iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106702

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01066908

Gene Name

RNF139

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000006820.1	ENSSHAT00000007921.1	ENSSHAP00000007858.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.50e-08	35.2	549	587

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+ +f +  +++pC+H fha Cl kw       + +++CP C
   Q: 549  CAICYHEFTTSARITPCNHYFHALCLRKW------LYIQDTCPMC 587
           ********999******************......********** PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

LSLIGPPTPE AKAATYKIWL IVELSKSVPC LFIIDAIFNS YYDASQGRFS VGLQILIRLL 60
GIFVSSVVLI LSQRSLFKFY MYSSAFLLAA TSVLVNYYAS LHIDFYGAYN TSAFGIEFLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTCCCTGA TCGGCCCCCC AACTCCTGAA GCTAAGGCTG CCACCTATAA AACTGCCTCC 60
AAAGCTTGCT GTTTGTTGAG TTGGTGGTAT CTGCTCAACT GTATCTGTAC TTCTCTGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13705--TRC8_N
PF13639--zf-RING_2

SMART

SM00184--RING
SM00744--RINGv

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0036503--P:ERAD pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0017148--P:negative regulation of translation
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031648--P:protein destabilization
GO:0060628--P:regulation of ER to Golgi vesicle-mediated transport
GO:0070613--P:regulation of protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002401	Ailuropoda melanoleuca	87.86	0.00e+00	1151.00
IUUC-Apl-004214	Anas platyrhynchos	87.50	0.00e+00	981.00
IUUC-Aca-005326	Anolis carolinensis	77.92	0.00e+00	961.00
IUUC-Ame-011687	Astyanax mexicanus	74.11	0.00e+00	853.00
IUUC-Bta-013394	Bos taurus	87.16	0.00e+00	1182.00
IUUC-Bci-013813	Botrytis cinerea	62.96	2.00e-07	50.10
IUUC-Cja-019499	Callithrix jacchus	86.42	0.00e+00	1172.00
IUUC-Cfa-020357	Canis familiaris	87.46	0.00e+00	1157.00
IUUC-Cpo-021924	Cavia porcellus	89.79	0.00e+00	1113.00
IUUC-Csa-023513	Chlorocebus sabaeus	86.57	0.00e+00	1165.00
IUUC-Cho-024285	Choloepus hoffmanni	81.34	0.00e+00	1021.00
IUUC-Cin-025223	Ciona intestinalis	53.56	3.00e-74	271.00
IUUC-Csv-026018	Ciona savignyi	47.32	6.00e-64	237.00
IUUC-Dre-028660	Danio rerio	67.28	0.00e+00	771.00
IUUC-Dno-029463	Dasypus novemcinctus	81.01	9.00e-147	513.00
IUUC-Dor-030728	Dipodomys ordii	89.61	0.00e+00	1081.00
IUUC-Dse-031284	Dothistroma septosporum	41.94	2.00e-09	56.20
IUUC-Dme-032186	Drosophila melanogaster	44.25	4.00e-97	348.00
IUUC-Ete-032368	Echinops telfairi	82.24	0.00e+00	1087.00
IUUC-Eca-034325	Equus caballus	87.61	0.00e+00	1136.00
IUUC-Fca-035537	Felis catus	86.97	0.00e+00	1120.00
IUUC-Fal-037459	Ficedula albicollis	87.01	0.00e+00	955.00
IUUC-Gmo-039442	Gadus morhua	77.99	4.00e-99	355.00
IUUC-Gga-041071	Gallus gallus	82.60	0.00e+00	988.00
IUUC-Gac-042483	Gasterosteus aculeatus	66.46	0.00e+00	895.00
IUUC-Ggo-044672	Gorilla gorilla	86.27	0.00e+00	1161.00
IUUC-Hsa-045836	Homo sapiens	85.52	0.00e+00	1127.00
IUUC-Itr-048588	Ictidomys tridecemlineatus	88.35	0.00e+00	1165.00
IUUC-Lch-050073	Latimeria chalumnae	72.81	0.00e+00	983.00
IUUC-Loc-052908	Lepisosteus oculatus	71.82	0.00e+00	941.00
IUUC-Laf-053519	Loxodonta africana	85.07	0.00e+00	1170.00
IUUC-Mcc-054674	Macaca mulatta	77.39	1.00e-86	311.00
IUUC-Mga-059922	Meleagris gallopavo	86.80	0.00e+00	964.00
IUUC-Mmr-061452	Microcebus murinus	85.82	0.00e+00	1140.00
IUUC-Mdo-062412	Monodelphis domestica	95.68	0.00e+00	1250.00
IUUC-Mmu-063147	Mus musculus	85.29	0.00e+00	1154.00
IUUC-Mpu-065929	Mustela putorius furo	87.31	0.00e+00	1154.00
IUUC-Mlu-067899	Myotis lucifugus	84.93	0.00e+00	1120.00
IUUC-Nle-070083	Nomascus leucogenys	86.27	0.00e+00	1160.00
IUUC-Opr-070461	Ochotona princeps	83.21	0.00e+00	1129.00
IUUC-Ont-072256	Oreochromis niloticus	70.00	0.00e+00	904.00
IUUC-Oan-073150	Ornithorhynchus anatinus	84.60	0.00e+00	941.00
IUUC-Ocu-073748	Oryctolagus cuniculus	84.05	0.00e+00	1106.00
IUUC-Oga-088565	Otolemur garnettii	87.44	0.00e+00	1161.00
IUUC-Oar-089432	Ovis aries	91.30	0.00e+00	1130.00
IUUC-Ptr-091422	Pan troglodytes	86.12	0.00e+00	1160.00
IUUC-Pan-092331	Papio anubis	86.42	0.00e+00	1162.00
IUUC-Psi-092933	Pelodiscus sinensis	85.54	0.00e+00	953.00
IUUC-Pfo-097466	Poecilia formosa	64.46	0.00e+00	904.00
IUUC-Pab-098702	Pongo abelii	86.12	0.00e+00	1159.00
IUUC-Pca-100125	Procavia capensis	84.30	0.00e+00	1127.00
IUUC-Pva-102628	Pteropus vampyrus	86.83	0.00e+00	1152.00
IUUC-Rno-104886	Rattus norvegicus	87.12	0.00e+00	1158.00
IUUC-Ssc-116164	Sus scrofa	85.97	0.00e+00	1164.00
IUUC-Tgu-116829	Taeniopygia guttata	84.76	0.00e+00	989.00
IUUC-Tru-118557	Takifugu rubripes	71.82	0.00e+00	877.00
IUUC-Tsy-119399	Tarsius syrichta	86.44	0.00e+00	663.00
IUUC-Tni-120006	Tetraodon nigroviridis	60.64	0.00e+00	749.00
IUUC-Tbe-127664	Tupaia belangeri	86.98	0.00e+00	1151.00
IUUC-Ttr-129144	Tursiops truncatus	87.31	0.00e+00	1194.00
IUUC-Vpa-130226	Vicugna pacos	86.87	0.00e+00	1176.00
IUUC-Xtr-132461	Xenopus tropicalis	71.85	0.00e+00	922.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence