00e+00	782.00
IUUC-Kpa-049386	Komagataella pastoris	29.04	2.00e-42	166.00
IUUC-Lch-050590	Latimeria chalumnae	80.75	7.00e-163	566.00
IUUC-Lpe-051725	Leersia perrieri	33.76	5.00e-37	148.00
IUUC-Loc-051788	Lepisosteus oculatus	76.02	0.00e+00	629.00
IUUC-Lma-053082	Leptosphaeria maculans	34.27	5.00e-54	205.00
IUUC-Laf-053809	Loxodonta africana	94.96	0.00e+00	796.00
IUUC-Mcc-054998	Macaca mulatta	94.66	2.00e-161	561.00
IUUC-Meu-055929	Macropus eugenii	77.64	0.00e+00	638.00
IUUC-Mor-057003	Magnaporthe oryzae	33.33	9.00e-48	184.00
IUUC-Mtr-057921	Medicago truncatula	32.57	1.00e-57	216.00
IUUC-Mga-059449	Meleagris gallopavo	65.98	4.00e-125	441.00
IUUC-Mmr-061609	Microcebus murinus	91.58	0.00e+00	731.00
IUUC-Mdo-062564	Monodelphis domestica	85.93	0.00e+00	723.00
IUUC-Mmu-063904	Mus musculus	90.43	0.00e+00	748.00
IUUC-Mac-064716	Musa acuminata	27.21	4.00e-41	162.00
IUUC-Mpu-066617	Mustela putorius furo	94.96	0.00e+00	781.00
IUUC-Mlu-067054	Myotis lucifugus	93.20	0.00e+00	770.00
IUUC-Nfi-068467	Neosartorya fischeri	36.90	7.00e-34	137.00
IUUC-Nle-069731	Nomascus leucogenys	93.95	0.00e+00	780.00
IUUC-Opr-070297	Ochotona princeps	68.20	3.00e-87	315.00
IUUC-Ont-072558	Oreochromis niloticus	70.82	1.00e-165	575.00
IUUC-Oan-072864	Ornithorhynchus anatinus	89.47	1.00e-27	113.00
IUUC-Ocu-074415	Oryctolagus cuniculus	93.95	0.00e+00	781.00
IUUC-Oba-075759	Oryza barthii	41.58	7.00e-43	168.00
IUUC-Obr-076387	Oryza brachyantha	29.38	1.00e-45	177.00
IUUC-Ogl-077924	Oryza glaberrima	39.55	3.00e-18	84.70
IUUC-Ogu-078186	Oryza glumaepatula	34.88	2.00e-62	233.00
IUUC-Oin-079389	Oryza indica	34.18	5.00e-47	181.00
IUUC-Olo-080916	Oryza longistaminata	28.92	7.00e-17	80.10
IUUC-Ome-081471	Oryza meridionalis	40.53	4.00e-40	159.00
IUUC-Oni-082449	Oryza nivara	41.05	6.00e-40	158.00
IUUC-Opu-083210	Oryza punctata	29.55	3.00e-53	202.00
IUUC-Oru-085159	Oryza rufipogon	41.58	4.00e-43	169.00
IUUC-Osa-085926	Oryza sativa	41.89	5.00e-33	133.00
IUUC-Ola-087084	Oryzias latipes	69.27	3.00e-168	584.00
IUUC-Olu-087853	Ostreococcus lucimarinus	29.37	9.00e-39	154.00
IUUC-Oga-089008	Otolemur garnettii	93.48	0.00e+00	782.00
IUUC-Oar-089259	Ovis aries	99.24	0.00e+00	823.00
IUUC-Ptr-091112	Pan troglodytes	93.15	0.00e+00	769.00
IUUC-Pan-092303	Papio anubis	91.47	4.00e-67	246.00
IUUC-Psi-093050	Pelodiscus sinensis	83.21	0.00e+00	697.00
IUUC-Pma-094259	Petromyzon marinus	57.92	4.00e-131	461.00
IUUC-Pno-094798	Phaeosphaeria nodorum	31.89	7.00e-52	197.00
IUUC-Ppa-095477	Physcomitrella patens	31.37	7.00e-56	211.00
IUUC-Pfo-096855	Poecilia formosa	67.91	3.00e-164	571.00
IUUC-Pab-098096	Pongo abelii	93.20	0.00e+00	773.00
IUUC-Pop-098800	Populus trichocarpa	26.96	5.00e-47	181.00
IUUC-Pca-100187	Procavia capensis	95.63	2.00e-116	412.00
IUUC-Ppe-101759	Prunus persica	38.22	2.00e-44	173.00
IUUC-Pva-102438	Pteropus vampyrus	80.49	1.00e-93	336.00
IUUC-Pte-104197	Pyrenophora teres	33.05	2.00e-49	189.00
IUUC-Pyt-104421	Pyrenophora triticirepentis	33.90	4.00e-49	188.00
IUUC-Rno-106087	Rattus norvegicus	91.18	0.00e+00	766.00
IUUC-Sce-106276	Saccharomyces cerevisiae	27.32	2.00e-12	67.00
IUUC-Sha-106831	Sarcophilus harrisii	82.66	0.00e+00	694.00
IUUC-Sja-107681	Schizosaccharomyces japonicus	33.33	2.00e-55	209.00
IUUC-Spo-108294	Schizosaccharomyces pombe	35.07	3.00e-64	238.00
IUUC-Ssl-108613	Sclerotinia sclerotiorum	32.67	9.00e-52	197.00
IUUC-Smo-109008	Selaginella moellendorffii	40.05	4.00e-75	275.00
IUUC-Sit-110300	Setaria italica	31.58	6.00e-54	204.00
IUUC-Sly-111441	Solanum lycopersicum	30.02	1.00e-47	184.00
IUUC-Stu-111995	Solanum tuberosum	30.66	1.00e-47	183.00
IUUC-Sar-113196	Sorex araneus	83.65	2.00e-125	442.00
IUUC-Sbi-113790	Sorghum bicolor	40.49	1.00e-42	167.00
IUUC-Ssc-115609	Sus scrofa	95.97	0.00e+00	795.00
IUUC-Tgu-116927	Taeniopygia guttata	80.70	0.00e+00	663.00
IUUC-Tru-118164	Takifugu rubripes	69.98	4.00e-172	597.00
IUUC-Tsy-119151	Tarsius syrichta	88.41	0.00e+00	726.00
IUUC-Tni-120896	Tetraodon nigroviridis	69.15	6.00e-162	563.00
IUUC-Tca-121592	Theobroma cacao	38.22	6.00e-45	174.00
IUUC-Tre-122023	Trichoderma reesei	35.15	5.00e-50	191.00
IUUC-Tvi-122507	Trichoderma virens	36.99	7.00e-52	197.00
IUUC-Tae-125730	Triticum aestivum	40.82	6.00e-43	168.00
IUUC-Tur-126092	Triticum urartu	31.27	1.00e-35	143.00
IUUC-Tbe-127422	Tupaia belangeri	71.16	3.00e-148	517.00
IUUC-Ttr-129097	Tursiops truncatus	93.20	0.00e+00	769.00
IUUC-Vda-130014	Verticillium dahliae	36.05	6.00e-50	191.00
IUUC-Vpa-130782	Vicugna pacos	95.47	0.00e+00	795.00
IUUC-Vvi-131494	Vitis vinifera	27.67	3.00e-47	182.00
IUUC-Xtr-132165	Xenopus tropicalis	78.11	2.00e-180	624.00
IUUC-Xma-133205	Xiphophorus maculatus	68.58	2.00e-167	581.00
IUUC-Yli-134614	Yarrowia lipolytica	33.33	3.00e-57	215.00
IUUC-Zma-135861	Zea mays	35.21	4.00e-62	231.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence