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Tag Content
iUUCD ID IUUC-Mor-057164
Ensembl Protein ID MGG_09262T0
UniProt Accession Q525E4; A4R0W4; A4UTN9; G4MQ90; ATG5_MAGO7
Genbank Protein ID ABO93146.1; EHA57283.1
Protein Name Autophagy protein 5
Genbank Nucleotide ID EF486490; CM001231
Gene Name ATG5; MGG_09262
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
MGG_09262 MGG_09262T0 MGG_09262T0
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/Other 25.49 7.00e-05 42.70 IUUC-Sce-106216
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Magnaporthe oryzae
Functional Description
(View)

Functional Description



     Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity). Required for cell differentiation and pathogenesis.
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity). Required for cell differentiation and pathogenesis.
Protein Sequence
(Fasta)
MASPRRSEAD LASPARGPGS GPPSPPHPGP DSARPLSRIT SAAASPPPPG QRTAEPPTTI 60
SIPRTLWRLS IPLYITHPSL PNTPFITSLP RVSYLSLLLP RIRAFLPPSI PAPTSFHHEG 120
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Protein Fasta Sequence



>IUUC-Mor-057164|E3,Cullin RING/Other|Magnaporthe oryzae
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Nucleotide Sequence
(Fasta)
AAAAAAAAAA AAAAAAAAAA AAGGCTGCCT AGAGTAACAT TTGAACTACC TACGAATAAT 60
CGGCGGGGTA CTGCATAGGT AGTACAATAG TCGGGAGATA TTTAGTCTTT TTGGGTTGGT 120
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Nucleotide Fasta Sequence



>IUUC-Mor-057164|E3,Cullin RING/Other|Magnaporthe oryzae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034045--C:pre-autophagosomal structure membrane
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG mgr:MGG_09262
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000583 Aegilops tauschii 34.04 8.00e-15 73.90
IUUC-Aml-002403 Ailuropoda melanoleuca 26.77 5.00e-16 76.30
IUUC-Atr-002645 Amborella trichopoda 33.77 8.00e-16 75.90
IUUC-Apl-003611 Anas platyrhynchos 24.60 2.00e-17 80.50
IUUC-Aca-004411 Anolis carolinensis 26.77 2.00e-18 84.30
IUUC-Aly-005636 Arabidopsis lyrata 31.93 4.00e-12 63.50
IUUC-Ath-006959 Arabidopsis thaliana 31.93 5.00e-12 63.20
IUUC-Ago-007978 Ashbya gossypii 24.40 8.00e-06 42.70
IUUC-Acl-008328 Aspergillus clavatus 39.69 2.00e-36 144.00
IUUC-Afl-008638 Aspergillus flavus 36.05 9.00e-40 155.00
IUUC-Afu-009042 Aspergillus fumigatus 39.81 2.00e-44 171.00
IUUC-Ani-009364 Aspergillus nidulans 39.62 7.00e-30 122.00
IUUC-Aor-009889 Aspergillus oryzae 35.74 7.00e-40 155.00
IUUC-Ate-010511 Aspergillus terreus 41.11 5.00e-08 47.80
IUUC-Bgr-012153 Blumeria graminis 42.32 2.00e-49 187.00
IUUC-Bta-012360 Bos taurus 29.69 7.00e-07 45.10
IUUC-Bci-013723 Botrytis cinerea 50.94 1.00e-70 257.00
IUUC-Bdi-014520 Brachypodium distachyon 34.13 2.00e-12 64.70
IUUC-Bol-016053 Brassica oleracea 31.33 3.00e-13 67.40
IUUC-Bra-017072 Brassica rapa 30.08 4.00e-13 67.00
IUUC-Cel-018529 Caenorhabditis elegans 23.34 3.00e-09 53.90
IUUC-Cja-019569 Callithrix jacchus 25.40 9.00e-16 75.50
IUUC-Cfa-020473 Canis familiaris 25.79 3.00e-16 77.00
IUUC-Cpo-021421 Cavia porcellus 25.79 6.00e-16 76.30
IUUC-Csa-024197 Chlorocebus sabaeus 25.40 9.00e-16 75.50
IUUC-Cho-024521 Choloepus hoffmanni 25.10 1.00e-13 68.20
IUUC-Cin-025119 Ciona intestinalis 25.62 2.00e-14 70.90
IUUC-Csv-026192 Ciona savignyi 25.45 6.00e-15 72.40
IUUC-Cgl-026686 Colletotrichum gloeosporioides 61.59 8.00e-79 285.00
IUUC-Dre-028466 Danio rerio 26.59 3.00e-18 83.60
IUUC-Dno-029740 Dasypus novemcinctus 27.14 5.60e-01 26.60
IUUC-Dse-031228 Dothistroma septosporum 35.46 4.00e-38 149.00
IUUC-Dme-031703 Drosophila melanogaster 25.90 2.00e-11 61.20
IUUC-Ete-032482 Echinops telfairi 25.51 1.00e-14 71.60
IUUC-Eca-034036 Equus caballus 26.59 9.00e-17 78.60
IUUC-Eeu-035235 Erinaceus europaeus 30.47 8.00e-07 45.80
IUUC-Fca-036263 Felis catus 26.19 1.00e-16 78.20
IUUC-Fal-037064 Ficedula albicollis 25.00 2.00e-17 80.90
IUUC-Fox-037813 Fusarium oxysporum 57.65 4.00e-82 295.00
IUUC-Fso-038139 Fusarium solani 60.00 4.00e-83 298.00
IUUC-Gmo-039509 Gadus morhua 30.19 8.00e-12 62.00
IUUC-Ggr-040111 Gaeumannomyces graminis 68.48 1.00e-89 321.00
IUUC-Gga-040517 Gallus gallus 25.40 8.00e-18 82.40
IUUC-Gac-042270 Gasterosteus aculeatus 25.69 1.00e-13 68.20
IUUC-Gma-044400 Glycine max 32.93 6.00e-15 72.80
IUUC-Ggo-045048 Gorilla gorilla 25.40 5.00e-16 76.30
IUUC-Hsa-046744 Homo sapiens 25.40 7.00e-16 75.90
IUUC-Kpa-049174 Komagataella pastoris 26.02 2.00e-14 71.20
IUUC-Lch-049475 Latimeria chalumnae 27.38 2.00e-19 87.80
IUUC-Lpe-051283 Leersia perrieri 35.82 2.00e-13 69.70
IUUC-Loc-052446 Lepisosteus oculatus 26.98 2.00e-19 87.80
IUUC-Lma-053278 Leptosphaeria maculans 37.87 4.00e-44 169.00
IUUC-Laf-054020 Loxodonta africana 26.38 1.00e-15 74.70
IUUC-Mcc-055176 Macaca mulatta 25.40 7.00e-16 75.90
IUUC-Mpo-057428 Magnaporthe poae 64.77 3.00e-87 313.00
IUUC-Mtr-058424 Medicago truncatula 33.58 7.00e-14 68.90
IUUC-Mla-058872 Melampsora laricipopulina 24.56 8.00e-13 66.20
IUUC-Mga-059859 Meleagris gallopavo 25.40 8.00e-18 82.40
IUUC-Mmr-061482 Microcebus murinus 25.40 8.00e-16 75.50
IUUC-Mdo-062371 Monodelphis domestica 26.88 3.00e-17 80.50
IUUC-Mmu-063139 Mus musculus 26.59 1.00e-16 78.20
IUUC-Mac-065332 Musa acuminata 31.34 2.00e-12 65.10
IUUC-Mpu-066783 Mustela putorius furo 25.40 1.00e-15 75.10
IUUC-Mlu-068165 Myotis lucifugus 27.56 2.00e-16 78.20
IUUC-Nfi-068578 Neosartorya fischeri 39.05 4.00e-44 170.00
IUUC-Ncr-068636 Neurospora crassa 61.83 2.00e-83 300.00
IUUC-Nle-069740 Nomascus leucogenys 26.95 8.00e-16 75.50
IUUC-Opr-070802 Ochotona princeps 28.91 4.00e-06 43.50
IUUC-Ont-072222 Oreochromis niloticus 26.32 8.00e-16 75.50
IUUC-Oan-072760 Ornithorhynchus anatinus 28.30 4.00e-11 59.70
IUUC-Ocu-074844 Oryctolagus cuniculus 24.22 1.00e-10 57.80
IUUC-Oba-075834 Oryza barthii 33.33 2.00e-14 71.60
IUUC-Obr-076230 Oryza brachyantha 32.99 4.00e-09 53.50
IUUC-Ogl-077554 Oryza glaberrima 33.33 2.00e-14 72.00
IUUC-Ogu-078687 Oryza glumaepatula 32.78 2.00e-14 71.60
IUUC-Oin-079677 Oryza indica 32.37 4.00e-15 73.90
IUUC-Olo-081078 Oryza longistaminata 36.30 1.00e-14 72.80
IUUC-Ome-081548 Oryza meridionalis 34.04 1.00e-16 80.10
IUUC-Oni-082050 Oryza nivara 33.33 2.00e-14 71.20
IUUC-Opu-083609 Oryza punctata 33.33 1.00e-14 72.80
IUUC-Oru-085057 Oryza rufipogon 33.33 1.00e-14 72.40
IUUC-Osa-085917 Oryza sativa 33.33 1.00e-14 72.40
IUUC-Ola-087032 Oryzias latipes 24.60 9.00e-16 75.50
IUUC-Oga-088468 Otolemur garnettii 27.17 2.00e-17 80.90
IUUC-Oar-089751 Ovis aries 25.40 7.00e-16 75.90
IUUC-Ptr-091064 Pan troglodytes 25.40 7.00e-16 75.90
IUUC-Pan-092505 Papio anubis 26.38 1.00e-15 75.10
IUUC-Psi-093086 Pelodiscus sinensis 26.48 8.00e-18 82.00
IUUC-Pno-094825 Phaeosphaeria nodorum 37.78 2.00e-41 160.00
IUUC-Ppa-095419 Physcomitrella patens 30.49 1.00e-13 68.90
IUUC-Pfo-096224 Poecilia formosa 26.91 1.00e-15 74.70
IUUC-Pab-098501 Pongo abelii 26.95 8.00e-16 75.50
IUUC-Pop-099243 Populus trichocarpa 33.13 3.00e-13 67.40
IUUC-Ppe-101255 Prunus persica 31.14 7.00e-12 63.20
IUUC-Pva-102828 Pteropus vampyrus 25.40 2.00e-15 74.70
IUUC-Pgr-103672 Puccinia graminis 26.67 7.00e-11 59.70
IUUC-Ptt-104013 Puccinia triticina 25.53 2.00e-08 51.20
IUUC-Pyt-104615 Pyrenophora triticirepentis 35.74 8.00e-42 162.00
IUUC-Rno-106089 Rattus norvegicus 26.19 2.00e-16 77.00
IUUC-Sce-106216 Saccharomyces cerevisiae 25.49 6.00e-06 43.10
IUUC-Sha-106484 Sarcophilus harrisii 27.27 5.00e-17 79.70
IUUC-Sja-107699 Schizosaccharomyces japonicus 28.73 3.00e-25 106.00
IUUC-Spo-108177 Schizosaccharomyces pombe 29.09 2.00e-24 103.00
IUUC-Ssl-108475 Sclerotinia sclerotiorum 49.81 3.00e-70 256.00
IUUC-Smo-109473 Selaginella moellendorffii 29.37 1.00e-07 48.90
IUUC-Sit-110736 Setaria italica 31.33 9.00e-16 75.90
IUUC-Sly-111657 Solanum lycopersicum 32.34 1.00e-16 79.30
IUUC-Sar-113050 Sorex araneus 28.57 1.00e-09 55.10
IUUC-Sbi-114258 Sorghum bicolor 33.81 4.00e-15 73.90
IUUC-Sre-114902 Sporisorium reilianum 35.29 4.00e-06 44.70
IUUC-Ssc-116166 Sus scrofa 24.21 7.00e-13 65.90
IUUC-Tgu-116814 Taeniopygia guttata 25.00 2.00e-17 80.90
IUUC-Tru-118172 Takifugu rubripes 26.09 1.00e-17 81.60
IUUC-Tsy-119010 Tarsius syrichta 27.67 2.00e-10 57.80
IUUC-Tni-120397 Tetraodon nigroviridis 29.56 8.00e-12 62.00
IUUC-Tca-121283 Theobroma cacao 31.14 2.00e-14 71.60
IUUC-Tvi-122545 Trichoderma virens 60.00 3.00e-80 289.00
IUUC-Tae-122685 Triticum aestivum 33.58 2.00e-14 71.20
IUUC-Tur-126407 Triticum urartu 33.81 6.00e-16 76.30
IUUC-Tme-126913 Tuber melanosporum 35.52 2.00e-35 140.00
IUUC-Tbe-127738 Tupaia belangeri 25.49 4.00e-11 59.30
IUUC-Ttr-128528 Tursiops truncatus 25.40 2.00e-15 74.30
IUUC-Uma-129625 Ustilago maydis 35.29 4.00e-06 44.30
IUUC-Vda-129906 Verticillium dahliae 64.06 1.00e-78 283.00
IUUC-Vpa-130223 Vicugna pacos 24.80 4.00e-12 63.20
IUUC-Vvi-131617 Vitis vinifera 33.53 2.00e-14 72.00
IUUC-Xtr-132288 Xenopus tropicalis 26.09 2.00e-19 87.80
IUUC-Xma-134214 Xiphophorus maculatus 29.68 5.00e-10 55.80
IUUC-Yli-134377 Yarrowia lipolytica 30.00 5.00e-14 69.30
IUUC-Zma-135108 Zea mays 34.33 4.00e-15 73.90
Created Date 25-Jun-2017

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