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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046661
UUCD1 version UUC-HoS-00443
Ensembl Protein ID ENSP00000334474.5
UniProt Accession Q9ULJ6; Q5JSH9; Q7Z7E6; ZMIZ1_HUMAN
Genbank Protein ID AAP13542.1; CAI40993.2; BAA86538.2
Protein Name Zinc finger MIZ domain-containing protein 1; PIAS-like protein Zimp10; Retinoic acid-induced protein 17
Genbank Nucleotide ID AY235683; AL391665; AB033050
Gene Name ZMIZ1; KIAA1224; RAI17; ZIMP10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000108175.16 ENST00000334512.9 ENSP00000334474.5
ENSG00000108175.16 ENST00000611351.1 ENSP00000481736.1
ENSG00000108175.16 ENST00000446377.3 ENSP00000401558.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18218095
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 58.28 2.00e-105 381.00 IUUC-Dme-032001
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity).
 Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity).
Protein Sequence
(Fasta)
MNSMDRHIQQ TNDRLQCIKQ HLQNPANFHN AATELLDWCG DPRAFQRPFE QSLMGCLTVV 60
SRVAAQQGFD LDLGYRLLAV CAANRDKFTP KSAALLSSWC EELGRLLLLR HQKSRQSDPP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046661|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
CGGGCGCCGG GGAGAGCGGG CGGCCGGGCG GCAGGCGGGC GAGCAGCGAT CGGGCGGCCG 60
AGCGAGCGAG CAACGCCGGC GCAGCGCGGT GACCCCAGCC CCAGCCGGCG CGGAGCAGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046661|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004181--Znf_MIZ
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51044--ZF_SP_RING
Pfam

PF02891--zf-MIZ
Gene Ontology

GO:0005737--C:cytoplasm
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0008270--F:zinc ion binding
GO:0048844--P:artery morphogenesis
GO:0007569--P:cell aging
GO:0048589--P:developmental growth
GO:0003007--P:heart morphogenesis
GO:0001701--P:in utero embryonic development
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0045747--P:positive regulation of Notch signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0001570--P:vasculogenesis
GO:0007296--P:vitellogenesis
KEGG hsa:57178
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001794 Ailuropoda melanoleuca 96.54 0.00e+00 1698.00
IUUC-Apl-003273 Anas platyrhynchos 87.03 0.00e+00 1409.00
IUUC-Aca-004401 Anolis carolinensis 87.18 0.00e+00 1576.00
IUUC-Aly-005490 Arabidopsis lyrata 26.97 6.00e-20 93.20
IUUC-Ath-006888 Arabidopsis thaliana 38.53 2.00e-20 94.40
IUUC-Ame-010808 Astyanax mexicanus 80.91 0.00e+00 1280.00
IUUC-Bta-012614 Bos taurus 98.17 0.00e+00 1698.00
IUUC-Bol-016077 Brassica oleracea 34.82 1.00e-17 85.50
IUUC-Bra-017443 Brassica rapa 42.70 9.00e-18 85.50
IUUC-Cja-018964 Callithrix jacchus 99.02 0.00e+00 1618.00
IUUC-Cfa-020641 Canis familiaris 97.99 0.00e+00 1696.00
IUUC-Cpo-022418 Cavia porcellus 97.88 0.00e+00 1702.00
IUUC-Cre-022902 Chlamydomonas reinhardtii 23.23 1.00e-04 40.80
IUUC-Csa-023718 Chlorocebus sabaeus 99.81 0.00e+00 1633.00
IUUC-Cin-025758 Ciona intestinalis 60.86 3.00e-110 393.00
IUUC-Csv-026050 Ciona savignyi 60.07 1.00e-104 374.00
IUUC-Dre-028668 Danio rerio 80.32 0.00e+00 1251.00
IUUC-Dno-029204 Dasypus novemcinctus 90.77 0.00e+00 1533.00
IUUC-Dor-030159 Dipodomys ordii 99.12 0.00e+00 1002.00
IUUC-Dme-032001 Drosophila melanogaster 59.26 4.00e-106 379.00
IUUC-Ete-032521 Echinops telfairi 94.46 0.00e+00 1644.00
IUUC-Eca-034269 Equus caballus 98.46 0.00e+00 1701.00
IUUC-Eeu-034484 Erinaceus europaeus 98.92 0.00e+00 1191.00
IUUC-Fca-036463 Felis catus 99.32 0.00e+00 764.00
IUUC-Fal-036827 Ficedula albicollis 87.04 0.00e+00 1384.00
IUUC-Gmo-039165 Gadus morhua 77.42 0.00e+00 709.00
IUUC-Gga-040680 Gallus gallus 88.15 0.00e+00 1508.00
IUUC-Gac-041570 Gasterosteus aculeatus 80.86 0.00e+00 1384.00
IUUC-Ggo-045289 Gorilla gorilla 99.90 0.00e+00 1670.00
IUUC-Itr-049077 Ictidomys tridecemlineatus 97.92 0.00e+00 914.00
IUUC-Lch-050080 Latimeria chalumnae 84.38 0.00e+00 1377.00
IUUC-Lpe-050926 Leersia perrieri 44.34 5.00e-20 93.60
IUUC-Loc-052797 Lepisosteus oculatus 84.80 0.00e+00 1362.00
IUUC-Laf-054407 Loxodonta africana 91.32 0.00e+00 1484.00
IUUC-Mcc-055011 Macaca mulatta 99.33 0.00e+00 1629.00
IUUC-Meu-056748 Macropus eugenii 88.25 0.00e+00 1399.00
IUUC-Mga-059480 Meleagris gallopavo 89.56 0.00e+00 1361.00
IUUC-Mmr-061745 Microcebus murinus 97.99 0.00e+00 1693.00
IUUC-Mdo-062087 Monodelphis domestica 95.71 0.00e+00 1332.00
IUUC-Mmu-063802 Mus musculus 96.46 0.00e+00 1637.00
IUUC-Mpu-065779 Mustela putorius furo 88.25 0.00e+00 1303.00
IUUC-Mlu-067227 Myotis lucifugus 90.98 0.00e+00 1464.00
IUUC-Nle-069784 Nomascus leucogenys 99.23 0.00e+00 1662.00
IUUC-Opr-070817 Ochotona princeps 95.56 0.00e+00 989.00
IUUC-Ont-072059 Oreochromis niloticus 79.16 0.00e+00 1295.00
IUUC-Oan-073685 Ornithorhynchus anatinus 91.80 0.00e+00 749.00
IUUC-Ocu-073807 Oryctolagus cuniculus 96.94 0.00e+00 1662.00
IUUC-Ola-087350 Oryzias latipes 74.45 0.00e+00 988.00
IUUC-Olu-087742 Ostreococcus lucimarinus 33.64 3.00e-10 59.70
IUUC-Oga-088062 Otolemur garnettii 95.82 0.00e+00 1447.00
IUUC-Oar-089253 Ovis aries 90.07 0.00e+00 1386.00
IUUC-Ptr-090863 Pan troglodytes 99.90 0.00e+00 1672.00
IUUC-Pan-092229 Papio anubis 99.23 0.00e+00 1625.00
IUUC-Psi-094030 Pelodiscus sinensis 85.58 0.00e+00 1485.00
IUUC-Pfo-096851 Poecilia formosa 80.49 0.00e+00 1323.00
IUUC-Pab-097748 Pongo abelii 99.89 0.00e+00 1568.00
IUUC-Ppe-101666 Prunus persica 25.56 1.00e-18 89.00
IUUC-Pva-103063 Pteropus vampyrus 95.19 0.00e+00 1635.00
IUUC-Rno-105875 Rattus norvegicus 96.37 0.00e+00 1691.00
IUUC-Sha-107172 Sarcophilus harrisii 91.09 0.00e+00 1484.00
IUUC-Ssl-108401 Sclerotinia sclerotiorum 22.07 1.00e-15 79.30
IUUC-Smo-109072 Selaginella moellendorffii 33.33 3.00e-13 71.60
IUUC-Ssc-116368 Sus scrofa 98.18 0.00e+00 1679.00
IUUC-Tgu-117017 Taeniopygia guttata 87.20 0.00e+00 1333.00
IUUC-Tru-118190 Takifugu rubripes 78.53 0.00e+00 1058.00
IUUC-Tsy-119246 Tarsius syrichta 71.70 1.00e-76 281.00
IUUC-Tni-120276 Tetraodon nigroviridis 74.06 0.00e+00 1071.00
IUUC-Tbe-127370 Tupaia belangeri 87.36 0.00e+00 895.00
IUUC-Ttr-128851 Tursiops truncatus 95.19 0.00e+00 1644.00
IUUC-Uma-129549 Ustilago maydis 31.08 7.00e-27 116.00
IUUC-Xtr-132102 Xenopus tropicalis 78.33 0.00e+00 1337.00
Created Date 25-Jun-2017

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