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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045867
Ensembl Protein ID ENSP00000380317.2
UniProt Accession Q13131; A8MTQ6; B2R7E1; O00286; Q5D0E1; Q86VS1; Q9UNQ4; AAPK1_HUMAN
Genbank Protein ID AAH48980.1; BAA36547.1; BAG35788.1; AAH37303.1; AAD43027.1; AAA64850.1; CAA73361.1
Protein Name 5'-AMP-activated protein kinase catalytic subunit alpha-1; Acetyl-CoA carboxylase kinase; Hydroxymethylglutaryl-CoA reductase kinase; Tau-protein kinase PRKAA1
Genbank Nucleotide ID AC008810; AB022017; AK312947; BC037303; AF100763; U22456; Y12856
Gene Name PRKAA1; AMPK1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000132356.11 ENST00000397128.6 ENSP00000380317.2
ENSG00000132356.11 ENST00000354209.7 ENSP00000346148.3
ENSG00000132356.11 ENST00000296800.4 ENSP00000296800.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Drug and target
TTDDrugBankGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 40.28 3.00e-98 353.00 IUUC-Spo-108202
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.
 Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.
Protein Sequence
(Fasta)
MRRLSSWRKM ATAEKQKHDG RVKIGHYILG DTLGVGTFGK VKVGKHELTG HKVAVKILNR 60
QKIRSLDVVG KIRREIQNLK LFRHPHIIKL YQVISTPSDI FMVMEYVSGG ELFDYICKNG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045867|UBD,UBA|Homo sapiens
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Nucleotide Sequence
(Fasta)
ATTCTCCTGG CAGCCCCCGC CCGCCCCGCC AGGGGGAGCG TCTGCGCCCG ACGTAGGCTG 60
CGGGGCCTGG GCTGGCGGCG CAGGGCGGTG ACTCGGCTCG GTGGCTGCCC TCCCGCGTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045867|UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0072--Autophagy
KW-0090--Biological rhythms
KW-0152--Cholesterol biosynthesis
KW-0153--Cholesterol metabolism
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0418--Kinase
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0752--Steroid biosynthesis
KW-0753--Steroid metabolism
KW-0756--Sterol biosynthesis
KW-1207--Sterol metabolism
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0879--Wnt signaling pathway
Interpro

IPR032270--AMPK_C
IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF16579--AdenylateSensor
PF00069--Pkinase
SMART

SM00220--S_TKc
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0031588--C:nucleotide-activated protein kinase complex
GO:0005634--C:nucleus
GO:0050405--F:[acetyl-CoA carboxylase] kinase activity
GO:0047322--F:[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0004679--F:AMP-activated protein kinase activity
GO:0005524--F:ATP binding
GO:0004691--F:cAMP-dependent protein kinase activity
GO:0003682--F:chromatin binding
GO:0035174--F:histone serine kinase activity
GO:0046872--F:metal ion binding
GO:0004672--F:protein kinase activity
GO:0050321--F:tau-protein kinase activity
GO:0000187--P:activation of MAPK activity
GO:0061762--P:CAMKK-AMPK signaling cascade
GO:0007050--P:cell cycle arrest
GO:0071361--P:cellular response to ethanol
GO:0042149--P:cellular response to glucose starvation
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071456--P:cellular response to hypoxia
GO:0031669--P:cellular response to nutrient levels
GO:0071417--P:cellular response to organonitrogen compound
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:0006695--P:cholesterol biosynthetic process
GO:0009631--P:cold acclimation
GO:0006633--P:fatty acid biosynthetic process
GO:0055089--P:fatty acid homeostasis
GO:0019395--P:fatty acid oxidation
GO:0042593--P:glucose homeostasis
GO:0006006--P:glucose metabolic process
GO:0035556--P:intracellular signal transduction
GO:0008610--P:lipid biosynthetic process
GO:0016236--P:macroautophagy
GO:0043066--P:negative regulation of apoptotic process
GO:2001274--P:negative regulation of glucose import in response to insulin stimulus
GO:0046318--P:negative regulation of glucosylceramide biosynthetic process
GO:0050995--P:negative regulation of lipid catabolic process
GO:0032007--P:negative regulation of TOR signaling
GO:0010508--P:positive regulation of autophagy
GO:0008284--P:positive regulation of cell proliferation
GO:0045542--P:positive regulation of cholesterol biosynthetic process
GO:0010628--P:positive regulation of gene expression
GO:0045821--P:positive regulation of glycolytic process
GO:0048643--P:positive regulation of skeletal muscle tissue development
GO:0051291--P:protein heterooligomerization
GO:0006468--P:protein phosphorylation
GO:0042752--P:regulation of circadian rhythm
GO:2000505--P:regulation of energy homeostasis
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0006355--P:regulation of transcription, DNA-templated
GO:0060627--P:regulation of vesicle-mediated transport
GO:0014823--P:response to activity
GO:0031000--P:response to caffeine
GO:1901563--P:response to camptothecin
GO:0010332--P:response to gamma radiation
GO:0001666--P:response to hypoxia
GO:0009411--P:response to UV
GO:0048511--P:rhythmic process
GO:0007165--P:signal transduction
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway
KEGG hsa:5562
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001907 Ailuropoda melanoleuca 99.28 0.00e+00 1056.00
IUUC-Atr-002770 Amborella trichopoda 48.47 5.00e-125 441.00
IUUC-Bta-012786 Bos taurus 99.28 0.00e+00 1066.00
IUUC-Cfa-020177 Canis familiaris 99.42 0.00e+00 1003.00
IUUC-Cho-024859 Choloepus hoffmanni 96.99 0.00e+00 989.00
IUUC-Cme-027289 Cyanidioschyzon merolae 46.44 2.00e-111 395.00
IUUC-Dre-027749 Danio rerio 83.28 0.00e+00 947.00
IUUC-Dno-030006 Dasypus novemcinctus 98.93 0.00e+00 1048.00
IUUC-Ete-033055 Echinops telfairi 95.94 0.00e+00 1058.00
IUUC-Eca-034239 Equus caballus 99.81 0.00e+00 1003.00
IUUC-Fca-035754 Felis catus 96.32 0.00e+00 1034.00
IUUC-Fal-037363 Ficedula albicollis 93.59 0.00e+00 1006.00
IUUC-Gmo-039633 Gadus morhua 82.43 0.00e+00 974.00
IUUC-Ggo-044797 Gorilla gorilla 99.82 0.00e+00 1058.00
IUUC-Lch-049623 Latimeria chalumnae 90.02 0.00e+00 952.00
IUUC-Lpe-051392 Leersia perrieri 52.24 2.00e-125 442.00
IUUC-Loc-052362 Lepisosteus oculatus 90.00 0.00e+00 932.00
IUUC-Laf-053799 Loxodonta africana 99.28 0.00e+00 1089.00
IUUC-Mor-057170 Magnaporthe oryzae 49.87 6.00e-102 365.00
IUUC-Mtr-058309 Medicago truncatula 48.64 2.00e-125 442.00
IUUC-Mmr-061761 Microcebus murinus 99.64 0.00e+00 1055.00
IUUC-Mlu-068227 Myotis lucifugus 98.45 0.00e+00 996.00
IUUC-Opr-070272 Ochotona princeps 95.64 0.00e+00 1032.00
IUUC-Ont-072027 Oreochromis niloticus 83.68 0.00e+00 948.00
IUUC-Oan-073322 Ornithorhynchus anatinus 88.17 0.00e+00 983.00
IUUC-Ocu-074188 Oryctolagus cuniculus 96.63 0.00e+00 1021.00
IUUC-Oba-075436 Oryza barthii 48.24 2.00e-126 446.00
IUUC-Obr-076507 Oryza brachyantha 48.16 9.00e-127 447.00
IUUC-Ogu-078349 Oryza glumaepatula 47.59 2.00e-126 446.00
IUUC-Ome-081630 Oryza meridionalis 48.03 5.00e-126 444.00
IUUC-Oni-082211 Oryza nivara 48.24 8.00e-127 447.00
IUUC-Opu-083617 Oryza punctata 47.47 1.00e-125 443.00
IUUC-Oru-084252 Oryza rufipogon 48.24 2.00e-126 446.00
IUUC-Osa-085548 Oryza sativa 48.24 2.00e-126 446.00
IUUC-Ola-086366 Oryzias latipes 83.88 0.00e+00 960.00
IUUC-Olu-087861 Ostreococcus lucimarinus 48.75 5.00e-118 418.00
IUUC-Oga-088003 Otolemur garnettii 99.82 0.00e+00 1057.00
IUUC-Oar-089933 Ovis aries 99.28 0.00e+00 1066.00
IUUC-Ptr-090718 Pan troglodytes 100.00 0.00e+00 1058.00
IUUC-Pan-092526 Papio anubis 99.82 0.00e+00 1057.00
IUUC-Psi-094034 Pelodiscus sinensis 93.40 0.00e+00 1006.00
IUUC-Pfo-097050 Poecilia formosa 83.80 0.00e+00 951.00
IUUC-Pab-098519 Pongo abelii 100.00 0.00e+00 1058.00
IUUC-Pop-099781 Populus trichocarpa 54.01 1.00e-126 447.00
IUUC-Pca-101104 Procavia capensis 95.43 0.00e+00 764.00
IUUC-Sha-107603 Sarcophilus harrisii 97.32 0.00e+00 1042.00
IUUC-Spo-108202 Schizosaccharomyces pombe 40.67 2.00e-107 382.00
IUUC-Smo-109309 Selaginella moellendorffii 46.26 1.00e-122 433.00
IUUC-Sit-109745 Setaria italica 53.16 2.00e-127 449.00
IUUC-Sar-113521 Sorex araneus 89.73 0.00e+00 866.00
IUUC-Sbi-114764 Sorghum bicolor 48.36 2.00e-128 452.00
IUUC-Ssc-115732 Sus scrofa 99.42 0.00e+00 1000.00
IUUC-Tgu-117190 Taeniopygia guttata 93.06 0.00e+00 999.00
IUUC-Tni-119833 Tetraodon nigroviridis 83.88 0.00e+00 944.00
IUUC-Tre-122070 Trichoderma reesei 49.21 1.00e-103 370.00
IUUC-Tme-127174 Tuber melanosporum 39.38 2.00e-68 253.00
IUUC-Ttr-129224 Tursiops truncatus 95.47 0.00e+00 1052.00
IUUC-Vvi-131649 Vitis vinifera 48.57 1.00e-125 443.00
IUUC-Xma-134082 Xiphophorus maculatus 84.03 0.00e+00 874.00
IUUC-Zma-135621 Zea mays 53.49 1.00e-121 431.00
Created Date 25-Jun-2017

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