iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ang-009531

Ensembl Protein ID

CAK40653

UniProt Accession

A2QW83; PAN2_ASPNC

Genbank Protein ID

CAK40653.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit pan2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AM270233

Gene Name

pan2; An11g04210

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
An11g04210	CAK40653	CAK40653

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.30e-10	37.8	479	813

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs..........gyeqqDa 92
           Gl+ + +  + N++LQ   +ip +r+  l++  +++  e      ++ll+++  lf  l k + ++ + ++llk+++++ e  +          ++     
   Q: 479  GLETHIANSFTNALLQLFKFIPYIRNVALHHAASSCIFE------TCLLCEMGYLFDMLEKASGQNCQATNLLKTFSSYREASNlglfeenltnKSLSAAI 573
           788888889*********************888888765......7*******************************999987655333333222222333 PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls.....lpvpgkeetkkeslq 188
           q + +f+l q++ +                          +  + +++ +++ +    +++i+c  c+n+ +r  + l  +     +++++ + +    ++
   Q: 574  QAVNRFFLGQISHD-------------------------FRMISPSSDDLDHRLATVASESIRCMFCQNEIVRPGNSLVNElnypaIDIKQARRNPAFRFS 649
           33333333333333.........................46677777778888888888999999999999876655544400111555566666666*** PP
   S: 189  dcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRf......sfseeqksrekinkkvefpleLdls..pfctspeekqkekkkYeLi 281
           ++L++  ++e  +   + +c+ c+++q++  + +++++P+vL+l+           +   ++ +e +   +e  + L  +      + + k    + Y+L+
   Q: 650  NILRASIEREAQN---RGWCNYCRRYQQVAIRKSVHRMPQVLMLNAALTnpicrrLWAIPGWLPEEVGIVIEGGQILCFEgeDLKLRVQAKMPGLVVYDLV 747
           *******999887...59**************************976553333335666667777777777755444333223333344445559****** PP
   S: 282  avvvHsG..slssGHYvayvkn........ekgkWllfdDskVtevkeeevleetg..staYvlfY 335
           + v+     ++++ H v++++         +k+kW lf+D  Vtev++ee l++++  + + vl Y
   Q: 748  GLVCEIDipEHQKAHLVSFINVsissrepeTKNKWHLFNDFLVTEVDKEEALRFNQpwKIPCVLAY 813
           ****9998999***********898888877888*****************998876655555555 PP

Organism

Aspergillus niger

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein pab1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MEADWDELSR IPVPAPSVHA LPTIATAIAF DDVMELLWGR ITSFFGPELQ RYTSVRAHPA 60
TEPVRQIIFH DRGVISLSPK SVHMITRRGL TQWHIAHEEM TDLRCMSFTA QTNRIIVAGC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGCCG ATTGGGATGA ACTGTCGCGC ATTCCGGTGC CTGCACCGAG CGTGCATGCC 60
CTGCCGACAA TCGCAACCGC AATAGCCTTT GATGATGTGA TGGAGTTGTT GTGGGTGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	31.01	6.00e-146	510.00
IUUC-Apl-003500	Anas platyrhynchos	31.33	4.00e-129	454.00
IUUC-Aca-004930	Anolis carolinensis	30.96	3.00e-144	504.00
IUUC-Acl-008214	Aspergillus clavatus	87.88	0.00e+00	2080.00
IUUC-Afu-009112	Aspergillus fumigatus	86.39	0.00e+00	2064.00
IUUC-Ame-011259	Astyanax mexicanus	31.90	9.00e-148	516.00
IUUC-Bta-012371	Bos taurus	31.18	5.00e-146	510.00
IUUC-Bci-013684	Botrytis cinerea	49.05	0.00e+00	1041.00
IUUC-Cja-019297	Callithrix jacchus	30.43	5.00e-144	503.00
IUUC-Cfa-020489	Canis familiaris	30.56	1.00e-145	509.00
IUUC-Cpo-022392	Cavia porcellus	31.18	2.00e-147	515.00
IUUC-Csa-023220	Chlorocebus sabaeus	30.92	4.00e-145	507.00
IUUC-Csv-025841	Ciona savignyi	29.23	8.00e-119	420.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	49.45	0.00e+00	1102.00
IUUC-Cne-026932	Cryptococcus neoformans	33.91	2.00e-154	538.00
IUUC-Dre-028482	Danio rerio	28.22	6.00e-75	274.00
IUUC-Dno-029398	Dasypus novemcinctus	30.89	8.00e-146	509.00
IUUC-Dor-030307	Dipodomys ordii	31.38	4.00e-96	344.00
IUUC-Dme-032111	Drosophila melanogaster	29.55	5.00e-76	278.00
IUUC-Eca-033985	Equus caballus	31.01	9.00e-146	509.00
IUUC-Eeu-034928	Erinaceus europaeus	29.75	3.00e-35	142.00
IUUC-Fca-035587	Felis catus	30.98	6.00e-147	513.00
IUUC-Fal-037587	Ficedula albicollis	31.35	2.00e-144	504.00
IUUC-Fso-038133	Fusarium solani	48.76	3.00e-177	613.00
IUUC-Gmo-039076	Gadus morhua	28.01	9.00e-69	253.00
IUUC-Ggr-039957	Gaeumannomyces graminis	47.41	0.00e+00	977.00
IUUC-Gga-040948	Gallus gallus	31.18	3.00e-143	501.00
IUUC-Gac-042396	Gasterosteus aculeatus	31.13	6.00e-141	493.00
IUUC-Ggo-045412	Gorilla gorilla	30.92	8.00e-146	509.00
IUUC-Hsa-046076	Homo sapiens	30.92	1.00e-145	509.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	29.50	2.00e-129	455.00
IUUC-Kpa-049178	Komagataella pastoris	32.75	2.00e-165	574.00
IUUC-Lch-050279	Latimeria chalumnae	27.76	2.00e-114	405.00
IUUC-Loc-052872	Lepisosteus oculatus	28.89	2.00e-73	269.00
IUUC-Lma-052986	Leptosphaeria maculans	51.56	0.00e+00	1152.00
IUUC-Laf-054181	Loxodonta africana	30.76	1.00e-143	503.00
IUUC-Mcc-054812	Macaca mulatta	31.12	9.00e-146	509.00
IUUC-Meu-056325	Macropus eugenii	31.30	3.00e-144	504.00
IUUC-Mor-057246	Magnaporthe oryzae	42.77	0.00e+00	833.00
IUUC-Mpo-057464	Magnaporthe poae	46.86	0.00e+00	994.00
IUUC-Mla-058911	Melampsora laricipopulina	38.77	7.00e-115	407.00
IUUC-Mga-059335	Meleagris gallopavo	29.59	2.00e-77	282.00
IUUC-Mvi-060461	Microbotryum violaceum	34.06	1.00e-156	546.00
IUUC-Mmr-060636	Microcebus murinus	31.18	2.00e-144	505.00
IUUC-Mmu-063503	Mus musculus	31.04	1.00e-147	516.00
IUUC-Mpu-066670	Mustela putorius furo	30.92	3.00e-145	508.00
IUUC-Mlu-068119	Myotis lucifugus	30.59	5.00e-147	513.00
IUUC-Nfi-068398	Neosartorya fischeri	87.25	0.00e+00	2070.00
IUUC-Ncr-068927	Neurospora crassa	42.81	0.00e+00	856.00
IUUC-Nle-069651	Nomascus leucogenys	30.10	4.00e-138	484.00
IUUC-Opr-070614	Ochotona princeps	30.81	9.00e-145	506.00
IUUC-Ont-072433	Oreochromis niloticus	32.09	3.00e-145	508.00
IUUC-Oan-073283	Ornithorhynchus anatinus	38.75	2.00e-61	229.00
IUUC-Ocu-074401	Oryctolagus cuniculus	30.56	4.00e-144	504.00
IUUC-Ola-087522	Oryzias latipes	30.58	2.00e-141	495.00
IUUC-Oga-088226	Otolemur garnettii	30.86	5.00e-146	510.00
IUUC-Oar-089241	Ovis aries	31.18	1.00e-148	519.00
IUUC-Pan-092297	Papio anubis	31.45	9.00e-137	479.00
IUUC-Psi-094043	Pelodiscus sinensis	28.42	9.00e-74	270.00
IUUC-Pma-094394	Petromyzon marinus	30.97	3.00e-139	488.00
IUUC-Pno-095053	Phaeosphaeria nodorum	51.04	0.00e+00	1056.00
IUUC-Ppa-095188	Physcomitrella patens	27.88	4.00e-110	391.00
IUUC-Pfo-097517	Poecilia formosa	31.88	3.00e-147	514.00
IUUC-Pca-100471	Procavia capensis	31.04	3.00e-148	518.00
IUUC-Pva-102805	Pteropus vampyrus	31.87	4.00e-90	324.00
IUUC-Pte-104021	Pyrenophora teres	52.11	0.00e+00	1169.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	52.01	0.00e+00	1165.00
IUUC-Rno-105471	Rattus norvegicus	31.17	7.00e-150	523.00
IUUC-Sce-106235	Saccharomyces cerevisiae	30.74	2.00e-127	448.00
IUUC-Sha-106883	Sarcophilus harrisii	31.00	4.00e-140	491.00
IUUC-Spo-108169	Schizosaccharomyces pombe	35.71	0.00e+00	635.00
IUUC-Sar-113323	Sorex araneus	32.01	3.00e-121	427.00
IUUC-Sre-115075	Sporisorium reilianum	39.71	1.00e-64	240.00
IUUC-Ssc-116363	Sus scrofa	30.91	6.00e-148	516.00
IUUC-Tru-118427	Takifugu rubripes	30.90	1.00e-144	506.00
IUUC-Tni-120218	Tetraodon nigroviridis	28.99	3.00e-78	285.00
IUUC-Tre-122177	Trichoderma reesei	48.99	0.00e+00	1086.00
IUUC-Tme-127176	Tuber melanosporum	46.31	0.00e+00	904.00
IUUC-Tbe-127641	Tupaia belangeri	26.86	2.00e-29	123.00
IUUC-Ttr-128888	Tursiops truncatus	32.96	2.00e-102	365.00
IUUC-Uma-129361	Ustilago maydis	41.54	2.00e-65	242.00
IUUC-Xtr-132811	Xenopus tropicalis	30.31	6.00e-134	470.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence