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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Cel-018481
UUCD1 version UUC-CaE-00560
Ensembl Protein ID Y110A7A.17a
UniProt Accession Q9N593; Q6AW18; Q8T4K4; CDC27_CAEEL
Genbank Protein ID CCD66209.1; AAL92523.1; CCD66210.1
Protein Name Cell division cycle protein 27 homolog; Anaphase-promoting complex subunit 3; Metaphase-to-anaphase transition defect protein 1
Genbank Nucleotide ID FO080728; AY081955; FO080728
Gene Name mat-1; apc-3; cdc-27; pod-5; Y110A7A.17
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00003132 Y110A7A.17a Y110A7A.17a
WBGene00003132 Y110A7A.17b Y110A7A.17b
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
Mentha
Post-translational Modifications (PTMs)
dbPAFPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 32.46 5.00e-43 171.00 IUUC-Sce-106187
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells (PubMed:12620985, PubMed:11134076). Required for embryonic anterior-posterior axis formation (PubMed:11832245). Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion (PubMed:15556870).
 Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells (PubMed:12620985, PubMed:11134076). Required for embryonic anterior-posterior axis formation (PubMed:11832245). Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion (PubMed:15556870).
Protein Sequence
(Fasta)
MKESAASVAV RPQLREVFER FPADAHRTIE DEIHEMMKCY AFDDAIFLAE LHYETDKSNN 60
SESLLLYADC LYRANKKEEC YGLLSSVKLS GARLFYLLAR VSYDLNKIDD CRGALFEHDD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018481|E3,APC_C|Caenorhabditis elegans
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Nucleotide Sequence
(Fasta)
GTCGCGAAGA GAATGAAAGA ATCAGCTGCG TCTGTAGCTG TGCGGCCTCA ATTGAGAGAG 60
GTGTTCGAGC GTTTTCCAGC GGACGCACAC CGAACAATTG AAGATGAGAT TCATGAAATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018481|E3,APC_C|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0469--Meiosis
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR007330--MIT
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
PROSITE

PS50005--TPR
PS50293--TPR_REGION
Pfam

PF13181--TPR_8
SMART

SM00028--TPR
Gene Ontology

GO:0005634--C:nucleus
GO:0051301--P:cell division
GO:0051321--P:meiotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0007275--P:multicellular organism development
GO:0016567--P:protein ubiquitination
KEGG cel:CELE_Y110A7A.17
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000478 Aegilops tauschii 31.76 7.00e-44 171.00
IUUC-Aml-002123 Ailuropoda melanoleuca 40.51 5.00e-77 281.00
IUUC-Atr-002921 Amborella trichopoda 32.20 2.00e-47 182.00
IUUC-Apl-003652 Anas platyrhynchos 40.19 1.00e-76 280.00
IUUC-Aca-004797 Anolis carolinensis 39.87 1.00e-75 276.00
IUUC-Aly-006146 Arabidopsis lyrata 30.32 8.00e-42 164.00
IUUC-Ath-007523 Arabidopsis thaliana 31.99 5.00e-43 168.00
IUUC-Ago-007939 Ashbya gossypii 31.10 3.00e-38 152.00
IUUC-Acl-008169 Aspergillus clavatus 34.38 7.00e-52 197.00
IUUC-Afl-008631 Aspergillus flavus 36.07 9.00e-48 183.00
IUUC-Afu-008990 Aspergillus fumigatus 36.43 1.00e-51 196.00
IUUC-Ani-009208 Aspergillus nidulans 36.90 9.00e-28 117.00
IUUC-Ang-009561 Aspergillus niger 34.38 2.00e-52 199.00
IUUC-Aor-009958 Aspergillus oryzae 36.07 2.00e-47 182.00
IUUC-Ate-010597 Aspergillus terreus 33.44 3.00e-50 192.00
IUUC-Ame-010734 Astyanax mexicanus 44.88 8.00e-52 196.00
IUUC-Bgr-012282 Blumeria graminis 33.23 2.00e-47 182.00
IUUC-Bta-013499 Bos taurus 40.51 4.00e-77 281.00
IUUC-Bdi-014213 Brachypodium distachyon 32.16 3.00e-43 168.00
IUUC-Bol-016307 Brassica oleracea 32.36 1.00e-43 170.00
IUUC-Bra-017042 Brassica rapa 31.65 3.00e-43 168.00
IUUC-Cja-019393 Callithrix jacchus 40.51 4.00e-77 281.00
IUUC-Cfa-020221 Canis familiaris 40.51 4.00e-77 281.00
IUUC-Cpo-021792 Cavia porcellus 40.19 7.00e-77 280.00
IUUC-Csa-023091 Chlorocebus sabaeus 40.51 4.00e-77 281.00
IUUC-Cin-025231 Ciona intestinalis 38.19 1.00e-56 213.00
IUUC-Csv-025983 Ciona savignyi 37.15 6.00e-58 218.00
IUUC-Cgl-026436 Colletotrichum gloeosporioides 35.23 3.00e-44 172.00
IUUC-Cne-026779 Cryptococcus neoformans 36.69 5.00e-50 191.00
IUUC-Cme-027126 Cyanidioschyzon merolae 31.94 3.00e-36 145.00
IUUC-Dre-028038 Danio rerio 40.94 2.00e-76 278.00
IUUC-Dno-029681 Dasypus novemcinctus 40.51 3.00e-77 281.00
IUUC-Dor-030742 Dipodomys ordii 29.78 1.00e-30 127.00
IUUC-Dse-031468 Dothistroma septosporum 32.36 6.00e-38 151.00
IUUC-Dme-031900 Drosophila melanogaster 40.29 3.00e-59 222.00
IUUC-Ete-032396 Echinops telfairi 37.97 2.00e-68 253.00
IUUC-Eca-034414 Equus caballus 40.51 5.00e-77 281.00
IUUC-Eeu-034864 Erinaceus europaeus 37.34 5.00e-64 238.00
IUUC-Fca-036459 Felis catus 40.82 2.00e-77 282.00
IUUC-Fox-037700 Fusarium oxysporum 35.27 5.00e-49 186.00
IUUC-Fso-038112 Fusarium solani 34.59 9.00e-50 190.00
IUUC-Gmo-038876 Gadus morhua 41.44 8.00e-72 263.00
IUUC-Ggr-039822 Gaeumannomyces graminis 35.61 3.00e-46 179.00
IUUC-Gga-040585 Gallus gallus 40.19 9.00e-77 280.00
IUUC-Gac-042126 Gasterosteus aculeatus 39.87 4.00e-75 275.00
IUUC-Gma-044263 Glycine max 31.99 3.00e-45 175.00
IUUC-Ggo-045272 Gorilla gorilla 36.08 2.00e-62 232.00
IUUC-Hsa-045682 Homo sapiens 40.51 4.00e-77 281.00
IUUC-Hvu-047421 Hordeum vulgare 32.71 9.00e-37 145.00
IUUC-Itr-048133 Ictidomys tridecemlineatus 40.51 4.00e-77 280.00
IUUC-Kpa-049367 Komagataella pastoris 33.33 3.00e-50 191.00
IUUC-Lch-049755 Latimeria chalumnae 38.92 3.00e-72 265.00
IUUC-Lpe-051689 Leersia perrieri 31.14 1.00e-41 163.00
IUUC-Loc-052907 Lepisosteus oculatus 41.00 1.00e-74 273.00
IUUC-Lma-053272 Leptosphaeria maculans 36.07 2.00e-44 172.00
IUUC-Laf-054312 Loxodonta africana 40.51 6.00e-77 280.00
IUUC-Mcc-055312 Macaca mulatta 40.51 4.00e-77 281.00
IUUC-Meu-056290 Macropus eugenii 35.44 1.00e-60 226.00
IUUC-Mor-057118 Magnaporthe oryzae 33.86 6.00e-47 181.00
IUUC-Mpo-057620 Magnaporthe poae 35.61 5.00e-47 181.00
IUUC-Mtr-058302 Medicago truncatula 31.42 5.00e-46 177.00
IUUC-Mla-058835 Melampsora laricipopulina 27.37 1.00e-28 119.00
IUUC-Mga-060010 Meleagris gallopavo 40.19 1.00e-76 280.00
IUUC-Mvi-060340 Microbotryum violaceum 32.96 7.00e-37 147.00
IUUC-Mmr-060610 Microcebus murinus 40.82 3.00e-73 268.00
IUUC-Mdo-062216 Monodelphis domestica 40.51 7.00e-77 280.00
IUUC-Mmu-063476 Mus musculus 40.19 2.00e-76 279.00
IUUC-Mac-065409 Musa acuminata 34.42 2.00e-47 182.00
IUUC-Mpu-066213 Mustela putorius furo 40.51 4.00e-77 281.00
IUUC-Mlu-067540 Myotis lucifugus 40.51 4.00e-77 281.00
IUUC-Nfi-068437 Neosartorya fischeri 36.43 7.00e-52 197.00
IUUC-Ncr-068882 Neurospora crassa 31.42 4.00e-45 175.00
IUUC-Nle-068976 Nomascus leucogenys 40.51 4.00e-77 281.00
IUUC-Opr-071171 Ochotona princeps 37.66 1.00e-65 243.00
IUUC-Ont-071295 Oreochromis niloticus 39.37 2.00e-73 269.00
IUUC-Oan-072896 Ornithorhynchus anatinus 40.66 4.00e-64 237.00
IUUC-Ocu-074828 Oryctolagus cuniculus 40.51 4.00e-77 281.00
IUUC-Oba-075176 Oryza barthii 29.67 1.00e-34 140.00
IUUC-Obr-076622 Oryza brachyantha 31.87 4.00e-45 174.00
IUUC-Ogu-078158 Oryza glumaepatula 30.77 1.00e-40 160.00
IUUC-Oin-079840 Oryza indica 31.14 2.00e-44 172.00
IUUC-Olo-080632 Oryza longistaminata 31.14 2.00e-44 172.00
IUUC-Ome-081193 Oryza meridionalis 31.14 2.00e-44 172.00
IUUC-Oni-082335 Oryza nivara 29.67 1.00e-34 140.00
IUUC-Opu-083857 Oryza punctata 30.57 1.00e-42 166.00
IUUC-Oru-085165 Oryza rufipogon 29.67 2.00e-34 139.00
IUUC-Osa-085529 Oryza sativa 31.14 2.00e-43 167.00
IUUC-Olu-087803 Ostreococcus lucimarinus 31.29 3.00e-42 164.00
IUUC-Oga-088851 Otolemur garnettii 40.82 3.00e-77 281.00
IUUC-Oar-089794 Ovis aries 40.51 4.00e-77 281.00
IUUC-Ptr-091588 Pan troglodytes 40.51 4.00e-77 281.00
IUUC-Pan-092083 Papio anubis 40.51 6.00e-77 280.00
IUUC-Psi-093368 Pelodiscus sinensis 40.19 1.00e-76 280.00
IUUC-Pma-094306 Petromyzon marinus 40.88 6.00e-75 274.00
IUUC-Pno-094898 Phaeosphaeria nodorum 30.65 5.00e-44 171.00
IUUC-Ppa-095288 Physcomitrella patens 30.03 6.00e-41 161.00
IUUC-Pfo-097263 Poecilia formosa 39.24 1.00e-73 270.00
IUUC-Pab-097782 Pongo abelii 40.51 4.00e-77 281.00
IUUC-Pca-100771 Procavia capensis 36.28 3.00e-56 212.00
IUUC-Ppe-102042 Prunus persica 30.72 6.00e-45 174.00
IUUC-Pva-103207 Pteropus vampyrus 40.51 4.00e-77 281.00
IUUC-Pgr-103352 Puccinia graminis 31.46 4.00e-32 132.00
IUUC-Ptt-103992 Puccinia triticina 33.06 1.00e-14 74.30
IUUC-Pte-104138 Pyrenophora teres 34.02 2.00e-47 182.00
IUUC-Pyt-104652 Pyrenophora triticirepentis 34.02 1.00e-47 183.00
IUUC-Rno-105451 Rattus norvegicus 40.19 2.00e-76 279.00
IUUC-Sce-106187 Saccharomyces cerevisiae 32.46 8.00e-44 171.00
IUUC-Sha-107398 Sarcophilus harrisii 40.82 2.00e-76 279.00
IUUC-Sja-107984 Schizosaccharomyces japonicus 36.65 7.00e-48 184.00
IUUC-Spo-108274 Schizosaccharomyces pombe 38.08 2.00e-54 205.00
IUUC-Smo-109678 Selaginella moellendorffii 30.94 5.00e-48 184.00
IUUC-Sit-110813 Setaria italica 32.94 7.00e-45 174.00
IUUC-Sly-111637 Solanum lycopersicum 31.11 5.00e-45 174.00
IUUC-Stu-112086 Solanum tuberosum 31.97 4.00e-44 171.00
IUUC-Sar-113214 Sorex araneus 40.51 9.00e-77 280.00
IUUC-Sre-114904 Sporisorium reilianum 30.14 2.00e-19 90.50
IUUC-Ssc-115692 Sus scrofa 46.00 2.00e-52 199.00
IUUC-Tgu-116466 Taeniopygia guttata 40.19 1.00e-76 279.00
IUUC-Tru-118417 Takifugu rubripes 40.00 1.00e-74 273.00
IUUC-Tsy-118796 Tarsius syrichta 40.51 2.00e-77 282.00
IUUC-Tni-120331 Tetraodon nigroviridis 40.00 2.00e-74 271.00
IUUC-Tca-121321 Theobroma cacao 30.88 1.00e-42 166.00
IUUC-Tre-122083 Trichoderma reesei 34.81 7.00e-46 177.00
IUUC-Tvi-122558 Trichoderma virens 35.79 3.00e-46 178.00
IUUC-Tae-125209 Triticum aestivum 31.76 1.00e-43 169.00
IUUC-Tur-126187 Triticum urartu 25.10 3.00e-25 109.00
IUUC-Tme-127012 Tuber melanosporum 36.05 3.00e-50 192.00
IUUC-Tbe-127774 Tupaia belangeri 34.81 3.00e-60 225.00
IUUC-Ttr-128605 Tursiops truncatus 37.97 1.00e-68 253.00
IUUC-Vda-129996 Verticillium dahliae 35.18 3.00e-41 160.00
IUUC-Vpa-130122 Vicugna pacos 40.51 4.00e-77 281.00
IUUC-Vvi-131580 Vitis vinifera 29.81 2.00e-45 176.00
IUUC-Xtr-131756 Xenopus tropicalis 39.56 1.00e-71 263.00
IUUC-Xma-133214 Xiphophorus maculatus 38.92 2.00e-72 266.00
IUUC-Yli-134473 Yarrowia lipolytica 35.35 5.00e-50 191.00
IUUC-Zma-135179 Zea mays 33.33 3.00e-45 175.00
Created Date 25-Jun-2017

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