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Tag Content
UUCD2 ID IUUC-Mdo-062518
UUCD1 version UUC-MoD-00806
Ensembl Protein ID ENSMODP00000037638.1
UniProt Accession F7EP78; F7EP78_MONDO
Protein Name Uncharacterized protein
Gene Name HERC2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMODG00000000682.3 ENSMODT00000039239.2 ENSMODP00000037638.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 3.10e-86 290.0 4450 4779
Active Site
Position(s) Description Evidence
4748 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
    ++++v+fvgE++ d+gG +e +a++++elqn ++l+ ++n++ + n+d +l np h+++F+flG+llg+a+++g +l
   Q: 4450 RVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPaakssLHTNMFRFLGVLLGIAIRTGSPL 4536
    4566*********************************************************************************** PP
   S: 89 dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
    l+l+++++k+l g +l++ dl+evd++++ l++i++n+ ++ e +++ l f+ +++++ +++ +++ +++t +N+ eYv+
   Q: 4537 SLNLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFT-----VPSASGQDIQLSSKYTHITLDNRAEYVR 4618
    ***************************************9999999999***99.....788999999******************* PP
   S: 176 lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
    l ++yrl+e ++eqv a+reG+ +v+p llslFt ele+++cG+++i ++ lk+ ++ykg ++++ + iqwFwev+e+fs++er+
   Q: 4619 LAINYRLHE-FDEQVSAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPTASLIQWFWEVMESFSNTERS 4703
    *********.**************************************************77.************************ PP
   S: 263 afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
    fL+Fv+g+ rlP + +a+++ r fvi+ + d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4704 LFLRFVWGRTRLP-RTIADFRGRDFVIQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4779
    *************.8*************999988888***********************************99875 PP
   

Organism Monodelphis domestica
Protein Sequence
(Fasta)
MSSEPFCLAA QARFDSKWLK TDLQLAFTRD GLCGLWNEMV KDGEILYPGT ELIQNGELPP 60
RKDDTAECQS GTKKEDQSEK EKKDEEETPV PMYRAKSIVE SWVWGKQPDV NELKECLYVL 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mdo-062518|E3,HECT|Monodelphis domestica
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCTTCTG AACCCTTCTG TTTGGCTGCC CAGGCTAGGT TTGACTCCAA GTGGTTGAAA 60
ACAGATTTAC AGGTAAGATT CTAATATGAA TTTGGTTTCT TTTTTTTTTC CTAGTATGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mdo-062518|E3,HECT|Monodelphis domestica
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR015940--UBA
IPR009060--UBA-like
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS50030--UBA
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00291--ZnF_ZZ

Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007283--P:spermatogenesis

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002112 Ailuropoda melanoleuca 89.26 0.00e+00 6642.00
IUUC-Atr-003065 Amborella trichopoda 35.29 3.00e-51 197.00
IUUC-Apl-003983 Anas platyrhynchos 92.39 0.00e+00 8452.00
IUUC-Aca-004300 Anolis carolinensis 91.46 0.00e+00 8299.00
IUUC-Aly-006441 Arabidopsis lyrata 34.15 8.00e-45 176.00
IUUC-Ame-010621 Astyanax mexicanus 84.39 0.00e+00 6843.00
IUUC-Bta-013067 Bos taurus 88.98 0.00e+00 8042.00
IUUC-Bdi-014093 Brachypodium distachyon 33.76 1.00e-49 192.00
IUUC-Bol-015203 Brassica oleracea 34.27 2.00e-52 201.00
IUUC-Bra-016737 Brassica rapa 34.27 7.00e-48 186.00
IUUC-Cja-019687 Callithrix jacchus 87.93 0.00e+00 7869.00
IUUC-Cfa-020672 Canis familiaris 89.71 0.00e+00 8130.00
IUUC-Cpo-021819 Cavia porcellus 86.88 0.00e+00 7823.00
IUUC-Csa-023817 Chlorocebus sabaeus 89.56 0.00e+00 8081.00
IUUC-Cho-024387 Choloepus hoffmanni 92.28 0.00e+00 1858.00
IUUC-Cin-025709 Ciona intestinalis 52.51 0.00e+00 1240.00
IUUC-Csv-026336 Ciona savignyi 36.76 0.00e+00 1592.00
IUUC-Dre-027717 Danio rerio 79.08 0.00e+00 6903.00
IUUC-Dno-029296 Dasypus novemcinctus 89.58 0.00e+00 8090.00
IUUC-Dor-030979 Dipodomys ordii 86.23 0.00e+00 2773.00
IUUC-Dme-032171 Drosophila melanogaster 62.47 0.00e+00 1076.00
IUUC-Ete-032687 Echinops telfairi 86.07 0.00e+00 2684.00
IUUC-Eca-034046 Equus caballus 89.11 0.00e+00 8059.00
IUUC-Eeu-034859 Erinaceus europaeus 78.20 0.00e+00 1836.00
IUUC-Fca-036262 Felis catus 89.46 0.00e+00 8128.00
IUUC-Fal-037562 Ficedula albicollis 92.18 0.00e+00 8377.00
IUUC-Gmo-039054 Gadus morhua 88.24 0.00e+00 1111.00
IUUC-Gga-040359 Gallus gallus 92.49 0.00e+00 8410.00
IUUC-Gac-041879 Gasterosteus aculeatus 92.70 0.00e+00 1060.00
IUUC-Ggo-044692 Gorilla gorilla 89.98 0.00e+00 4005.00
IUUC-Hsa-045995 Homo sapiens 89.64 0.00e+00 8133.00
IUUC-Hvu-047529 Hordeum vulgare 35.65 2.00e-49 191.00
IUUC-Itr-048553 Ictidomys tridecemlineatus 87.85 0.00e+00 2239.00
IUUC-Lch-049808 Latimeria chalumnae 83.34 0.00e+00 3171.00
IUUC-Lpe-051482 Leersia perrieri 34.46 1.00e-46 182.00
IUUC-Loc-052685 Lepisosteus oculatus 81.39 0.00e+00 7245.00
IUUC-Laf-053372 Loxodonta africana 89.01 0.00e+00 8048.00
IUUC-Mcc-054693 Macaca mulatta 89.62 0.00e+00 8117.00
IUUC-Meu-056660 Macropus eugenii 87.72 0.00e+00 1720.00
IUUC-Mga-059371 Meleagris gallopavo 92.01 0.00e+00 7194.00
IUUC-Mmr-060787 Microcebus murinus 89.77 0.00e+00 8163.00
IUUC-Mmu-063690 Mus musculus 88.63 0.00e+00 8012.00
IUUC-Mpu-066478 Mustela putorius furo 89.40 0.00e+00 8067.00
IUUC-Mlu-067596 Myotis lucifugus 81.56 0.00e+00 4004.00
IUUC-Nle-069445 Nomascus leucogenys 88.31 0.00e+00 2000.00
IUUC-Opr-070990 Ochotona princeps 80.58 0.00e+00 2707.00
IUUC-Ont-072285 Oreochromis niloticus 82.89 0.00e+00 7292.00
IUUC-Oan-072721 Ornithorhynchus anatinus 86.43 0.00e+00 3273.00
IUUC-Ocu-074273 Oryctolagus cuniculus 89.07 0.00e+00 8034.00
IUUC-Oba-075573 Oryza barthii 33.68 1.00e-45 178.00
IUUC-Obr-076107 Oryza brachyantha 33.77 4.00e-50 193.00
IUUC-Ogl-077193 Oryza glaberrima 33.68 1.00e-45 178.00
IUUC-Ogu-078817 Oryza glumaepatula 33.68 1.00e-45 178.00
IUUC-Oin-079609 Oryza indica 33.00 1.00e-49 192.00
IUUC-Olo-080629 Oryza longistaminata 33.68 2.00e-45 178.00
IUUC-Ome-081686 Oryza meridionalis 33.68 5.00e-46 179.00
IUUC-Opu-084137 Oryza punctata 33.94 3.00e-46 180.00
IUUC-Oru-085013 Oryza rufipogon 33.68 1.00e-45 178.00
IUUC-Osa-085597 Oryza sativa 33.68 1.00e-45 178.00
IUUC-Ola-087346 Oryzias latipes 94.28 0.00e+00 1211.00
IUUC-Oga-088742 Otolemur garnettii 88.81 0.00e+00 7979.00
IUUC-Oar-090093 Ovis aries 88.91 0.00e+00 8027.00
IUUC-Ptr-091034 Pan troglodytes 86.73 0.00e+00 5424.00
IUUC-Pan-092783 Papio anubis 87.45 0.00e+00 7889.00
IUUC-Psi-094027 Pelodiscus sinensis 92.44 0.00e+00 8036.00
IUUC-Pfo-096208 Poecilia formosa 82.19 0.00e+00 6031.00
IUUC-Pab-097681 Pongo abelii 86.64 0.00e+00 2411.00
IUUC-Pca-100705 Procavia capensis 93.35 0.00e+00 1150.00
IUUC-Pva-103147 Pteropus vampyrus 81.03 0.00e+00 2348.00
IUUC-Rno-105458 Rattus norvegicus 88.61 0.00e+00 7997.00
IUUC-Sha-106959 Sarcophilus harrisii 80.98 0.00e+00 6857.00
IUUC-Sit-109917 Setaria italica 36.39 5.00e-48 186.00
IUUC-Sly-110961 Solanum lycopersicum 35.33 2.00e-53 204.00
IUUC-Sar-113532 Sorex araneus 84.05 0.00e+00 1617.00
IUUC-Sbi-114352 Sorghum bicolor 32.65 6.00e-50 192.00
IUUC-Ssc-115337 Sus scrofa 85.17 0.00e+00 2796.00
IUUC-Tgu-116789 Taeniopygia guttata 92.28 0.00e+00 8400.00
IUUC-Tru-118129 Takifugu rubripes 82.14 0.00e+00 7314.00
IUUC-Tsy-119302 Tarsius syrichta 82.88 0.00e+00 1246.00
IUUC-Tni-120374 Tetraodon nigroviridis 80.84 0.00e+00 7151.00
IUUC-Tca-121094 Theobroma cacao 35.59 2.00e-54 207.00
IUUC-Tae-124157 Triticum aestivum 33.51 2.00e-49 191.00
IUUC-Tur-126300 Triticum urartu 35.29 9.00e-50 192.00
IUUC-Tbe-128137 Tupaia belangeri 82.62 0.00e+00 2186.00
IUUC-Ttr-128273 Tursiops truncatus 86.58 0.00e+00 2689.00
IUUC-Vpa-130471 Vicugna pacos 84.90 0.00e+00 1156.00
IUUC-Xtr-132185 Xenopus tropicalis 82.58 0.00e+00 7428.00
IUUC-Xma-133233 Xiphophorus maculatus 82.64 0.00e+00 7260.00
Created Date 25-Jun-2017

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