iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088103

Ensembl Protein ID

ENSOGAP00000001816.2

UniProt Accession

H0WJW7; H0WJW7_OTOGA

Genbank Protein ID

ENSOGAP00000001816

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03157610

Gene Name

ARHGEF7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000002032.2	ENSOGAT00000002036.2	ENSOGAP00000001816.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.50e-14	51.7	89	143

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL++ kGdv++v     +++gW++g  +  g+ G fP+n+v++++
   Q: 89   VVRAKFNFQQTNEDELSFSKGDVIHVT--RVEEGGWWEG--THGGRTGWFPSNYVREIK 143
           78999*********************7..999*******..89*************996 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

SNFSFQTFDA NDLYQGQNFN KVLSSLVTLN KVTADIGLGS DSVCARPPSH RIKSFDSLGS 60
QSLHSRTSKL LQGQYRSLDM TDHTNNQLVV RAKFNFQQTN EDELSFSKGD VIHVTRVEEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTAATTTTT CCTTTCAGAC ATTTGATGCA AATGATTTGT ACCAGGGGCA GAATTTTAAC 60
AAGGTCCTCA GTTCCCTAGT GACTCTAAAT AAAGTAACAG CAGGTAAGCT CTTTTTATTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000322--C:storage vacuole
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	94.36	0.00e+00	1186.00
IUUC-Aca-004591	Anolis carolinensis	90.56	0.00e+00	1234.00
IUUC-Ago-008003	Ashbya gossypii	25.20	1.00e-14	75.10
IUUC-Ame-010759	Astyanax mexicanus	75.76	0.00e+00	1150.00
IUUC-Bta-013328	Bos taurus	94.48	0.00e+00	1380.00
IUUC-Cja-018742	Callithrix jacchus	95.09	0.00e+00	1201.00
IUUC-Cfa-020756	Canis familiaris	94.30	0.00e+00	1149.00
IUUC-Cpo-021284	Cavia porcellus	93.49	0.00e+00	1315.00
IUUC-Csa-023162	Chlorocebus sabaeus	95.15	0.00e+00	1378.00
IUUC-Cho-024736	Choloepus hoffmanni	72.66	1.00e-171	596.00
IUUC-Cin-025535	Ciona intestinalis	40.12	1.00e-93	337.00
IUUC-Dre-028646	Danio rerio	75.51	0.00e+00	1139.00
IUUC-Dno-029461	Dasypus novemcinctus	94.77	0.00e+00	1366.00
IUUC-Dor-030623	Dipodomys ordii	83.26	0.00e+00	1000.00
IUUC-Dme-032219	Drosophila melanogaster	44.89	1.00e-100	361.00
IUUC-Ete-032236	Echinops telfairi	79.43	0.00e+00	800.00
IUUC-Eca-034137	Equus caballus	95.76	0.00e+00	1361.00
IUUC-Fca-035742	Felis catus	93.96	0.00e+00	1108.00
IUUC-Fal-037205	Ficedula albicollis	93.19	0.00e+00	1186.00
IUUC-Gmo-039475	Gadus morhua	67.52	0.00e+00	936.00
IUUC-Gga-040539	Gallus gallus	91.89	0.00e+00	966.00
IUUC-Gac-042615	Gasterosteus aculeatus	64.50	0.00e+00	859.00
IUUC-Ggo-044470	Gorilla gorilla	90.71	0.00e+00	1305.00
IUUC-Hsa-046398	Homo sapiens	94.79	0.00e+00	1194.00
IUUC-Loc-052146	Lepisosteus oculatus	85.20	0.00e+00	1242.00
IUUC-Laf-053891	Loxodonta africana	94.01	0.00e+00	1405.00
IUUC-Mcc-055483	Macaca mulatta	95.08	0.00e+00	1197.00
IUUC-Mga-059410	Meleagris gallopavo	92.97	0.00e+00	1329.00
IUUC-Mmr-060758	Microcebus murinus	96.97	0.00e+00	1169.00
IUUC-Mdo-061900	Monodelphis domestica	91.64	0.00e+00	1116.00
IUUC-Mmu-063849	Mus musculus	93.22	0.00e+00	1135.00
IUUC-Mpu-065876	Mustela putorius furo	94.28	0.00e+00	1137.00
IUUC-Mlu-067970	Myotis lucifugus	95.38	0.00e+00	1361.00
IUUC-Nle-069685	Nomascus leucogenys	91.53	0.00e+00	1034.00
IUUC-Opr-071132	Ochotona princeps	62.88	0.00e+00	697.00
IUUC-Ont-071815	Oreochromis niloticus	75.89	0.00e+00	1136.00
IUUC-Oan-073057	Ornithorhynchus anatinus	92.77	0.00e+00	1210.00
IUUC-Ola-086663	Oryzias latipes	73.92	0.00e+00	1056.00
IUUC-Ptr-091162	Pan troglodytes	95.23	0.00e+00	1206.00
IUUC-Pan-092093	Papio anubis	84.74	0.00e+00	1230.00
IUUC-Pma-094261	Petromyzon marinus	66.56	3.00e-126	444.00
IUUC-Pfo-096932	Poecilia formosa	63.91	0.00e+00	939.00
IUUC-Pab-097641	Pongo abelii	94.16	0.00e+00	1144.00
IUUC-Pva-102819	Pteropus vampyrus	90.33	0.00e+00	1114.00
IUUC-Ptt-103822	Puccinia triticina	20.18	6.00e-07	50.10
IUUC-Rno-106099	Rattus norvegicus	93.62	0.00e+00	1305.00
IUUC-Sha-106845	Sarcophilus harrisii	91.30	0.00e+00	1113.00
IUUC-Ssc-116036	Sus scrofa	93.35	0.00e+00	1119.00
IUUC-Tgu-117498	Taeniopygia guttata	92.47	0.00e+00	1326.00
IUUC-Tru-118278	Takifugu rubripes	73.32	0.00e+00	1060.00
IUUC-Tsy-118990	Tarsius syrichta	93.89	0.00e+00	972.00
IUUC-Tni-120852	Tetraodon nigroviridis	74.37	0.00e+00	884.00
IUUC-Ttr-128922	Tursiops truncatus	91.12	0.00e+00	1101.00
IUUC-Xtr-132012	Xenopus tropicalis	84.97	0.00e+00	1126.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence