iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000015140.1	ENSSHAT00000017979.1	ENSSHAP00000017832.1
ENSSHAG00000015140.1	ENSSHAT00000017980.1	ENSSHAP00000017833.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-33	116.5	459	765

Active Site

Position(s)	Description	Evidence
735	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 8    rlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksf 96
            +ev+f + +g d++G++ efl+ll+k+l++++  lf  + + +++++ n+++      +++l++ +Gr+++++l++g + +  +sk++
   Q: 459  TIEVQFCNGNG-DADGSKHEFLSLLMKHLESSS--LF--EGSMSKNISFNSEA-----LKENLYYEAGRMIAISLVHGGPPPFLFSKTL 537
           68999999986.566*****************9..57..55555666666666.....4789*************************** PP
   S: 97   yklllgk....klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
           + +l++     + +led+e  d+++++ +++ik++     ++l  +l++      + ++ e+    g+ +     ++k+  vk+++ y+
   Q: 538  FHCLISGpenvEPTLEDVE--DSNTMQIITKIKSS-----KNL-THLRSA-----IRDYFEYLSHIGCLRLVTMLSDKDVLVKDILTYH 613
           ******9333334444444..44555556666643.....333.344444.....33333342236888888888************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFw.evleefsseerkafLq... 266
           + ++++  +++f++G++++  le ++ + e   ++l+++ e ++ + l++  + ++  ++++     Fw + l++++s e    L+   
   Q: 614  VIKRVQAPLDSFQQGLRTLGVLETMQKYPEAFYSILCHKPERLTTKILSDLFTIHKLSEAQDTRTMGFWmNYLQNVESGESVVTLEdil 702
           **************************************************88664445555555556663778*****99876655555 PP
   S: 267  .FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
            F+Tg+ ++P+ Gf++ + ++  ++      ++P   +C n+L LP   ++++++e++ +Ai+++ g+e
   Q: 703  aFATGCRSIPPVGFQPTP-SIEFLHA-----DYPVGTKCCNRLTLPITCTYKEFQENMDFAIRNALGLE 765
           5****************9.6666666.....9*******************************987765 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MEKIEIVAAG PCGGLPAASS DSISKAHIMN ENNLCQIENF ACVLCRRTDD YPEKYGEKKI 60
YQDHNLTIHY YCLLMSSGIW QRGEEKDGVY GFLIEDIKKE VNRASKLKCC ICKKNGASIG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGCAGTCC CCTTCCGGGA TGCAGGCGGA AGTCGGTTAA ATTTGAATCT TCGGGGCCGT 60
TGGTCGGGGT TCAGATCGGG GTTCTCGCGG CTGCCTGAGG AGAAAGAGGA GGAGGAAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS50089--ZF_RING_2

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	65.23	0.00e+00	1019.00
IUUC-Apl-003763	Anas platyrhynchos	62.37	0.00e+00	897.00
IUUC-Aca-004328	Anolis carolinensis	59.73	0.00e+00	887.00
IUUC-Ame-011288	Astyanax mexicanus	40.87	1.00e-167	583.00
IUUC-Bta-012496	Bos taurus	64.11	0.00e+00	995.00
IUUC-Cja-019756	Callithrix jacchus	65.23	0.00e+00	1002.00
IUUC-Cfa-020806	Canis familiaris	64.97	0.00e+00	1014.00
IUUC-Cpo-022519	Cavia porcellus	64.60	0.00e+00	976.00
IUUC-Csa-023957	Chlorocebus sabaeus	65.64	0.00e+00	1016.00
IUUC-Cho-024375	Choloepus hoffmanni	60.79	0.00e+00	877.00
IUUC-Cin-025325	Ciona intestinalis	39.53	1.00e-60	226.00
IUUC-Csv-026262	Ciona savignyi	41.61	1.00e-64	239.00
IUUC-Dre-027829	Danio rerio	40.38	2.00e-160	558.00
IUUC-Dno-029362	Dasypus novemcinctus	64.85	0.00e+00	985.00
IUUC-Dor-030710	Dipodomys ordii	63.71	0.00e+00	974.00
IUUC-Dme-031692	Drosophila melanogaster	32.46	1.00e-41	164.00
IUUC-Ete-032282	Echinops telfairi	58.13	0.00e+00	868.00
IUUC-Eca-033963	Equus caballus	65.37	0.00e+00	1020.00
IUUC-Eeu-035029	Erinaceus europaeus	65.50	0.00e+00	1004.00
IUUC-Fca-036229	Felis catus	65.33	0.00e+00	1021.00
IUUC-Fal-037015	Ficedula albicollis	60.87	0.00e+00	910.00
IUUC-Gmo-039715	Gadus morhua	40.75	2.00e-80	292.00
IUUC-Gga-040298	Gallus gallus	60.75	0.00e+00	937.00
IUUC-Gac-041444	Gasterosteus aculeatus	37.59	1.00e-140	493.00
IUUC-Ggo-045456	Gorilla gorilla	65.10	0.00e+00	1006.00
IUUC-Hsa-046297	Homo sapiens	65.64	0.00e+00	1015.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	63.10	0.00e+00	694.00
IUUC-Lch-050287	Latimeria chalumnae	63.20	4.00e-103	368.00
IUUC-Loc-052839	Lepisosteus oculatus	57.43	4.00e-31	125.00
IUUC-Laf-053581	Loxodonta africana	65.26	0.00e+00	1001.00
IUUC-Mcc-055615	Macaca mulatta	65.37	0.00e+00	1013.00
IUUC-Meu-056753	Macropus eugenii	69.47	7.00e-101	361.00
IUUC-Mga-059902	Meleagris gallopavo	61.42	0.00e+00	946.00
IUUC-Mmr-061522	Microcebus murinus	66.85	0.00e+00	1028.00
IUUC-Mdo-063022	Monodelphis domestica	88.21	0.00e+00	1271.00
IUUC-Mmu-063609	Mus musculus	61.78	0.00e+00	948.00
IUUC-Mpu-066656	Mustela putorius furo	65.07	0.00e+00	1017.00
IUUC-Mlu-067011	Myotis lucifugus	65.21	0.00e+00	999.00
IUUC-Nle-069949	Nomascus leucogenys	65.37	0.00e+00	1010.00
IUUC-Opr-071224	Ochotona princeps	62.74	4.00e-95	342.00
IUUC-Ont-072174	Oreochromis niloticus	36.07	1.00e-135	477.00
IUUC-Oan-072712	Ornithorhynchus anatinus	71.35	0.00e+00	1014.00
IUUC-Ocu-073776	Oryctolagus cuniculus	65.23	0.00e+00	992.00
IUUC-Ola-087247	Oryzias latipes	35.99	6.00e-126	444.00
IUUC-Oga-088094	Otolemur garnettii	64.95	0.00e+00	944.00
IUUC-Oar-090248	Ovis aries	62.32	0.00e+00	986.00
IUUC-Ptr-090634	Pan troglodytes	65.37	0.00e+00	1012.00
IUUC-Pan-092876	Papio anubis	65.50	0.00e+00	1014.00
IUUC-Psi-093580	Pelodiscus sinensis	64.85	0.00e+00	917.00
IUUC-Pma-094295	Petromyzon marinus	51.98	5.00e-74	270.00
IUUC-Pfo-096351	Poecilia formosa	37.65	6.00e-146	511.00
IUUC-Pab-097596	Pongo abelii	65.77	0.00e+00	1016.00
IUUC-Pca-100309	Procavia capensis	76.37	6.00e-142	497.00
IUUC-Pva-102526	Pteropus vampyrus	65.62	0.00e+00	654.00
IUUC-Rno-105432	Rattus norvegicus	62.63	0.00e+00	955.00
IUUC-Sar-113667	Sorex araneus	60.00	1.00e-113	403.00
IUUC-Ssc-116200	Sus scrofa	65.07	0.00e+00	1009.00
IUUC-Tgu-116467	Taeniopygia guttata	60.74	0.00e+00	901.00
IUUC-Tru-117690	Takifugu rubripes	37.43	8.00e-154	537.00
IUUC-Tsy-119481	Tarsius syrichta	61.62	0.00e+00	674.00
IUUC-Tni-119669	Tetraodon nigroviridis	36.83	4.00e-135	475.00
IUUC-Tbe-127241	Tupaia belangeri	62.34	0.00e+00	866.00
IUUC-Ttr-129057	Tursiops truncatus	64.27	0.00e+00	781.00
IUUC-Vpa-130685	Vicugna pacos	63.98	0.00e+00	949.00
IUUC-Xtr-132555	Xenopus tropicalis	50.69	0.00e+00	724.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence