iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090153

Ensembl Protein ID

ENSOARP00000003535.1

UniProt Accession

W5NZD7; W5NZD7_SHEEP

Genbank Protein ID

ENSOARP00000003535

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01105076

Gene Name

EML5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000003285.1	ENSOART00000003599.1	ENSOARP00000003535.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.40e-58	190.8	1633	1664
UBD/Beta-Prp	1.30e-123	412.1	665	881

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htd.svtclaf.sd.tllvsGsdDgtikvWDl 30
           H d +v++la  ++ ++++s++ Dgt+++WD+
   Q: 1633 HVDgPVWGLAThPSrDFFLSAAEDGTVRLWDI 1664
           555369999989888****************7 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatg..srdgtikvwdvttgkllrsl.sgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlkg 92
           h++ i c++++p k+++atg  +rd +i +wd++t k l+ l   h+ +v av+fs dgk l++++ D  +t+ +wd ++g+ +++ +g
   Q: 665  HDDDILCLAVHPLKDYVATGqvGRDPSIHIWDTETIKPLSILkGYHQYGVCAVDFSADGKRLASVGIDdsHTVVLWDWKKGEKLSVARG 753
           4555566************95569******************5559******************9999999****************** PP
   S: 93   hedsvlslsfspsg.dklvsGshdrtirvwdletgqclee......tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrt 174
            +d++  ++++p+  dkl++++  +  + w+  +               g++++ +c+v+  ++ + +sG+  + v +W  +  +l++t
   Q: 754  SKDKIFVVKMNPYVpDKLITAG-IKHMKFWHRAEPGGGLIgrkgyvGTLGKSDTMMCAVYGWTEEMAFSGTSTGDVCIW--RDIFLVKT 839
           ************9978888888.99999997554333333578888445677799************************..889***** PP
   S: 175  ltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtln 219
            +  h+++v s+   +  k +v+g++dg v lwd + ++c++t+ 
   Q: 840  VKA-HDGPVFSMHALE--KGFVTGGKDGVVALWDDSFERCLKTYA 881
           *98.********9888..67**********************996 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

DLFCSLALHP ERALVATGQV GKEPYICVWD SYTVQTVSVL KDVHTHGIAC LAFDLDGQRL 60
VSVGLDSKNA VCVWDWKRGK MLSMAPGHTD RIFDISWDLY QPNKLVSCGV KHIKFWSLCG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTTATTTT GCAGCCTTGC GTTGCATCCT GAACGAGCAC TGGTAGCAAC AGGACAAGTT 60
GGGAAAGAGC CTTATATCTG TGTCTGGGAT TCGTATACTG TGCAGACCGT ATCAGTTCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR024977--Apc4_WD40_dom
IPR005108--HELP
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF03451--HELP
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002225	Ailuropoda melanoleuca	95.99	0.00e+00	3731.00
IUUC-Apl-003360	Anas platyrhynchos	91.15	0.00e+00	3554.00
IUUC-Ame-011681	Astyanax mexicanus	85.09	0.00e+00	3386.00
IUUC-Bta-012838	Bos taurus	97.86	0.00e+00	3786.00
IUUC-Cja-019068	Callithrix jacchus	95.41	0.00e+00	3691.00
IUUC-Cfa-020531	Canis familiaris	96.75	0.00e+00	3772.00
IUUC-Cpo-022304	Cavia porcellus	93.39	0.00e+00	3635.00
IUUC-Csa-023621	Chlorocebus sabaeus	95.90	0.00e+00	3516.00
IUUC-Cho-024944	Choloepus hoffmanni	76.12	0.00e+00	1483.00
IUUC-Dre-028772	Danio rerio	84.42	0.00e+00	3365.00
IUUC-Dno-030063	Dasypus novemcinctus	94.02	0.00e+00	3647.00
IUUC-Dor-030980	Dipodomys ordii	86.79	0.00e+00	1583.00
IUUC-Ete-032554	Echinops telfairi	94.12	0.00e+00	1047.00
IUUC-Eca-033909	Equus caballus	96.57	0.00e+00	3565.00
IUUC-Eeu-035180	Erinaceus europaeus	79.89	0.00e+00	1471.00
IUUC-Fal-037219	Ficedula albicollis	91.48	0.00e+00	3573.00
IUUC-Gmo-039146	Gadus morhua	80.38	0.00e+00	3180.00
IUUC-Gga-041095	Gallus gallus	91.07	0.00e+00	2526.00
IUUC-Gac-041341	Gasterosteus aculeatus	82.84	0.00e+00	3267.00
IUUC-Hsa-045997	Homo sapiens	95.88	0.00e+00	3705.00
IUUC-Lch-050306	Latimeria chalumnae	84.70	0.00e+00	3167.00
IUUC-Loc-052215	Lepisosteus oculatus	84.93	0.00e+00	3402.00
IUUC-Laf-054044	Loxodonta africana	94.48	0.00e+00	3675.00
IUUC-Mcc-054733	Macaca mulatta	95.78	0.00e+00	3702.00
IUUC-Mga-059666	Meleagris gallopavo	89.31	0.00e+00	3482.00
IUUC-Mmr-060995	Microcebus murinus	96.19	0.00e+00	3705.00
IUUC-Mdo-062482	Monodelphis domestica	92.06	0.00e+00	3609.00
IUUC-Mmu-063533	Mus musculus	94.68	0.00e+00	3638.00
IUUC-Mpu-066704	Mustela putorius furo	96.14	0.00e+00	3737.00
IUUC-Mlu-067592	Myotis lucifugus	95.52	0.00e+00	3690.00
IUUC-Nle-069911	Nomascus leucogenys	95.88	0.00e+00	3704.00
IUUC-Ont-071966	Oreochromis niloticus	84.74	0.00e+00	3378.00
IUUC-Ola-086738	Oryzias latipes	83.87	0.00e+00	3327.00
IUUC-Oga-088436	Otolemur garnettii	93.79	0.00e+00	3624.00
IUUC-Ptr-091008	Pan troglodytes	95.57	0.00e+00	3679.00
IUUC-Pan-092404	Papio anubis	96.18	0.00e+00	3707.00
IUUC-Psi-093417	Pelodiscus sinensis	89.98	0.00e+00	3513.00
IUUC-Pfo-096073	Poecilia formosa	84.71	0.00e+00	3382.00
IUUC-Pab-097900	Pongo abelii	95.15	0.00e+00	3677.00
IUUC-Pca-100107	Procavia capensis	80.54	0.00e+00	2528.00
IUUC-Pva-102880	Pteropus vampyrus	93.18	0.00e+00	3539.00
IUUC-Rno-106084	Rattus norvegicus	94.73	0.00e+00	3702.00
IUUC-Sha-106974	Sarcophilus harrisii	93.13	0.00e+00	3628.00
IUUC-Sar-113401	Sorex araneus	85.37	0.00e+00	1837.00
IUUC-Ssc-116057	Sus scrofa	96.46	0.00e+00	3793.00
IUUC-Tru-118444	Takifugu rubripes	83.13	0.00e+00	3287.00
IUUC-Tsy-118941	Tarsius syrichta	84.30	0.00e+00	2813.00
IUUC-Tni-120683	Tetraodon nigroviridis	83.06	0.00e+00	3267.00
IUUC-Tbe-127467	Tupaia belangeri	88.40	0.00e+00	1855.00
IUUC-Ttr-129138	Tursiops truncatus	92.86	0.00e+00	3551.00
IUUC-Vpa-130083	Vicugna pacos	91.08	0.00e+00	3457.00
IUUC-Xtr-131835	Xenopus tropicalis	87.36	0.00e+00	3485.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence