iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-004477

Ensembl Protein ID

ENSACAP00000001255.3

UniProt Accession

G1K9B9; G1K9B9_ANOCA

Protein Name

Uncharacterized protein

Gene Name

VAV3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000000782.3	ENSACAT00000001288.3	ENSACAP00000001255.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.50e-14	52.9	821	872

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGdvv++   +   +gW++g  e +g+ G fP+ +ve+
   Q: 821  IARYDFCARDMRELSLLKGDVVKIY-TKISANGWWRG--EVNGRVGWFPSTYVEE 872
           688*********************9.889999*****..9*************86 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MEPWKQCAHW LIQCRVLPPN HRVTWEAAQV FDLAQTLRDG VLLCQLLNNL RPRSINLKEI 60
NLRPQMSQFL CLKNIRTFLS ACCETFGMKK SELFEAFDLF DVRDFGKVIE TLSKLSRTSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGGGTTAT GAATATTATT TCCTAATTGG TTCTTTTATA AATACATAGA AAAAACCTGA 60
CTTGCTTAAT TTCCAACAAA CCTCCCAACC TCTGATGATG TGGGCGAAAC GTCAGGAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
IPR003096--SM22_calponin

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007229--P:integrin-mediated signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0030593--P:neutrophil chemotaxis
GO:0030890--P:positive regulation of B cell proliferation
GO:0045785--P:positive regulation of cell adhesion
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0042493--P:response to drug
GO:0007264--P:small GTPase mediated signal transduction
GO:0006906--P:vesicle fusion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	82.40	0.00e+00	1398.00
IUUC-Apl-003734	Anas platyrhynchos	85.86	0.00e+00	1365.00
IUUC-Ame-011279	Astyanax mexicanus	64.38	0.00e+00	1109.00
IUUC-Bta-012722	Bos taurus	81.71	0.00e+00	1388.00
IUUC-Cel-018578	Caenorhabditis elegans	30.20	5.00e-75	276.00
IUUC-Cja-018941	Callithrix jacchus	82.70	0.00e+00	1390.00
IUUC-Cfa-020266	Canis familiaris	81.73	0.00e+00	1233.00
IUUC-Cpo-021966	Cavia porcellus	80.69	0.00e+00	1192.00
IUUC-Csa-023892	Chlorocebus sabaeus	81.98	0.00e+00	1282.00
IUUC-Cin-025115	Ciona intestinalis	36.37	8.00e-137	481.00
IUUC-Csv-025995	Ciona savignyi	35.08	6.00e-144	504.00
IUUC-Dre-028199	Danio rerio	67.24	0.00e+00	1141.00
IUUC-Dno-029474	Dasypus novemcinctus	82.74	0.00e+00	1407.00
IUUC-Eca-033961	Equus caballus	81.60	0.00e+00	1258.00
IUUC-Eeu-034719	Erinaceus europaeus	63.20	0.00e+00	667.00
IUUC-Fca-036572	Felis catus	81.69	0.00e+00	1359.00
IUUC-Fal-036802	Ficedula albicollis	89.24	0.00e+00	1577.00
IUUC-Gmo-039409	Gadus morhua	66.33	0.00e+00	1125.00
IUUC-Gga-040884	Gallus gallus	85.35	0.00e+00	1484.00
IUUC-Gac-041395	Gasterosteus aculeatus	69.51	0.00e+00	1224.00
IUUC-Ggo-044460	Gorilla gorilla	80.38	0.00e+00	1211.00
IUUC-Hsa-046099	Homo sapiens	85.94	0.00e+00	1483.00
IUUC-Itr-048144	Ictidomys tridecemlineatus	84.82	0.00e+00	1300.00
IUUC-Lch-049650	Latimeria chalumnae	71.37	2.00e-101	361.00
IUUC-Loc-052487	Lepisosteus oculatus	70.37	0.00e+00	1218.00
IUUC-Laf-054564	Loxodonta africana	82.17	0.00e+00	1395.00
IUUC-Mcc-054622	Macaca mulatta	85.60	0.00e+00	1481.00
IUUC-Meu-056680	Macropus eugenii	75.29	0.00e+00	1277.00
IUUC-Mga-060013	Meleagris gallopavo	81.81	0.00e+00	1402.00
IUUC-Mmr-061251	Microcebus murinus	84.12	0.00e+00	1499.00
IUUC-Mdo-061875	Monodelphis domestica	81.69	0.00e+00	1404.00
IUUC-Mmu-063735	Mus musculus	81.71	0.00e+00	1415.00
IUUC-Mpu-065856	Mustela putorius furo	82.63	0.00e+00	1406.00
IUUC-Mlu-068108	Myotis lucifugus	83.43	0.00e+00	1366.00
IUUC-Nle-069863	Nomascus leucogenys	84.70	0.00e+00	1446.00
IUUC-Opr-070372	Ochotona princeps	74.14	0.00e+00	913.00
IUUC-Ont-072286	Oreochromis niloticus	70.05	0.00e+00	1209.00
IUUC-Ocu-074194	Oryctolagus cuniculus	82.63	0.00e+00	1407.00
IUUC-Ola-086336	Oryzias latipes	68.15	0.00e+00	1199.00
IUUC-Oga-089104	Otolemur garnettii	58.45	0.00e+00	972.00
IUUC-Oar-089272	Ovis aries	81.37	0.00e+00	1424.00
IUUC-Ptr-090652	Pan troglodytes	80.80	0.00e+00	1392.00
IUUC-Pan-092550	Papio anubis	85.03	0.00e+00	1311.00
IUUC-Psi-093784	Pelodiscus sinensis	86.51	0.00e+00	1358.00
IUUC-Pma-094372	Petromyzon marinus	50.43	0.00e+00	665.00
IUUC-Ppa-095161	Physcomitrella patens	43.64	1.00e-09	57.00
IUUC-Pfo-097308	Poecilia formosa	72.41	0.00e+00	1282.00
IUUC-Pab-098698	Pongo abelii	80.57	0.00e+00	1391.00
IUUC-Pva-102262	Pteropus vampyrus	81.55	0.00e+00	1335.00
IUUC-Rno-105421	Rattus norvegicus	81.26	0.00e+00	1417.00
IUUC-Sha-107325	Sarcophilus harrisii	81.81	0.00e+00	1424.00
IUUC-Sar-113456	Sorex araneus	77.37	0.00e+00	1333.00
IUUC-Ssc-115338	Sus scrofa	56.49	0.00e+00	871.00
IUUC-Tgu-116595	Taeniopygia guttata	81.89	0.00e+00	1392.00
IUUC-Tru-118577	Takifugu rubripes	67.78	0.00e+00	1117.00
IUUC-Tsy-119429	Tarsius syrichta	75.71	0.00e+00	1154.00
IUUC-Tni-119951	Tetraodon nigroviridis	66.70	0.00e+00	1123.00
IUUC-Tbe-127995	Tupaia belangeri	77.00	3.00e-161	562.00
IUUC-Ttr-128281	Tursiops truncatus	82.17	0.00e+00	1392.00
IUUC-Vpa-130066	Vicugna pacos	50.00	2.00e-35	144.00
IUUC-Xtr-132427	Xenopus tropicalis	68.37	0.00e+00	1227.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence