iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088357

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03109421

Gene Name

TBL1XR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000006708.2	ENSOGAT00000006715.2	ENSOGAP00000006005.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.30e-50	166.3	342	380
UBD/Beta-Prp	3.80e-61	206.9	310	508

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt++v+++++ ++ +ll+s+sdD t+k+W+++++++++
   Q: 342  GHTNEVNAIKWdPTgNLLASCSDDMTLKIWSMKQDNCVH 380
           8***********778*********************987 PP

UBD/Beta-Prp

   S: 17   kfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp. 104
           ++ ++++ +a+ s+d +i v ++ +   +++++gh++ev+a+k++p+g++l+++s+D+t+k+w++++  cvh l++h+++++++++sp 
   Q: 310  DW-QSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPt 397
           44.77888888888888888888888888888888888888888888888888888888888888888888888888888888888886 PP
   S: 105  .......sg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvys 185
                  +    l+s+s d+t+r+wd++ g c++ tl++h++ v +v+++pdg++l+sGs D++v +W+ +tg l++  +g  t+ +  
   Q: 398  gpgtnnpNAnLMLASASFDSTVRLWDVDRGICIH-TLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG--TGGIFE 483
           6666544222578888888888888888888888.8888888888888888888888888888888888888888888888..888888 PP
   S: 186  lsfdsngkelvsgsldgtvklwdlq 210
           + ++  g  + + + dg+v + dl+
   Q: 484  VCWNAAGDKVGASASDGSVCVLDLR 508
           8888888888888888888887776 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MSISSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GALVPPAALI SIIQKGLQYV 60
EAEVSINEDG TLFDGRPIES LSLIDAVMPD VVQTRQQAYR DKLAQQQAAA AAANQQGSAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATTGCTTCT CACCCCCCGG AGGGGTTATT TTGGGGGTGG TTGGAGGCGG TGGCGGCGGC 60
GAGGAGGGGA ATTTCCTTGT GCCTCCGTTC CCGGGAGGGG GGAGCGGCGT TGGAGGCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0060613--P:fat pad development
GO:0016042--P:lipid catabolic process
GO:0035264--P:multicellular organism growth
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030814--P:regulation of cAMP metabolic process
GO:0090207--P:regulation of triglyceride metabolic process
GO:0002021--P:response to dietary excess
GO:0050872--P:white fat cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000916	Aegilops tauschii	60.71	5.00e-55	206.00
IUUC-Aml-001717	Ailuropoda melanoleuca	91.44	0.00e+00	910.00
IUUC-Atr-002514	Amborella trichopoda	63.46	2.00e-138	486.00
IUUC-Apl-003708	Anas platyrhynchos	94.93	0.00e+00	874.00
IUUC-Aca-004611	Anolis carolinensis	95.13	0.00e+00	915.00
IUUC-Aly-005622	Arabidopsis lyrata	56.47	4.00e-113	402.00
IUUC-Ath-007137	Arabidopsis thaliana	57.30	2.00e-114	406.00
IUUC-Ago-007869	Ashbya gossypii	27.38	3.00e-29	123.00
IUUC-Ame-011601	Astyanax mexicanus	89.22	0.00e+00	867.00
IUUC-Bta-012418	Bos taurus	95.14	0.00e+00	940.00
IUUC-Bdi-014315	Brachypodium distachyon	58.92	1.00e-126	446.00
IUUC-Bol-016277	Brassica oleracea	55.70	7.00e-121	427.00
IUUC-Bra-016944	Brassica rapa	58.89	2.00e-120	426.00
IUUC-Cja-018832	Callithrix jacchus	94.94	0.00e+00	916.00
IUUC-Cfa-020029	Canis familiaris	91.63	0.00e+00	912.00
IUUC-Cpo-022080	Cavia porcellus	90.98	0.00e+00	876.00
IUUC-Cre-022979	Chlamydomonas reinhardtii	58.20	6.00e-124	437.00
IUUC-Csa-024075	Chlorocebus sabaeus	91.83	0.00e+00	912.00
IUUC-Cho-024872	Choloepus hoffmanni	95.30	6.00e-110	390.00
IUUC-Cin-025704	Ciona intestinalis	68.40	0.00e+00	753.00
IUUC-Csv-026257	Ciona savignyi	67.60	0.00e+00	731.00
IUUC-Cne-026946	Cryptococcus neoformans	37.56	3.00e-28	120.00
IUUC-Cme-027258	Cyanidioschyzon merolae	39.11	1.00e-99	357.00
IUUC-Dre-028075	Danio rerio	89.67	0.00e+00	887.00
IUUC-Dno-029196	Dasypus novemcinctus	95.33	0.00e+00	918.00
IUUC-Dor-030732	Dipodomys ordii	94.51	0.00e+00	691.00
IUUC-Dme-031939	Drosophila melanogaster	78.14	4.00e-165	574.00
IUUC-Ete-032822	Echinops telfairi	78.61	0.00e+00	794.00
IUUC-Eca-033897	Equus caballus	83.87	0.00e+00	892.00
IUUC-Eeu-034952	Erinaceus europaeus	84.90	0.00e+00	783.00
IUUC-Fca-035734	Felis catus	95.14	0.00e+00	917.00
IUUC-Fal-037185	Ficedula albicollis	95.32	0.00e+00	915.00
IUUC-Gmo-038870	Gadus morhua	87.84	0.00e+00	892.00
IUUC-Gga-041161	Gallus gallus	95.32	0.00e+00	916.00
IUUC-Gac-041844	Gasterosteus aculeatus	89.32	0.00e+00	916.00
IUUC-Gma-042796	Glycine max	47.36	2.00e-145	508.00
IUUC-Ggo-044882	Gorilla gorilla	91.83	0.00e+00	912.00
IUUC-Hsa-046488	Homo sapiens	91.83	0.00e+00	912.00
IUUC-Itr-047958	Ictidomys tridecemlineatus	95.08	0.00e+00	699.00
IUUC-Lch-050672	Latimeria chalumnae	92.62	0.00e+00	929.00
IUUC-Lpe-051084	Leersia perrieri	59.89	3.00e-128	452.00
IUUC-Loc-052030	Lepisosteus oculatus	92.28	0.00e+00	924.00
IUUC-Laf-054280	Loxodonta africana	94.55	0.00e+00	937.00
IUUC-Mcc-055203	Macaca mulatta	91.83	0.00e+00	912.00
IUUC-Mtr-058624	Medicago truncatula	58.52	4.00e-122	431.00
IUUC-Mga-059660	Meleagris gallopavo	95.32	0.00e+00	916.00
IUUC-Mvi-060557	Microbotryum violaceum	35.45	1.00e-64	241.00
IUUC-Mmr-060925	Microcebus murinus	93.61	0.00e+00	877.00
IUUC-Mdo-062078	Monodelphis domestica	94.56	0.00e+00	912.00
IUUC-Mmu-063603	Mus musculus	95.14	0.00e+00	919.00
IUUC-Mac-065508	Musa acuminata	58.43	8.00e-86	310.00
IUUC-Mpu-066741	Mustela putorius furo	91.63	0.00e+00	912.00
IUUC-Mlu-068152	Myotis lucifugus	95.14	0.00e+00	911.00
IUUC-Nle-069229	Nomascus leucogenys	91.83	0.00e+00	912.00
IUUC-Opr-070277	Ochotona princeps	84.22	0.00e+00	769.00
IUUC-Ont-072623	Oreochromis niloticus	89.51	0.00e+00	917.00
IUUC-Oan-073562	Ornithorhynchus anatinus	83.52	0.00e+00	894.00
IUUC-Ocu-074280	Oryctolagus cuniculus	93.31	0.00e+00	907.00
IUUC-Obr-076718	Oryza brachyantha	60.16	6.00e-129	454.00
IUUC-Oin-079515	Oryza indica	52.59	3.00e-66	246.00
IUUC-Olo-080427	Oryza longistaminata	60.17	2.00e-123	436.00
IUUC-Opu-083505	Oryza punctata	46.85	8.00e-133	467.00
IUUC-Ola-087365	Oryzias latipes	91.26	0.00e+00	914.00
IUUC-Olu-087589	Ostreococcus lucimarinus	51.23	4.00e-148	518.00
IUUC-Oar-089214	Ovis aries	95.14	0.00e+00	942.00
IUUC-Ptr-091532	Pan troglodytes	91.83	0.00e+00	912.00
IUUC-Pan-091927	Papio anubis	91.83	0.00e+00	912.00
IUUC-Psi-093941	Pelodiscus sinensis	88.24	0.00e+00	895.00
IUUC-Pma-094105	Petromyzon marinus	65.86	1.00e-100	359.00
IUUC-Ppa-095868	Physcomitrella patens	62.77	2.00e-132	466.00
IUUC-Pfo-096158	Poecilia formosa	89.13	0.00e+00	916.00
IUUC-Pab-098705	Pongo abelii	91.83	0.00e+00	912.00
IUUC-Pop-098989	Populus trichocarpa	59.62	2.00e-121	428.00
IUUC-Pca-100256	Procavia capensis	94.11	0.00e+00	902.00
IUUC-Ppe-101572	Prunus persica	61.06	4.00e-120	425.00
IUUC-Pva-102616	Pteropus vampyrus	94.67	0.00e+00	897.00
IUUC-Rno-105411	Rattus norvegicus	94.94	0.00e+00	915.00
IUUC-Sce-106132	Saccharomyces cerevisiae	24.78	2.00e-39	157.00
IUUC-Sha-106636	Sarcophilus harrisii	94.17	0.00e+00	911.00
IUUC-Smo-109301	Selaginella moellendorffii	61.31	3.00e-135	475.00
IUUC-Sit-110710	Setaria italica	60.94	2.00e-134	472.00
IUUC-Sly-111042	Solanum lycopersicum	49.80	1.00e-143	502.00
IUUC-Stu-112786	Solanum tuberosum	47.78	4.00e-136	478.00
IUUC-Sar-112971	Sorex araneus	82.55	0.00e+00	820.00
IUUC-Sbi-114420	Sorghum bicolor	60.16	4.00e-134	471.00
IUUC-Sre-115175	Sporisorium reilianum	36.00	5.00e-51	196.00
IUUC-Ssc-115695	Sus scrofa	93.39	0.00e+00	895.00
IUUC-Tgu-117009	Taeniopygia guttata	95.25	0.00e+00	899.00
IUUC-Tru-118581	Takifugu rubripes	91.46	0.00e+00	919.00
IUUC-Tsy-119424	Tarsius syrichta	81.07	0.00e+00	722.00
IUUC-Tni-119986	Tetraodon nigroviridis	91.65	0.00e+00	920.00
IUUC-Tca-121739	Theobroma cacao	54.95	3.00e-118	419.00
IUUC-Tae-125368	Triticum aestivum	47.67	3.00e-146	511.00
IUUC-Tur-126856	Triticum urartu	55.56	7.00e-54	204.00
IUUC-Tme-127126	Tuber melanosporum	37.83	1.00e-55	210.00
IUUC-Tbe-127665	Tupaia belangeri	79.26	0.00e+00	783.00
IUUC-Ttr-128826	Tursiops truncatus	82.99	0.00e+00	811.00
IUUC-Uma-129469	Ustilago maydis	40.78	7.00e-52	199.00
IUUC-Vpa-130768	Vicugna pacos	91.36	0.00e+00	898.00
IUUC-Vvi-131193	Vitis vinifera	57.97	1.00e-121	430.00
IUUC-Xtr-132842	Xenopus tropicalis	88.57	0.00e+00	867.00
IUUC-Xma-134020	Xiphophorus maculatus	89.13	0.00e+00	916.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence