iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132941

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Suppressor of cytokine signaling 2 variant 1; Suppressor of cytokine-signaling 2

Genbank Nucleotide ID

AAMC01044802

Gene Name

socs2; SOCS2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000023815.3	ENSXETT00000051346.3	ENSXETP00000051346.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.40e-13	50.7	157	199

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 5    wllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
           ++l ++ +SLqhLCR+++++c+++     id+LPLP +Lk+Y+ ++ y
   Q: 157  KPLYTSAPSLQHLCRMTVNKCTDK-----IDELPLPMRLKEYITEYRY 199
           678899*****************9.....8*************99965 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MTLRSPETSD SPSTIQSSSG ESGSPPGGIK EGRDREDRIA ESMSELRRSG WYWGNMTVDE 60
AKEKLQDAPE GTFLVRDSSH TDYLLTISVK TSAGPTNLRI EYREGKFRLD SVVCVRSRLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGATGTTG AAGAAGGAAC CCACACAAGA CCAGAGAGGG GGAGATGTAT AGAAGCATTC 60
AGCCTTTGGA GGTTTGTTTC TGCATGGAAA AACACCGAGA GCTGCTTTAG GCACCCCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028410--SOCS2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0001558--P:regulation of cell growth

KEGG

xtr:100151723

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002075	Ailuropoda melanoleuca	69.33	2.00e-68	251.00
IUUC-Apl-003484	Anas platyrhynchos	77.12	2.00e-68	250.00
IUUC-Aca-004253	Anolis carolinensis	62.19	5.00e-70	256.00
IUUC-Ame-011267	Astyanax mexicanus	63.31	2.00e-59	221.00
IUUC-Bta-013183	Bos taurus	71.90	1.00e-66	244.00
IUUC-Bdi-014316	Brachypodium distachyon	51.85	2.50e+00	26.20
IUUC-Cja-018862	Callithrix jacchus	73.38	1.00e-67	248.00
IUUC-Cfa-020226	Canis familiaris	73.03	2.00e-66	244.00
IUUC-Cpo-022414	Cavia porcellus	73.20	2.00e-67	247.00
IUUC-Csa-023758	Chlorocebus sabaeus	72.08	4.00e-67	246.00
IUUC-Cho-024471	Choloepus hoffmanni	66.46	5.00e-56	209.00
IUUC-Dre-028288	Danio rerio	61.54	4.00e-59	220.00
IUUC-Dno-029036	Dasypus novemcinctus	69.94	2.00e-69	254.00
IUUC-Dor-030447	Dipodomys ordii	72.85	2.00e-65	241.00
IUUC-Ete-033023	Echinops telfairi	69.70	9.00e-70	255.00
IUUC-Fca-036469	Felis catus	72.08	5.00e-67	246.00
IUUC-Fal-036642	Ficedula albicollis	72.84	2.00e-67	247.00
IUUC-Gmo-039331	Gadus morhua	63.00	1.00e-35	141.00
IUUC-Gga-040809	Gallus gallus	77.99	9.00e-72	261.00
IUUC-Gac-041398	Gasterosteus aculeatus	62.87	3.00e-60	224.00
IUUC-Ggo-045341	Gorilla gorilla	72.73	1.00e-67	248.00
IUUC-Hsa-046557	Homo sapiens	70.73	2.00e-70	258.00
IUUC-Itr-049013	Ictidomys tridecemlineatus	70.25	1.00e-66	244.00
IUUC-Lch-050160	Latimeria chalumnae	66.00	6.00e-56	209.00
IUUC-Loc-051825	Lepisosteus oculatus	65.27	7.00e-64	236.00
IUUC-Laf-053560	Loxodonta africana	72.08	1.00e-66	245.00
IUUC-Mcc-055890	Macaca mulatta	71.43	2.00e-66	244.00
IUUC-Meu-056218	Macropus eugenii	72.56	2.00e-71	261.00
IUUC-Mga-059755	Meleagris gallopavo	78.29	1.00e-68	252.00
IUUC-Mmr-061387	Microcebus murinus	72.08	4.00e-67	246.00
IUUC-Mdo-062383	Monodelphis domestica	73.78	3.00e-72	264.00
IUUC-Mmu-063443	Mus musculus	70.13	2.00e-65	241.00
IUUC-Mpu-066459	Mustela putorius furo	70.13	7.00e-65	239.00
IUUC-Mlu-068040	Myotis lucifugus	69.94	4.00e-69	253.00
IUUC-Nle-069016	Nomascus leucogenys	69.51	6.00e-68	249.00
IUUC-Opr-071087	Ochotona princeps	63.58	2.00e-65	241.00
IUUC-Ont-072340	Oreochromis niloticus	60.12	3.00e-59	220.00
IUUC-Oan-073443	Ornithorhynchus anatinus	74.85	5.00e-73	266.00
IUUC-Ocu-074539	Oryctolagus cuniculus	70.59	1.00e-64	239.00
IUUC-Ola-087004	Oryzias latipes	60.13	6.00e-55	206.00
IUUC-Oga-088438	Otolemur garnettii	72.73	1.00e-67	248.00
IUUC-Oar-089932	Ovis aries	73.20	2.00e-67	247.00
IUUC-Ptr-091037	Pan troglodytes	72.73	1.00e-67	248.00
IUUC-Pan-092767	Papio anubis	72.08	3.00e-67	247.00
IUUC-Psi-093099	Pelodiscus sinensis	77.99	8.00e-72	261.00
IUUC-Pma-094671	Petromyzon marinus	46.79	3.00e-36	144.00
IUUC-Pfo-097073	Poecilia formosa	56.55	2.00e-55	208.00
IUUC-Pab-098319	Pongo abelii	70.55	1.00e-69	254.00
IUUC-Pca-101117	Procavia capensis	72.08	1.00e-65	242.00
IUUC-Pva-102117	Pteropus vampyrus	72.55	3.00e-66	244.00
IUUC-Rno-105913	Rattus norvegicus	70.13	3.00e-66	244.00
IUUC-Sha-106500	Sarcophilus harrisii	66.00	3.00e-72	263.00
IUUC-Ssc-115252	Sus scrofa	72.55	9.00e-67	245.00
IUUC-Tgu-117524	Taeniopygia guttata	76.10	3.00e-70	256.00
IUUC-Tsy-119335	Tarsius syrichta	71.52	2.00e-64	237.00
IUUC-Tni-120263	Tetraodon nigroviridis	58.38	1.00e-56	212.00
IUUC-Tbe-127915	Tupaia belangeri	72.08	1.00e-66	245.00
IUUC-Ttr-128372	Tursiops truncatus	72.55	1.00e-66	245.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence