iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107653

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01215236

Gene Name

FBXW7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000002129.1	ENSSHAT00000002429.1	ENSSHAP00000002403.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.60e-60	197.4	624	657
UBD/Beta-Prp	8.70e-103	343.7	375	657

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 624  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 657
           9*********449******************976 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl 
   Q: 375  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAITGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLY 459
           6799************..*******************************************..************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           gh+++v+++++++  +++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht
   Q: 460  GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HT 542
           *************..************************.****************..***************************9.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           ++vysl+fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq++n++ ++
   Q: 543  NRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 627
           *********9..9**************************************..************************************ PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkknep 299
           v++l+f++n +++ s+d++v++w+lk+ e+
   Q: 628  VTCLQFNKNFVITSSDDGTVKLWDLKTGEF 657
           *************************98776 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MNQELLSVGS KRRRTGGSLR GNSSSSQVDE DQMNRVVEEE QHQQQQLRQE EEHIARNGEV 60
IGADPRHGDQ NDSQQEQLEE NNNRFISVDE ESTGIQEEQE DDEEHAGEQD EEDEEEEEMD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAGAATGAA AGAAAAATAG ATGAATATTG AAAATATGTA TTTTTTTCAT TTTCTCAACA 60
GAATGTGAAA ACCTTTGCAT CTTCAGATAG TCTAGCCAAG GTCCAAGAAG TAGCAAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0032876--P:negative regulation of DNA endoreduplication
GO:0045741--P:positive regulation of epidermal growth factor-activated receptor activity
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:1903146--P:regulation of mitophagy
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007062--P:sister chromatid cohesion

KEGG

shr:100935329

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	33.63	2.00e-30	128.00
IUUC-Aml-002406	Ailuropoda melanoleuca	97.03	0.00e+00	1221.00
IUUC-Apl-003489	Anas platyrhynchos	90.40	0.00e+00	1188.00
IUUC-Aca-005318	Anolis carolinensis	97.64	0.00e+00	1098.00
IUUC-Ago-007794	Ashbya gossypii	31.07	1.00e-61	231.00
IUUC-Acl-008123	Aspergillus clavatus	32.40	7.00e-75	275.00
IUUC-Afl-008730	Aspergillus flavus	31.33	7.00e-74	271.00
IUUC-Afu-009014	Aspergillus fumigatus	32.33	3.00e-75	276.00
IUUC-Ani-009332	Aspergillus nidulans	33.47	3.00e-80	292.00
IUUC-Ang-009790	Aspergillus niger	31.52	4.00e-75	275.00
IUUC-Aor-010215	Aspergillus oryzae	30.71	1.00e-74	274.00
IUUC-Ate-010535	Aspergillus terreus	32.09	5.00e-75	275.00
IUUC-Ame-010898	Astyanax mexicanus	93.80	0.00e+00	1045.00
IUUC-Bgr-012075	Blumeria graminis	33.47	2.00e-79	290.00
IUUC-Bta-012391	Bos taurus	98.37	0.00e+00	1109.00
IUUC-Bci-013725	Botrytis cinerea	33.20	4.00e-78	285.00
IUUC-Cel-018495	Caenorhabditis elegans	48.73	2.00e-131	462.00
IUUC-Cja-018902	Callithrix jacchus	95.76	0.00e+00	1214.00
IUUC-Cfa-020237	Canis familiaris	95.79	0.00e+00	1214.00
IUUC-Cpo-022234	Cavia porcellus	98.37	0.00e+00	1111.00
IUUC-Cre-022837	Chlamydomonas reinhardtii	37.54	7.00e-49	187.00
IUUC-Csa-023532	Chlorocebus sabaeus	95.62	0.00e+00	1190.00
IUUC-Cho-025026	Choloepus hoffmanni	83.19	0.00e+00	769.00
IUUC-Cin-025516	Ciona intestinalis	70.64	3.00e-141	494.00
IUUC-Csv-026312	Ciona savignyi	75.47	0.00e+00	754.00
IUUC-Cgl-026492	Colletotrichum gloeosporioides	34.82	7.00e-85	308.00
IUUC-Cne-027018	Cryptococcus neoformans	33.08	4.00e-73	269.00
IUUC-Cme-027168	Cyanidioschyzon merolae	31.10	5.00e-31	129.00
IUUC-Dre-028303	Danio rerio	93.54	0.00e+00	1048.00
IUUC-Dno-029576	Dasypus novemcinctus	93.79	0.00e+00	1196.00
IUUC-Dor-030196	Dipodomys ordii	91.67	0.00e+00	1203.00
IUUC-Dse-031558	Dothistroma septosporum	38.98	2.00e-70	260.00
IUUC-Dme-031702	Drosophila melanogaster	76.41	0.00e+00	801.00
IUUC-Ete-032791	Echinops telfairi	90.56	0.00e+00	1001.00
IUUC-Eca-033424	Equus caballus	98.37	0.00e+00	1109.00
IUUC-Eeu-034996	Erinaceus europaeus	92.25	0.00e+00	1175.00
IUUC-Fca-036422	Felis catus	95.92	0.00e+00	1230.00
IUUC-Fal-037267	Ficedula albicollis	97.99	0.00e+00	1096.00
IUUC-Fox-037800	Fusarium oxysporum	34.07	3.00e-84	306.00
IUUC-Fso-038258	Fusarium solani	34.21	2.00e-83	303.00
IUUC-Gmo-039119	Gadus morhua	83.55	0.00e+00	901.00
IUUC-Ggr-039781	Gaeumannomyces graminis	34.46	5.00e-85	308.00
IUUC-Gga-040667	Gallus gallus	93.50	0.00e+00	1180.00
IUUC-Gac-042423	Gasterosteus aculeatus	74.63	0.00e+00	803.00
IUUC-Ggo-044422	Gorilla gorilla	95.62	0.00e+00	1193.00
IUUC-Hsa-045898	Homo sapiens	95.48	0.00e+00	1193.00
IUUC-Itr-048241	Ictidomys tridecemlineatus	99.36	0.00e+00	974.00
IUUC-Kpa-049097	Komagataella pastoris	31.92	3.00e-76	279.00
IUUC-Lch-050414	Latimeria chalumnae	95.69	0.00e+00	1086.00
IUUC-Loc-052348	Lepisosteus oculatus	96.16	0.00e+00	1071.00
IUUC-Lma-053185	Leptosphaeria maculans	32.20	7.00e-72	265.00
IUUC-Laf-054054	Loxodonta africana	95.92	0.00e+00	1231.00
IUUC-Mcc-055056	Macaca mulatta	95.62	0.00e+00	1190.00
IUUC-Meu-056778	Macropus eugenii	96.41	0.00e+00	752.00
IUUC-Mor-057133	Magnaporthe oryzae	39.13	9.00e-74	271.00
IUUC-Mpo-057423	Magnaporthe poae	40.06	8.00e-72	264.00
IUUC-Mla-059081	Melampsora laricipopulina	32.57	1.00e-76	280.00
IUUC-Mga-059255	Meleagris gallopavo	93.08	0.00e+00	1170.00
IUUC-Mvi-060490	Microbotryum violaceum	38.75	4.00e-67	250.00
IUUC-Mmr-061292	Microcebus murinus	95.62	0.00e+00	1214.00
IUUC-Mdo-062304	Monodelphis domestica	95.77	0.00e+00	1217.00
IUUC-Mmu-063610	Mus musculus	92.97	0.00e+00	1238.00
IUUC-Mpu-065931	Mustela putorius furo	96.75	0.00e+00	1219.00
IUUC-Mlu-066976	Myotis lucifugus	95.76	0.00e+00	1231.00
IUUC-Nfi-068428	Neosartorya fischeri	31.73	5.00e-75	275.00
IUUC-Ncr-068688	Neurospora crassa	35.97	2.00e-87	316.00
IUUC-Nle-070174	Nomascus leucogenys	95.34	0.00e+00	1192.00
IUUC-Opr-070851	Ochotona princeps	86.05	0.00e+00	653.00
IUUC-Ont-071997	Oreochromis niloticus	94.15	0.00e+00	1072.00
IUUC-Oan-072936	Ornithorhynchus anatinus	94.22	0.00e+00	1247.00
IUUC-Ocu-074742	Oryctolagus cuniculus	99.28	0.00e+00	1137.00
IUUC-Obr-076806	Oryza brachyantha	31.52	1.00e-29	125.00
IUUC-Oin-079809	Oryza indica	31.52	7.00e-30	126.00
IUUC-Ola-087098	Oryzias latipes	93.90	0.00e+00	1059.00
IUUC-Olu-087837	Ostreococcus lucimarinus	34.47	4.00e-38	150.00
IUUC-Oga-088884	Otolemur garnettii	99.47	0.00e+00	785.00
IUUC-Oar-090220	Ovis aries	94.10	0.00e+00	1181.00
IUUC-Ptr-090492	Pan troglodytes	95.48	0.00e+00	1193.00
IUUC-Pan-091770	Papio anubis	96.05	0.00e+00	1190.00
IUUC-Psi-093207	Pelodiscus sinensis	98.37	0.00e+00	1110.00
IUUC-Pma-094749	Petromyzon marinus	83.49	0.00e+00	944.00
IUUC-Pno-095026	Phaeosphaeria nodorum	38.83	7.00e-71	262.00
IUUC-Pfo-096493	Poecilia formosa	94.37	0.00e+00	1060.00
IUUC-Pab-098141	Pongo abelii	98.37	0.00e+00	1109.00
IUUC-Pca-100571	Procavia capensis	95.77	0.00e+00	846.00
IUUC-Pva-102988	Pteropus vampyrus	96.47	0.00e+00	1216.00
IUUC-Pgr-103612	Puccinia graminis	35.41	6.00e-62	232.00
IUUC-Ptt-103698	Puccinia triticina	35.55	1.00e-41	164.00
IUUC-Pte-104275	Pyrenophora teres	32.17	2.00e-73	270.00
IUUC-Pyt-104438	Pyrenophora triticirepentis	38.81	9.00e-70	258.00
IUUC-Rno-105706	Rattus norvegicus	98.57	0.00e+00	1136.00
IUUC-Sce-106314	Saccharomyces cerevisiae	29.59	8.00e-61	228.00
IUUC-Sja-107840	Schizosaccharomyces japonicus	33.83	6.00e-79	288.00
IUUC-Spo-108115	Schizosaccharomyces pombe	31.72	9.00e-63	234.00
IUUC-Sar-113600	Sorex araneus	91.10	0.00e+00	1109.00
IUUC-Sre-114901	Sporisorium reilianum	48.13	2.00e-67	251.00
IUUC-Ssc-115787	Sus scrofa	94.21	0.00e+00	1181.00
IUUC-Tgu-117510	Taeniopygia guttata	93.08	0.00e+00	1173.00
IUUC-Tru-117819	Takifugu rubripes	94.33	0.00e+00	1083.00
IUUC-Tsy-118828	Tarsius syrichta	96.75	0.00e+00	1230.00
IUUC-Tni-120468	Tetraodon nigroviridis	94.52	0.00e+00	1072.00
IUUC-Tre-122193	Trichoderma reesei	36.25	4.00e-85	308.00
IUUC-Tvi-122615	Trichoderma virens	35.03	9.00e-84	304.00
IUUC-Tme-127021	Tuber melanosporum	34.89	8.00e-84	304.00
IUUC-Tbe-127925	Tupaia belangeri	99.63	0.00e+00	1102.00
IUUC-Ttr-128899	Tursiops truncatus	95.48	0.00e+00	1209.00
IUUC-Uma-129449	Ustilago maydis	46.89	1.00e-66	248.00
IUUC-Vda-129802	Verticillium dahliae	36.40	1.00e-87	317.00
IUUC-Vpa-130082	Vicugna pacos	94.99	0.00e+00	1032.00
IUUC-Xtr-132213	Xenopus tropicalis	87.80	0.00e+00	1154.00
IUUC-Xma-133646	Xiphophorus maculatus	94.71	0.00e+00	1053.00
IUUC-Yli-134429	Yarrowia lipolytica	34.07	2.00e-86	313.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence