iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108316

Ensembl Protein ID

SPCC1020.09.1:pep

UniProt Accession

O59762; GNR1_SCHPO

Genbank Protein ID

CAA18997.1

Protein Name

Guanine nucleotide-binding protein negative regulator 1; WD repeat-containing protein gnr1

Genbank Nucleotide ID

CU329672

Gene Name

gnr1; SPCC1020.09

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPCC1020.09	SPCC1020.09.1	SPCC1020.09.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
HINT
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-12	45.1	103	142

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 5    svtclaf........sd.tllvsGsdDgtikvWDlrtgvl 35
            v++ ++        ++ +l++++s+D  ik+ +++tg+ 
   Q: 103  TVYSYSWysrmklddPSsNLFAVSSRDQPIKLINFTTGKN 142
           689999999999998556*******************986 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Negatively regulates the pheromone-response pathway. Acts as a structural mimic of the G protein beta subunit thereby interacting with gpa1 which then inhibits gpa1 signaling.

Protein Sequence
(Fasta)

MDNCVNSFED QKDDLVHKKK SQNFGYVCGS INLGTNVIAQ SPTKPLNFFH SSRWSPDGST 60
ILSLTEDQCL NCWNVPFSDL SKKADGPLNF SKHLSYKYQS PETVYSYSWY SRMKLDDPSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTACTACATA TGATTACAAT TCGTTTTTTA AAGAAGGACT ATTCGTTTTC AACCCTTATG 60
ACCAGATAGA AAGAAATCCA TATATATATT ATATATTTAA AAAATTAAAG TTGACATTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005834--C:heterotrimeric G-protein complex
GO:0045744--P:negative regulation of G-protein coupled receptor protein signaling pathway
GO:0090029--P:negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
GO:0007165--P:signal transduction

KEGG

spo:SPCC1020.09

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000305	Aegilops tauschii	31.67	1.00e-25	108.00
IUUC-Aml-001893	Ailuropoda melanoleuca	30.79	2.00e-30	125.00
IUUC-Atr-002472	Amborella trichopoda	29.55	6.00e-26	109.00
IUUC-Aca-004937	Anolis carolinensis	28.96	1.00e-28	118.00
IUUC-Aly-006492	Arabidopsis lyrata	32.05	3.00e-34	137.00
IUUC-Ath-006592	Arabidopsis thaliana	31.19	8.00e-34	135.00
IUUC-Acl-008296	Aspergillus clavatus	34.09	6.00e-20	89.00
IUUC-Ani-009149	Aspergillus nidulans	31.16	1.00e-28	118.00
IUUC-Aor-009938	Aspergillus oryzae	28.34	1.00e-28	119.00
IUUC-Ate-010481	Aspergillus terreus	29.94	1.00e-33	135.00
IUUC-Ame-011296	Astyanax mexicanus	30.66	5.00e-30	123.00
IUUC-Bgr-012232	Blumeria graminis	27.15	1.00e-25	108.00
IUUC-Bta-012362	Bos taurus	30.61	6.00e-29	120.00
IUUC-Bdi-014971	Brachypodium distachyon	30.97	3.00e-31	127.00
IUUC-Bol-016557	Brassica oleracea	30.23	2.00e-32	131.00
IUUC-Bra-016734	Brassica rapa	30.45	1.00e-31	128.00
IUUC-Cja-019681	Callithrix jacchus	28.91	4.00e-27	114.00
IUUC-Cfa-020148	Canis familiaris	29.93	2.00e-29	121.00
IUUC-Cpo-022128	Cavia porcellus	30.85	2.00e-28	117.00
IUUC-Cre-022680	Chlamydomonas reinhardtii	29.91	2.00e-31	127.00
IUUC-Csa-023779	Chlorocebus sabaeus	29.86	9.00e-29	119.00
IUUC-Cin-025318	Ciona intestinalis	30.82	8.00e-30	122.00
IUUC-Cne-026778	Cryptococcus neoformans	30.65	6.00e-25	106.00
IUUC-Dre-027809	Danio rerio	30.18	9.00e-29	119.00
IUUC-Dno-028896	Dasypus novemcinctus	31.14	2.00e-22	97.80
IUUC-Dor-030656	Dipodomys ordii	31.58	6.00e-24	103.00
IUUC-Dme-031828	Drosophila melanogaster	26.32	9.00e-19	86.30
IUUC-Eca-033305	Equus caballus	29.83	1.00e-28	118.00
IUUC-Eeu-034936	Erinaceus europaeus	30.83	9.00e-08	49.70
IUUC-Fca-036371	Felis catus	29.93	4.00e-29	120.00
IUUC-Gmo-039283	Gadus morhua	31.67	4.00e-24	102.00
IUUC-Gac-042297	Gasterosteus aculeatus	31.74	9.00e-23	98.20
IUUC-Gma-044331	Glycine max	30.46	5.00e-35	139.00
IUUC-Ggo-044938	Gorilla gorilla	29.93	1.00e-28	119.00
IUUC-Hsa-046795	Homo sapiens	29.86	2.00e-28	118.00
IUUC-Itr-048964	Ictidomys tridecemlineatus	28.03	5.00e-29	120.00
IUUC-Lch-050551	Latimeria chalumnae	27.27	1.00e-14	72.40
IUUC-Lpe-051458	Leersia perrieri	27.41	1.00e-24	105.00
IUUC-Loc-052833	Lepisosteus oculatus	31.07	5.00e-28	116.00
IUUC-Laf-054404	Loxodonta africana	28.38	2.00e-26	111.00
IUUC-Mcc-055500	Macaca mulatta	29.93	9.00e-29	119.00
IUUC-Mtr-058157	Medicago truncatula	32.99	1.00e-38	151.00
IUUC-Mla-058898	Melampsora laricipopulina	31.29	7.00e-28	115.00
IUUC-Mvi-060351	Microbotryum violaceum	30.04	4.00e-30	123.00
IUUC-Mmr-061204	Microcebus murinus	29.49	6.00e-28	116.00
IUUC-Mdo-062997	Monodelphis domestica	29.82	9.00e-26	108.00
IUUC-Mmu-063379	Mus musculus	29.17	1.00e-27	115.00
IUUC-Mac-065509	Musa acuminata	29.97	6.00e-28	118.00
IUUC-Mpu-066898	Mustela putorius furo	28.91	9.00e-29	119.00
IUUC-Mlu-067405	Myotis lucifugus	29.96	4.00e-27	113.00
IUUC-Nle-069679	Nomascus leucogenys	27.52	8.00e-20	89.70
IUUC-Opr-070544	Ochotona princeps	31.09	3.00e-10	58.20
IUUC-Oan-073233	Ornithorhynchus anatinus	25.36	7.00e-13	65.50
IUUC-Ocu-074700	Oryctolagus cuniculus	28.91	3.00e-28	117.00
IUUC-Oba-075164	Oryza barthii	28.88	9.00e-27	115.00
IUUC-Ogl-077700	Oryza glaberrima	31.58	4.00e-32	133.00
IUUC-Ogu-078612	Oryza glumaepatula	31.55	5.00e-12	67.00
IUUC-Oin-079494	Oryza indica	31.58	3.00e-33	133.00
IUUC-Olo-081051	Oryza longistaminata	32.59	1.00e-26	111.00
IUUC-Ome-081868	Oryza meridionalis	27.02	3.00e-17	84.00
IUUC-Oni-082904	Oryza nivara	31.58	4.00e-32	133.00
IUUC-Opu-084082	Oryza punctata	31.01	4.00e-31	130.00
IUUC-Oru-084683	Oryza rufipogon	31.58	5.00e-33	133.00
IUUC-Osa-085518	Oryza sativa	31.58	4.00e-33	133.00
IUUC-Ola-086492	Oryzias latipes	29.37	2.00e-09	53.50
IUUC-Oga-088207	Otolemur garnettii	29.59	6.00e-28	116.00
IUUC-Oar-089463	Ovis aries	30.61	9.00e-30	122.00
IUUC-Ptr-090994	Pan troglodytes	29.93	2.00e-28	118.00
IUUC-Pan-091793	Papio anubis	30.27	1.00e-28	119.00
IUUC-Psi-093816	Pelodiscus sinensis	29.41	4.00e-28	117.00
IUUC-Ppa-095348	Physcomitrella patens	30.82	1.00e-31	128.00
IUUC-Pfo-096740	Poecilia formosa	29.79	1.00e-32	132.00
IUUC-Pab-098447	Pongo abelii	30.70	6.00e-23	99.40
IUUC-Pop-099065	Populus trichocarpa	32.07	8.00e-34	135.00
IUUC-Pca-101130	Procavia capensis	27.62	5.00e-26	110.00
IUUC-Ppe-101669	Prunus persica	31.25	7.00e-33	132.00
IUUC-Pva-102685	Pteropus vampyrus	33.62	2.00e-12	65.10
IUUC-Pgr-103262	Puccinia graminis	27.65	5.00e-32	130.00
IUUC-Ptt-103932	Puccinia triticina	27.88	3.00e-28	117.00
IUUC-Pte-104073	Pyrenophora teres	23.99	3.00e-18	84.30
IUUC-Pyt-104496	Pyrenophora triticirepentis	24.66	4.00e-20	90.50
IUUC-Rno-105017	Rattus norvegicus	29.93	5.00e-28	117.00
IUUC-Sce-106389	Saccharomyces cerevisiae	25.19	1.00e-04	38.50
IUUC-Sha-107405	Sarcophilus harrisii	30.04	4.00e-25	107.00
IUUC-Sja-107997	Schizosaccharomyces japonicus	32.94	1.00e-51	194.00
IUUC-Smo-108985	Selaginella moellendorffii	30.96	5.00e-33	133.00
IUUC-Sit-109820	Setaria italica	31.07	2.00e-32	130.00
IUUC-Sly-110899	Solanum lycopersicum	30.00	3.00e-32	130.00
IUUC-Stu-112753	Solanum tuberosum	30.00	7.00e-32	129.00
IUUC-Sar-113155	Sorex araneus	29.14	2.00e-26	111.00
IUUC-Sbi-114408	Sorghum bicolor	31.07	5.00e-32	129.00
IUUC-Sre-115186	Sporisorium reilianum	26.82	6.00e-20	90.10
IUUC-Ssc-116125	Sus scrofa	30.27	4.00e-29	120.00
IUUC-Tru-117888	Takifugu rubripes	31.08	7.00e-31	125.00
IUUC-Tsy-119064	Tarsius syrichta	26.48	1.00e-18	85.90
IUUC-Tni-120323	Tetraodon nigroviridis	29.73	2.00e-30	124.00
IUUC-Tca-121784	Theobroma cacao	30.88	2.00e-32	130.00
IUUC-Tae-123366	Triticum aestivum	30.65	1.00e-30	125.00
IUUC-Tur-126046	Triticum urartu	31.73	2.00e-26	110.00
IUUC-Tbe-127406	Tupaia belangeri	31.65	3.00e-11	61.20
IUUC-Ttr-128268	Tursiops truncatus	30.27	6.00e-29	120.00
IUUC-Vpa-130534	Vicugna pacos	27.45	1.00e-13	68.20
IUUC-Vvi-131612	Vitis vinifera	29.02	1.00e-29	123.00
IUUC-Xtr-132969	Xenopus tropicalis	30.26	2.00e-29	121.00
IUUC-Xma-134075	Xiphophorus maculatus	29.79	3.00e-32	130.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence