iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-054814

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

JSUE03004986

Gene Name

USP18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000003272.3	ENSMMUT00000004628.3	ENSMMUP00000004362.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-58	199.8	57	372

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl+N+g tC +NS++Q+ ++  ++++ l++    ++++ + +e+  ++  ++  l+e++++s++kav p el  +l+k+++    + q
   Q: 57   VGLHNIGQTCCLNSLIQVFVMNMDFTRILKR---ITVPRGA-DEQRRSVPFQMLLLLEKMQDSRQKAVRPLELAYCLQKYNVP--MFVQ 139
           6******************************...5555443.567889*********************************98..79** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da  +   l + +++++                          ++ +  + ++ l+ +++k++++cl+c+ +ssr++++l+l+l++ +
   Q: 140  HDAAQLYLKLWNLIKDQI--------------------------TDVHLVERLQALYMIRVKDSLICLDCAMESSRNSSMLTLPLSLFD 202
           ******************..........................67788899************************************* PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls...pf 264
            +++ +++l+d+L+ f+++ el ++ k++c++c kk++ ++ lkl++lP++L++hL+Rfs ++  ++ +ki   ++fp++Ld s   p+
   Q: 203  VNSKPLKTLEDALHCFFQPRELSSKSKCFCKNCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRN--SQTRKICHALHFPESLDFSqvlPM 289
           ***********************************************************7755..6888***************54444 PP
   S: 265  ctspeekqke.kkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......staYvlfYkrr 338
             +p++++++   +YeL+av+ H G ++sGHY++y++n  +gkW++f+Ds++  v++e+++ + g       +taY+l+Y+++
   Q: 290  EREPCDAEEQpGGQYELFAVIAHVGVADSGHYCVYIRNaVDGKWFCFNDSNICLVSWEDIQCTYGnpnyhwqETAYLLVYMKM 372
           4455554443489*************************55777*******************888***************986 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MGKVFGLKRQ TCKSVLAESP QSRADLVEKK EEDSNMKRKT EQPREHPRAW DYPHGLVGLH 60
NIGQTCCLNS LIQVFVMNMD FTRILKRITV PRGADEQRRS VPFQMLLLLE KMQDSRQKAV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAACTTCG GCCGCAGCTG CGTCCCCAGC TCAGTCACGC CGTGGAACTC AGCAGCGGAG 60
GCTGGACGCT TGCGTGGCGC TTGAGGCAAG TTTGGGGCTC ATTTTGGAAG TTTTCTTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035634--P:response to stilbenoid
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	77.18	7.00e-157	546.00
IUUC-Apl-004006	Anas platyrhynchos	56.88	2.00e-105	375.00
IUUC-Aca-005088	Anolis carolinensis	53.54	4.00e-91	328.00
IUUC-Ame-010606	Astyanax mexicanus	33.23	5.00e-38	151.00
IUUC-Bta-013036	Bos taurus	75.24	7.00e-148	516.00
IUUC-Cja-019052	Callithrix jacchus	83.90	1.00e-159	555.00
IUUC-Cfa-020554	Canis familiaris	80.77	3.00e-166	577.00
IUUC-Cpo-022421	Cavia porcellus	72.87	1.00e-160	558.00
IUUC-Csa-023737	Chlorocebus sabaeus	99.02	3.00e-122	430.00
IUUC-Cho-024807	Choloepus hoffmanni	68.88	4.00e-70	258.00
IUUC-Dre-027408	Danio rerio	32.31	3.00e-43	168.00
IUUC-Dno-029813	Dasypus novemcinctus	64.34	3.00e-122	431.00
IUUC-Dor-030532	Dipodomys ordii	71.66	2.00e-158	551.00
IUUC-Ete-032254	Echinops telfairi	69.00	2.00e-155	541.00
IUUC-Eca-033482	Equus caballus	80.25	2.00e-158	551.00
IUUC-Eeu-034451	Erinaceus europaeus	73.93	3.00e-94	337.00
IUUC-Fca-036313	Felis catus	76.08	7.00e-165	573.00
IUUC-Fal-037216	Ficedula albicollis	51.34	2.00e-106	379.00
IUUC-Gmo-038649	Gadus morhua	31.43	2.00e-39	156.00
IUUC-Gga-041082	Gallus gallus	54.63	1.00e-94	339.00
IUUC-Gac-042439	Gasterosteus aculeatus	35.44	3.00e-50	192.00
IUUC-Ggo-044957	Gorilla gorilla	94.87	1.00e-157	548.00
IUUC-Hsa-046381	Homo sapiens	92.78	0.00e+00	727.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	76.14	2.00e-170	591.00
IUUC-Loc-052688	Lepisosteus oculatus	34.16	5.00e-49	188.00
IUUC-Laf-054109	Loxodonta africana	77.75	0.00e+00	627.00
IUUC-Meu-056253	Macropus eugenii	66.43	2.00e-108	385.00
IUUC-Mmr-061613	Microcebus murinus	80.18	7.00e-166	576.00
IUUC-Mdo-061890	Monodelphis domestica	63.13	1.00e-121	429.00
IUUC-Mmu-064329	Mus musculus	69.81	4.00e-146	510.00
IUUC-Mpu-066342	Mustela putorius furo	77.99	1.00e-166	578.00
IUUC-Mlu-067010	Myotis lucifugus	74.46	3.00e-168	584.00
IUUC-Nle-069148	Nomascus leucogenys	92.51	0.00e+00	723.00
IUUC-Opr-070988	Ochotona princeps	71.97	4.00e-67	248.00
IUUC-Ont-072039	Oreochromis niloticus	33.75	5.00e-47	181.00
IUUC-Oan-073740	Ornithorhynchus anatinus	57.71	4.00e-77	281.00
IUUC-Ocu-074498	Oryctolagus cuniculus	73.80	2.00e-154	538.00
IUUC-Ola-086753	Oryzias latipes	36.48	1.00e-47	183.00
IUUC-Oga-088497	Otolemur garnettii	78.27	5.00e-171	593.00
IUUC-Oar-089505	Ovis aries	75.24	2.00e-148	518.00
IUUC-Ptr-091656	Pan troglodytes	92.25	0.00e+00	724.00
IUUC-Pan-092498	Papio anubis	99.20	0.00e+00	777.00
IUUC-Psi-093409	Pelodiscus sinensis	53.76	3.00e-110	391.00
IUUC-Pfo-096507	Poecilia formosa	34.29	3.00e-47	182.00
IUUC-Pab-097828	Pongo abelii	92.88	0.00e+00	630.00
IUUC-Pca-100299	Procavia capensis	73.66	5.00e-103	367.00
IUUC-Pva-102972	Pteropus vampyrus	76.22	1.00e-163	568.00
IUUC-Rno-105738	Rattus norvegicus	68.46	2.00e-150	525.00
IUUC-Sha-107309	Sarcophilus harrisii	61.99	2.00e-115	408.00
IUUC-Sar-112983	Sorex araneus	72.03	6.00e-118	417.00
IUUC-Ssc-116049	Sus scrofa	76.80	4.00e-153	533.00
IUUC-Tgu-117115	Taeniopygia guttata	55.06	4.00e-102	364.00
IUUC-Tru-118022	Takifugu rubripes	32.08	7.00e-41	160.00
IUUC-Tsy-118986	Tarsius syrichta	61.61	4.00e-65	241.00
IUUC-Tni-120306	Tetraodon nigroviridis	32.28	8.00e-40	157.00
IUUC-Tbe-127768	Tupaia belangeri	70.90	5.00e-121	427.00
IUUC-Ttr-128686	Tursiops truncatus	74.78	1.00e-152	532.00
IUUC-Xtr-132032	Xenopus tropicalis	43.08	9.00e-71	260.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence