iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
POPTR_0014s15180	POPTR_0014s15180.2	POPTR_0014s15180.2
POPTR_0014s15180	POPTR_0014s15180.1	POPTR_0014s15180.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	5.10e-114	382.8	8	512

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnve 91
           YDRQ+r+wGe++q++l++a ++l+++g++G+E+lKnLvl+Gvgsitv+D+++ve+ +l+++F+++++ vg+sKA++++ +l+eln+ v+++
   Q: 8    YDRQLRIWGEQGQAALEKATICLLNCGPTGSETLKNLVLGGVGSITVIDGSKVELGDLGNNFMVDESCVGQSKAKCVCTFLQELNDAVKAK 98
           ******************************************************************************************* PP
   S: 92   aheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlke 178
           + ee +++l  +++ Ff++f++Vv+++  ++++ k++++c++a+v li ++++Gl G+vr+++k++ +++s++d   d++++++P+++lk 
   Q: 99   FIEEYPEALIGSNPsFFSQFTLVVATQLAEDSMIKLDKICREANVLLIFARSYGLTGFVRISVKEHAVIESKPDhflDDLRLNNPWPELKR 189
           ************99***************************************************************************** PP
   S: 179  tpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksf 260
           + +         +a+++++++v++ k++ee+++++ ++ ++++ ek+e+k++ k++++++de+n++eaie+++k fa++ i++ k + +s 
   Q: 190  FAEtidlnvtdpVAHKHTPYVVILVKIAEEWTKAHGGALPSTRDEKKEFKELLKAGMVAMDEDNYKEAIEASFKVFAPRGISEYKIIHDS- 279
           *98899999999***********************************************************************9999888. PP
   S: 261  ecdivtkskspfwv...........................................................................sf 276
            c +v +++s+fwv                                                                           sf
   Q: 280  -CSEVESNSSDFWVmvaalkefianeggeeaplegsipdmtsstelyvnlqkiyqakaeadflaiqqrvksilkrmgrdpdsiskemikSF 369
           .999*************************************************************************************** PP
   S: 277  csnaealq...........vpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep 351
           c+na++l+            ++ v++ +++++++++     +y+llr+++rf++++++ pg+++ e+d d + +l+t++  l  ++lg+++
   Q: 370  CKNARKLKicryrpiedefNNPAVTELQKYLTDEEYsvamgFYILLRSVDRFAANYNSFPGQFEGEMDGD-ISRLKTTVVGLL-SDLGCNG 458
           ********8888888777777999999999999999**********************************.*********998.******* PP
   S: 352  .kldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
             +++dli e++++++++++ ++a++gG+a+qEviK ++++f+p+  +f+f+++
   Q: 459  aTVTEDLINEMCRFGASELHAVAAFIGGIASQEVIKPITKQFVPMVGTFIFNGI 512
           ***************************************************986 PP

Organism

Populus trichocarpa

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAEPKTKYDR QLRIWGEQGQ AALEKATICL LNCGPTGSET LKNLVLGGVG SITVIDGSKV 60
ELGDLGNNFM VDESCVGQSK AKCVCTFLQE LNDAVKAKFI EEYPEALIGS NPSFFSQFTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAATATTGG GTTCGTTCTC TGATATATAC GCAATTCTCT TCCTTCAGCC TTCCCCCTCC 60
CCTCACTCAC AAACTGCGTA GCGAACTTGA CAGTGGACAG TAGTGTAGTT AGCAAAAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

pop:POPTR_0014s15180g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003446	Anas platyrhynchos	40.34	2.00e-115	409.00
IUUC-Acl-008333	Aspergillus clavatus	32.79	6.00e-70	257.00
IUUC-Afu-009071	Aspergillus fumigatus	32.97	3.00e-70	258.00
IUUC-Cne-026884	Cryptococcus neoformans	31.55	8.00e-68	251.00
IUUC-Dor-030513	Dipodomys ordii	50.91	5.00e-27	115.00
IUUC-Dse-031536	Dothistroma septosporum	31.40	5.00e-68	251.00
IUUC-Fal-037600	Ficedula albicollis	40.49	1.00e-116	413.00
IUUC-Fox-038037	Fusarium oxysporum	32.60	9.00e-68	250.00
IUUC-Ggr-040005	Gaeumannomyces graminis	31.93	1.00e-62	233.00
IUUC-Gga-041129	Gallus gallus	39.89	6.00e-117	414.00
IUUC-Kpa-049309	Komagataella pastoris	33.91	4.00e-73	268.00
IUUC-Lma-053112	Leptosphaeria maculans	32.79	2.00e-75	275.00
IUUC-Mpo-057514	Magnaporthe poae	31.43	4.00e-63	234.00
IUUC-Mla-059183	Melampsora laricipopulina	34.01	1.00e-87	316.00
IUUC-Mga-060144	Meleagris gallopavo	39.81	1.00e-113	402.00
IUUC-Mvi-060221	Microbotryum violaceum	32.06	6.00e-71	261.00
IUUC-Nfi-068245	Neosartorya fischeri	33.03	1.00e-69	256.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.91	5.00e-62	232.00
IUUC-Pte-104355	Pyrenophora teres	32.85	9.00e-73	267.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	33.94	7.00e-75	274.00
IUUC-Sce-106397	Saccharomyces cerevisiae	29.90	4.00e-34	138.00
IUUC-Sha-106770	Sarcophilus harrisii	44.49	1.00e-69	256.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.25	2.00e-75	275.00
IUUC-Spo-108276	Schizosaccharomyces pombe	32.56	4.00e-84	304.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.36	1.00e-59	223.00
IUUC-Sre-115058	Sporisorium reilianum	33.18	2.00e-65	243.00
IUUC-Tgu-116772	Taeniopygia guttata	41.29	8.00e-117	413.00
IUUC-Tre-122103	Trichoderma reesei	33.15	2.00e-70	259.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence