iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010694

Ensembl Protein ID

ENSAMXP00000020364.1

UniProt Accession

W5LKK2; W5LKK2_ASTMX

Genbank Protein ID

ENSAMXP00000020364

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

APWO01023221

Gene Name

TXK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000019769.1	ENSAMXT00000020364.1	ENSAMXP00000020364.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.20e-12	46.1	86	144

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++kv +lyd+e++++ +L+l kG+  +v+  ++qd+ W++ + + +g +G++P+n+v+ ++
   Q: 86   EQQKVVALYDFEPSESYDLNLIKGEEYTVL--HKQDQLWWRVQ-DKHGNKGFIPSNYVTGIN 144
           5789*************************9..9*******986.**************9876 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MIESSHSIYS IFCCCCAVES RSLSLSLSTS TRVDLNSKSE EFSKPPGYTN RVCTPSLFIH 60
SSIYPPERLT KKLPQPPPVN EDDEGEQQKV VALYDFEPSE SYDLNLIKGE EYTVLHKQDQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGCACAG ACACACACAC TCAGTTAGAT GACTGGCCGC TTATCACACA CGCTGGAATG 60
AGGACCTCTC ACTGGGGTGA AGATGATCGA GTCCAGTAAG TACACCTTAT AAAAAATATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001365	Ailuropoda melanoleuca	56.95	3.00e-152	532.00
IUUC-Apl-003669	Anas platyrhynchos	63.25	1.00e-159	556.00
IUUC-Aca-004978	Anolis carolinensis	57.24	6.00e-144	504.00
IUUC-Bta-012467	Bos taurus	56.95	7.00e-152	530.00
IUUC-Cja-018841	Callithrix jacchus	56.95	4.00e-152	531.00
IUUC-Cfa-020983	Canis familiaris	58.33	9.00e-151	527.00
IUUC-Cpo-021307	Cavia porcellus	57.18	1.00e-152	533.00
IUUC-Csa-023508	Chlorocebus sabaeus	58.06	2.00e-151	528.00
IUUC-Dre-028544	Danio rerio	75.37	0.00e+00	636.00
IUUC-Dno-029828	Dasypus novemcinctus	57.24	1.00e-152	533.00
IUUC-Dor-030102	Dipodomys ordii	54.90	2.00e-140	492.00
IUUC-Ete-032981	Echinops telfairi	48.52	2.00e-119	423.00
IUUC-Eca-033594	Equus caballus	56.95	7.00e-152	530.00
IUUC-Eeu-035281	Erinaceus europaeus	52.02	2.00e-101	363.00
IUUC-Fca-035495	Felis catus	58.33	4.00e-151	528.00
IUUC-Fal-036771	Ficedula albicollis	63.48	4.00e-160	558.00
IUUC-Gga-041193	Gallus gallus	57.70	1.00e-151	530.00
IUUC-Gac-042383	Gasterosteus aculeatus	56.67	7.00e-161	560.00
IUUC-Hsa-045931	Homo sapiens	58.06	2.00e-150	526.00
IUUC-Itr-048061	Ictidomys tridecemlineatus	57.18	2.00e-152	532.00
IUUC-Lch-050516	Latimeria chalumnae	64.61	1.00e-164	573.00
IUUC-Loc-052730	Lepisosteus oculatus	62.33	0.00e+00	664.00
IUUC-Laf-053516	Loxodonta africana	57.18	1.00e-152	533.00
IUUC-Mcc-054795	Macaca mulatta	58.06	1.00e-150	526.00
IUUC-Meu-056157	Macropus eugenii	59.84	2.00e-136	479.00
IUUC-Mga-060196	Meleagris gallopavo	63.90	2.00e-165	575.00
IUUC-Mmr-060824	Microcebus murinus	58.06	6.00e-151	527.00
IUUC-Mdo-062054	Monodelphis domestica	63.42	8.00e-164	570.00
IUUC-Mmu-064047	Mus musculus	56.95	3.00e-152	532.00
IUUC-Mpu-066786	Mustela putorius furo	62.71	1.00e-163	569.00
IUUC-Mlu-067671	Myotis lucifugus	56.95	3.00e-146	512.00
IUUC-Nle-069108	Nomascus leucogenys	58.06	8.00e-151	527.00
IUUC-Opr-070505	Ochotona princeps	45.31	3.00e-107	382.00
IUUC-Ont-072585	Oreochromis niloticus	63.39	0.00e+00	657.00
IUUC-Oan-073495	Ornithorhynchus anatinus	57.34	5.00e-154	538.00
IUUC-Ocu-074416	Oryctolagus cuniculus	56.95	3.00e-152	532.00
IUUC-Ola-086938	Oryzias latipes	70.77	0.00e+00	627.00
IUUC-Oga-088995	Otolemur garnettii	58.06	2.00e-150	526.00
IUUC-Oar-089632	Ovis aries	56.95	5.00e-152	531.00
IUUC-Ptr-090941	Pan troglodytes	58.06	8.00e-151	527.00
IUUC-Pan-091900	Papio anubis	55.92	4.00e-142	498.00
IUUC-Psi-093565	Pelodiscus sinensis	64.37	2.00e-164	572.00
IUUC-Pfo-096955	Poecilia formosa	63.04	0.00e+00	657.00
IUUC-Pab-097587	Pongo abelii	58.06	1.00e-150	526.00
IUUC-Pva-102583	Pteropus vampyrus	56.72	7.00e-146	511.00
IUUC-Rno-104868	Rattus norvegicus	55.91	1.00e-146	513.00
IUUC-Sha-106744	Sarcophilus harrisii	56.98	2.00e-151	529.00
IUUC-Sar-113041	Sorex araneus	58.10	2.00e-149	522.00
IUUC-Ssc-115294	Sus scrofa	57.18	9.00e-153	533.00
IUUC-Tgu-116458	Taeniopygia guttata	63.48	5.00e-163	568.00
IUUC-Tsy-118945	Tarsius syrichta	57.58	2.00e-147	516.00
IUUC-Ttr-128769	Tursiops truncatus	58.10	3.00e-141	495.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence