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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Cel-018511
Ensembl Protein ID Y67H2A.6a
UniProt Accession Q95PZ0; CSN6_CAEEL
Genbank Protein ID CAC44307.1
Protein Name COP9 signalosome complex subunit 6
Genbank Nucleotide ID AL132951
Gene Name csn-6; Y67H2A.6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00000818 Y67H2A.6a Y67H2A.6a
WBGene00000818 Y67H2A.6b Y67H2A.6b
Annotation
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
DUB/JAMM 31.65 3.00e-32 137.00 IUUC-Dre-028843
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description



     Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
Protein Sequence
(Fasta)
MALNAPSGSC SSKVLLHPLV IMQMSEHYSR TKVQQGPTVK KVFGAILGRQ NGRQVEAINS 60
FVLKMETEEM AEPVTFSTEH LLQRADQYLE VFPELQVIGL YCAGEDDNLT PEEKPLLSKL 120
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Protein Fasta Sequence



>IUUC-Cel-018511|DUB,JAMM|Caenorhabditis elegans
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Nucleotide Sequence
(Fasta)
AAATGGCATT GAACGCACCA AGCGGGAGCT GTAGCTCGAA GGTGCTTTTG CATCCTTTGG 60
TTATTATGCA AATGTCCGAA CACTACTCCA GAACAAAGGT CCAACAGGGT CCTACTGTGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Cel-018511|DUB,JAMM|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0539--Nucleus
KW-0896--Oogenesis
KW-1185--Reference proteome
KW-0736--Signalosome

Interpro

IPR000555--JAMM/MPN+_dom
IPR033859--MPN_CSN6
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

Gene Ontology

GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0007275--P:multicellular organism development
GO:0048477--P:oogenesis
GO:0000338--P:protein deneddylation

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000900 Aegilops tauschii 27.78 7.00e-17 80.10
IUUC-Aml-001678 Ailuropoda melanoleuca 33.72 4.00e-28 117.00
IUUC-Atr-002442 Amborella trichopoda 27.62 1.00e-17 82.00
IUUC-Aca-004366 Anolis carolinensis 25.39 9.00e-08 48.90
IUUC-Aly-005748 Arabidopsis lyrata 24.29 3.00e-19 87.80
IUUC-Ath-006830 Arabidopsis thaliana 26.67 4.00e-19 87.40
IUUC-Acl-008087 Aspergillus clavatus 31.52 2.00e-07 48.90
IUUC-Afl-008629 Aspergillus flavus 35.48 1.00e-06 45.80
IUUC-Afu-008973 Aspergillus fumigatus 29.46 3.00e-07 48.10
IUUC-Ani-009239 Aspergillus nidulans 26.06 3.00e-07 48.10
IUUC-Ang-009845 Aspergillus niger 22.22 5.00e-08 50.80
IUUC-Aor-010137 Aspergillus oryzae 22.31 9.00e-08 50.10
IUUC-Ate-010588 Aspergillus terreus 25.32 7.00e-06 43.50
IUUC-Ame-011532 Astyanax mexicanus 28.92 4.00e-06 41.20
IUUC-Bgr-012126 Blumeria graminis 27.94 4.00e-10 57.80
IUUC-Bta-012891 Bos taurus 33.72 4.00e-28 117.00
IUUC-Bci-013650 Botrytis cinerea 28.30 9.00e-08 50.10
IUUC-Bdi-014189 Brachypodium distachyon 29.75 2.00e-19 88.20
IUUC-Bol-015194 Brassica oleracea 24.45 1.00e-20 92.40
IUUC-Bra-017180 Brassica rapa 26.98 1.00e-19 89.40
IUUC-Cja-019862 Callithrix jacchus 34.10 1.00e-28 119.00
IUUC-Cfa-020552 Canis familiaris 33.72 3.00e-28 117.00
IUUC-Cpo-022433 Cavia porcellus 34.10 1.00e-28 119.00
IUUC-Cre-022699 Chlamydomonas reinhardtii 25.81 9.00e-11 59.70
IUUC-Csa-023484 Chlorocebus sabaeus 34.10 1.00e-28 119.00
IUUC-Cho-024874 Choloepus hoffmanni 29.17 2.00e-09 55.10
IUUC-Cin-025747 Ciona intestinalis 32.17 5.00e-27 113.00
IUUC-Csv-025914 Ciona savignyi 30.60 3.00e-30 124.00
IUUC-Cgl-026665 Colletotrichum gloeosporioides 21.72 1.00e-06 46.60
IUUC-Cne-026818 Cryptococcus neoformans 26.90 1.00e-24 105.00
IUUC-Dre-028843 Danio rerio 31.65 3.00e-34 137.00
IUUC-Dno-029674 Dasypus novemcinctus 33.72 3.00e-28 117.00
IUUC-Dme-032196 Drosophila melanogaster 32.12 5.00e-38 150.00
IUUC-Ete-032593 Echinops telfairi 26.39 2.00e+00 24.30
IUUC-Eca-033933 Equus caballus 33.72 3.00e-28 117.00
IUUC-Fca-035946 Felis catus 33.72 4.00e-28 117.00
IUUC-Fso-038175 Fusarium solani 23.08 1.00e-06 46.60
IUUC-Gmo-038747 Gadus morhua 31.40 4.00e-29 120.00
IUUC-Gac-042199 Gasterosteus aculeatus 30.38 2.00e-28 118.00
IUUC-Gma-043702 Glycine max 25.31 1.00e-18 85.50
IUUC-Ggo-044978 Gorilla gorilla 34.10 2.00e-28 118.00
IUUC-Hsa-045797 Homo sapiens 34.10 1.00e-28 119.00
IUUC-Hvu-047511 Hordeum vulgare 29.20 1.00e-19 89.00
IUUC-Itr-048615 Ictidomys tridecemlineatus 34.10 1.00e-28 119.00
IUUC-Lch-049546 Latimeria chalumnae 29.81 4.00e-29 119.00
IUUC-Lpe-051207 Leersia perrieri 29.18 4.00e-20 90.50
IUUC-Loc-052106 Lepisosteus oculatus 30.14 3.00e-28 117.00
IUUC-Lma-053122 Leptosphaeria maculans 25.37 5.00e-08 51.60
IUUC-Laf-054454 Loxodonta africana 33.72 4.00e-28 117.00
IUUC-Mcc-054679 Macaca mulatta 34.10 1.00e-28 119.00
IUUC-Meu-056427 Macropus eugenii 33.33 3.00e-27 114.00
IUUC-Mor-057093 Magnaporthe oryzae 27.81 2.00e-04 38.90
IUUC-Mtr-058343 Medicago truncatula 25.62 9.00e-20 89.40
IUUC-Mla-059002 Melampsora laricipopulina 25.56 4.00e-17 80.90
IUUC-Mvi-060487 Microbotryum violaceum 30.68 5.00e-25 107.00
IUUC-Mmr-060577 Microcebus murinus 33.72 3.00e-28 117.00
IUUC-Mdo-061918 Monodelphis domestica 34.10 1.00e-28 119.00
IUUC-Mmu-063355 Mus musculus 33.72 3.00e-28 117.00
IUUC-Mac-064465 Musa acuminata 23.41 2.00e-15 75.10
IUUC-Mpu-066813 Mustela putorius furo 33.72 2.00e-28 118.00
IUUC-Mlu-067500 Myotis lucifugus 34.10 1.00e-28 119.00
IUUC-Nfi-068452 Neosartorya fischeri 29.46 5.00e-07 47.80
IUUC-Nle-070166 Nomascus leucogenys 34.10 2.00e-28 118.00
IUUC-Opr-071028 Ochotona princeps 33.72 3.00e-28 117.00
IUUC-Ont-072575 Oreochromis niloticus 30.03 5.00e-28 116.00
IUUC-Oan-073514 Ornithorhynchus anatinus 36.96 4.80e-01 28.10
IUUC-Ocu-074744 Oryctolagus cuniculus 33.72 4.00e-28 117.00
IUUC-Oba-075665 Oryza barthii 28.03 2.00e-18 85.10
IUUC-Obr-076094 Oryza brachyantha 27.46 1.00e-10 58.50
IUUC-Ogl-077223 Oryza glaberrima 28.03 2.00e-18 85.10
IUUC-Ogu-077975 Oryza glumaepatula 28.03 2.00e-18 85.10
IUUC-Oin-079690 Oryza indica 27.94 1.00e-17 82.40
IUUC-Ome-081114 Oryza meridionalis 28.15 8.00e-18 83.20
IUUC-Oni-082275 Oryza nivara 27.94 2.00e-17 81.60
IUUC-Opu-083281 Oryza punctata 27.92 1.00e-17 82.40
IUUC-Oru-084767 Oryza rufipogon 27.94 9.00e-18 82.80
IUUC-Osa-085506 Oryza sativa 27.94 9.00e-18 82.80
IUUC-Ola-086468 Oryzias latipes 30.03 6.00e-28 116.00
IUUC-Oga-088732 Otolemur garnettii 33.72 3.00e-28 117.00
IUUC-Oar-089714 Ovis aries 33.72 2.00e-28 118.00
IUUC-Ptr-091383 Pan troglodytes 34.10 1.00e-28 119.00
IUUC-Pan-091752 Papio anubis 34.10 1.00e-28 119.00
IUUC-Psi-094080 Pelodiscus sinensis 30.48 3.00e-28 117.00
IUUC-Pma-094665 Petromyzon marinus 51.02 7.00e-11 57.80
IUUC-Ppa-095312 Physcomitrella patens 26.44 1.00e-25 108.00
IUUC-Pfo-096180 Poecilia formosa 30.72 6.00e-29 119.00
IUUC-Pab-098521 Pongo abelii 34.10 1.00e-28 119.00
IUUC-Pop-099014 Populus trichocarpa 27.24 1.00e-18 85.50
IUUC-Pca-100331 Procavia capensis 31.14 2.00e-24 104.00
IUUC-Ppe-101223 Prunus persica 25.64 5.00e-16 77.00
IUUC-Pva-103061 Pteropus vampyrus 33.72 3.00e-28 117.00
IUUC-Pgr-103302 Puccinia graminis 25.53 2.00e-14 71.60
IUUC-Ptt-103773 Puccinia triticina 27.07 3.00e-16 78.20
IUUC-Pte-104297 Pyrenophora teres 27.33 2.00e-08 52.40
IUUC-Rno-105606 Rattus norvegicus 33.33 1.00e-27 115.00
IUUC-Sha-106621 Sarcophilus harrisii 34.10 2.00e-28 118.00
IUUC-Ssl-108446 Sclerotinia sclerotiorum 36.46 1.00e-07 49.70
IUUC-Smo-108791 Selaginella moellendorffii 26.35 5.00e-21 93.60
IUUC-Sit-110800 Setaria italica 27.50 2.00e-17 81.60
IUUC-Sly-111003 Solanum lycopersicum 25.08 4.00e-18 84.00
IUUC-Stu-112083 Solanum tuberosum 25.56 1.00e-18 85.50
IUUC-Sbi-113936 Sorghum bicolor 28.22 2.00e-17 82.00
IUUC-Sre-114955 Sporisorium reilianum 26.13 2.00e-22 98.60
IUUC-Tru-118518 Takifugu rubripes 30.14 2.00e-28 117.00
IUUC-Tsy-119285 Tarsius syrichta 44.83 5.30e-01 26.20
IUUC-Tni-120511 Tetraodon nigroviridis 30.14 4.00e-28 117.00
IUUC-Tca-121233 Theobroma cacao 26.44 8.00e-18 83.20
IUUC-Tae-123297 Triticum aestivum 29.20 9.00e-20 89.70
IUUC-Tur-126485 Triticum urartu 32.21 8.00e-13 66.20
IUUC-Tme-127071 Tuber melanosporum 22.01 1.00e-06 46.20
IUUC-Tbe-127457 Tupaia belangeri 32.18 8.00e-22 96.30
IUUC-Ttr-128708 Tursiops truncatus 32.18 4.00e-23 100.00
IUUC-Uma-129646 Ustilago maydis 25.56 2.00e-22 98.20
IUUC-Vpa-130606 Vicugna pacos 34.06 1.00e-13 68.90
IUUC-Vvi-131045 Vitis vinifera 25.39 2.00e-18 84.70
IUUC-Xtr-132674 Xenopus tropicalis 31.29 7.00e-33 132.00
IUUC-Xma-133413 Xiphophorus maculatus 30.38 1.00e-28 118.00
IUUC-Yli-134661 Yarrowia lipolytica 26.22 2.00e-15 75.10
IUUC-Zma-135166 Zea mays 28.10 5.00e-18 83.60
Created Date 25-Jun-2017

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