iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132572

UUCD1 version

UUC-XeT-00727

Ensembl Protein ID

ENSXETP00000056578.2

UniProt Accession

Q28IK8; Q6GL81; MARH8_XENTR

Genbank Protein ID

CAJ82358.1; AAH74623.1

Protein Name

E3 ubiquitin-protein ligase MARCH8; Membrane-associated RING finger protein 8; Membrane-associated RING-CH protein VIII; RING-type E3 ubiquitin transferase MARCH8

Genbank Nucleotide ID

CR760341; BC074623

Gene Name

march8; TNeu072c23.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000026961.2	ENSXETT00000064507.1	ENSXETP00000061447.1
ENSXETG00000026961.2	ENSXETT00000056578.2	ENSXETP00000056578.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	86.82	3.00e-124	441.00	IUUC-Hsa-045936
E3 activity/RING/RING	86.49	7.00e-128	453.00	IUUC-Mmu-063373

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Xenopus tropicalis

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination of cd86 and MHC class II proteins, such as hla-dr alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies.

Protein Sequence
(Fasta)

MKLQNEKTLG HSVSRSSNIS KAGSPTSVSA PSSFPRTSVT PSSQDICRIC HCEGDDESPL 60
ITPCHCTGSL HFVHQACLQQ WIKSSDTRCC ELCKFEFIME TKLKPLRKWE KLQMTASERR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGAAGCG CTCTGGCCAC TATCCTCTCT GTTAACCCTA GTGGGGCTAT AACAAGCCCA 60
GGCAAGTCAA CTTTTTCCTA TCCCTCTACA GGCAAATGTA GGGCAAGCAG CAGATGTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0391--Immunity
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0031901--C:early endosome membrane
GO:0005768--C:endosome
GO:0016021--C:integral component of membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0002376--P:immune system process

KEGG

xtr:448095

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013415	Bos taurus	85.16	1.00e-123	435.00
IUUC-Cel-018329	Caenorhabditis elegans	41.89	3.00e-10	59.70
IUUC-Cfa-020901	Canis familiaris	82.81	7.00e-119	419.00
IUUC-Cpo-021679	Cavia porcellus	82.81	1.00e-125	441.00
IUUC-Csa-023704	Chlorocebus sabaeus	83.72	2.00e-117	415.00
IUUC-Cin-025566	Ciona intestinalis	56.45	2.00e-15	75.50
IUUC-Dre-027670	Danio rerio	85.49	3.00e-128	451.00
IUUC-Dno-028902	Dasypus novemcinctus	84.77	1.00e-122	432.00
IUUC-Dme-031717	Drosophila melanogaster	56.63	9.00e-60	224.00
IUUC-Eca-033918	Equus caballus	83.83	4.00e-115	406.00
IUUC-Gmo-039585	Gadus morhua	82.42	1.00e-123	435.00
IUUC-Gga-040516	Gallus gallus	90.59	3.00e-141	494.00
IUUC-Gac-041554	Gasterosteus aculeatus	83.20	1.00e-124	438.00
IUUC-Hsa-045936	Homo sapiens	84.50	3.00e-118	417.00
IUUC-Lch-049853	Latimeria chalumnae	88.24	4.00e-136	476.00
IUUC-Loc-052142	Lepisosteus oculatus	85.66	5.00e-130	456.00
IUUC-Laf-054075	Loxodonta africana	85.78	1.00e-114	404.00
IUUC-Mcc-054834	Macaca mulatta	84.11	4.00e-118	417.00
IUUC-Mmr-061603	Microcebus murinus	85.27	4.00e-124	437.00
IUUC-Mdo-062578	Monodelphis domestica	87.89	1.00e-132	465.00
IUUC-Mmu-063373	Mus musculus	84.17	8.00e-122	429.00
IUUC-Nle-069774	Nomascus leucogenys	85.27	7.00e-120	422.00
IUUC-Ocu-074342	Oryctolagus cuniculus	91.04	7.00e-107	379.00
IUUC-Obr-076417	Oryza brachyantha	28.57	6.00e-10	57.80
IUUC-Ola-086344	Oryzias latipes	80.23	5.00e-122	429.00
IUUC-Olu-087805	Ostreococcus lucimarinus	30.83	6.00e-07	48.90
IUUC-Oga-088670	Otolemur garnettii	83.20	1.00e-119	422.00
IUUC-Ptr-090574	Pan troglodytes	83.33	3.00e-117	414.00
IUUC-Pan-092925	Papio anubis	82.95	5.00e-117	413.00
IUUC-Psi-093085	Pelodiscus sinensis	90.98	9.00e-140	489.00
IUUC-Pma-094229	Petromyzon marinus	58.52	3.00e-71	261.00
IUUC-Pfo-097524	Poecilia formosa	83.72	2.00e-126	444.00
IUUC-Pab-098165	Pongo abelii	84.50	1.00e-118	418.00
IUUC-Rno-105837	Rattus norvegicus	84.17	8.00e-122	429.00
IUUC-Sha-107014	Sarcophilus harrisii	84.05	3.00e-114	405.00
IUUC-Tru-117951	Takifugu rubripes	80.08	9.00e-116	409.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence