iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000052407.1	ENSRNOT00000077547.1	ENSRNOP00000071684.1
ENSRNOG00000052407.1	ENSRNOT00000086863.1	ENSRNOP00000073875.1

Annotation

mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-13	50.4	218	275

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++kv +lydy++ n ++L+l+kG+  +++  ee +  W+++ ++ +g++G +P+n+v+++e
   Q: 218  LKKVVALYDYMPMNANDLQLRKGEEYFIL--EESNLPWWRA-RDKNGQEGYIPSNYVTEAE 275
           689*************************9..9999******.6***************987 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVHKLSYY EYDFERGGKK SRVLGSYYVE 60
NYYCVENILP PKIPPTRDQV LQRRGEESSE MEQISIIERF PYPFQVVYDE GPLYVFSPTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGCTG TGATACTGGA GAGCATCTTT CTGAAGCGCT CCCAGCAGAA AAAGAAAACA 60
TCACCTTTAA ATTTTAAGAA GCGCCTATTT CTCCTGACTG TGCACAAACT TTCATACTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom
IPR001562--Znf_Btk_motif

PROSITE

PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3
PS51113--ZF_BTK

Pfam

PF00779--BTK
PF00169--PH
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00402--TECBTKDOMAIN
PR00109--TYRKINASE

SMART

SM00107--BTK
SM00233--PH
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0042629--C:mast cell granule
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0002344--P:B cell affinity maturation
GO:0030154--P:cell differentiation
GO:0048469--P:cell maturation
GO:0098761--P:cellular response to interleukin-7
GO:0071226--P:cellular response to molecule of fungal origin
GO:0034614--P:cellular response to reactive oxygen species
GO:0002553--P:histamine secretion by mast cell
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0045087--P:innate immune response
GO:0030889--P:negative regulation of B cell proliferation
GO:0001818--P:negative regulation of cytokine production
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0001812--P:positive regulation of type I hypersensitivity
GO:0001805--P:positive regulation of type III hypersensitivity
GO:0046777--P:protein autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0010033--P:response to organic substance
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001365	Ailuropoda melanoleuca	93.35	0.00e+00	1221.00
IUUC-Apl-003907	Anas platyrhynchos	81.76	0.00e+00	1081.00
IUUC-Aca-004978	Anolis carolinensis	72.70	0.00e+00	992.00
IUUC-Ame-010694	Astyanax mexicanus	55.91	4.00e-147	514.00
IUUC-Bta-012467	Bos taurus	93.35	0.00e+00	1221.00
IUUC-Cja-018841	Callithrix jacchus	92.90	0.00e+00	1216.00
IUUC-Cfa-020983	Canis familiaris	93.66	0.00e+00	1182.00
IUUC-Cpo-021307	Cavia porcellus	93.66	0.00e+00	1224.00
IUUC-Csa-023508	Chlorocebus sabaeus	95.98	0.00e+00	944.00
IUUC-Dre-028544	Danio rerio	56.82	2.00e-142	498.00
IUUC-Dno-029828	Dasypus novemcinctus	91.99	0.00e+00	1194.00
IUUC-Dor-030102	Dipodomys ordii	85.74	0.00e+00	1007.00
IUUC-Ete-032981	Echinops telfairi	84.29	0.00e+00	1079.00
IUUC-Eca-033594	Equus caballus	93.81	0.00e+00	1225.00
IUUC-Eeu-035281	Erinaceus europaeus	88.26	0.00e+00	954.00
IUUC-Fca-035495	Felis catus	92.90	0.00e+00	1173.00
IUUC-Fal-036719	Ficedula albicollis	81.57	0.00e+00	1095.00
IUUC-Gga-041193	Gallus gallus	81.27	0.00e+00	1080.00
IUUC-Gac-042383	Gasterosteus aculeatus	49.24	4.00e-121	428.00
IUUC-Hsa-045931	Homo sapiens	93.66	0.00e+00	1195.00
IUUC-Itr-048061	Ictidomys tridecemlineatus	93.05	0.00e+00	1218.00
IUUC-Lch-049868	Latimeria chalumnae	72.86	0.00e+00	944.00
IUUC-Loc-052730	Lepisosteus oculatus	56.50	7.00e-158	550.00
IUUC-Laf-053516	Loxodonta africana	92.77	0.00e+00	1241.00
IUUC-Mcc-054795	Macaca mulatta	93.66	0.00e+00	1195.00
IUUC-Meu-056157	Macropus eugenii	80.36	0.00e+00	1016.00
IUUC-Mga-059529	Meleagris gallopavo	83.67	0.00e+00	952.00
IUUC-Mmr-060824	Microcebus murinus	91.54	0.00e+00	1162.00
IUUC-Mdo-063036	Monodelphis domestica	90.19	0.00e+00	1176.00
IUUC-Mmu-064047	Mus musculus	94.56	0.00e+00	1233.00
IUUC-Mpu-066810	Mustela putorius furo	93.05	0.00e+00	1219.00
IUUC-Mlu-067671	Myotis lucifugus	92.48	0.00e+00	1214.00
IUUC-Nle-069108	Nomascus leucogenys	93.66	0.00e+00	1195.00
IUUC-Opr-070505	Ochotona princeps	75.51	0.00e+00	656.00
IUUC-Ont-072585	Oreochromis niloticus	57.34	2.00e-154	539.00
IUUC-Oan-073495	Ornithorhynchus anatinus	87.92	0.00e+00	1196.00
IUUC-Ocu-074416	Oryctolagus cuniculus	93.81	0.00e+00	1228.00
IUUC-Ola-086938	Oryzias latipes	57.54	1.00e-149	523.00
IUUC-Oga-088995	Otolemur garnettii	92.62	0.00e+00	1183.00
IUUC-Oar-089632	Ovis aries	92.15	0.00e+00	1216.00
IUUC-Ptr-090941	Pan troglodytes	93.50	0.00e+00	1194.00
IUUC-Pan-091900	Papio anubis	90.79	0.00e+00	1147.00
IUUC-Psi-093048	Pelodiscus sinensis	81.02	0.00e+00	1055.00
IUUC-Pfo-096955	Poecilia formosa	58.99	3.00e-157	548.00
IUUC-Pab-097587	Pongo abelii	93.50	0.00e+00	1194.00
IUUC-Pca-100374	Procavia capensis	82.45	5.00e-136	478.00
IUUC-Pva-102583	Pteropus vampyrus	93.05	0.00e+00	1194.00
IUUC-Sha-106744	Sarcophilus harrisii	88.67	0.00e+00	1189.00
IUUC-Sar-113041	Sorex araneus	92.26	0.00e+00	1044.00
IUUC-Ssc-115294	Sus scrofa	93.66	0.00e+00	1225.00
IUUC-Tgu-116458	Taeniopygia guttata	51.50	0.00e+00	678.00
IUUC-Tsy-118945	Tarsius syrichta	94.38	0.00e+00	835.00
IUUC-Ttr-128769	Tursiops truncatus	83.99	0.00e+00	1086.00
IUUC-Vpa-130517	Vicugna pacos	87.56	0.00e+00	676.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence