iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065876

Ensembl Protein ID

ENSMPUP00000010530.1

UniProt Accession

M3YGS3; M3YGS3_MUSPF

Genbank Protein ID

ENSMPUP00000010530

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01019335

Gene Name

ARHGEF7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000010609.1	ENSMPUT00000010700.1	ENSMPUP00000010530.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-14	53.2	208	262

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL++ kGdv++v     +++gW++g    +g+ G fP+n+v++++
   Q: 208  VVRAKFNFQQTNEDELSFAKGDVIHVT--RVEEGGWWEG--MHNGRTGWFPSNYVREVK 262
           78999*********************7..999*******..8**************996 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MRSPRPLPGI PASPVRLASP DRGALLGPGS PAPPRELRVT GRGLRSGPAA SPRPASGASA 60
LARLRPAAGE EPAAASAPCP AAESAEVSVR RGQAPAGLLE EKPEAPEPAT DRCSERGPRT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNCGGGCGGC CCCCGGGACC CGCGTCCGGT 60
GTGCGCCGGG CCCTCGCGGT TCCCAGCGGG CAGGACGAGC GGGCGGGCGC CCCCAGCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000322--C:storage vacuole
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	96.98	0.00e+00	1168.00
IUUC-Aca-004591	Anolis carolinensis	87.63	0.00e+00	1056.00
IUUC-Ame-010759	Astyanax mexicanus	75.31	0.00e+00	919.00
IUUC-Bta-013328	Bos taurus	93.82	0.00e+00	1139.00
IUUC-Bci-013864	Botrytis cinerea	41.54	3.00e-11	64.70
IUUC-Cja-018742	Callithrix jacchus	93.96	0.00e+00	1131.00
IUUC-Cfa-020756	Canis familiaris	97.92	0.00e+00	1359.00
IUUC-Cpo-021284	Cavia porcellus	93.34	0.00e+00	1110.00
IUUC-Csa-023162	Chlorocebus sabaeus	93.26	0.00e+00	1141.00
IUUC-Cho-024736	Choloepus hoffmanni	71.94	1.00e-171	597.00
IUUC-Cin-025535	Ciona intestinalis	40.12	6.00e-95	341.00
IUUC-Cgl-026676	Colletotrichum gloeosporioides	42.86	5.00e-12	67.40
IUUC-Cne-026866	Cryptococcus neoformans	52.38	1.00e-13	73.20
IUUC-Dre-028646	Danio rerio	64.75	0.00e+00	930.00
IUUC-Dno-029461	Dasypus novemcinctus	93.42	0.00e+00	1152.00
IUUC-Dor-030623	Dipodomys ordii	83.28	0.00e+00	975.00
IUUC-Dse-031165	Dothistroma septosporum	39.47	7.00e-12	66.60
IUUC-Dme-032219	Drosophila melanogaster	45.48	5.00e-101	362.00
IUUC-Ete-032236	Echinops telfairi	79.02	0.00e+00	806.00
IUUC-Eca-034137	Equus caballus	95.87	0.00e+00	1160.00
IUUC-Fca-035742	Felis catus	96.84	0.00e+00	1325.00
IUUC-Fal-037205	Ficedula albicollis	91.53	0.00e+00	972.00
IUUC-Fso-038433	Fusarium solani	41.67	1.00e-12	68.90
IUUC-Gmo-039475	Gadus morhua	75.21	0.00e+00	1008.00
IUUC-Gga-040539	Gallus gallus	92.72	0.00e+00	1147.00
IUUC-Gac-042615	Gasterosteus aculeatus	72.61	0.00e+00	935.00
IUUC-Ggo-044470	Gorilla gorilla	94.12	0.00e+00	1136.00
IUUC-Hsa-046398	Homo sapiens	94.11	0.00e+00	1130.00
IUUC-Loc-052146	Lepisosteus oculatus	83.54	0.00e+00	1028.00
IUUC-Laf-053891	Loxodonta africana	94.59	0.00e+00	1187.00
IUUC-Mcc-055483	Macaca mulatta	93.95	0.00e+00	1130.00
IUUC-Mga-059410	Meleagris gallopavo	91.41	0.00e+00	1110.00
IUUC-Mmr-060758	Microcebus murinus	94.20	0.00e+00	1106.00
IUUC-Mdo-061900	Monodelphis domestica	92.46	0.00e+00	1304.00
IUUC-Mmu-063849	Mus musculus	93.03	0.00e+00	1097.00
IUUC-Mlu-067970	Myotis lucifugus	95.07	0.00e+00	1154.00
IUUC-Nle-069685	Nomascus leucogenys	91.80	0.00e+00	1203.00
IUUC-Opr-071132	Ochotona princeps	60.67	0.00e+00	643.00
IUUC-Ont-071815	Oreochromis niloticus	75.91	0.00e+00	909.00
IUUC-Oan-073057	Ornithorhynchus anatinus	91.35	0.00e+00	980.00
IUUC-Ola-086663	Oryzias latipes	74.02	0.00e+00	853.00
IUUC-Oga-088103	Otolemur garnettii	94.28	0.00e+00	1098.00
IUUC-Ptr-091162	Pan troglodytes	93.96	0.00e+00	1130.00
IUUC-Pan-092093	Papio anubis	80.37	0.00e+00	993.00
IUUC-Pma-094261	Petromyzon marinus	66.25	3.00e-125	441.00
IUUC-Pfo-096736	Poecilia formosa	73.83	0.00e+00	1023.00
IUUC-Pab-097641	Pongo abelii	93.96	0.00e+00	1318.00
IUUC-Pva-102819	Pteropus vampyrus	90.44	0.00e+00	1091.00
IUUC-Pte-104123	Pyrenophora teres	45.00	1.00e-10	62.80
IUUC-Rno-106099	Rattus norvegicus	92.87	0.00e+00	1098.00
IUUC-Sha-106845	Sarcophilus harrisii	93.06	0.00e+00	1301.00
IUUC-Ssc-116036	Sus scrofa	94.31	0.00e+00	1301.00
IUUC-Tgu-117498	Taeniopygia guttata	89.31	0.00e+00	1118.00
IUUC-Tru-118278	Takifugu rubripes	73.74	0.00e+00	870.00
IUUC-Tsy-118990	Tarsius syrichta	94.50	0.00e+00	982.00
IUUC-Tni-120852	Tetraodon nigroviridis	73.82	0.00e+00	1009.00
IUUC-Tre-121917	Trichoderma reesei	42.65	1.00e-11	66.20
IUUC-Ttr-128922	Tursiops truncatus	90.29	0.00e+00	1063.00
IUUC-Xtr-132012	Xenopus tropicalis	80.15	0.00e+00	911.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence