iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-047897

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01025865

Gene Name

G2E3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000008924.2	ENSSTOT00000008923.2	ENSSTOP00000007996.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-43	149.1	185	493

Active Site

Position(s)	Description	Evidence
463	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           + +e++fv+E+   + +l+G+++efl+ll+++l+n++  lf  + + +++l+ n+++      +++l++ +G++l+++l++g + + ++
   Q: 185  YAIEITFVNENdkfARELPGSKQEFLSLLMQHLENSS--LF--EGSLSKNLSLNSQAL-----KENLYYEAGKMLAISLVHGGPSPGFF 264
           6789*****9988899*********************..45..677788888888885.....689*********************** PP
   S: 93   sksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           sk+++++l+  +   e+++ + +++ ++ + +i  +   ++ +   dl++     +++e++++  + g+ +   t ++k++ vk+++ y
   Q: 265  SKTLFNCLVYGP---ENTQPILDDVSDFdVAQIIVRI--NTATNMTDLNS-----VVNECYNYLELIGCLRLLTTLSDKYMLVKDILFY 343
           ***********8...9***********9988888663..23332245555.....488999**99************************ PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq.. 266
           ++ ++++  +e+f++G++++  le+++ + e  +++l+++ e+++++ l++   ++ ++ +d +a+  Fw+ + + +++ + ++ L+  
   Q: 344  HVIKRVQAPFESFKQGLKTLGVLEKIQTYPEAFCNILCHKPENLSAKILRD--LFTVHTLPDVQAL-GFWNSYlQTVEDGKSATTLEdi 429
           **************************************************9..888899******8.9999875888888888888788 PP
   S: 267  ..FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
             F+Tg+s++P++Gf++ + ++ +++      ++P  n+C n L LP  s++++++e++ +Ai++t +++
   Q: 430  liFATGCSSIPPAGFKPTP-SIECLHM-----DFPIGNKCNNSLTLPITSTYKEFQENMDFAIRNTLRLG 493
           88****************9.9999999.....********************************987665 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MGIHIPEKDA SWELEENAYQ DLLQHYEHCD VRRCRCKEGR DYNAPDSKWE IKRCQCCGSS 60
GTHLACSSLR SWEQNWECLE CRSIIYNSGN NFQKAKKHAL SNSNNVAITD CLLEESSPKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAAAATGAA TGAAAATAAA CCTGGTGACT CACAAACGCT TGGTAAGTAA CTATATTTAA 60
AACATTTCCT TTACAGTAAA TCTTTTTAGA ATACTGCCCA ATTAATAGGA ATGATTTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	89.07	0.00e+00	938.00
IUUC-Apl-003763	Anas platyrhynchos	56.72	9.00e-172	596.00
IUUC-Aca-004328	Anolis carolinensis	57.79	4.00e-172	597.00
IUUC-Ame-011288	Astyanax mexicanus	34.83	3.00e-89	322.00
IUUC-Bta-012496	Bos taurus	84.80	0.00e+00	895.00
IUUC-Cja-019756	Callithrix jacchus	87.00	0.00e+00	910.00
IUUC-Cfa-020806	Canis familiaris	87.08	0.00e+00	920.00
IUUC-Cpo-022519	Cavia porcellus	86.68	0.00e+00	889.00
IUUC-Csa-023957	Chlorocebus sabaeus	88.67	0.00e+00	936.00
IUUC-Cho-024375	Choloepus hoffmanni	87.50	0.00e+00	805.00
IUUC-Cin-025325	Ciona intestinalis	44.71	6.00e-18	84.30
IUUC-Csv-026262	Ciona savignyi	39.22	1.00e-17	84.00
IUUC-Dre-027829	Danio rerio	36.06	2.00e-88	320.00
IUUC-Dno-029362	Dasypus novemcinctus	86.90	0.00e+00	890.00
IUUC-Dor-030710	Dipodomys ordii	81.91	0.00e+00	867.00
IUUC-Dme-031692	Drosophila melanogaster	36.92	2.00e-08	53.50
IUUC-Ete-032282	Echinops telfairi	84.03	0.00e+00	885.00
IUUC-Eca-033963	Equus caballus	87.28	0.00e+00	925.00
IUUC-Eeu-035029	Erinaceus europaeus	85.60	0.00e+00	902.00
IUUC-Fca-036229	Felis catus	87.67	0.00e+00	930.00
IUUC-Fal-037015	Ficedula albicollis	55.08	9.00e-164	570.00
IUUC-Gmo-039715	Gadus morhua	40.48	3.00e-78	285.00
IUUC-Gga-040298	Gallus gallus	56.27	2.00e-174	605.00
IUUC-Gac-041444	Gasterosteus aculeatus	33.47	6.00e-74	271.00
IUUC-Ggo-045456	Gorilla gorilla	88.27	0.00e+00	928.00
IUUC-Hsa-046297	Homo sapiens	88.67	0.00e+00	936.00
IUUC-Lch-050287	Latimeria chalumnae	52.63	3.00e-82	299.00
IUUC-Laf-053581	Loxodonta africana	87.28	0.00e+00	919.00
IUUC-Mcc-055615	Macaca mulatta	88.47	0.00e+00	933.00
IUUC-Meu-056753	Macropus eugenii	48.58	4.00e-128	451.00
IUUC-Mga-059902	Meleagris gallopavo	56.09	7.00e-174	603.00
IUUC-Mmr-061522	Microcebus murinus	91.25	0.00e+00	953.00
IUUC-Mdo-063022	Monodelphis domestica	62.80	8.00e-167	580.00
IUUC-Mmu-063609	Mus musculus	72.99	0.00e+00	786.00
IUUC-Mpu-066656	Mustela putorius furo	87.48	0.00e+00	928.00
IUUC-Mlu-067011	Myotis lucifugus	86.08	0.00e+00	905.00
IUUC-Nle-069949	Nomascus leucogenys	88.07	0.00e+00	931.00
IUUC-Opr-071224	Ochotona princeps	88.72	2.00e-140	492.00
IUUC-Ont-072174	Oreochromis niloticus	32.71	3.00e-73	269.00
IUUC-Oan-072712	Ornithorhynchus anatinus	63.82	0.00e+00	690.00
IUUC-Ocu-073776	Oryctolagus cuniculus	90.46	0.00e+00	941.00
IUUC-Ola-087247	Oryzias latipes	32.63	1.00e-67	251.00
IUUC-Oga-088094	Otolemur garnettii	87.28	0.00e+00	920.00
IUUC-Oar-090248	Ovis aries	84.80	0.00e+00	881.00
IUUC-Ptr-090634	Pan troglodytes	88.47	0.00e+00	934.00
IUUC-Pan-092876	Papio anubis	88.67	0.00e+00	934.00
IUUC-Psi-093580	Pelodiscus sinensis	58.33	1.00e-180	625.00
IUUC-Pma-094295	Petromyzon marinus	56.82	4.00e-21	94.40
IUUC-Pfo-096351	Poecilia formosa	34.03	4.00e-81	295.00
IUUC-Pab-097596	Pongo abelii	89.26	0.00e+00	943.00
IUUC-Pca-100309	Procavia capensis	79.72	0.00e+00	827.00
IUUC-Pva-102526	Pteropus vampyrus	87.50	2.00e-127	449.00
IUUC-Rno-105432	Rattus norvegicus	78.76	0.00e+00	828.00
IUUC-Sha-107089	Sarcophilus harrisii	63.10	0.00e+00	694.00
IUUC-Sar-113667	Sorex araneus	68.40	0.00e+00	699.00
IUUC-Ssc-116200	Sus scrofa	88.67	0.00e+00	939.00
IUUC-Tgu-116467	Taeniopygia guttata	54.38	5.00e-159	554.00
IUUC-Tru-117690	Takifugu rubripes	34.71	8.00e-87	314.00
IUUC-Tsy-119481	Tarsius syrichta	82.83	3.00e-141	495.00
IUUC-Tni-119669	Tetraodon nigroviridis	33.99	2.00e-69	256.00
IUUC-Tbe-127241	Tupaia belangeri	82.00	0.00e+00	813.00
IUUC-Ttr-129057	Tursiops truncatus	87.85	3.00e-178	618.00
IUUC-Vpa-130685	Vicugna pacos	87.00	0.00e+00	877.00
IUUC-Xtr-132555	Xenopus tropicalis	48.16	7.00e-130	457.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence