iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105828

Ensembl Protein ID

ENSRNOP00000068552.1

UniProt Accession

A0A0G2JT33; A0A0G2JT33_RAT

Genbank Protein ID

ENSRNOP00000068552

Protein Name

Telomerase protein component 1

Genbank Nucleotide ID

AC126900

Gene Name

Tep1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000051706.1	ENSRNOT00000088981.1	ENSRNOP00000068552.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-47	157.5	2129	2163
UBD/Beta-Prp	1.10e-76	258.3	1955	2210

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sdtllvsGsdDgtikvWDlrtgvl 35
           H d++t++ +  d++l+s+s Dg++ +W++  g +
   Q: 2129 HRDWITGCTWtKDNILISCSSDGSVGLWNPEAGQQ 2163
           9*********877****************988766 PP

UBD/Beta-Prp

   S: 15   cvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk..ghedsvls 99
           +v+  pd++++a+g+r + ik++++++g   ++ ++ + +v+a+ + + + +lv+g+eD+ ++ w l+ ++  + +     ++ vl 
   Q: 1955 SVALNPDGDQVAVGYRGDGIKIYRISSGPQEAQCQELNVAVSALVWLSPS-VLVSGAEDGSLHGWMLRRNSLQSLWLssVCQKPVLG 2040
           5777899***********************99999999999999887776.9*************8876655555542245778888 PP
   S: 100  lsfspsgdklvsGshdrtirvwdletgqclee........tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl...ktgkllrtl 175
           l+ s+  ++l+s+s+d t+r+w  +  +  ++         l+gh+g v+c +++pdg++l++++ Dr +  Wd+   +   l++t+
   Q: 2041 LAASQ--EFLASASEDFTVRLWPRQLLTQPHAveelpcaaELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWDVkvaQAPLLIHTF 2125
           88888..9*************86555554444777888889**********************************88778889**** PP
   S: 176  tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlql 262
           ++ h d ++  +++++ + l+s+s dg+v lw+ ++g+ + ++ gh++ v+ v +   +e++vs+s Dg++++Wd r+g  l+++  
   Q: 2126 SSCHRDWITGCTWTKD-NILISCSSDGSVGLWNPEAGQQLGQFPGHQSAVSAVVAV--EEHIVSVSRDGTLKVWD-RQGVELTSIPA 2208
           999***********98.79********************************99999..99**************9.55555555555 PP
   S: 263  hn 264
           h 
   Q: 2209 HS 2210
           55 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MWPQAHRDCA AAMEKLCGYV PVHPDILSLK NRCLTMLSDI QPLEKIHGQR SVNPDILSLE 60
NRCLTLLPDL QPMEKIHGQR SVHPDILSSE NRCLTLLPDL QSLEKLCGHM SSHPDVLSLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTCCGCCC CTCCCCTTGC CCAGCCTCGC CCCTTCGCCT CTCTAGGGTG TTGGTTTCCT 60
TTCAGTTCTC TTTCTTCAAC CTATCCACTG GCTGACCTAG GCCGGTTTCT GCTCCTTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR025139--DUF4062
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase
IPR011047--Quinoprotein_ADH-like_supfam
IPR008850--TEP1_N
IPR008858--TROVE_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50837--NACHT
PS51226--TEP1_N
PS50988--TROVE
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13271--DUF4062
PF05386--TEP1_N
PF05731--TROVE
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016363--C:nuclear matrix
GO:0005697--C:telomerase holoenzyme complex
GO:0003720--F:telomerase activity
GO:0070034--F:telomerase RNA binding
GO:0000722--P:telomere maintenance via recombination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001482	Ailuropoda melanoleuca	71.08	0.00e+00	3487.00
IUUC-Aca-005102	Anolis carolinensis	41.90	0.00e+00	1620.00
IUUC-Ame-011822	Astyanax mexicanus	32.55	2.00e-173	604.00
IUUC-Bta-012323	Bos taurus	70.92	0.00e+00	3455.00
IUUC-Cja-019005	Callithrix jacchus	73.71	0.00e+00	3786.00
IUUC-Cfa-020803	Canis familiaris	66.77	0.00e+00	3127.00
IUUC-Cpo-022312	Cavia porcellus	69.94	0.00e+00	3288.00
IUUC-Csa-023287	Chlorocebus sabaeus	74.67	0.00e+00	3777.00
IUUC-Dre-028825	Danio rerio	34.26	0.00e+00	1100.00
IUUC-Dno-029455	Dasypus novemcinctus	71.03	0.00e+00	3435.00
IUUC-Dor-030328	Dipodomys ordii	70.06	0.00e+00	2417.00
IUUC-Ete-032385	Echinops telfairi	69.18	0.00e+00	1814.00
IUUC-Eca-033726	Equus caballus	74.20	0.00e+00	3708.00
IUUC-Eeu-034665	Erinaceus europaeus	60.05	0.00e+00	923.00
IUUC-Fca-035365	Felis catus	71.79	0.00e+00	3565.00
IUUC-Gmo-039584	Gadus morhua	31.88	5.00e-113	403.00
IUUC-Gac-042307	Gasterosteus aculeatus	36.13	0.00e+00	984.00
IUUC-Ggo-045432	Gorilla gorilla	72.73	0.00e+00	3541.00
IUUC-Hsa-046182	Homo sapiens	74.39	0.00e+00	3773.00
IUUC-Itr-049021	Ictidomys tridecemlineatus	74.03	0.00e+00	3733.00
IUUC-Lch-050186	Latimeria chalumnae	36.59	2.00e-75	276.00
IUUC-Laf-054524	Loxodonta africana	71.42	0.00e+00	3579.00
IUUC-Mcc-055628	Macaca mulatta	75.08	0.00e+00	3794.00
IUUC-Meu-056338	Macropus eugenii	60.91	0.00e+00	1243.00
IUUC-Mmr-060854	Microcebus murinus	74.10	0.00e+00	3726.00
IUUC-Mdo-062247	Monodelphis domestica	60.90	0.00e+00	2655.00
IUUC-Mmu-064406	Mus musculus	88.64	0.00e+00	4414.00
IUUC-Mpu-065806	Mustela putorius furo	70.35	0.00e+00	3509.00
IUUC-Mlu-068116	Myotis lucifugus	72.97	0.00e+00	3493.00
IUUC-Nle-069628	Nomascus leucogenys	75.77	0.00e+00	3384.00
IUUC-Opr-070242	Ochotona princeps	71.87	0.00e+00	2564.00
IUUC-Oan-073598	Ornithorhynchus anatinus	50.96	0.00e+00	1907.00
IUUC-Ocu-073933	Oryctolagus cuniculus	71.79	0.00e+00	3504.00
IUUC-Ola-086886	Oryzias latipes	33.57	0.00e+00	1093.00
IUUC-Oga-088609	Otolemur garnettii	71.72	0.00e+00	3561.00
IUUC-Oar-089957	Ovis aries	70.22	0.00e+00	3382.00
IUUC-Ptr-090577	Pan troglodytes	73.32	0.00e+00	3700.00
IUUC-Pan-092397	Papio anubis	74.45	0.00e+00	3762.00
IUUC-Pma-094373	Petromyzon marinus	32.36	9.00e-66	244.00
IUUC-Pfo-096497	Poecilia formosa	35.62	0.00e+00	1040.00
IUUC-Pab-098028	Pongo abelii	74.07	0.00e+00	3720.00
IUUC-Pca-101002	Procavia capensis	75.23	0.00e+00	1696.00
IUUC-Pva-102144	Pteropus vampyrus	68.43	0.00e+00	1610.00
IUUC-Sha-106469	Sarcophilus harrisii	57.56	0.00e+00	2739.00
IUUC-Sar-113035	Sorex araneus	63.80	0.00e+00	1808.00
IUUC-Ssc-116122	Sus scrofa	74.50	0.00e+00	2678.00
IUUC-Tru-118412	Takifugu rubripes	33.10	0.00e+00	1166.00
IUUC-Tsy-119257	Tarsius syrichta	65.18	0.00e+00	1374.00
IUUC-Tni-120032	Tetraodon nigroviridis	32.74	5.00e-29	121.00
IUUC-Tbe-127312	Tupaia belangeri	62.74	0.00e+00	964.00
IUUC-Ttr-128335	Tursiops truncatus	72.29	0.00e+00	3075.00
IUUC-Xtr-132524	Xenopus tropicalis	39.54	0.00e+00	1358.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence