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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046928
UUCD1 version UUC-HoS-00183
Ensembl Protein ID ENSP00000259939.3
UniProt Accession Q7Z419; B3KUA8; B4DZI2; Q5TB85; Q6P4Q0; Q8N3R7; Q9BX38; R144B_HUMAN
Genbank Protein ID BAC02434.1; BAG53370.1; BAG64094.1; CAD38622.1; CAI15148.2; EAW55407.1; AAH63311.1
Protein Name E3 ubiquitin-protein ligase RNF144B; IBR domain-containing protein 2; RING finger protein 144B; p53-inducible RING finger protein
Genbank Nucleotide ID AB076367; AK096832; AK302935; AL832329; AL138725; CH471087; BC063311
Gene Name RNF144B; IBRDC2; P53RFP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000137393.9 ENST00000259939.3 ENSP00000259939.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
PhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RBR RBR 17367545; 20615966; 20300062; 20864535
Classification
Family E-value Score Start End
E3 activity/RBR 1.20e-51 176.0 30 222
Active Site
Position(s) Description Evidence
206 N/A {ECO:0000250|UniProtKB:Q9Y4X5}
Domain Profile

   E3 activity/RBR
   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpek..leeseikellveeelykryekllleevveadaal 88
           Ck+Cl+e+s +++t+l+eC+++fC++Clkqy++l+i+eg+ + i+cp++ c ++  l+e+ei++ lv  ++++ y++l++e++v+ d+ +
   Q: 30   CKLCLCEQSLDKMTTLQECQCIFCTACLKQYMQLAIREGCGSPITCPDMVCLNHgtLQEAEIAC-LVPVDQFQLYQRLKFEREVHLDPYR 118
           ***************************************************9988899******.6999********************* PP
   S: 89   kwcpapdCslvvllekea..eklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyiekneg 176
           +wcp +dC++v+ +++++  + + vec++c+ +fC++Ck++wH+++sC++ +  +  te   ++a   + +ea +k+Cp C+vyie+neg
   Q: 119  TWCPVADCQTVCPVASSDpgQPVLVECPSCHLKFCSCCKDAWHAEVSCRDSQPIVLPTE---HRALFGTDAEAPIKQCPVCRVYIERNEG 205
           *************9998877899999*****************************9999...99************************** PP
   S: 177  CnhmtCakCkaefCwlC 193
           C++m+C++Ck++fCw+C
   Q: 206  CAQMMCKNCKHTFCWYC 222
           ***************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
 E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
Protein Sequence
(Fasta)
MGSAGRLHYL AMTAENPTPG DLAPAPLITC KLCLCEQSLD KMTTLQECQC IFCTACLKQY 60
MQLAIREGCG SPITCPDMVC LNHGTLQEAE IACLVPVDQF QLYQRLKFER EVHLDPYRTW 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046928|E3,RBR|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGCTGTGCC CCACGCTCCC GCTGCAACAG TCCCGGGCAT CGCAGCTGCC AGTCAAGGCT 60
AGGAGGCGGT CGGGGACTCC GCCTCCTCCC GACCCGTAGG TCTGGGAGCG CAAGTCCTGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046928|E3,RBR|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
Pfam

PF01485--IBR
SMART

SM00647--IBR
SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0031966--C:mitochondrial membrane
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:255488
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001257 Ailuropoda melanoleuca 94.39 4.00e-171 593.00
IUUC-Apl-004112 Anas platyrhynchos 81.85 8.00e-130 456.00
IUUC-Aca-004533 Anolis carolinensis 76.57 3.00e-137 481.00
IUUC-Bta-012641 Bos taurus 94.41 3.00e-169 587.00
IUUC-Cja-019626 Callithrix jacchus 82.84 2.00e-145 508.00
IUUC-Cfa-020702 Canis familiaris 95.38 9.00e-173 598.00
IUUC-Cpo-022147 Cavia porcellus 95.71 2.00e-170 591.00
IUUC-Csa-023473 Chlorocebus sabaeus 98.35 3.00e-178 617.00
IUUC-Cho-024298 Choloepus hoffmanni 91.05 1.00e-140 492.00
IUUC-Dre-028099 Danio rerio 65.41 2.00e-91 328.00
IUUC-Dno-029122 Dasypus novemcinctus 88.49 6.00e-158 550.00
IUUC-Dor-030669 Dipodomys ordii 96.14 3.00e-133 467.00
IUUC-Ete-033141 Echinops telfairi 80.53 1.00e-131 462.00
IUUC-Eca-034360 Equus caballus 97.36 2.00e-175 607.00
IUUC-Eeu-034538 Erinaceus europaeus 73.24 7.00e-85 306.00
IUUC-Fca-036055 Felis catus 93.73 1.00e-169 588.00
IUUC-Fal-037339 Ficedula albicollis 80.65 2.00e-132 464.00
IUUC-Gmo-038780 Gadus morhua 61.17 3.00e-86 311.00
IUUC-Gga-040256 Gallus gallus 79.72 4.00e-132 464.00
IUUC-Gac-042127 Gasterosteus aculeatus 62.24 4.00e-94 337.00
IUUC-Ggo-044867 Gorilla gorilla 99.67 1.00e-179 622.00
IUUC-Hvu-047484 Hordeum vulgare 30.14 1.00e-17 84.00
IUUC-Itr-048250 Ictidomys tridecemlineatus 97.41 7.00e-110 389.00
IUUC-Lch-050168 Latimeria chalumnae 73.44 6.00e-132 463.00
IUUC-Loc-052150 Lepisosteus oculatus 60.93 4.00e-87 314.00
IUUC-Laf-053967 Loxodonta africana 94.72 1.00e-170 592.00
IUUC-Mcc-055898 Macaca mulatta 98.35 3.00e-178 617.00
IUUC-Meu-056628 Macropus eugenii 97.44 2.00e-43 168.00
IUUC-Mtr-057989 Medicago truncatula 26.76 4.00e-19 88.60
IUUC-Mga-059820 Meleagris gallopavo 78.65 3.00e-130 457.00
IUUC-Mmr-060680 Microcebus murinus 94.39 5.00e-170 590.00
IUUC-Mdo-062839 Monodelphis domestica 85.86 4.00e-154 536.00
IUUC-Mmu-063339 Mus musculus 87.79 2.00e-148 518.00
IUUC-Mac-065414 Musa acuminata 28.44 1.00e-19 90.90
IUUC-Mpu-065973 Mustela putorius furo 93.73 4.00e-171 593.00
IUUC-Mlu-067112 Myotis lucifugus 95.38 1.00e-163 568.00
IUUC-Nle-069795 Nomascus leucogenys 99.67 3.00e-180 624.00
IUUC-Opr-070390 Ochotona princeps 88.45 6.00e-154 536.00
IUUC-Ont-072329 Oreochromis niloticus 64.73 3.00e-90 324.00
IUUC-Oan-072980 Ornithorhynchus anatinus 77.92 6.00e-137 479.00
IUUC-Ocu-073845 Oryctolagus cuniculus 94.72 2.00e-170 591.00
IUUC-Ola-086872 Oryzias latipes 61.80 9.00e-86 310.00
IUUC-Oga-088954 Otolemur garnettii 95.38 4.00e-172 597.00
IUUC-Oar-089879 Ovis aries 95.07 3.00e-170 590.00
IUUC-Ptr-090685 Pan troglodytes 100.00 4.00e-180 623.00
IUUC-Pan-092086 Papio anubis 98.02 5.00e-178 616.00
IUUC-Psi-093481 Pelodiscus sinensis 81.52 5.00e-138 483.00
IUUC-Pfo-096065 Poecilia formosa 65.15 4.00e-92 331.00
IUUC-Pab-098031 Pongo abelii 99.34 5.00e-179 619.00
IUUC-Pca-100936 Procavia capensis 91.75 3.00e-165 573.00
IUUC-Pva-102864 Pteropus vampyrus 85.81 8.00e-150 522.00
IUUC-Rno-105503 Rattus norvegicus 87.79 5.00e-148 516.00
IUUC-Sha-107425 Sarcophilus harrisii 86.51 4.00e-155 540.00
IUUC-Stu-112736 Solanum tuberosum 28.30 3.00e-19 89.00
IUUC-Ssc-115458 Sus scrofa 93.49 1.00e-158 551.00
IUUC-Tgu-117226 Taeniopygia guttata 79.57 4.00e-132 464.00
IUUC-Tru-118362 Takifugu rubripes 65.04 1.00e-94 339.00
IUUC-Tsy-119255 Tarsius syrichta 96.70 2.00e-174 604.00
IUUC-Tni-120140 Tetraodon nigroviridis 61.73 4.00e-88 317.00
IUUC-Tae-124420 Triticum aestivum 31.82 3.00e-18 87.00
IUUC-Tbe-127306 Tupaia belangeri 94.72 2.00e-170 591.00
IUUC-Ttr-128923 Tursiops truncatus 95.07 1.00e-158 552.00
IUUC-Vpa-130148 Vicugna pacos 94.72 5.00e-170 589.00
Created Date 25-Jun-2017

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