iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088980

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03133423

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000009885.2	ENSOGAT00000009888.2	ENSOGAP00000008842.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-66	217.2	197	240
UBD/Beta-Prp	2.90e-78	263.0	106	301

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t++++      ++ ++++s+s Dg+++vWD++ g++++
   Q: 197  GHSKWITAMSWeplhtnPEcRYVASSSKDGSVRVWDTTAGRCER 240
           8**************998899*********************86 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdl+t ++  t +gh + vls+s+sp+g++l+sG +   i +wd +tg  +  t
   Q: 106  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLNTETPHFTCNGHRHWVLSISWSPDGKRLASGCKNGQILLWDPSTGMQVGRT 194
           5789************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++ +++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv++l +  +g  l s+s+d+t+k+w  + g   r
   Q: 195  LTGHSKWITAMSWeplhtNPECRYVASSSKDGSVRVWDTTAGRCERILTG-HTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 281
           *********98762222267889**************************9.************98.9********************** PP
   S: 217  tlnghtdnvksvrfspnderl 237
           tl+gh  +v+ +++s  d  l
   Q: 282  TLQGHGHWVNTMALS-TDYAL 301
           *************99.44444 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MAAAVVDEAA AGDVQRLLVQ FQDEGGQLLG SPFDVPVDIT PDRLQLVCNA LLAQEDPLPL 60
AFYVHDAEIT SSLGKTLESQ AVETEKVVDI IYQPQAIFRV RAVTRCTSSL EGHSEAVISV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGCTG CGGTGGTGGT GGGTGTGCGT GGATGGGGGA GGGGGCGTCA CTGCAGAGCG 60
TTCGGGCTCG GGTCCGCCAG GCCGGAGGGA GGCGAAGCGG GGGCCTTACG GCCGGCCGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	58.37	9.00e-170	589.00
IUUC-Aml-001793	Ailuropoda melanoleuca	95.98	0.00e+00	938.00
IUUC-Atr-002507	Amborella trichopoda	58.64	2.00e-168	585.00
IUUC-Apl-003964	Anas platyrhynchos	83.04	0.00e+00	805.00
IUUC-Aly-006396	Arabidopsis lyrata	54.47	4.00e-160	557.00
IUUC-Ath-007278	Arabidopsis thaliana	54.68	4.00e-160	557.00
IUUC-Ago-007951	Ashbya gossypii	47.44	1.00e-128	452.00
IUUC-Acl-008298	Aspergillus clavatus	46.88	6.00e-119	421.00
IUUC-Afl-008581	Aspergillus flavus	51.53	9.00e-108	383.00
IUUC-Afu-008906	Aspergillus fumigatus	46.20	1.00e-119	422.00
IUUC-Ani-009189	Aspergillus nidulans	44.31	2.00e-115	409.00
IUUC-Ang-009630	Aspergillus niger	50.49	4.00e-122	431.00
IUUC-Aor-010038	Aspergillus oryzae	46.89	2.00e-125	442.00
IUUC-Ate-010278	Aspergillus terreus	46.49	1.00e-121	429.00
IUUC-Ame-011890	Astyanax mexicanus	80.17	0.00e+00	824.00
IUUC-Bgr-012011	Blumeria graminis	47.41	2.00e-128	452.00
IUUC-Bta-012964	Bos taurus	95.77	0.00e+00	937.00
IUUC-Bci-013592	Botrytis cinerea	49.02	1.00e-118	419.00
IUUC-Bdi-015035	Brachypodium distachyon	58.67	9.00e-172	596.00
IUUC-Bol-015501	Brassica oleracea	55.34	3.00e-160	557.00
IUUC-Bra-017642	Brassica rapa	55.13	1.00e-159	555.00
IUUC-Cel-018430	Caenorhabditis elegans	57.08	3.00e-165	574.00
IUUC-Cja-019125	Callithrix jacchus	95.77	0.00e+00	936.00
IUUC-Cfa-021013	Canis familiaris	95.38	0.00e+00	855.00
IUUC-Cpo-021743	Cavia porcellus	95.77	0.00e+00	937.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	45.80	4.00e-116	411.00
IUUC-Csa-024270	Chlorocebus sabaeus	95.77	0.00e+00	937.00
IUUC-Cin-025795	Ciona intestinalis	65.88	0.00e+00	681.00
IUUC-Csv-025953	Ciona savignyi	66.52	0.00e+00	680.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	51.99	8.00e-109	387.00
IUUC-Cne-026901	Cryptococcus neoformans	49.20	5.00e-139	487.00
IUUC-Cme-027281	Cyanidioschyzon merolae	47.25	4.00e-116	411.00
IUUC-Dre-028515	Danio rerio	76.58	0.00e+00	796.00
IUUC-Dno-029596	Dasypus novemcinctus	95.35	0.00e+00	933.00
IUUC-Dor-030494	Dipodomys ordii	95.33	0.00e+00	926.00
IUUC-Dse-031538	Dothistroma septosporum	47.08	3.00e-128	452.00
IUUC-Dme-031974	Drosophila melanogaster	59.61	1.00e-169	589.00
IUUC-Ete-032948	Echinops telfairi	97.13	1.00e-117	416.00
IUUC-Eca-033399	Equus caballus	96.60	0.00e+00	939.00
IUUC-Eeu-035013	Erinaceus europaeus	95.69	6.00e-117	414.00
IUUC-Fca-035860	Felis catus	95.14	0.00e+00	929.00
IUUC-Fal-037069	Ficedula albicollis	87.60	5.00e-132	463.00
IUUC-Fox-038059	Fusarium oxysporum	46.00	7.00e-125	440.00
IUUC-Fso-038445	Fusarium solani	46.20	3.00e-125	441.00
IUUC-Gmo-039319	Gadus morhua	75.37	0.00e+00	735.00
IUUC-Ggr-040095	Gaeumannomyces graminis	46.67	5.00e-121	427.00
IUUC-Gga-040303	Gallus gallus	85.60	3.00e-130	457.00
IUUC-Gac-042267	Gasterosteus aculeatus	78.27	0.00e+00	763.00
IUUC-Gma-043974	Glycine max	56.60	2.00e-167	582.00
IUUC-Ggo-044637	Gorilla gorilla	95.75	0.00e+00	928.00
IUUC-Hsa-046128	Homo sapiens	95.98	0.00e+00	939.00
IUUC-Hvu-047373	Hordeum vulgare	57.84	3.00e-170	591.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	95.19	0.00e+00	936.00
IUUC-Kpa-049274	Komagataella pastoris	44.02	4.00e-125	441.00
IUUC-Lch-049907	Latimeria chalumnae	82.77	0.00e+00	826.00
IUUC-Lpe-050778	Leersia perrieri	53.81	5.00e-153	533.00
IUUC-Loc-051889	Lepisosteus oculatus	80.17	0.00e+00	828.00
IUUC-Lma-053041	Leptosphaeria maculans	48.25	7.00e-116	411.00
IUUC-Laf-053598	Loxodonta africana	95.77	0.00e+00	939.00
IUUC-Mcc-055660	Macaca mulatta	95.56	0.00e+00	934.00
IUUC-Meu-056197	Macropus eugenii	79.79	0.00e+00	774.00
IUUC-Mor-056949	Magnaporthe oryzae	45.64	1.00e-117	416.00
IUUC-Mpo-057571	Magnaporthe poae	53.70	4.00e-63	235.00
IUUC-Mtr-058530	Medicago truncatula	57.66	4.00e-165	574.00
IUUC-Mla-059133	Melampsora laricipopulina	46.03	6.00e-123	434.00
IUUC-Mga-059252	Meleagris gallopavo	83.56	0.00e+00	658.00
IUUC-Mvi-060522	Microbotryum violaceum	50.20	4.00e-137	481.00
IUUC-Mmr-061117	Microcebus murinus	96.84	0.00e+00	940.00
IUUC-Mdo-062892	Monodelphis domestica	88.61	0.00e+00	887.00
IUUC-Mmu-064108	Mus musculus	95.78	0.00e+00	916.00
IUUC-Mac-064430	Musa acuminata	59.10	1.00e-172	599.00
IUUC-Mpu-065882	Mustela putorius furo	95.57	0.00e+00	934.00
IUUC-Mlu-068123	Myotis lucifugus	95.14	0.00e+00	935.00
IUUC-Nfi-068484	Neosartorya fischeri	46.76	1.00e-119	423.00
IUUC-Ncr-068649	Neurospora crassa	43.54	4.00e-115	408.00
IUUC-Nle-069140	Nomascus leucogenys	95.75	0.00e+00	930.00
IUUC-Opr-070220	Ochotona princeps	87.66	0.00e+00	808.00
IUUC-Ont-072643	Oreochromis niloticus	79.75	0.00e+00	815.00
IUUC-Ocu-074007	Oryctolagus cuniculus	95.35	0.00e+00	905.00
IUUC-Oba-075904	Oryza barthii	59.10	7.00e-173	600.00
IUUC-Obr-076280	Oryza brachyantha	58.24	4.00e-171	593.00
IUUC-Ogl-077425	Oryza glaberrima	59.10	5.00e-173	600.00
IUUC-Ogu-078586	Oryza glumaepatula	59.10	5.00e-173	600.00
IUUC-Oin-079489	Oryza indica	56.96	6.00e-164	570.00
IUUC-Olo-080766	Oryza longistaminata	58.97	1.00e-172	599.00
IUUC-Ome-081905	Oryza meridionalis	59.10	4.00e-173	600.00
IUUC-Oni-083022	Oryza nivara	59.10	4.00e-173	600.00
IUUC-Opu-083615	Oryza punctata	59.10	6.00e-173	600.00
IUUC-Oru-085076	Oryza rufipogon	59.10	4.00e-173	600.00
IUUC-Osa-085516	Oryza sativa	59.10	4.00e-173	600.00
IUUC-Ola-087290	Oryzias latipes	77.43	0.00e+00	800.00
IUUC-Olu-087898	Ostreococcus lucimarinus	52.94	1.00e-143	503.00
IUUC-Oar-089580	Ovis aries	95.60	0.00e+00	813.00
IUUC-Ptr-090845	Pan troglodytes	95.33	0.00e+00	923.00
IUUC-Pan-092836	Papio anubis	95.56	0.00e+00	936.00
IUUC-Psi-093965	Pelodiscus sinensis	81.74	2.00e-56	209.00
IUUC-Pno-095052	Phaeosphaeria nodorum	46.19	2.00e-121	429.00
IUUC-Ppa-095432	Physcomitrella patens	58.64	4.00e-170	590.00
IUUC-Pfo-096963	Poecilia formosa	71.10	0.00e+00	698.00
IUUC-Pab-097716	Pongo abelii	92.14	0.00e+00	885.00
IUUC-Pop-099224	Populus trichocarpa	58.09	2.00e-170	591.00
IUUC-Pca-100682	Procavia capensis	91.83	0.00e+00	673.00
IUUC-Ppe-101819	Prunus persica	58.00	7.00e-168	583.00
IUUC-Pva-102338	Pteropus vampyrus	95.24	0.00e+00	709.00
IUUC-Pgr-103583	Puccinia graminis	54.28	2.00e-131	462.00
IUUC-Ptt-103737	Puccinia triticina	44.11	2.00e-99	356.00
IUUC-Pte-104150	Pyrenophora teres	48.87	1.00e-119	423.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	48.64	3.00e-119	422.00
IUUC-Rno-105987	Rattus norvegicus	95.55	0.00e+00	933.00
IUUC-Sce-106315	Saccharomyces cerevisiae	46.95	2.00e-129	456.00
IUUC-Sha-107273	Sarcophilus harrisii	89.87	0.00e+00	899.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	46.33	3.00e-118	418.00
IUUC-Spo-108092	Schizosaccharomyces pombe	48.28	1.00e-122	432.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	44.31	4.00e-116	411.00
IUUC-Smo-108855	Selaginella moellendorffii	55.24	5.00e-162	563.00
IUUC-Sit-110329	Setaria italica	59.10	4.00e-172	598.00
IUUC-Sly-111830	Solanum lycopersicum	59.31	2.00e-173	601.00
IUUC-Stu-112603	Solanum tuberosum	59.31	2.00e-173	601.00
IUUC-Sar-113504	Sorex araneus	90.07	3.00e-72	265.00
IUUC-Sbi-114560	Sorghum bicolor	58.03	6.00e-169	587.00
IUUC-Sre-115133	Sporisorium reilianum	41.12	9.00e-123	434.00
IUUC-Ssc-115903	Sus scrofa	95.98	0.00e+00	935.00
IUUC-Tgu-116798	Taeniopygia guttata	83.72	0.00e+00	849.00
IUUC-Tru-118361	Takifugu rubripes	78.06	0.00e+00	801.00
IUUC-Tsy-118849	Tarsius syrichta	96.59	0.00e+00	935.00
IUUC-Tni-120094	Tetraodon nigroviridis	78.27	0.00e+00	800.00
IUUC-Tca-121634	Theobroma cacao	57.87	1.00e-167	582.00
IUUC-Tre-122051	Trichoderma reesei	46.31	1.00e-119	423.00
IUUC-Tvi-122322	Trichoderma virens	46.93	6.00e-124	437.00
IUUC-Tae-125822	Triticum aestivum	58.24	5.00e-170	590.00
IUUC-Tur-126766	Triticum urartu	51.70	9.00e-162	563.00
IUUC-Tme-127175	Tuber melanosporum	51.16	3.00e-130	458.00
IUUC-Tbe-127779	Tupaia belangeri	94.38	0.00e+00	823.00
IUUC-Ttr-128224	Tursiops truncatus	91.59	0.00e+00	808.00
IUUC-Uma-129537	Ustilago maydis	41.48	1.00e-124	440.00
IUUC-Vda-129927	Verticillium dahliae	46.56	5.00e-112	397.00
IUUC-Vpa-130658	Vicugna pacos	83.40	0.00e+00	790.00
IUUC-Vvi-131659	Vitis vinifera	57.78	9.00e-170	589.00
IUUC-Xtr-132918	Xenopus tropicalis	76.58	0.00e+00	786.00
IUUC-Xma-133700	Xiphophorus maculatus	79.54	0.00e+00	812.00
IUUC-Yli-134478	Yarrowia lipolytica	50.00	5.00e-139	487.00
IUUC-Zma-135835	Zea mays	55.58	6.00e-166	577.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence