iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ani-009229

Ensembl Protein ID

CADANIAP00001416

UniProt Accession

Q5BE22; C8VST3; PRP46_EMENI

Genbank Protein ID

EAA65801.1; CBF87932.1

Protein Name

Pre-mRNA-splicing factor prp46; Pre-mRNA-processing protein 46

Genbank Nucleotide ID

AACD01000017; BN001308

Gene Name

ANIA_01208; prp46; AN1208

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADANIAG00001416	CADANIAT00001416	CADANIAP00001416

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.70e-40	133.7	141	175
UBD/Beta-Prp	8.50e-62	208.1	144	432

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           gH ++v++la  ++   ++sG++D tik+W+l tg
   Q: 141  GHLGWVRSLAVePNnEWFASGAGDRTIKIWNLATG 175
           8***********66699***************998 PP

UBD/Beta-Prp

   S: 11   svitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfs 103
           + ++++++ p+++++a+g  d+tik+w++ tg l  +l gh ++v+ +  sp+ ++l +++eD+++k wdl+t+k +++++gh + v++l+++
   Q: 144  GWVRSLAVEPNNEWFASGAGDRTIKIWNLATGALRLTLTGHISTVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYTLALH 236
           45778999************************************************************************************* PP
   S: 104  psgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelv 196
           p  d lv+G++d ++rvwd++t++ ++ +lsgh+g+v  v+ ++ +  +++GslD tvrlWdl+ gk +  lt  h++ ++sl+ ++  + ++
   Q: 237  PRLDLLVTGGRDGVARVWDMRTRSNIH-VLSGHTGTVADVQCQEADPQVITGSLDATVRLWDLAAGKTMGVLTH-HKKGIRSLATHPREFTFA 327
           ***************************.*********************************************9.************999999 PP
   S: 197  sgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn.......ssvisvavlsfgdnvlvl 282
           s+s+ g++k w +  ge ++ ++gh++ ++ + +  +d+ l sg++ gs ++Wd ++g   +t+  ++       +  i  ++++ ++  l++
   Q: 328  SAST-GSIKQWKCPGGEFMQNFEGHNAIINTLSVN-EDNVLFSGGDNGSMSFWDWKTGYRYQTIDTTAqpgsleaEAGIMTSTFDRTGLRLIT 418
           9987.89***************************9.9*****************************999999988777777778999****** PP
   S: 283  gsedskvniwklkk 296
           g++d+++++wk++ 
   Q: 419  GEADKTIKVWKQDD 432
           ***********875 PP

Organism

Aspergillus nidulans

Functional Description
(View)

Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.

Protein Sequence
(Fasta)

MDVIPSTTPG EAVRISAKRT AELFGPEYLM VTPSASNGSI GVSYRRKTEY EHVKELPPAL 60
AAKQAQAAAA RSKRPKISSR SEGSGSGDKS GASTALVRRG GRASGAAGDD KPTSLIQRPS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGACCTCCTT CCTCCTGCTG AACCCCTCTC ATTACGATTC CACTCGCTCG AAACTCCTCA 60
AAACTAGAAC TTACAAACCC AACCCACTTG ACCTCATACG CGTTTGGGCG AGACATCGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0071011--C:precatalytic spliceosome
GO:0000974--C:Prp19 complex
GO:0000398--P:mRNA splicing, via spliceosome

KEGG

ani:AN1208.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000084	Aegilops tauschii	48.75	5.00e-123	432.00
IUUC-Aml-001605	Ailuropoda melanoleuca	62.82	3.00e-137	479.00
IUUC-Atr-002757	Amborella trichopoda	61.83	7.00e-124	435.00
IUUC-Apl-003198	Anas platyrhynchos	62.82	3.00e-137	479.00
IUUC-Aca-004683	Anolis carolinensis	62.54	2.00e-137	480.00
IUUC-Aly-005775	Arabidopsis lyrata	62.08	3.00e-126	443.00
IUUC-Ath-007460	Arabidopsis thaliana	61.77	1.00e-125	441.00
IUUC-Ago-007884	Ashbya gossypii	55.69	5.00e-120	422.00
IUUC-Acl-008153	Aspergillus clavatus	83.92	0.00e+00	745.00
IUUC-Afl-008384	Aspergillus flavus	86.78	0.00e+00	772.00
IUUC-Afu-009045	Aspergillus fumigatus	83.74	0.00e+00	735.00
IUUC-Ang-009812	Aspergillus niger	91.17	2.00e-171	593.00
IUUC-Aor-010059	Aspergillus oryzae	86.78	0.00e+00	772.00
IUUC-Ate-010351	Aspergillus terreus	85.02	0.00e+00	769.00
IUUC-Ame-011613	Astyanax mexicanus	43.48	1.00e-76	278.00
IUUC-Bgr-012042	Blumeria graminis	79.23	3.00e-178	615.00
IUUC-Bta-012406	Bos taurus	60.38	1.00e-136	478.00
IUUC-Bci-013760	Botrytis cinerea	66.95	2.00e-176	609.00
IUUC-Bdi-014776	Brachypodium distachyon	51.12	8.00e-126	442.00
IUUC-Bol-016189	Brassica oleracea	60.12	1.00e-125	441.00
IUUC-Bra-018044	Brassica rapa	60.12	2.00e-125	441.00
IUUC-Cel-018651	Caenorhabditis elegans	62.81	4.00e-141	493.00
IUUC-Cja-019974	Callithrix jacchus	62.72	7.00e-137	478.00
IUUC-Cfa-021085	Canis familiaris	62.82	3.00e-137	480.00
IUUC-Cpo-021458	Cavia porcellus	62.43	1.00e-136	478.00
IUUC-Cre-022880	Chlamydomonas reinhardtii	62.31	2.00e-126	443.00
IUUC-Csa-023883	Chlorocebus sabaeus	62.43	2.00e-136	477.00
IUUC-Cho-024623	Choloepus hoffmanni	62.17	1.00e-132	464.00
IUUC-Cin-025190	Ciona intestinalis	64.20	7.00e-138	482.00
IUUC-Csv-026367	Ciona savignyi	63.91	2.00e-137	480.00
IUUC-Cgl-026499	Colletotrichum gloeosporioides	74.34	0.00e+00	635.00
IUUC-Cne-027069	Cryptococcus neoformans	55.28	6.00e-140	488.00
IUUC-Cme-027233	Cyanidioschyzon merolae	30.34	3.00e-37	147.00
IUUC-Dre-028260	Danio rerio	65.59	5.00e-140	489.00
IUUC-Dno-029112	Dasypus novemcinctus	62.43	2.00e-136	477.00
IUUC-Dor-031118	Dipodomys ordii	61.96	7.00e-136	474.00
IUUC-Dse-031493	Dothistroma septosporum	64.24	7.00e-165	572.00
IUUC-Dme-032138	Drosophila melanogaster	65.33	3.00e-138	483.00
IUUC-Ete-032411	Echinops telfairi	53.52	6.00e-111	392.00
IUUC-Eca-033521	Equus caballus	60.83	4.00e-136	476.00
IUUC-Eeu-035249	Erinaceus europaeus	52.60	1.00e-105	375.00
IUUC-Fca-036358	Felis catus	62.25	3.00e-136	476.00
IUUC-Fal-036933	Ficedula albicollis	61.16	2.00e-137	480.00
IUUC-Fox-037713	Fusarium oxysporum	82.63	0.00e+00	625.00
IUUC-Fso-038380	Fusarium solani	86.18	0.00e+00	627.00
IUUC-Gmo-039133	Gadus morhua	63.69	5.00e-138	482.00
IUUC-Ggr-039915	Gaeumannomyces graminis	81.95	6.00e-166	575.00
IUUC-Gga-041176	Gallus gallus	60.61	9.00e-137	478.00
IUUC-Gac-042344	Gasterosteus aculeatus	66.67	5.00e-138	482.00
IUUC-Gma-042892	Glycine max	58.73	2.00e-126	443.00
IUUC-Ggo-044478	Gorilla gorilla	62.43	2.00e-136	477.00
IUUC-Hsa-046037	Homo sapiens	62.43	2.00e-136	477.00
IUUC-Hvu-047349	Hordeum vulgare	51.79	9.00e-127	445.00
IUUC-Itr-048390	Ictidomys tridecemlineatus	62.43	2.00e-136	477.00
IUUC-Kpa-049343	Komagataella pastoris	58.54	3.00e-124	436.00
IUUC-Lch-049830	Latimeria chalumnae	60.61	6.00e-137	478.00
IUUC-Lpe-051442	Leersia perrieri	50.56	6.00e-127	446.00
IUUC-Loc-051794	Lepisosteus oculatus	66.98	2.00e-133	467.00
IUUC-Lma-053137	Leptosphaeria maculans	58.93	2.00e-161	560.00
IUUC-Laf-053471	Loxodonta africana	61.96	3.00e-136	476.00
IUUC-Mcc-055627	Macaca mulatta	62.43	2.00e-136	477.00
IUUC-Meu-056148	Macropus eugenii	59.65	8.00e-131	458.00
IUUC-Mor-056960	Magnaporthe oryzae	84.50	2.00e-175	606.00
IUUC-Mtr-057816	Medicago truncatula	49.67	7.00e-126	442.00
IUUC-Mla-059031	Melampsora laricipopulina	64.66	2.00e-137	480.00
IUUC-Mga-059337	Meleagris gallopavo	62.54	1.00e-136	478.00
IUUC-Mvi-060217	Microbotryum violaceum	72.41	1.00e-144	504.00
IUUC-Mmr-061018	Microcebus murinus	62.54	7.00e-137	478.00
IUUC-Mdo-062863	Monodelphis domestica	64.42	1.00e-134	471.00
IUUC-Mmu-063988	Mus musculus	62.43	4.00e-135	473.00
IUUC-Mac-064459	Musa acuminata	60.57	3.00e-119	420.00
IUUC-Mpu-066559	Mustela putorius furo	62.82	4.00e-137	479.00
IUUC-Mlu-067361	Myotis lucifugus	62.43	3.00e-136	476.00
IUUC-Nfi-068492	Neosartorya fischeri	84.18	0.00e+00	741.00
IUUC-Ncr-068808	Neurospora crassa	78.35	4.00e-174	602.00
IUUC-Nle-069875	Nomascus leucogenys	62.43	1.00e-136	478.00
IUUC-Opr-070462	Ochotona princeps	63.91	5.00e-108	382.00
IUUC-Ont-071365	Oreochromis niloticus	61.54	1.00e-138	484.00
IUUC-Oan-072708	Ornithorhynchus anatinus	60.88	2.00e-136	477.00
IUUC-Ocu-074594	Oryctolagus cuniculus	62.43	3.00e-136	476.00
IUUC-Oba-075570	Oryza barthii	50.33	3.00e-127	446.00
IUUC-Obr-076366	Oryza brachyantha	62.55	2.00e-90	323.00
IUUC-Ogl-077153	Oryza glaberrima	50.56	6.00e-127	445.00
IUUC-Ogu-078540	Oryza glumaepatula	50.56	3.00e-127	446.00
IUUC-Oin-079612	Oryza indica	50.00	2.00e-125	441.00
IUUC-Olo-081077	Oryza longistaminata	50.00	2.00e-125	441.00
IUUC-Ome-081236	Oryza meridionalis	49.78	2.00e-125	440.00
IUUC-Oni-082499	Oryza nivara	50.56	3.00e-127	446.00
IUUC-Opu-083499	Oryza punctata	49.78	2.00e-125	440.00
IUUC-Oru-084276	Oryza rufipogon	50.56	3.00e-127	446.00
IUUC-Osa-085849	Oryza sativa	50.56	3.00e-127	446.00
IUUC-Ola-086655	Oryzias latipes	60.70	1.00e-139	488.00
IUUC-Olu-087637	Ostreococcus lucimarinus	63.00	3.00e-128	449.00
IUUC-Oga-087934	Otolemur garnettii	62.25	1.00e-136	478.00
IUUC-Oar-090185	Ovis aries	60.66	3.00e-137	479.00
IUUC-Ptr-091198	Pan troglodytes	62.43	1.00e-136	478.00
IUUC-Pan-092622	Papio anubis	62.43	2.00e-136	477.00
IUUC-Psi-093320	Pelodiscus sinensis	62.54	2.00e-136	476.00
IUUC-Pma-094638	Petromyzon marinus	62.26	7.00e-140	488.00
IUUC-Pno-094826	Phaeosphaeria nodorum	63.85	3.00e-136	476.00
IUUC-Ppa-095576	Physcomitrella patens	63.72	8.00e-124	435.00
IUUC-Pfo-096894	Poecilia formosa	64.45	8.00e-139	485.00
IUUC-Pab-098020	Pongo abelii	62.43	1.00e-136	478.00
IUUC-Pop-099180	Populus trichocarpa	49.34	4.00e-119	419.00
IUUC-Pca-100909	Procavia capensis	64.23	2.00e-108	384.00
IUUC-Ppe-101346	Prunus persica	57.70	3.00e-125	440.00
IUUC-Pva-102167	Pteropus vampyrus	53.18	4.00e-111	393.00
IUUC-Pgr-103516	Puccinia graminis	69.59	3.00e-138	483.00
IUUC-Ptt-103738	Puccinia triticina	69.59	3.00e-137	479.00
IUUC-Pte-104352	Pyrenophora teres	58.69	1.00e-165	574.00
IUUC-Pyt-104632	Pyrenophora triticirepentis	58.25	8.00e-166	575.00
IUUC-Rno-105291	Rattus norvegicus	60.11	1.00e-134	471.00
IUUC-Sce-106204	Saccharomyces cerevisiae	57.77	3.00e-123	433.00
IUUC-Sha-106943	Sarcophilus harrisii	63.00	2.00e-131	460.00
IUUC-Sja-107659	Schizosaccharomyces japonicus	74.76	5.00e-145	505.00
IUUC-Spo-108049	Schizosaccharomyces pombe	72.35	6.00e-149	518.00
IUUC-Smo-109043	Selaginella moellendorffii	59.82	3.00e-126	442.00
IUUC-Sit-110431	Setaria italica	49.89	7.00e-126	442.00
IUUC-Sly-111391	Solanum lycopersicum	61.25	4.00e-120	423.00
IUUC-Stu-112364	Solanum tuberosum	54.93	5.00e-95	338.00
IUUC-Sar-113450	Sorex araneus	62.25	2.00e-135	474.00
IUUC-Sbi-113829	Sorghum bicolor	50.00	1.00e-126	444.00
IUUC-Sre-115153	Sporisorium reilianum	65.00	6.00e-127	446.00
IUUC-Ssc-116274	Sus scrofa	60.61	7.00e-137	478.00
IUUC-Tgu-117417	Taeniopygia guttata	61.16	2.00e-137	480.00
IUUC-Tru-117615	Takifugu rubripes	63.82	2.00e-131	460.00
IUUC-Tsy-119480	Tarsius syrichta	62.43	2.00e-136	477.00
IUUC-Tni-119847	Tetraodon nigroviridis	65.00	2.00e-138	484.00
IUUC-Tca-121287	Theobroma cacao	56.87	5.00e-123	432.00
IUUC-Tre-122010	Trichoderma reesei	85.54	1.00e-179	620.00
IUUC-Tvi-122475	Trichoderma virens	80.22	1.00e-179	620.00
IUUC-Tae-124397	Triticum aestivum	51.78	1.00e-127	447.00
IUUC-Tur-126116	Triticum urartu	50.43	7.00e-95	339.00
IUUC-Tme-126992	Tuber melanosporum	77.71	5.00e-166	575.00
IUUC-Tbe-127803	Tupaia belangeri	65.27	1.00e-105	374.00
IUUC-Ttr-128933	Tursiops truncatus	62.25	2.00e-136	477.00
IUUC-Uma-129447	Ustilago maydis	63.12	7.00e-126	442.00
IUUC-Vda-129780	Verticillium dahliae	83.68	8.00e-179	618.00
IUUC-Vpa-130557	Vicugna pacos	43.28	6.00e-48	183.00
IUUC-Vvi-130918	Vitis vinifera	59.94	2.00e-119	420.00
IUUC-Xtr-132409	Xenopus tropicalis	62.11	7.00e-136	475.00
IUUC-Xma-133420	Xiphophorus maculatus	63.87	3.00e-138	483.00
IUUC-Yli-134362	Yarrowia lipolytica	60.89	4.00e-133	466.00
IUUC-Zma-135804	Zea mays	57.39	6.00e-122	429.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence