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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063428
UUCD1 version UUC-MuM-00231
Ensembl Protein ID ENSMUSP00000116252.1
UniProt Accession Q810D6; G3UVT6; Q922H3; GRWD1_MOUSE
Genbank Protein ID BAC66461.1; EDL22902.1; AAH08121.1
Protein Name Glutamate-rich WD repeat-containing protein 1; Protein A301
Genbank Nucleotide ID AB001539; AC149053; BC008121
Gene Name Grwd1; A301
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000053801.18 ENSMUST00000131384.2 ENSMUSP00000116252.1
ENSMUSG00000053801.18 ENSMUST00000209484.1 ENSMUSP00000148100.1
ENSMUSG00000053801.18 ENSMUST00000211265.1 ENSMUSP00000147629.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.60e-24 86.0 307 341
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrtgv 34
           H ++v+ +++   +++l+sG+dDg +kvWDlr+++
   Q: 307  HDGDVNVISWsrREPFLLSGGDDGALKVWDLRQFK 341
           99********97669****************9876 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness.
 Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness.
Protein Sequence
(Fasta)
MAARKGRSRT CETGEPMEAE TCDPGTEGPS QVYLPGRGPP LSEGEELVMD EEAYVLYHRA 60
QTGAPCLSFD IVRDHLGDNR TELPLSLYLC AGTQAESAQS NRLMMLRMHN LHGTRPSPSE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063428|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGACGCGGT TACTTTGTGG CGGCCATCTC TCTGCGCATT ACCTTCTTCT GGCTGGTTCA 60
CAGGTTTCCA AGGTAACAGT ACAGTGGGAC GGGTCTTAGA CTGTGGGAGG TGAAACCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063428|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12265--CAF1C_H4-bd
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003688--F:DNA replication origin binding
GO:0042393--F:histone binding
GO:0003723--F:RNA binding
GO:0006260--P:DNA replication
GO:0006334--P:nucleosome assembly
GO:0006337--P:nucleosome disassembly
KEGG mmu:101612
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000677 Aegilops tauschii 41.47 6.00e-76 278.00
IUUC-Aml-002309 Ailuropoda melanoleuca 92.17 0.00e+00 832.00
IUUC-Atr-002461 Amborella trichopoda 45.62 4.00e-94 338.00
IUUC-Aca-004760 Anolis carolinensis 73.51 5.00e-176 610.00
IUUC-Aly-005405 Arabidopsis lyrata 42.14 5.00e-86 311.00
IUUC-Ath-007178 Arabidopsis thaliana 42.05 2.00e-86 313.00
IUUC-Ago-007735 Ashbya gossypii 36.13 1.00e-67 250.00
IUUC-Acl-008294 Aspergillus clavatus 41.69 4.00e-80 291.00
IUUC-Afl-008486 Aspergillus flavus 41.19 1.00e-77 284.00
IUUC-Afu-009019 Aspergillus fumigatus 41.23 1.00e-80 293.00
IUUC-Ani-009465 Aspergillus nidulans 41.06 4.00e-78 285.00
IUUC-Ang-009641 Aspergillus niger 41.28 2.00e-77 283.00
IUUC-Ate-010426 Aspergillus terreus 41.00 2.00e-79 290.00
IUUC-Ame-010856 Astyanax mexicanus 62.17 8.00e-150 523.00
IUUC-Bgr-012258 Blumeria graminis 38.26 7.00e-64 238.00
IUUC-Bta-012437 Bos taurus 91.03 0.00e+00 819.00
IUUC-Bci-013647 Botrytis cinerea 41.15 2.00e-76 280.00
IUUC-Bdi-014728 Brachypodium distachyon 45.37 6.00e-95 341.00
IUUC-Bol-015126 Brassica oleracea 42.31 3.00e-85 309.00
IUUC-Bra-017677 Brassica rapa 47.45 2.00e-42 165.00
IUUC-Cel-018454 Caenorhabditis elegans 44.21 6.00e-105 374.00
IUUC-Cja-018859 Callithrix jacchus 90.36 0.00e+00 806.00
IUUC-Cfa-020912 Canis familiaris 89.46 0.00e+00 812.00
IUUC-Cpo-021368 Cavia porcellus 89.24 0.00e+00 800.00
IUUC-Cre-022850 Chlamydomonas reinhardtii 48.58 3.00e-50 192.00
IUUC-Csa-023599 Chlorocebus sabaeus 91.26 0.00e+00 827.00
IUUC-Cin-025718 Ciona intestinalis 56.94 7.00e-141 493.00
IUUC-Csv-025806 Ciona savignyi 57.76 2.00e-107 381.00
IUUC-Cgl-026766 Colletotrichum gloeosporioides 38.97 3.00e-65 242.00
IUUC-Cne-026781 Cryptococcus neoformans 43.42 2.00e-85 309.00
IUUC-Cme-027129 Cyanidioschyzon merolae 34.75 2.00e-44 173.00
IUUC-Dre-028225 Danio rerio 63.51 1.00e-152 533.00
IUUC-Dno-029792 Dasypus novemcinctus 89.58 0.00e+00 793.00
IUUC-Dor-030773 Dipodomys ordii 87.85 1.00e-105 376.00
IUUC-Dse-031289 Dothistroma septosporum 41.94 2.00e-77 283.00
IUUC-Dme-031676 Drosophila melanogaster 51.70 1.00e-131 462.00
IUUC-Ete-033042 Echinops telfairi 84.62 5.00e-66 245.00
IUUC-Eca-033618 Equus caballus 92.11 0.00e+00 803.00
IUUC-Fca-036102 Felis catus 91.52 0.00e+00 824.00
IUUC-Fox-037899 Fusarium oxysporum 40.22 4.00e-81 295.00
IUUC-Fso-038130 Fusarium solani 40.61 2.00e-80 293.00
IUUC-Gmo-038741 Gadus morhua 62.83 8.00e-148 516.00
IUUC-Ggr-040086 Gaeumannomyces graminis 39.27 5.00e-78 285.00
IUUC-Gac-042243 Gasterosteus aculeatus 61.39 4.00e-148 517.00
IUUC-Gma-044177 Glycine max 42.86 6.00e-89 321.00
IUUC-Ggo-044564 Gorilla gorilla 90.36 0.00e+00 822.00
IUUC-Hsa-046021 Homo sapiens 91.48 0.00e+00 826.00
IUUC-Hvu-047721 Hordeum vulgare 43.58 5.00e-90 325.00
IUUC-Itr-048189 Ictidomys tridecemlineatus 91.70 0.00e+00 822.00
IUUC-Kpa-049271 Komagataella pastoris 38.17 9.00e-69 254.00
IUUC-Lch-049974 Latimeria chalumnae 63.13 2.00e-161 562.00
IUUC-Lpe-051388 Leersia perrieri 41.77 1.00e-72 266.00
IUUC-Lma-053010 Leptosphaeria maculans 39.91 7.00e-74 271.00
IUUC-Laf-054058 Loxodonta africana 91.70 0.00e+00 830.00
IUUC-Mcc-055246 Macaca mulatta 91.03 0.00e+00 819.00
IUUC-Meu-056795 Macropus eugenii 78.79 0.00e+00 685.00
IUUC-Mor-057175 Magnaporthe oryzae 39.51 3.00e-77 282.00
IUUC-Mpo-057388 Magnaporthe poae 36.98 1.00e-61 230.00
IUUC-Mtr-057752 Medicago truncatula 43.32 5.00e-85 308.00
IUUC-Mla-058904 Melampsora laricipopulina 42.02 6.00e-82 298.00
IUUC-Mvi-060525 Microbotryum violaceum 40.92 6.00e-75 275.00
IUUC-Mmr-060905 Microcebus murinus 91.93 0.00e+00 827.00
IUUC-Mac-065276 Musa acuminata 43.91 7.00e-88 317.00
IUUC-Mpu-066062 Mustela putorius furo 92.17 0.00e+00 831.00
IUUC-Mlu-068115 Myotis lucifugus 93.18 6.00e-121 426.00
IUUC-Nfi-068512 Neosartorya fischeri 41.23 2.00e-77 283.00
IUUC-Ncr-068629 Neurospora crassa 39.55 2.00e-76 279.00
IUUC-Nle-070016 Nomascus leucogenys 86.77 0.00e+00 768.00
IUUC-Ont-072230 Oreochromis niloticus 63.07 8.00e-151 526.00
IUUC-Oan-072759 Ornithorhynchus anatinus 28.50 6.00e-49 188.00
IUUC-Ocu-074511 Oryctolagus cuniculus 90.38 0.00e+00 785.00
IUUC-Oba-075093 Oryza barthii 42.92 5.00e-85 308.00
IUUC-Obr-076130 Oryza brachyantha 43.91 1.00e-93 336.00
IUUC-Ogl-077167 Oryza glaberrima 45.01 2.00e-94 339.00
IUUC-Ogu-078111 Oryza glumaepatula 42.40 6.00e-80 293.00
IUUC-Oin-079162 Oryza indica 43.06 3.00e-86 312.00
IUUC-Olo-080909 Oryza longistaminata 36.47 8.00e-74 271.00
IUUC-Ome-081768 Oryza meridionalis 43.52 2.00e-81 297.00
IUUC-Oni-082453 Oryza nivara 43.60 4.00e-85 309.00
IUUC-Opu-084133 Oryza punctata 41.73 5.00e-73 269.00
IUUC-Oru-085056 Oryza rufipogon 41.32 3.00e-68 252.00
IUUC-Osa-085735 Oryza sativa 45.14 7.00e-94 337.00
IUUC-Ola-087066 Oryzias latipes 61.49 8.00e-149 520.00
IUUC-Olu-087594 Ostreococcus lucimarinus 39.73 6.00e-74 271.00
IUUC-Oga-087974 Otolemur garnettii 89.24 0.00e+00 811.00
IUUC-Oar-089902 Ovis aries 91.26 0.00e+00 825.00
IUUC-Ptr-090469 Pan troglodytes 85.20 0.00e+00 773.00
IUUC-Pan-092858 Papio anubis 91.26 0.00e+00 823.00
IUUC-Psi-094092 Pelodiscus sinensis 58.97 8.00e-98 350.00
IUUC-Pno-094919 Phaeosphaeria nodorum 39.34 1.00e-66 247.00
IUUC-Ppa-095849 Physcomitrella patens 42.34 2.00e-92 332.00
IUUC-Pfo-096535 Poecilia formosa 62.95 2.00e-147 515.00
IUUC-Pab-098478 Pongo abelii 91.48 0.00e+00 827.00
IUUC-Pop-100032 Populus trichocarpa 45.13 2.00e-92 332.00
IUUC-Pca-100403 Procavia capensis 93.45 6.00e-164 569.00
IUUC-Ppe-101997 Prunus persica 45.29 6.00e-95 341.00
IUUC-Pva-102423 Pteropus vampyrus 90.36 0.00e+00 816.00
IUUC-Pgr-103339 Puccinia graminis 42.51 1.00e-84 307.00
IUUC-Ptt-103937 Puccinia triticina 41.07 2.00e-82 300.00
IUUC-Pte-104051 Pyrenophora teres 39.73 4.00e-71 262.00
IUUC-Pyt-104644 Pyrenophora triticirepentis 39.50 1.00e-71 263.00
IUUC-Rno-106118 Rattus norvegicus 94.84 0.00e+00 826.00
IUUC-Sce-106330 Saccharomyces cerevisiae 34.79 2.00e-63 236.00
IUUC-Sha-106564 Sarcophilus harrisii 75.65 6.00e-156 543.00
IUUC-Sja-107969 Schizosaccharomyces japonicus 41.31 2.00e-85 309.00
IUUC-Spo-108351 Schizosaccharomyces pombe 39.72 4.00e-83 301.00
IUUC-Ssl-108452 Sclerotinia sclerotiorum 41.61 2.00e-77 283.00
IUUC-Smo-108943 Selaginella moellendorffii 42.69 7.00e-88 317.00
IUUC-Sit-110719 Setaria italica 44.68 2.00e-88 319.00
IUUC-Sly-111245 Solanum lycopersicum 43.05 4.00e-86 311.00
IUUC-Stu-112645 Solanum tuberosum 43.39 3.00e-92 332.00
IUUC-Sar-113342 Sorex araneus 85.65 0.00e+00 729.00
IUUC-Sbi-114359 Sorghum bicolor 44.21 1.00e-89 323.00
IUUC-Sre-115098 Sporisorium reilianum 44.62 4.00e-90 325.00
IUUC-Ssc-115496 Sus scrofa 91.48 0.00e+00 829.00
IUUC-Tru-117662 Takifugu rubripes 63.79 1.00e-145 509.00
IUUC-Tni-120564 Tetraodon nigroviridis 63.43 1.00e-127 449.00
IUUC-Tca-121710 Theobroma cacao 43.98 3.00e-91 329.00
IUUC-Tre-122239 Trichoderma reesei 42.09 1.00e-79 290.00
IUUC-Tvi-122589 Trichoderma virens 42.09 2.00e-80 293.00
IUUC-Tae-124597 Triticum aestivum 45.41 7.00e-96 344.00
IUUC-Tur-126135 Triticum urartu 46.20 5.00e-75 275.00
IUUC-Tme-127073 Tuber melanosporum 38.17 1.00e-60 227.00
IUUC-Ttr-128383 Tursiops truncatus 89.24 0.00e+00 793.00
IUUC-Uma-129345 Ustilago maydis 45.31 1.00e-93 337.00
IUUC-Vda-129893 Verticillium dahliae 39.78 8.00e-79 287.00
IUUC-Vvi-131067 Vitis vinifera 44.27 7.00e-89 321.00
IUUC-Xtr-132603 Xenopus tropicalis 71.36 0.00e+00 626.00
IUUC-Xma-133149 Xiphophorus maculatus 64.75 3.00e-152 531.00
IUUC-Yli-134459 Yarrowia lipolytica 37.02 6.00e-65 241.00
IUUC-Zma-135548 Zea mays 43.98 4.00e-88 318.00
Created Date 25-Jun-2017

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