iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-036116

Ensembl Protein ID

ENSFCAP00000021173.1

UniProt Accession

M3X3H3; M3X3H3_FELCA

Genbank Protein ID

ENSFCAP00000021173

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02105727

Gene Name

RNF125

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000023041.1	ENSFCAT00000028869.1	ENSFCAP00000021173.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	8.30e-11	41.8	33	98
E3 activity/RING/RING	1.30e-08	35.2	37	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawc 69
             f C++ le+ ++Pv + +G+++ rs+I+  l++++ tcP +r+ l +e +    + rr+ +++ 
   Q: 33   TSFDCSVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVARRMKSEYQ 98
           579******************************99999**********999999999999999885 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++Cle + + p+ ++CgHvf+++C+   +      ++++++CP+Cr
   Q: 37   CSVCLEVLHQ-PVRTRCGHVFCRSCIaTSL------KNNKWTCPYCR 76
           ********99.777***********95555......**********8 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MGSVLSSDSG KSAAASAAPR ALERRGDPEL PVTSFDCSVC LEVLHQPVRT RCGHVFCRSC 60
IATSLKNNKW TCPYCRAYLP SEGVPATDVA RRMKSEYQNC AECDSLVCLS EMRAHIRSCQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCTCCG TGCTTAGCAG CGATAGCGGC AAATCCGCCG CCGCCTCGGC CGCCCCGCGG 60
GCCCTGGAGC GCAGGGGGGA CCCGGAGCTG CCCGTCACGT CCTTCGACTG CTCCGTGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19

SMART

SM00184--RING

Gene Ontology

GO:0000139--C:Golgi membrane
GO:0005622--C:intracellular
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0039536--P:negative regulation of RIG-I signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

fca:101086183

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001992	Ailuropoda melanoleuca	96.98	3.00e-126	443.00
IUUC-Aca-004839	Anolis carolinensis	62.57	2.00e-66	244.00
IUUC-Bta-012827	Bos taurus	89.66	2.00e-117	414.00
IUUC-Cja-018794	Callithrix jacchus	91.38	5.00e-119	419.00
IUUC-Cfa-021234	Canis familiaris	96.12	1.00e-122	431.00
IUUC-Cpo-022412	Cavia porcellus	88.44	2.00e-105	374.00
IUUC-Csa-023406	Chlorocebus sabaeus	92.67	3.00e-121	427.00
IUUC-Cho-024427	Choloepus hoffmanni	75.14	4.00e-74	270.00
IUUC-Dno-030085	Dasypus novemcinctus	92.67	1.00e-120	425.00
IUUC-Dor-030911	Dipodomys ordii	69.83	6.00e-69	253.00
IUUC-Ete-032469	Echinops telfairi	86.21	5.00e-113	399.00
IUUC-Eca-034352	Equus caballus	93.97	2.00e-122	431.00
IUUC-Eeu-034889	Erinaceus europaeus	78.02	4.00e-95	340.00
IUUC-Hsa-046518	Homo sapiens	92.24	6.00e-120	422.00
IUUC-Itr-048344	Ictidomys tridecemlineatus	94.92	2.00e-99	353.00
IUUC-Laf-053363	Loxodonta africana	91.03	1.00e-118	418.00
IUUC-Meu-056101	Macropus eugenii	78.20	1.00e-95	342.00
IUUC-Mdo-062046	Monodelphis domestica	78.92	8.00e-97	345.00
IUUC-Mmu-063184	Mus musculus	82.86	3.00e-57	213.00
IUUC-Mpu-065708	Mustela putorius furo	94.83	3.00e-123	433.00
IUUC-Mlu-067561	Myotis lucifugus	88.70	2.00e-93	333.00
IUUC-Nle-069665	Nomascus leucogenys	90.65	3.00e-108	383.00
IUUC-Opr-070301	Ochotona princeps	78.88	3.00e-99	354.00
IUUC-Ocu-074562	Oryctolagus cuniculus	92.86	3.00e-66	242.00
IUUC-Oga-088958	Otolemur garnettii	93.10	7.00e-122	429.00
IUUC-Oar-089541	Ovis aries	89.27	2.00e-94	337.00
IUUC-Ptr-090989	Pan troglodytes	92.67	6.00e-121	426.00
IUUC-Pan-092372	Papio anubis	91.81	2.00e-120	424.00
IUUC-Pab-098718	Pongo abelii	79.74	3.00e-96	343.00
IUUC-Pca-100453	Procavia capensis	89.22	4.00e-116	410.00
IUUC-Pva-102931	Pteropus vampyrus	91.81	4.00e-111	393.00
IUUC-Rno-105771	Rattus norvegicus	86.79	1.00e-99	355.00
IUUC-Sha-107557	Sarcophilus harrisii	76.17	7.00e-100	355.00
IUUC-Sar-113435	Sorex araneus	95.24	6.00e-69	251.00
IUUC-Ssc-116388	Sus scrofa	93.53	3.00e-123	434.00
IUUC-Tsy-119439	Tarsius syrichta	92.66	1.00e-97	348.00
IUUC-Tbe-127417	Tupaia belangeri	66.30	2.00e-66	244.00
IUUC-Ttr-129212	Tursiops truncatus	93.10	2.00e-122	431.00
IUUC-Uma-129518	Ustilago maydis	38.57	1.00e-07	52.00
IUUC-Vpa-130153	Vicugna pacos	90.09	6.00e-119	419.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence