iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028482

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

BX927210

Gene Name

pan2; PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000074675.4	ENSDART00000140351.1	ENSDARP00000118293.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.80e-20	72.9	527	911

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqEfl 96
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e    g    D+ E +
   Q: 527  NAYCNCMIQVLYFLEPIRCLVQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQASNFLRAFRTIPEASAlGLILADSDEQT 606
           56*********************...55654......57*******************************9999855655566666655 PP
   S: 97   .aflldqleeelkk....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
            +  l +l ++ ++    + ++++ e+e+ +   +  ++++   ++++s+is+lF+ +++++  c  c+++++r +  l ++++ p+++
   Q: 607  gKARLGRLIQSWNRfilaQLHQETLEQEGPQ-AYRGASSSSVLSSSGESVISRLFGCEVENSSLC-CCGKETVRSSLTLLFTMHYPEQS 693
           1234555555555555534444444444444.556666778899999*************99999.8*******************999 PP
   S: 181  etkke....slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfc 265
           + +k+    ++    +   k   le++ + +c++c+k+q ++++  ++ lP+vL+++    s +e+     k ++++ f++ L+ +   
   Q: 694  SLEKKieeyEFV---DILRKSICLEQSTQAWCDNCEKYQPTVQTRNIRCLPDVLVINCEVNSAKEA--EFWKAQTEYVFNKALKKEAAE 777
           553333233333...33344555677778******************************9977665..445899999999888887322 PP
   S: 266  ts...............................................................peekqke.....kkkYeLiavvvH 286
                                                                            +     +       +Y+L+  v+H
   Q: 778  -PpkpkeplptewcleeelcnvegltfdtqaedmrhvwiplslrmciskaqglevssltegeeltE-----SeeaegVSIYDLFVTVSH 860
           .22444555555555566666666666666666666666666666666666666655555555543.....05555599********** PP
   S: 287  sG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevlee 325
              +  +G  va++k            ++++W+lf+D  +++++++e +++
   Q: 861  VQdTRTGGNMVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKAESVQF 911
           **9*************999988877777888************98777665 PP

Organism

Danio rerio

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MMNFEGLDPG LGDYAPGLHG GLEPGLDSSL DPRLDPALLQ GVEIDPDGLA VSESVHIVEG 60
MYSELHSVAA EVGIPVTATH FDLQEELLWM GNHRGHASSF FGPTMGRYSS FQVHMTDDIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAAGTGCG CGGTTGTTTT TGTTTTGAAT GAAGCGAGTA GCATGAGCAT ATGGATACGA 60
GGATAACTAT AGTCTAAAGG TATGATTTAT CTTGTACAAA TATTAAAAGA AGGACTTGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

KEGG

dre:792831

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	74.83	0.00e+00	1785.00
IUUC-Apl-003500	Anas platyrhynchos	75.35	0.00e+00	1678.00
IUUC-Aca-004930	Anolis carolinensis	74.00	0.00e+00	1793.00
IUUC-Acl-008214	Aspergillus clavatus	30.55	7.00e-148	518.00
IUUC-Afu-009112	Aspergillus fumigatus	30.06	3.00e-138	486.00
IUUC-Ang-009531	Aspergillus niger	31.00	2.00e-147	516.00
IUUC-Ame-011259	Astyanax mexicanus	90.40	0.00e+00	2170.00
IUUC-Bta-012371	Bos taurus	74.75	0.00e+00	1775.00
IUUC-Bci-013684	Botrytis cinerea	30.74	1.00e-133	471.00
IUUC-Cja-019297	Callithrix jacchus	72.65	0.00e+00	1731.00
IUUC-Cfa-020489	Canis familiaris	74.42	0.00e+00	1766.00
IUUC-Cpo-022392	Cavia porcellus	74.92	0.00e+00	1802.00
IUUC-Csa-023220	Chlorocebus sabaeus	74.09	0.00e+00	1772.00
IUUC-Csv-025841	Ciona savignyi	48.02	2.00e-141	496.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	31.63	2.00e-157	550.00
IUUC-Cne-026932	Cryptococcus neoformans	44.01	3.00e-72	267.00
IUUC-Dno-029398	Dasypus novemcinctus	74.96	0.00e+00	1780.00
IUUC-Dor-030307	Dipodomys ordii	70.35	0.00e+00	986.00
IUUC-Dme-032111	Drosophila melanogaster	41.08	0.00e+00	880.00
IUUC-Eca-033985	Equus caballus	74.75	0.00e+00	1774.00
IUUC-Eeu-034928	Erinaceus europaeus	75.81	3.00e-176	612.00
IUUC-Fca-035587	Felis catus	74.75	0.00e+00	1797.00
IUUC-Fal-037587	Ficedula albicollis	75.25	0.00e+00	1776.00
IUUC-Fso-038133	Fusarium solani	31.65	3.00e-93	337.00
IUUC-Gmo-039076	Gadus morhua	83.76	0.00e+00	2009.00
IUUC-Ggr-039957	Gaeumannomyces graminis	29.14	6.00e-75	276.00
IUUC-Gga-040948	Gallus gallus	75.93	0.00e+00	1810.00
IUUC-Gac-042396	Gasterosteus aculeatus	83.62	0.00e+00	2063.00
IUUC-Ggo-045412	Gorilla gorilla	74.26	0.00e+00	1775.00
IUUC-Hsa-046076	Homo sapiens	74.26	0.00e+00	1776.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	69.77	0.00e+00	1600.00
IUUC-Kpa-049178	Komagataella pastoris	40.90	5.00e-66	246.00
IUUC-Lch-050279	Latimeria chalumnae	69.11	0.00e+00	1645.00
IUUC-Loc-052872	Lepisosteus oculatus	85.57	0.00e+00	2033.00
IUUC-Lma-052986	Leptosphaeria maculans	29.77	5.00e-88	319.00
IUUC-Laf-054181	Loxodonta africana	72.33	0.00e+00	1740.00
IUUC-Mcc-054812	Macaca mulatta	74.09	0.00e+00	1764.00
IUUC-Meu-056325	Macropus eugenii	75.89	0.00e+00	1801.00
IUUC-Mor-057246	Magnaporthe oryzae	25.67	2.00e-58	221.00
IUUC-Mpo-057464	Magnaporthe poae	29.24	5.00e-71	263.00
IUUC-Mla-058911	Melampsora laricipopulina	33.61	4.00e-101	363.00
IUUC-Mga-059335	Meleagris gallopavo	76.33	0.00e+00	1784.00
IUUC-Mvi-060461	Microbotryum violaceum	44.64	7.00e-75	276.00
IUUC-Mmr-060636	Microcebus murinus	74.34	0.00e+00	1766.00
IUUC-Mmu-063503	Mus musculus	73.20	0.00e+00	1761.00
IUUC-Mpu-066670	Mustela putorius furo	74.83	0.00e+00	1779.00
IUUC-Mlu-068119	Myotis lucifugus	74.26	0.00e+00	1830.00
IUUC-Nfi-068398	Neosartorya fischeri	30.84	1.00e-147	517.00
IUUC-Ncr-068927	Neurospora crassa	28.69	2.00e-122	434.00
IUUC-Nle-069651	Nomascus leucogenys	71.23	0.00e+00	1687.00
IUUC-Opr-070614	Ochotona princeps	73.58	0.00e+00	1740.00
IUUC-Ont-072433	Oreochromis niloticus	84.38	0.00e+00	2097.00
IUUC-Oan-073283	Ornithorhynchus anatinus	67.27	0.00e+00	1268.00
IUUC-Ocu-074401	Oryctolagus cuniculus	73.77	0.00e+00	1767.00
IUUC-Ola-087522	Oryzias latipes	85.05	0.00e+00	2054.00
IUUC-Oga-088226	Otolemur garnettii	73.40	0.00e+00	1781.00
IUUC-Oar-089241	Ovis aries	74.59	0.00e+00	1800.00
IUUC-Pan-092297	Papio anubis	75.68	0.00e+00	1602.00
IUUC-Psi-094043	Pelodiscus sinensis	72.91	0.00e+00	1697.00
IUUC-Pma-094394	Petromyzon marinus	66.37	0.00e+00	1506.00
IUUC-Pno-095053	Phaeosphaeria nodorum	29.42	9.00e-74	272.00
IUUC-Ppa-095188	Physcomitrella patens	32.25	6.00e-161	562.00
IUUC-Pfo-097517	Poecilia formosa	85.92	0.00e+00	2127.00
IUUC-Pca-100471	Procavia capensis	75.88	0.00e+00	1704.00
IUUC-Pva-102805	Pteropus vampyrus	72.63	0.00e+00	1404.00
IUUC-Pte-104021	Pyrenophora teres	29.42	1.00e-87	318.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	28.99	1.00e-86	315.00
IUUC-Rno-105471	Rattus norvegicus	73.84	0.00e+00	1775.00
IUUC-Sce-106235	Saccharomyces cerevisiae	37.39	9.00e-59	222.00
IUUC-Sha-106883	Sarcophilus harrisii	75.58	0.00e+00	1680.00
IUUC-Spo-108169	Schizosaccharomyces pombe	31.74	4.00e-137	482.00
IUUC-Sar-113323	Sorex araneus	74.80	0.00e+00	1321.00
IUUC-Sre-115075	Sporisorium reilianum	48.65	9.00e-59	223.00
IUUC-Ssc-116363	Sus scrofa	73.77	0.00e+00	1784.00
IUUC-Tru-118427	Takifugu rubripes	84.39	0.00e+00	2108.00
IUUC-Tni-120218	Tetraodon nigroviridis	84.72	0.00e+00	2117.00
IUUC-Tre-122177	Trichoderma reesei	31.27	1.00e-151	531.00
IUUC-Tme-127176	Tuber melanosporum	31.30	1.00e-132	468.00
IUUC-Tbe-127641	Tupaia belangeri	65.33	6.00e-177	615.00
IUUC-Ttr-128888	Tursiops truncatus	74.63	0.00e+00	1102.00
IUUC-Uma-129361	Ustilago maydis	37.83	5.00e-61	230.00
IUUC-Xtr-132811	Xenopus tropicalis	73.82	0.00e+00	1759.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence