iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000026988.15	ENSMUST00000028368.13	ENSMUSP00000028368.7
ENSMUSG00000026988.15	ENSMUST00000102751.8	ENSMUSP00000099812.2
ENSMUSG00000026988.15	ENSMUST00000139689.7	ENSMUSP00000121438.1
ENSMUSG00000026988.15	ENSMUST00000133809.2	ENSMUSP00000114814.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.10e-25	89.7	402	473
E3 adaptor/Cullin RING/DCX/DWD	1.10e-35	121.2	278	308
UBD/Beta-Prp	2.50e-55	188.9	6	219

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceens 73
           +p+ef+CpI+ elM+dPv++++G++y+r+++e w+ ++++t+P+t+  l +  l+Pn tl+  i++w+e+++
   Q: 402  IPDEFICPITRELMKDPVIASDGYSYEREAMESWIHKKKRTSPMTNLALPSLVLTPNRTLKMAINRWLETHE 473
           8********************************************************************996 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           +Ht  vt +af ++  ll++Gs D+t+ +W 
   Q: 278  QHTRYVTTCAFaPNtLLLATGSMDKTVNIWQ 308
           59**********775778************7 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvht 89
            tl +h ++v +  +f  +  llat s d+ti+++++++      + l+ h+ +v +++fsp+g +l+++s+D+t  +w+  +g ++ +
   Q: 6    HTLADHGDDVSC-CAF--SAALLATCSLDKTIRLYSLSDFAElpYSPLKFHTYAVHCCCFSPSGHVLASCSTDGTTVLWSSHSGHTLTV 91
           567777776666.789..9********************65578899999*************************************** PP
   S: 90   lk.ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           l+    + v+ + fsp++ +l+sG +d  i +w+ +t++ ++ + s++d++    +++pdg l+v+Gs  + + +Wd  ++++l+  + 
   Q: 92   LEqPGGSPVRVCCFSPDSAYLASGAADGSIALWNAQTYKLYR-CGSVKDSSLVACAFSPDGGLFVTGSSGGDLTVWDD-RMRCLHSEKA 178
           99445678999999**99***********************9.*********************************98.6788888877 PP
   S: 178  ghtdsvyslsfdsng.........kelvsgsldgtvklwdlq 210
            h+  +++ sf+s+           +l+s+++d  +klw + 
   Q: 179  -HDLGITCCSFSSQPlsggeglqsYQLASCGQDCEIKLWAVT 219
           .************9899**********************875 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MVRLIHTLAD HGDDVSCCAF SAALLATCSL DKTIRLYSLS DFAELPYSPL KFHTYAVHCC 60
CFSPSGHVLA SCSTDGTTVL WSSHSGHTLT VLEQPGGSPV RVCCFSPDSA YLASGAADGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCCAGTGA GTCGGGCTCT GCCTAGTGAG CAGCCCAGCC CAGCAGCCCA GCTCGGGGCC 60
CAGCCCGGGG CCGAGCCCGG GGCAGTGCAG ACTTGGTGAC CTCAGAACCC GGAGGTGCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001660--SAM
IPR013761--SAM/pointed
IPR003613--Ubox_domain
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50105--SAM_DOMAIN
PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07647--SAM_2
PF04564--U-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00454--SAM
SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

mmu:72137

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000612	Aegilops tauschii	52.24	2.00e-16	81.60
IUUC-Aml-001614	Ailuropoda melanoleuca	82.77	0.00e+00	826.00
IUUC-Apl-003529	Anas platyrhynchos	71.64	0.00e+00	713.00
IUUC-Aca-004257	Anolis carolinensis	67.62	0.00e+00	663.00
IUUC-Ame-011357	Astyanax mexicanus	51.66	6.00e-115	407.00
IUUC-Bta-013032	Bos taurus	78.41	0.00e+00	784.00
IUUC-Cja-018743	Callithrix jacchus	81.72	0.00e+00	818.00
IUUC-Cfa-021197	Canis familiaris	80.67	0.00e+00	813.00
IUUC-Cpo-022279	Cavia porcellus	82.35	0.00e+00	815.00
IUUC-Csa-023954	Chlorocebus sabaeus	82.14	0.00e+00	813.00
IUUC-Cho-025083	Choloepus hoffmanni	65.25	5.00e-137	480.00
IUUC-Cin-025786	Ciona intestinalis	35.89	9.00e-78	284.00
IUUC-Dre-028087	Danio rerio	56.49	2.00e-143	502.00
IUUC-Dno-028919	Dasypus novemcinctus	81.72	0.00e+00	813.00
IUUC-Dor-031112	Dipodomys ordii	81.30	0.00e+00	805.00
IUUC-Ete-032405	Echinops telfairi	80.76	1.00e-163	569.00
IUUC-Eca-033254	Equus caballus	79.58	0.00e+00	798.00
IUUC-Eeu-034545	Erinaceus europaeus	75.42	0.00e+00	731.00
IUUC-Fca-035482	Felis catus	81.72	0.00e+00	818.00
IUUC-Fal-036976	Ficedula albicollis	58.02	3.00e-151	528.00
IUUC-Gmo-039213	Gadus morhua	55.06	1.00e-134	473.00
IUUC-Gga-040561	Gallus gallus	70.02	0.00e+00	696.00
IUUC-Gac-041471	Gasterosteus aculeatus	58.28	2.00e-141	495.00
IUUC-Ggo-045503	Gorilla gorilla	82.35	0.00e+00	818.00
IUUC-Hsa-045910	Homo sapiens	82.14	0.00e+00	818.00
IUUC-Hvu-047519	Hordeum vulgare	50.75	6.00e-16	79.30
IUUC-Itr-048214	Ictidomys tridecemlineatus	81.43	0.00e+00	637.00
IUUC-Loc-052307	Lepisosteus oculatus	59.44	2.00e-165	575.00
IUUC-Laf-053587	Loxodonta africana	80.88	0.00e+00	803.00
IUUC-Mcc-055679	Macaca mulatta	82.14	0.00e+00	818.00
IUUC-Meu-055962	Macropus eugenii	65.97	4.00e-176	610.00
IUUC-Mga-059652	Meleagris gallopavo	69.46	0.00e+00	692.00
IUUC-Mmr-060943	Microcebus murinus	80.50	0.00e+00	795.00
IUUC-Mdo-062592	Monodelphis domestica	78.08	0.00e+00	775.00
IUUC-Mac-064539	Musa acuminata	54.79	4.00e-20	93.60
IUUC-Mpu-066422	Mustela putorius furo	82.56	0.00e+00	818.00
IUUC-Mlu-067250	Myotis lucifugus	78.78	0.00e+00	783.00
IUUC-Nle-069517	Nomascus leucogenys	82.14	0.00e+00	816.00
IUUC-Opr-070776	Ochotona princeps	80.67	0.00e+00	793.00
IUUC-Ont-071821	Oreochromis niloticus	57.62	5.00e-149	521.00
IUUC-Oan-073706	Ornithorhynchus anatinus	76.84	0.00e+00	764.00
IUUC-Ocu-074766	Oryctolagus cuniculus	74.53	0.00e+00	724.00
IUUC-Obr-076154	Oryza brachyantha	48.48	4.00e-19	87.80
IUUC-Ola-086531	Oryzias latipes	57.35	1.00e-147	516.00
IUUC-Oga-088388	Otolemur garnettii	80.46	0.00e+00	801.00
IUUC-Oar-089748	Ovis aries	78.99	0.00e+00	791.00
IUUC-Ptr-090616	Pan troglodytes	82.03	0.00e+00	809.00
IUUC-Pan-091769	Papio anubis	81.98	1.00e-167	582.00
IUUC-Psi-093334	Pelodiscus sinensis	74.37	0.00e+00	684.00
IUUC-Pma-094383	Petromyzon marinus	49.02	2.00e-132	466.00
IUUC-Pfo-096801	Poecilia formosa	54.60	6.00e-143	500.00
IUUC-Pab-098139	Pongo abelii	80.93	0.00e+00	651.00
IUUC-Pca-100523	Procavia capensis	77.60	1.00e-147	516.00
IUUC-Pva-102286	Pteropus vampyrus	78.36	0.00e+00	763.00
IUUC-Rno-104831	Rattus norvegicus	92.21	0.00e+00	907.00
IUUC-Sha-107499	Sarcophilus harrisii	77.57	0.00e+00	772.00
IUUC-Sar-113389	Sorex araneus	78.36	0.00e+00	753.00
IUUC-Tgu-116769	Taeniopygia guttata	69.96	0.00e+00	682.00
IUUC-Tru-118774	Takifugu rubripes	55.67	2.00e-144	505.00
IUUC-Tsy-119595	Tarsius syrichta	68.69	2.00e-159	555.00
IUUC-Tni-119850	Tetraodon nigroviridis	56.78	3.00e-144	505.00
IUUC-Tur-126683	Triticum urartu	50.75	2.00e-16	81.30
IUUC-Tbe-127938	Tupaia belangeri	74.43	2.00e-129	454.00
IUUC-Ttr-128193	Tursiops truncatus	79.72	0.00e+00	673.00
IUUC-Vpa-130275	Vicugna pacos	81.09	0.00e+00	809.00
IUUC-Xtr-131982	Xenopus tropicalis	59.58	3.00e-161	561.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence