iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067373

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02041457

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000016807.2	ENSMLUT00000016815.2	ENSMLUP00000015323.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.40e-124	415.9	588	897

Active Site

Position(s)	Description	Evidence
866	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 26   reflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllgkklsledleevd 114
           re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+ +s +fyk++l+kkl+++dle++d
   Q: 588  REWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESID 675
           9**********************************98.89************************************************* PP
   S: 115  pelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
           pe+y+sl +i++   ++iee+gl++ fsv+ eilg++++++Lk gG++i Vt++Nk+eY+ l++e+r+ +g++eq++af +Gfnev+pl
   Q: 676  PEFYNSLIWISRD--NNIEECGLEMYFSVDMEILGKVTSHDLKLGGASILVTEDNKDEYIGLMTEWRFSRGVQEQTQAFLDGFNEVVPL 762
           ***********76..7************************************************************************* PP
   S: 204  ellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfv 288
           ++l++F+e+ele+++cG++e+d++d+++++ y++ yt++s++i wFw++++e ++e r ++LqFvTg++rlPlgGfael+    p++f+
   Q: 763  QWLQYFDEKELEVMLCGMQEVDLSDWQRNAVYRH-YTRNSKQIVWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMgsngPQKFC 850
           ********************************99.****************************************************** PP
   S: 289  irkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 851  IEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 897
           *********************************************96 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MATASPRSDT SNNHSGRLQL QVTVSSAKLK RKKNWFGTAI YTEVVVDGEI KKTAKSNSSS 60
NPKWDEQLTV SVSAQSTLEF RVWSHHTLRT DALLGRAAVD LRQALLTHNR KLERVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACTG CTTCCCCAAG GTCTGACACT AGTAATAACC ACAGTGGAAG GTTGCAGTTA 60
CAGGTAACTG GTAAGTTACT TCCATAATAG TGTAAAATAG TGGTTCCCAG GCAAATCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	70.42	0.00e+00	1192.00
IUUC-Apl-003310	Anas platyrhynchos	64.28	0.00e+00	1080.00
IUUC-Bta-012857	Bos taurus	69.45	0.00e+00	1158.00
IUUC-Cja-019448	Callithrix jacchus	70.63	0.00e+00	1205.00
IUUC-Cfa-020728	Canis familiaris	70.53	0.00e+00	1197.00
IUUC-Cpo-021635	Cavia porcellus	66.81	0.00e+00	1150.00
IUUC-Dno-029618	Dasypus novemcinctus	70.42	0.00e+00	1192.00
IUUC-Eca-033313	Equus caballus	69.88	0.00e+00	1153.00
IUUC-Fca-035420	Felis catus	68.64	0.00e+00	1179.00
IUUC-Ggo-045001	Gorilla gorilla	67.27	0.00e+00	996.00
IUUC-Hsa-046544	Homo sapiens	69.77	0.00e+00	1197.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	68.39	0.00e+00	1145.00
IUUC-Laf-053551	Loxodonta africana	69.27	0.00e+00	1151.00
IUUC-Mmu-063202	Mus musculus	67.53	0.00e+00	1127.00
IUUC-Mpu-065773	Mustela putorius furo	70.37	0.00e+00	1189.00
IUUC-Nle-069188	Nomascus leucogenys	70.10	0.00e+00	1203.00
IUUC-Opr-070965	Ochotona princeps	66.49	0.00e+00	1097.00
IUUC-Oan-073497	Ornithorhynchus anatinus	67.24	0.00e+00	1085.00
IUUC-Ocu-073891	Oryctolagus cuniculus	70.17	0.00e+00	1183.00
IUUC-Oga-087922	Otolemur garnettii	69.91	0.00e+00	1187.00
IUUC-Oar-089317	Ovis aries	69.30	0.00e+00	1142.00
IUUC-Ptr-090484	Pan troglodytes	69.77	0.00e+00	1197.00
IUUC-Pan-092117	Papio anubis	69.88	0.00e+00	1197.00
IUUC-Psi-093338	Pelodiscus sinensis	65.10	0.00e+00	1088.00
IUUC-Pva-102811	Pteropus vampyrus	61.32	0.00e+00	971.00
IUUC-Rno-106125	Rattus norvegicus	68.06	0.00e+00	1142.00
IUUC-Sha-107243	Sarcophilus harrisii	65.64	0.00e+00	1078.00
IUUC-Ssc-115368	Sus scrofa	70.30	0.00e+00	1159.00
IUUC-Tgu-117079	Taeniopygia guttata	62.96	0.00e+00	1059.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence