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Tag Content
iUUCD ID IUUC-Mdo-062301
Ensembl Protein ID ENSMODP00000012690.3
UniProt Accession F6WML5; F6WML5_MONDO
Protein Name Protein HIRA
Gene Name HIRA
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMODG00000010135.3 ENSMODT00000012921.3 ENSMODP00000012690.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.10e-19 68.4 69 98
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H + v+c+++ ++  +l+sG+dD+ i+vW 
   Q: 69   HLACVNCVRWsNSgMYLASGGDDKLIMVWK 98
           8899******955699*************7 PP
   
Organism Monodelphis domestica
Functional Description
(View)

Functional Description


     Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
 Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Protein Sequence
(Fasta)
MKLLKPTWVN HNGKPIFSVD IHPDGTKFAT GGQGQDSGKV VIWNMAPVLK EEDEKNENIP 60
KMLCQMDNHL ACVNCVRWSN SGMYLASGGD DKLIMVWKRA TYIGPSTVFG SSSKLANVEQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mdo-062301|E3,WD_repeat|Monodelphis domestica
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTAAGGGGG GCCGCTGAGC GCCCGCCCGC CCGCCCGGCC GGCCTTGCCT CGGCGGCAGC 60
AGGCAGCAGG CAGGCGGCCT CGGAGGCCTC GGACCCGGCC CGGCCCCAGC CCCGCGGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mdo-062301|E3,WD_repeat|Monodelphis domestica
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0000790--C:nuclear chromatin
GO:0043234--C:protein complex
GO:0031491--F:nucleosome binding
GO:0003714--F:transcription corepressor activity
GO:0016569--P:covalent chromatin modification
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0007369--P:gastrulation
GO:0042692--P:muscle cell differentiation
GO:0001649--P:osteoblast differentiation
GO:0031935--P:regulation of chromatin silencing
GO:0006351--P:transcription, DNA-templated
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001039 Aegilops tauschii 35.06 6.00e-88 319.00
IUUC-Aml-001723 Ailuropoda melanoleuca 86.63 0.00e+00 1614.00
IUUC-Atr-003132 Amborella trichopoda 36.36 3.00e-88 320.00
IUUC-Apl-003197 Anas platyrhynchos 87.34 0.00e+00 1666.00
IUUC-Aca-004733 Anolis carolinensis 84.31 0.00e+00 1639.00
IUUC-Aly-005446 Arabidopsis lyrata 35.66 1.00e-81 298.00
IUUC-Ath-007627 Arabidopsis thaliana 36.38 7.00e-85 309.00
IUUC-Ago-007766 Ashbya gossypii 31.31 2.00e-59 223.00
IUUC-Acl-008104 Aspergillus clavatus 30.10 3.00e-64 240.00
IUUC-Afl-008591 Aspergillus flavus 33.83 3.00e-62 233.00
IUUC-Afu-008781 Aspergillus fumigatus 33.33 1.00e-57 218.00
IUUC-Ani-009272 Aspergillus nidulans 32.63 1.00e-53 204.00
IUUC-Ang-009655 Aspergillus niger 33.42 2.00e-64 241.00
IUUC-Aor-010119 Aspergillus oryzae 30.02 1.00e-62 234.00
IUUC-Ate-010530 Aspergillus terreus 29.78 3.00e-54 207.00
IUUC-Ame-011147 Astyanax mexicanus 87.13 5.00e-53 198.00
IUUC-Bgr-012237 Blumeria graminis 33.50 7.00e-63 236.00
IUUC-Bta-013320 Bos taurus 83.63 0.00e+00 1642.00
IUUC-Bci-013795 Botrytis cinerea 29.57 5.00e-69 256.00
IUUC-Bdi-014075 Brachypodium distachyon 37.48 5.00e-92 332.00
IUUC-Bol-016440 Brassica oleracea 35.20 4.00e-89 323.00
IUUC-Bra-016651 Brassica rapa 36.75 2.00e-87 317.00
IUUC-Cel-018692 Caenorhabditis elegans 38.36 1.00e-75 278.00
IUUC-Cja-018987 Callithrix jacchus 85.92 0.00e+00 1551.00
IUUC-Cfa-020132 Canis familiaris 85.81 0.00e+00 1614.00
IUUC-Cpo-021484 Cavia porcellus 86.30 0.00e+00 1649.00
IUUC-Cre-022846 Chlamydomonas reinhardtii 35.42 5.00e-61 229.00
IUUC-Csa-023081 Chlorocebus sabaeus 86.89 0.00e+00 1652.00
IUUC-Cin-025182 Ciona intestinalis 53.67 3.00e-156 545.00
IUUC-Csv-026154 Ciona savignyi 55.87 2.00e-151 529.00
IUUC-Cgl-026655 Colletotrichum gloeosporioides 30.92 4.00e-68 253.00
IUUC-Cne-026891 Cryptococcus neoformans 41.24 5.00e-83 302.00
IUUC-Cme-027349 Cyanidioschyzon merolae 32.68 4.00e-51 197.00
IUUC-Dre-027655 Danio rerio 69.66 0.00e+00 1364.00
IUUC-Dno-029557 Dasypus novemcinctus 77.08 0.00e+00 1010.00
IUUC-Dor-030687 Dipodomys ordii 78.86 0.00e+00 720.00
IUUC-Dse-031334 Dothistroma septosporum 31.26 5.00e-63 236.00
IUUC-Dme-031746 Drosophila melanogaster 55.41 5.00e-158 551.00
IUUC-Ete-032384 Echinops telfairi 81.07 0.00e+00 1516.00
IUUC-Eca-033430 Equus caballus 86.24 0.00e+00 1606.00
IUUC-Fca-036121 Felis catus 85.93 0.00e+00 1618.00
IUUC-Fal-036817 Ficedula albicollis 87.04 0.00e+00 1667.00
IUUC-Fox-037906 Fusarium oxysporum 29.95 1.00e-67 251.00
IUUC-Fso-038409 Fusarium solani 31.57 3.00e-68 253.00
IUUC-Gmo-039151 Gadus morhua 86.79 0.00e+00 705.00
IUUC-Ggr-040016 Gaeumannomyces graminis 35.04 5.00e-70 259.00
IUUC-Gga-040936 Gallus gallus 87.71 0.00e+00 1754.00
IUUC-Gac-041405 Gasterosteus aculeatus 62.54 0.00e+00 1196.00
IUUC-Gma-044252 Glycine max 36.62 1.00e-88 321.00
IUUC-Ggo-045430 Gorilla gorilla 86.71 0.00e+00 1646.00
IUUC-Hsa-046442 Homo sapiens 86.79 0.00e+00 1653.00
IUUC-Hvu-047587 Hordeum vulgare 35.23 5.00e-78 286.00
IUUC-Itr-048910 Ictidomys tridecemlineatus 97.33 8.00e-172 595.00
IUUC-Kpa-049145 Komagataella pastoris 30.64 2.00e-59 224.00
IUUC-Lch-050474 Latimeria chalumnae 77.01 0.00e+00 1447.00
IUUC-Lpe-051209 Leersia perrieri 35.04 7.00e-84 305.00
IUUC-Loc-052119 Lepisosteus oculatus 73.29 0.00e+00 1405.00
IUUC-Lma-053237 Leptosphaeria maculans 32.87 1.00e-67 251.00
IUUC-Laf-053718 Loxodonta africana 87.17 0.00e+00 1651.00
IUUC-Mcc-055621 Macaca mulatta 86.31 0.00e+00 1556.00
IUUC-Meu-055914 Macropus eugenii 86.30 0.00e+00 1599.00
IUUC-Mor-057090 Magnaporthe oryzae 32.71 3.00e-67 250.00
IUUC-Mpo-057364 Magnaporthe poae 35.28 2.00e-71 264.00
IUUC-Mtr-057744 Medicago truncatula 37.08 1.00e-89 324.00
IUUC-Mla-058914 Melampsora laricipopulina 42.20 2.00e-85 310.00
IUUC-Mga-060181 Meleagris gallopavo 85.83 0.00e+00 1703.00
IUUC-Mvi-060432 Microbotryum violaceum 37.53 4.00e-74 273.00
IUUC-Mmr-060871 Microcebus murinus 86.30 0.00e+00 1688.00
IUUC-Mmu-063888 Mus musculus 86.20 0.00e+00 1629.00
IUUC-Mac-065137 Musa acuminata 38.49 3.00e-89 323.00
IUUC-Mpu-066732 Mustela putorius furo 86.34 0.00e+00 1645.00
IUUC-Mlu-067542 Myotis lucifugus 85.60 0.00e+00 1590.00
IUUC-Nfi-068396 Neosartorya fischeri 33.99 1.00e-57 218.00
IUUC-Ncr-068842 Neurospora crassa 31.04 4.00e-69 256.00
IUUC-Nle-070156 Nomascus leucogenys 87.08 0.00e+00 1656.00
IUUC-Opr-070808 Ochotona princeps 84.61 0.00e+00 1307.00
IUUC-Ont-072105 Oreochromis niloticus 67.44 0.00e+00 1340.00
IUUC-Ocu-074962 Oryctolagus cuniculus 86.93 0.00e+00 1635.00
IUUC-Oba-075178 Oryza barthii 41.84 8.00e-90 325.00
IUUC-Obr-076399 Oryza brachyantha 35.92 2.00e-91 330.00
IUUC-Ogu-078797 Oryza glumaepatula 41.84 8.00e-90 325.00
IUUC-Oin-080085 Oryza indica 40.62 2.00e-76 280.00
IUUC-Olo-081048 Oryza longistaminata 40.72 2.00e-65 244.00
IUUC-Ome-081324 Oryza meridionalis 41.84 9.00e-90 325.00
IUUC-Oni-082548 Oryza nivara 41.84 6.00e-90 325.00
IUUC-Opu-084008 Oryza punctata 41.84 8.00e-90 325.00
IUUC-Oru-084339 Oryza rufipogon 41.58 2.00e-89 323.00
IUUC-Osa-085782 Oryza sativa 41.58 2.00e-89 323.00
IUUC-Ola-087302 Oryzias latipes 68.32 0.00e+00 813.00
IUUC-Olu-087611 Ostreococcus lucimarinus 36.77 4.00e-91 329.00
IUUC-Oga-087935 Otolemur garnettii 86.38 0.00e+00 1605.00
IUUC-Oar-089229 Ovis aries 65.64 0.00e+00 1002.00
IUUC-Ptr-090715 Pan troglodytes 86.79 0.00e+00 1653.00
IUUC-Pan-092318 Papio anubis 86.66 0.00e+00 1621.00
IUUC-Psi-094053 Pelodiscus sinensis 87.15 0.00e+00 1692.00
IUUC-Pno-094985 Phaeosphaeria nodorum 32.85 2.00e-59 224.00
IUUC-Ppa-095819 Physcomitrella patens 36.53 4.00e-91 329.00
IUUC-Pfo-096857 Poecilia formosa 66.41 0.00e+00 1287.00
IUUC-Pab-098047 Pongo abelii 86.79 0.00e+00 1651.00
IUUC-Pop-099587 Populus trichocarpa 36.60 5.00e-89 322.00
IUUC-Pca-100558 Procavia capensis 84.00 0.00e+00 668.00
IUUC-Ppe-101261 Prunus persica 36.78 8.00e-91 328.00
IUUC-Pva-102683 Pteropus vampyrus 86.40 0.00e+00 1647.00
IUUC-Pgr-103660 Puccinia graminis 41.16 3.00e-78 286.00
IUUC-Ptt-103900 Puccinia triticina 42.38 9.00e-80 291.00
IUUC-Pte-104209 Pyrenophora teres 33.00 8.00e-66 245.00
IUUC-Pyt-104802 Pyrenophora triticirepentis 32.87 2.00e-65 244.00
IUUC-Rno-105566 Rattus norvegicus 85.91 0.00e+00 1645.00
IUUC-Sce-106291 Saccharomyces cerevisiae 30.14 4.00e-62 233.00
IUUC-Sha-107514 Sarcophilus harrisii 88.27 0.00e+00 1626.00
IUUC-Sja-107833 Schizosaccharomyces japonicus 40.69 5.00e-80 292.00
IUUC-Spo-108162 Schizosaccharomyces pombe 37.94 8.00e-78 285.00
IUUC-Smo-109533 Selaginella moellendorffii 37.04 2.00e-90 327.00
IUUC-Sit-110730 Setaria italica 37.50 2.00e-91 331.00
IUUC-Sly-111547 Solanum lycopersicum 37.72 7.00e-92 332.00
IUUC-Stu-112705 Solanum tuberosum 37.72 2.00e-91 331.00
IUUC-Sar-113222 Sorex araneus 81.24 0.00e+00 1427.00
IUUC-Sbi-114272 Sorghum bicolor 38.22 5.00e-94 339.00
IUUC-Sre-115061 Sporisorium reilianum 26.78 3.00e-94 340.00
IUUC-Ssc-116364 Sus scrofa 85.26 0.00e+00 1679.00
IUUC-Tgu-116645 Taeniopygia guttata 87.34 0.00e+00 1707.00
IUUC-Tru-117590 Takifugu rubripes 66.22 0.00e+00 1306.00
IUUC-Tsy-119212 Tarsius syrichta 83.02 0.00e+00 914.00
IUUC-Tni-119915 Tetraodon nigroviridis 66.87 0.00e+00 1288.00
IUUC-Tca-121765 Theobroma cacao 36.16 4.00e-89 323.00
IUUC-Tre-121887 Trichoderma reesei 33.66 2.00e-59 224.00
IUUC-Tvi-122262 Trichoderma virens 33.66 2.00e-59 224.00
IUUC-Tae-124148 Triticum aestivum 44.81 2.00e-37 151.00
IUUC-Tur-126483 Triticum urartu 37.33 5.00e-92 332.00
IUUC-Tme-127202 Tuber melanosporum 29.32 2.00e-56 214.00
IUUC-Tbe-127350 Tupaia belangeri 78.78 2.00e-176 612.00
IUUC-Ttr-129077 Tursiops truncatus 81.57 0.00e+00 1615.00
IUUC-Uma-129465 Ustilago maydis 36.36 1.00e-80 295.00
IUUC-Vda-129844 Verticillium dahliae 34.56 5.00e-66 246.00
IUUC-Vvi-131397 Vitis vinifera 36.60 4.00e-91 329.00
IUUC-Xtr-132057 Xenopus tropicalis 76.29 0.00e+00 1442.00
IUUC-Xma-134139 Xiphophorus maculatus 68.81 0.00e+00 810.00
IUUC-Yli-134424 Yarrowia lipolytica 31.25 2.00e-64 241.00
IUUC-Zma-135839 Zea mays 37.52 1.00e-91 331.00
Created Date 25-Jun-2017

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