iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046017

Ensembl Protein ID

ENSP00000289473.4

UniProt Accession

P14598; A6NEH2; A8K7S9; O43842; Q2PP07; Q53FR5; Q9BU90; Q9BXI7; Q9BXI8; Q9UDV9; Q9UMU2; NCF1_HUMAN

Genbank Protein ID

AAA57209.1; AAA59901.1; AAB95193.1; AAB95193.1; AAB95193.1; AAF34737.1; AAK19516.1; AAK19517.1; AAK19518.1; BAG54596.1; BAF84783.1; BAD96937.1; AAS07465.1; AAH02816.1; AAH65731.1; AAA93232.1; ABC40737.1

Protein Name

Neutrophil cytosol factor 1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phox

Genbank Nucleotide ID

M25665; M55067; U57835; U57833; U57834; AF184614; AF330625; AF330626; AF330627; AK127905; AK292094; AK223217; AC004883; AC124781; BC065731; U25793; DQ314878

Gene Name

NCF1; NOXO2; SH3PXD1A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000158517.13	ENST00000289473.8	ENSP00000289473.4
ENSG00000158517.13	ENST00000442021.6	ENSP00000401935.3
ENSG00000158517.13	ENST00000433458.5	ENSP00000392870.2
ENSG00000158517.13	ENST00000464878.5	ENSP00000484502.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	OMIM
Drug and target
TTD	DrugBank
Post-translational Modifications (PTMs)
dbPAF	PhosSNP	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PhosphoBase
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.10e-15	56.2	161	214

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +ye ++  e+ l  Gdvv+v+  e+ + gW+ +  + + krG +P+ F e l+
   Q: 161  YRAIANYEKTSGSEMALSTGDVVEVV--EKSESGWWFC--QMKAKRGWIPASFLEPLD 214
           5677789*******************..9999******..79***********99986 PP

Organism

Homo sapiens

Functional Description
(View)

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

Protein Sequence
(Fasta)

MGDTFIRHIA LLGFEKRFVP SQHYVYMFLV KWQDLSEKVV YRRFTEIYEF HKTLKEMFPI 60
EAGAINPENR IIPHLPAPKW FDGQRAAENR QGTLTEYCST LMSLPTKISR CPHLLDFFKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGACTTCCTC TTTCCAGTGC ATTTAAGGCG CAGCCTGGAA GTGCCAGGGA GCACTGGAGG 60
CCACCCAGTC ATGGGGGACA CCTTCATCCG TCACATCGCC CTGCTGGGCT TTGAGAAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0161--Chronic granulomatous disease
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain

Interpro

IPR015039--NADPH_oxidase_p47Phox_C
IPR032136--NECFESHC
IPR001655--P47PHOX
IPR001683--Phox
IPR001452--SH3_domain

PROSITE

PS50195--PX
PS50002--SH3

Pfam

PF16621--NECFESHC
PF08944--p47_phox_C
PF00787--PX
PF00018--SH3_1

PRINTS

PR00498--P47PHOX

SMART

SM00312--PX
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0019898--C:extrinsic component of membrane
GO:0005794--C:Golgi apparatus
GO:0043020--C:NADPH oxidase complex
GO:0043025--C:neuronal cell body
GO:0032010--C:phagolysosome
GO:0002102--C:podosome
GO:0005791--C:rough endoplasmic reticulum
GO:0009055--F:electron carrier activity
GO:0035091--F:phosphatidylinositol binding
GO:0043325--F:phosphatidylinositol-3,4-bisphosphate binding
GO:0017124--F:SH3 domain binding
GO:0016176--F:superoxide-generating NADPH oxidase activator activity
GO:0016175--F:superoxide-generating NADPH oxidase activity
GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006915--P:apoptotic process
GO:0045454--P:cell redox homeostasis
GO:0006968--P:cellular defense response
GO:0045087--P:innate immune response
GO:0071800--P:podosome assembly
GO:0006612--P:protein targeting to membrane
GO:0045730--P:respiratory burst
GO:0000302--P:response to reactive oxygen species
GO:0042554--P:superoxide anion generation
GO:0006801--P:superoxide metabolic process
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway

KEGG

hsa:653361

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001307	Ailuropoda melanoleuca	84.91	0.00e+00	649.00
IUUC-Apl-003633	Anas platyrhynchos	67.26	7.00e-156	543.00
IUUC-Ame-011567	Astyanax mexicanus	56.31	3.00e-124	438.00
IUUC-Bta-013024	Bos taurus	84.69	0.00e+00	658.00
IUUC-Cja-019026	Callithrix jacchus	94.39	0.00e+00	733.00
IUUC-Cfa-020704	Canis familiaris	86.96	0.00e+00	648.00
IUUC-Cpo-021794	Cavia porcellus	81.59	0.00e+00	675.00
IUUC-Csa-023617	Chlorocebus sabaeus	96.67	0.00e+00	754.00
IUUC-Dre-027789	Danio rerio	52.84	8.00e-127	446.00
IUUC-Dno-029091	Dasypus novemcinctus	65.29	2.00e-98	352.00
IUUC-Dor-030695	Dipodomys ordii	75.00	3.00e-88	318.00
IUUC-Eeu-035337	Erinaceus europaeus	77.13	1.00e-141	495.00
IUUC-Fca-035712	Felis catus	72.00	6.00e-153	533.00
IUUC-Fal-036697	Ficedula albicollis	67.43	8.00e-165	573.00
IUUC-Gmo-039060	Gadus morhua	48.74	5.00e-93	334.00
IUUC-Gga-040325	Gallus gallus	66.67	3.00e-160	557.00
IUUC-Gac-042580	Gasterosteus aculeatus	54.55	7.00e-116	410.00
IUUC-Itr-048254	Ictidomys tridecemlineatus	86.96	0.00e+00	719.00
IUUC-Lch-050575	Latimeria chalumnae	58.96	1.00e-134	473.00
IUUC-Loc-052607	Lepisosteus oculatus	60.53	3.00e-119	422.00
IUUC-Mcc-054644	Macaca mulatta	96.92	0.00e+00	755.00
IUUC-Mga-059367	Meleagris gallopavo	66.92	3.00e-166	577.00
IUUC-Mmr-061698	Microcebus murinus	86.26	0.00e+00	664.00
IUUC-Mdo-061949	Monodelphis domestica	74.68	4.00e-174	603.00
IUUC-Mmu-063793	Mus musculus	78.38	0.00e+00	664.00
IUUC-Mpu-066081	Mustela putorius furo	79.34	1.00e-177	615.00
IUUC-Ont-072602	Oreochromis niloticus	54.19	1.00e-127	449.00
IUUC-Ocu-073838	Oryctolagus cuniculus	62.88	9.00e-124	436.00
IUUC-Ola-086427	Oryzias latipes	53.71	3.00e-117	415.00
IUUC-Oga-088639	Otolemur garnettii	89.00	0.00e+00	701.00
IUUC-Oar-089376	Ovis aries	83.20	2.00e-174	604.00
IUUC-Ptr-090689	Pan troglodytes	99.74	0.00e+00	776.00
IUUC-Pan-092800	Papio anubis	96.92	0.00e+00	755.00
IUUC-Psi-093746	Pelodiscus sinensis	68.45	4.00e-170	590.00
IUUC-Pfo-096204	Poecilia formosa	53.22	1.00e-115	410.00
IUUC-Pab-098062	Pongo abelii	97.25	0.00e+00	735.00
IUUC-Pca-100793	Procavia capensis	84.22	0.00e+00	671.00
IUUC-Pva-102363	Pteropus vampyrus	80.05	2.00e-173	602.00
IUUC-Pgr-103429	Puccinia graminis	33.33	9.00e-07	49.30
IUUC-Ptt-103749	Puccinia triticina	33.33	3.00e-07	50.80
IUUC-Rno-105704	Rattus norvegicus	82.10	0.00e+00	650.00
IUUC-Sha-107450	Sarcophilus harrisii	73.46	0.00e+00	625.00
IUUC-Ssc-115354	Sus scrofa	82.65	0.00e+00	642.00
IUUC-Tgu-117439	Taeniopygia guttata	71.57	7.00e-137	479.00
IUUC-Tru-118215	Takifugu rubripes	53.33	2.00e-125	442.00
IUUC-Tni-120011	Tetraodon nigroviridis	55.31	2.00e-129	455.00
IUUC-Ttr-128852	Tursiops truncatus	70.29	9.00e-134	469.00
IUUC-Xtr-132894	Xenopus tropicalis	63.14	5.00e-148	517.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence