iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000001008.3	ENSXETT00000062973.1	ENSXETP00000060548.1
ENSXETG00000001008.3	ENSXETT00000002205.3	ENSXETP00000002205.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.40e-07	30.3	274	302

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantg 30
           +eta+e+++++FP+l+ys+++ +L+ +++
   Q: 274  VETAQERNETLFPALIYSSTMIWLVKMAD 302
           89************************998 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MTKLSASLTQ LQQIQETEDF TDNRPANMND YLFQRNDNDT NERRSNEHSE SQSNGQTQSS 60
SQQVLEQDEE EDEELTLKYG AKHVIMLFVP VTLCMVVVVA TIKSVSFYTR YDGQLIYTPF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACTAAAC TATCTGCATC TTTAACACAG CTTCAGCAAA TCCAAGAGAC GGAAGATTTC 60
ACTGACAACC GTCCAGCTAA TATGGTATGT ACCATTCATC ACTGCTCTGA CACAATGTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01073--PRESENILIN1

SMART

SM00730--PSN

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005790--C:smooth endoplasmic reticulum
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0060070--P:canonical Wnt signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
GO:0051563--P:smooth endoplasmic reticulum calcium ion homeostasis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	34.11	1.00e-22	102.00
IUUC-Aml-001648	Ailuropoda melanoleuca	81.64	2.00e-139	488.00
IUUC-Atr-003039	Amborella trichopoda	31.45	1.00e-38	154.00
IUUC-Apl-003727	Anas platyrhynchos	79.83	1.00e-172	598.00
IUUC-Aca-004582	Anolis carolinensis	78.30	5.00e-173	600.00
IUUC-Aly-005455	Arabidopsis lyrata	30.25	5.00e-34	138.00
IUUC-Ame-011500	Astyanax mexicanus	71.77	1.00e-144	505.00
IUUC-Bta-013026	Bos taurus	75.10	4.00e-164	570.00
IUUC-Bdi-014196	Brachypodium distachyon	33.83	8.00e-32	131.00
IUUC-Bol-015841	Brassica oleracea	35.31	3.00e-32	132.00
IUUC-Cja-019994	Callithrix jacchus	83.22	2.00e-165	575.00
IUUC-Cfa-020074	Canis familiaris	77.89	1.00e-167	582.00
IUUC-Cpo-022237	Cavia porcellus	80.46	8.00e-167	579.00
IUUC-Csa-023537	Chlorocebus sabaeus	78.34	1.00e-171	595.00
IUUC-Cho-024735	Choloepus hoffmanni	67.65	2.00e-152	531.00
IUUC-Cin-025780	Ciona intestinalis	62.65	9.00e-126	443.00
IUUC-Dre-028689	Danio rerio	77.17	9.00e-142	496.00
IUUC-Dno-029758	Dasypus novemcinctus	78.03	2.00e-169	588.00
IUUC-Eeu-035134	Erinaceus europaeus	80.84	2.00e-120	424.00
IUUC-Fca-036243	Felis catus	77.71	1.00e-165	575.00
IUUC-Fal-036600	Ficedula albicollis	82.30	7.00e-177	613.00
IUUC-Gga-040993	Gallus gallus	81.49	1.00e-177	615.00
IUUC-Gac-042342	Gasterosteus aculeatus	73.00	8.00e-130	456.00
IUUC-Hsa-046822	Homo sapiens	78.56	4.00e-172	597.00
IUUC-Lch-049946	Latimeria chalumnae	71.40	1.00e-146	513.00
IUUC-Laf-053979	Loxodonta africana	81.60	3.00e-153	534.00
IUUC-Mcc-055682	Macaca mulatta	78.56	4.00e-172	597.00
IUUC-Meu-056004	Macropus eugenii	70.55	2.00e-138	485.00
IUUC-Mga-059466	Meleagris gallopavo	81.49	7.00e-178	616.00
IUUC-Mdo-062122	Monodelphis domestica	78.81	2.00e-174	605.00
IUUC-Mmu-063176	Mus musculus	75.63	4.00e-162	564.00
IUUC-Mpu-065927	Mustela putorius furo	78.09	1.00e-168	585.00
IUUC-Mlu-067079	Myotis lucifugus	77.07	1.00e-171	595.00
IUUC-Nle-070180	Nomascus leucogenys	78.56	4.00e-172	597.00
IUUC-Opr-070847	Ochotona princeps	74.30	1.00e-155	542.00
IUUC-Ont-071846	Oreochromis niloticus	78.20	5.00e-146	510.00
IUUC-Oan-072783	Ornithorhynchus anatinus	79.20	2.00e-123	434.00
IUUC-Ocu-074527	Oryctolagus cuniculus	77.02	1.00e-169	589.00
IUUC-Oar-090348	Ovis aries	76.60	1.00e-170	592.00
IUUC-Ptr-091060	Pan troglodytes	78.56	4.00e-172	597.00
IUUC-Pan-091855	Papio anubis	73.46	6.00e-152	530.00
IUUC-Psi-093505	Pelodiscus sinensis	81.28	1.00e-175	609.00
IUUC-Pfo-097396	Poecilia formosa	74.59	4.00e-154	537.00
IUUC-Pab-098591	Pongo abelii	79.15	8.00e-174	602.00
IUUC-Pca-101029	Procavia capensis	75.73	2.00e-158	552.00
IUUC-Pva-102244	Pteropus vampyrus	73.40	8.00e-158	549.00
IUUC-Rno-105861	Rattus norvegicus	76.43	8.00e-163	566.00
IUUC-Sha-107045	Sarcophilus harrisii	77.57	3.00e-172	598.00
IUUC-Smo-109325	Selaginella moellendorffii	37.07	4.00e-37	148.00
IUUC-Sar-113169	Sorex araneus	77.75	3.00e-124	438.00
IUUC-Ssc-115766	Sus scrofa	77.71	1.00e-167	582.00
IUUC-Tgu-116469	Taeniopygia guttata	86.43	2.00e-137	481.00
IUUC-Tru-117732	Takifugu rubripes	77.78	1.00e-145	509.00
IUUC-Tsy-119624	Tarsius syrichta	71.13	5.00e-154	537.00
IUUC-Tni-119852	Tetraodon nigroviridis	72.41	2.00e-137	481.00
IUUC-Tae-125925	Triticum aestivum	35.28	1.00e-27	117.00
IUUC-Tur-126237	Triticum urartu	35.97	1.00e-27	117.00
IUUC-Tbe-128148	Tupaia belangeri	66.32	7.00e-121	426.00
IUUC-Ttr-128793	Tursiops truncatus	76.43	2.00e-160	558.00
IUUC-Vpa-130625	Vicugna pacos	68.86	6.00e-127	447.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence