iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089363

Ensembl Protein ID

ENSOARP00000005594.1

UniProt Accession

W5P591; W5P591_SHEEP

Genbank Protein ID

ENSOARP00000005594

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AMGL01089997

Gene Name

KMT2C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000005193.1	ENSOART00000005681.1	ENSOARP00000005594.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	7.50e-27	93.5	1008	1059

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCr 52
            C+vC++++++e+ +++C++C++w+H+ C + s eee++n  +  + C+ Cr
   Q: 1008 ACPVCHRNYREEDLILQCRQCDRWMHAVCQNFSTEEEVENVADigFDCSLCR 1059
           6********************************999999999899******8 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

VGVLSLTEKG SGVKAEIKEQ SAEEDAEAEV DSSKQPVPAL QRSVSEESAS SLVSVGVEAK 60
ISEQLCAFCY CGEKSSLGQG DLKQFRVTPG FILPWKNQPS NKKDGDDNSN GTCEKTQNSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGGAGTCT TGAGCTTAAC TGAAAAAGGC AGTGGAGTCA AGGTGTGTTC TTTTTAGTCA 60
TTTTGCTCTT AGAATGGCTG ACAATTAGAG ACTGTGTCAT GATTGTTTTA AATTAATGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011990--TPR-like_helical_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002314	Ailuropoda melanoleuca	83.99	0.00e+00	6961.00
IUUC-Apl-003311	Anas platyrhynchos	69.88	0.00e+00	5521.00
IUUC-Aca-004705	Anolis carolinensis	65.12	0.00e+00	5055.00
IUUC-Bta-012322	Bos taurus	93.54	0.00e+00	7677.00
IUUC-Cja-019983	Callithrix jacchus	82.39	0.00e+00	6902.00
IUUC-Cfa-020903	Canis familiaris	82.61	0.00e+00	6923.00
IUUC-Cpo-021732	Cavia porcellus	77.56	0.00e+00	6425.00
IUUC-Csa-023083	Chlorocebus sabaeus	80.61	0.00e+00	5147.00
IUUC-Cho-024469	Choloepus hoffmanni	77.47	0.00e+00	2138.00
IUUC-Dre-028110	Danio rerio	63.17	0.00e+00	1201.00
IUUC-Dor-030569	Dipodomys ordii	74.28	0.00e+00	4138.00
IUUC-Dme-031590	Drosophila melanogaster	33.40	1.00e-68	255.00
IUUC-Eca-033945	Equus caballus	83.40	0.00e+00	4960.00
IUUC-Fca-035922	Felis catus	82.83	0.00e+00	6773.00
IUUC-Gmo-039403	Gadus morhua	53.10	0.00e+00	1181.00
IUUC-Gac-041896	Gasterosteus aculeatus	47.33	0.00e+00	1344.00
IUUC-Ggo-044812	Gorilla gorilla	80.43	0.00e+00	6760.00
IUUC-Hsa-046595	Homo sapiens	82.50	0.00e+00	6925.00
IUUC-Itr-048303	Ictidomys tridecemlineatus	80.05	0.00e+00	6559.00
IUUC-Lch-050086	Latimeria chalumnae	56.29	0.00e+00	2556.00
IUUC-Loc-052891	Lepisosteus oculatus	52.34	0.00e+00	2077.00
IUUC-Laf-054348	Loxodonta africana	79.35	0.00e+00	2897.00
IUUC-Mcc-054868	Macaca mulatta	82.56	0.00e+00	6891.00
IUUC-Meu-056322	Macropus eugenii	62.66	0.00e+00	1062.00
IUUC-Mga-059541	Meleagris gallopavo	69.57	0.00e+00	5380.00
IUUC-Mmr-061092	Microcebus murinus	80.70	0.00e+00	5146.00
IUUC-Mdo-062610	Monodelphis domestica	73.68	0.00e+00	1987.00
IUUC-Mmu-063666	Mus musculus	78.62	0.00e+00	6433.00
IUUC-Mpu-066366	Mustela putorius furo	82.39	0.00e+00	6523.00
IUUC-Mlu-068201	Myotis lucifugus	82.17	0.00e+00	4137.00
IUUC-Nle-069232	Nomascus leucogenys	79.66	0.00e+00	5126.00
IUUC-Opr-070625	Ochotona princeps	72.60	0.00e+00	1221.00
IUUC-Oan-072945	Ornithorhynchus anatinus	71.17	0.00e+00	3192.00
IUUC-Ocu-074920	Oryctolagus cuniculus	78.05	0.00e+00	4969.00
IUUC-Ola-086436	Oryzias latipes	45.32	0.00e+00	1347.00
IUUC-Oga-088637	Otolemur garnettii	76.90	0.00e+00	3955.00
IUUC-Ptr-091527	Pan troglodytes	82.48	0.00e+00	6974.00
IUUC-Pan-092102	Papio anubis	80.10	0.00e+00	6618.00
IUUC-Pma-094252	Petromyzon marinus	40.04	0.00e+00	654.00
IUUC-Pfo-096288	Poecilia formosa	48.62	0.00e+00	1495.00
IUUC-Pab-098241	Pongo abelii	80.35	0.00e+00	4376.00
IUUC-Pca-100103	Procavia capensis	76.72	0.00e+00	1507.00
IUUC-Pva-102238	Pteropus vampyrus	78.25	0.00e+00	2580.00
IUUC-Rno-105395	Rattus norvegicus	70.87	0.00e+00	1031.00
IUUC-Sha-106550	Sarcophilus harrisii	69.35	0.00e+00	4242.00
IUUC-Sar-113183	Sorex araneus	90.06	3.00e-155	544.00
IUUC-Tgu-116677	Taeniopygia guttata	68.44	0.00e+00	5177.00
IUUC-Tru-118037	Takifugu rubripes	52.90	0.00e+00	1234.00
IUUC-Tsy-118932	Tarsius syrichta	81.12	0.00e+00	4941.00
IUUC-Tni-119970	Tetraodon nigroviridis	54.17	0.00e+00	1209.00
IUUC-Ttr-129051	Tursiops truncatus	82.98	0.00e+00	6621.00
IUUC-Vpa-130236	Vicugna pacos	79.88	0.00e+00	1919.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence