iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062974

UUCD1 version

UUC-MoD-01133

Ensembl Protein ID

ENSMODP00000019250.1

UniProt Accession

F6SMT5; F6SMT5_MONDO

Protein Name

Uncharacterized protein

Gene Name

USP37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000015421.3	ENSMODT00000019597.2	ENSMODP00000019250.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.60e-87	293.3	343	957

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++++++++ll+   + ++++  k p ++l++ +++l+++    +s++k+   +++++a++++ae+fsgy
   Q: 343  QGFSNLGNTCYMNAILQSLFSLQSFANDLLK---QGIPWK--KVPLNALIRRFAHLLAKKDvcNSETKKDLLKKVKNAISATAERFSGY 426
           69*****************************...*****9..5799***********998778************************** PP
   S: 88   eqqDaqEflaflldqleeelkk.eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
           +q+Da+Efl+++ldql+e+++k +k++++e  ++e++s    + +   ++ ++++++++++++++++i+c+ c+++  ++e+f+dls++
   Q: 427  MQNDAHEFLSQCLDQLKEDMEKlNKTWKTEPISGEENSPGRTSDDIAATRIYTCPVVTNLEFEVQHSIICKVCGETVHKREQFNDLSID 515
           ********************88677777777788888888888899999**************************************** PP
   S: 176  vpgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +p++++  ++ s+qd+L+ f+++eele    y+cekc +k+ a  ++k+++lP+vLilhLkR+sf+ + + ++k+ ++v +p+ L+ls+
   Q: 516  LPRRKKPLPPrSIQDSLDLFFRAEELE----YSCEKCGGKS-AIVTHKFNRLPRVLILHLKRYSFNVALSLNNKVGQQVVIPRYLTLSS 599
           **999886545***************9....********99.9********************************************** PP
   S: 264  fcts..................................................................................... 267
           +ct+                                                                                     
   Q: 600  HCTEntkppltlgwsahtaisrplkasqmvnsctiststpsrkytfkskssagfsidsdsedellkrsvvlnqrlfempsreqqedlek 688
           ****9999999999999999999999999999999999999999999999999999999999999999999999999988888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 689  vskkckmesdksdlgnsgfdgmsedellaavleiskreaslsltnedddkptsspdtgfaeddiqdmpenlesmeaekskapieagpas 777
           88888888888888888888888888888888888877777777777777777777777777777777777777766666666666666 PP
   S: 268  .....................peekqke............................................................. 274
                                      e                                                             
   Q: 778  fteitkdfdenkenktpegsqG-----Evdwlqqydmerereeeelqqalaqslqeqeareqkedddlkratelslqefnssfldgmgs 861
           6666666666655555555550.....05555555555555555555666666666666666777777788888888888888888888 PP
   S: 275  ...............................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgsta 330
                                          +++Y+Li+vv+H G ++ssGHY+++v++ k++ W++++D +V++++e++v++++++++
   Q: 862  dddsgnedvfdmeyteaeaeelkrnaetgnlPHSYRLISVVSHIGsTSSSGHYISDVYDIKKQaWFTYNDLEVSKIQEASVQSDRDRSG 950
           8888888888888888888889999999999****************************99999************************* PP
   S: 331  YvlfYkr 337
           Y++fY++
   Q: 951  YIFFYMH 957
           *****98 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MTPLKIHGPI RVRSIQTGIT KWKEGSFEIV EKENKVSLVV HYNAGGIPRT FQLSHNIKNV 60
VLRPNGAKQS RLILTLQDNS YLSIDKVPYK DADEMRLFLD SVHQNRLHTA MKPSQGSGSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAGTTGAT GTCTTCGGGA GGACTGGAAT AGCTGCAGAA TATGGGTAGT TCCCCAAGAA 60
GAGTTCTTTA CCTATGGCAC AAGCATCAGA ATAAAGGTGA ATTGTTATAA AGTAGCTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mdo:100011373

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	85.44	0.00e+00	1580.00
IUUC-Apl-004033	Anas platyrhynchos	80.71	0.00e+00	1538.00
IUUC-Aca-005370	Anolis carolinensis	72.65	0.00e+00	1399.00
IUUC-Ame-011884	Astyanax mexicanus	58.56	0.00e+00	1012.00
IUUC-Bta-012725	Bos taurus	84.16	0.00e+00	1558.00
IUUC-Cja-019939	Callithrix jacchus	84.62	0.00e+00	1533.00
IUUC-Cfa-020835	Canis familiaris	85.22	0.00e+00	1612.00
IUUC-Cpo-022067	Cavia porcellus	83.60	0.00e+00	1407.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.84	1.00e-25	111.00
IUUC-Csa-023085	Chlorocebus sabaeus	84.90	0.00e+00	1571.00
IUUC-Cho-024390	Choloepus hoffmanni	75.42	5.00e-148	518.00
IUUC-Cin-025496	Ciona intestinalis	33.24	2.00e-44	173.00
IUUC-Csv-025812	Ciona savignyi	35.52	5.00e-42	165.00
IUUC-Dre-028255	Danio rerio	57.11	0.00e+00	962.00
IUUC-Dno-028986	Dasypus novemcinctus	84.73	0.00e+00	1541.00
IUUC-Dor-031062	Dipodomys ordii	72.12	0.00e+00	809.00
IUUC-Ete-032359	Echinops telfairi	74.55	0.00e+00	757.00
IUUC-Eca-033964	Equus caballus	84.40	0.00e+00	1572.00
IUUC-Eeu-034492	Erinaceus europaeus	77.92	0.00e+00	724.00
IUUC-Fca-036359	Felis catus	84.82	0.00e+00	1578.00
IUUC-Fal-037640	Ficedula albicollis	81.41	0.00e+00	1511.00
IUUC-Gmo-039600	Gadus morhua	55.66	0.00e+00	951.00
IUUC-Gga-040126	Gallus gallus	80.91	0.00e+00	1470.00
IUUC-Gac-041557	Gasterosteus aculeatus	55.24	0.00e+00	926.00
IUUC-Ggo-045571	Gorilla gorilla	81.41	0.00e+00	1376.00
IUUC-Hsa-046043	Homo sapiens	85.22	0.00e+00	1555.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	84.40	0.00e+00	1541.00
IUUC-Lch-050357	Latimeria chalumnae	67.70	0.00e+00	1094.00
IUUC-Loc-052849	Lepisosteus oculatus	62.33	0.00e+00	1037.00
IUUC-Laf-054570	Loxodonta africana	84.01	0.00e+00	1518.00
IUUC-Mcc-054989	Macaca mulatta	84.33	0.00e+00	1447.00
IUUC-Meu-056273	Macropus eugenii	73.75	0.00e+00	693.00
IUUC-Mga-059814	Meleagris gallopavo	79.39	0.00e+00	1475.00
IUUC-Mmr-061726	Microcebus murinus	83.99	0.00e+00	1550.00
IUUC-Mmu-064069	Mus musculus	81.97	0.00e+00	1490.00
IUUC-Mpu-066008	Mustela putorius furo	84.92	0.00e+00	1550.00
IUUC-Mlu-068224	Myotis lucifugus	40.61	5.00e-163	568.00
IUUC-Nle-069259	Nomascus leucogenys	84.80	0.00e+00	1548.00
IUUC-Opr-070882	Ochotona princeps	72.75	8.00e-132	464.00
IUUC-Ont-072441	Oreochromis niloticus	56.91	0.00e+00	967.00
IUUC-Oan-073151	Ornithorhynchus anatinus	85.26	2.00e-125	442.00
IUUC-Ocu-074879	Oryctolagus cuniculus	83.35	0.00e+00	1531.00
IUUC-Ola-087007	Oryzias latipes	54.16	0.00e+00	898.00
IUUC-Oga-088385	Otolemur garnettii	83.65	0.00e+00	1547.00
IUUC-Oar-090305	Ovis aries	84.47	0.00e+00	1572.00
IUUC-Ptr-091299	Pan troglodytes	85.11	0.00e+00	1551.00
IUUC-Pan-091996	Papio anubis	85.10	0.00e+00	1527.00
IUUC-Psi-093176	Pelodiscus sinensis	81.55	0.00e+00	1535.00
IUUC-Pma-094331	Petromyzon marinus	48.93	0.00e+00	781.00
IUUC-Ppa-095732	Physcomitrella patens	29.20	5.00e-23	103.00
IUUC-Pfo-096503	Poecilia formosa	56.86	0.00e+00	937.00
IUUC-Pab-098543	Pongo abelii	85.13	0.00e+00	822.00
IUUC-Pca-101099	Procavia capensis	79.48	0.00e+00	1178.00
IUUC-Pva-103163	Pteropus vampyrus	79.51	0.00e+00	1462.00
IUUC-Rno-105766	Rattus norvegicus	82.47	0.00e+00	1494.00
IUUC-Sha-106610	Sarcophilus harrisii	90.53	0.00e+00	1685.00
IUUC-Sar-113624	Sorex araneus	39.72	3.00e-92	333.00
IUUC-Ssc-116353	Sus scrofa	84.13	0.00e+00	1533.00
IUUC-Tgu-116971	Taeniopygia guttata	81.31	0.00e+00	1481.00
IUUC-Tru-117932	Takifugu rubripes	46.08	0.00e+00	678.00
IUUC-Tsy-119185	Tarsius syrichta	79.97	0.00e+00	1028.00
IUUC-Tni-119842	Tetraodon nigroviridis	62.03	7.00e-116	410.00
IUUC-Tbe-127281	Tupaia belangeri	74.42	5.00e-175	608.00
IUUC-Ttr-128177	Tursiops truncatus	86.39	0.00e+00	1232.00
IUUC-Vpa-130031	Vicugna pacos	84.60	0.00e+00	1591.00
IUUC-Xtr-132949	Xenopus tropicalis	67.11	0.00e+00	1217.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence