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Tag Content
UUCD2 ID IUUC-Ssc-115654
UUCD1 version UUC-SuS-00687
Ensembl Protein ID ENSSSCP00000030780.1
UniProt Accession F1SQT5; F1SQT5_PIG
Genbank Protein ID ENSSSCP00000000947
Protein Name Apoptotic protease-activating factor 1
Genbank Nucleotide ID CU633605
Gene Name APAF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSSCG00000000884.3 ENSSSCT00000033603.1 ENSSSCP00000030780.1
ENSSSCG00000000884.3 ENSSSCT00000035909.1 ENSSSCP00000030819.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.80e-66 216.0 741 776
UBD/Beta-Prp 2.00e-94 316.4 612 776
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gHt+sv+ ++f +d +ll+s+s Dgt+k+WD+++ +
   Q: 741  GHTNSVSHCRFsPDdKLLASCSADGTLKLWDVKSAN 776
           8***********777****************98765 PP
   

   UBD/Beta-Prp
   S: 49   sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghd 137
             h+++v+  +fs+dg+ +++++ D+t++v+  +tg+ +  +k+hed+vl+++fs+++ ++++ s d+ +++w+  tg+ ++   ++h+
   Q: 612  RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSADDRFIATCSVDKKVKIWNSVTGELVQ-SYDEHS 699
           4577777777777777777777777777777777777777777777777777777777777777777777777777777777.666666 PP
   S: 138  gvvncvvvhpdg..nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtge 213
           + vnc ++  ++   ll++Gs D +++lWdl+++++  t+ g ht+sv +  f+++ k l+s+s dgt+klwd+++ +
   Q: 700  EQVNCCHFTNNSnhLLLATGSSDYFLKLWDLNQKECRNTMFG-HTNSVSHCRFSPDDKLLASCSADGTLKLWDVKSAN 776
           666666665555344667777777777777777777777766.77777777777777777777777777777777544 PP
   
Organism Sus scrofa
Functional Description
(View)

Functional Description


     Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
 Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
Protein Sequence
(Fasta)
MDAKARNCLL QHREALERDI KTSYIMDHMI SNGVLTLSEE EKVKNEPTQC QRAALLIKMI 60
LKKDNYAYIS FYNALLHEGY KDLAALLHGG LPVVSSSNSK DSVAGITSYV RTVLCEGGVP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ssc-115654|E3,WD_repeat;UBD,Beta-Prp|Sus scrofa
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGGCGGAG GCGGAGGCGG CGGCGGCGGC GGCGGCGGCG GCGGCGGCGG CGGCGGCGGC 60
GGCTGCTGCT GCCGGGAGAG GTTCTGGGCG TGTCTATTTG CATTCGCGGG CGGTCCTGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ssc-115654|E3,WD_repeat;UBD,Beta-Prp|Sus scrofa
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017251--Apaf-1
IPR024977--Apc4_WD40_dom
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF00619--CARD
PF00931--NB-ARC
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0043293--C:apoptosome
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0097190--P:apoptotic signaling pathway
KEGG ssc:100513283
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001432 Ailuropoda melanoleuca 91.13 0.00e+00 2344.00
IUUC-Apl-004201 Anas platyrhynchos 70.10 0.00e+00 1823.00
IUUC-Aca-004638 Anolis carolinensis 69.11 0.00e+00 1838.00
IUUC-Afu-008928 Aspergillus fumigatus 27.35 5.00e-56 213.00
IUUC-Ani-009285 Aspergillus nidulans 26.13 4.00e-70 259.00
IUUC-Ate-010309 Aspergillus terreus 28.20 2.00e-68 254.00
IUUC-Ame-011062 Astyanax mexicanus 54.75 0.00e+00 1383.00
IUUC-Bta-012865 Bos taurus 92.15 0.00e+00 2422.00
IUUC-Cel-018376 Caenorhabditis elegans 22.32 2.00e-31 131.00
IUUC-Cja-018815 Callithrix jacchus 81.01 0.00e+00 2054.00
IUUC-Cfa-020222 Canis familiaris 86.13 0.00e+00 2201.00
IUUC-Cpo-021524 Cavia porcellus 87.51 0.00e+00 2279.00
IUUC-Csa-023861 Chlorocebus sabaeus 90.15 0.00e+00 2322.00
IUUC-Cho-024484 Choloepus hoffmanni 78.51 0.00e+00 1199.00
IUUC-Dre-028006 Danio rerio 53.35 0.00e+00 1277.00
IUUC-Dno-029591 Dasypus novemcinctus 90.95 0.00e+00 2386.00
IUUC-Dor-030237 Dipodomys ordii 74.12 0.00e+00 1073.00
IUUC-Ete-032620 Echinops telfairi 85.32 0.00e+00 1100.00
IUUC-Eca-033569 Equus caballus 90.63 0.00e+00 2360.00
IUUC-Eeu-035354 Erinaceus europaeus 65.07 3.00e-179 622.00
IUUC-Fca-036337 Felis catus 91.60 0.00e+00 2395.00
IUUC-Fal-037077 Ficedula albicollis 69.98 0.00e+00 1825.00
IUUC-Gmo-039687 Gadus morhua 50.72 0.00e+00 934.00
IUUC-Ggr-039828 Gaeumannomyces graminis 23.32 2.00e-42 168.00
IUUC-Gga-040299 Gallus gallus 69.14 0.00e+00 1838.00
IUUC-Gac-041762 Gasterosteus aculeatus 51.88 0.00e+00 1282.00
IUUC-Ggo-045563 Gorilla gorilla 90.15 0.00e+00 2324.00
IUUC-Hsa-046771 Homo sapiens 89.75 0.00e+00 2316.00
IUUC-Lch-050200 Latimeria chalumnae 65.00 0.00e+00 1652.00
IUUC-Loc-052090 Lepisosteus oculatus 59.16 0.00e+00 1529.00
IUUC-Laf-053861 Loxodonta africana 89.68 0.00e+00 2330.00
IUUC-Mcc-055543 Macaca mulatta 90.71 0.00e+00 2333.00
IUUC-Meu-056688 Macropus eugenii 80.83 0.00e+00 2087.00
IUUC-Mga-059243 Meleagris gallopavo 69.75 0.00e+00 1858.00
IUUC-Mmr-061134 Microcebus murinus 85.61 0.00e+00 1994.00
IUUC-Mdo-062913 Monodelphis domestica 78.91 0.00e+00 2071.00
IUUC-Mmu-063811 Mus musculus 87.03 0.00e+00 2291.00
IUUC-Mpu-066780 Mustela putorius furo 90.48 0.00e+00 2321.00
IUUC-Mlu-067276 Myotis lucifugus 90.00 0.00e+00 2356.00
IUUC-Nfi-068459 Neosartorya fischeri 26.22 8.00e-59 222.00
IUUC-Nle-069129 Nomascus leucogenys 89.67 0.00e+00 2315.00
IUUC-Opr-071007 Ochotona princeps 65.81 0.00e+00 1102.00
IUUC-Ont-071348 Oreochromis niloticus 55.01 0.00e+00 1417.00
IUUC-Oan-072717 Ornithorhynchus anatinus 80.35 0.00e+00 2133.00
IUUC-Ocu-074286 Oryctolagus cuniculus 89.55 0.00e+00 1982.00
IUUC-Ola-086895 Oryzias latipes 49.83 0.00e+00 1192.00
IUUC-Oga-088678 Otolemur garnettii 89.11 0.00e+00 2310.00
IUUC-Oar-089359 Ovis aries 91.91 0.00e+00 2399.00
IUUC-Ptr-091062 Pan troglodytes 89.83 0.00e+00 2321.00
IUUC-Pan-092528 Papio anubis 92.98 0.00e+00 1377.00
IUUC-Psi-093430 Pelodiscus sinensis 74.24 0.00e+00 1951.00
IUUC-Pma-094690 Petromyzon marinus 37.78 9.00e-151 526.00
IUUC-Pfo-097204 Poecilia formosa 54.49 0.00e+00 1379.00
IUUC-Pab-097690 Pongo abelii 90.07 0.00e+00 2323.00
IUUC-Pca-100778 Procavia capensis 70.37 0.00e+00 1177.00
IUUC-Pva-102870 Pteropus vampyrus 87.97 0.00e+00 2113.00
IUUC-Pyt-104620 Pyrenophora triticirepentis 26.95 1.00e-60 228.00
IUUC-Rno-104889 Rattus norvegicus 86.47 0.00e+00 2244.00
IUUC-Sha-107465 Sarcophilus harrisii 79.68 0.00e+00 2124.00
IUUC-Sar-113268 Sorex araneus 88.60 0.00e+00 661.00
IUUC-Tgu-117302 Taeniopygia guttata 70.22 0.00e+00 1840.00
IUUC-Tru-118363 Takifugu rubripes 54.13 0.00e+00 1384.00
IUUC-Tsy-119007 Tarsius syrichta 85.75 0.00e+00 2215.00
IUUC-Tni-120910 Tetraodon nigroviridis 53.12 0.00e+00 1338.00
IUUC-Tbe-127413 Tupaia belangeri 76.02 0.00e+00 1400.00
IUUC-Ttr-129213 Tursiops truncatus 85.43 0.00e+00 2193.00
IUUC-Vpa-130146 Vicugna pacos 86.24 0.00e+00 1655.00
IUUC-Xtr-132559 Xenopus tropicalis 60.62 0.00e+00 1573.00
Created Date 25-Jun-2017

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