iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049772

Ensembl Protein ID

ENSLACP00000021469.1

UniProt Accession

H3BHU8; H3BHU8_LATCH

Genbank Protein ID

ENSLACP00000021469

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01003390

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000018866.1	ENSLACT00000021610.1	ENSLACP00000021469.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.60e-92	308.1	677	1011

Active Site

Position(s)	Description	Evidence
979	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg... 85
           sd+ k++ev+f++Ee+ld+gG+ re+++l++k+l++++++lf ++++n++  ++pnp++   ++ +lk++ef+Gr++gk+l+++   
   Q: 677  SDWIKNFEVTFLDEEALDWGGPRREWFELICKALFDTSNQLFtRFTDNSQGLVHPNPNRS--PNLRLKVYEFAGRIVGKCLYESalg 761
           688899************************************778999***********7..559******************9999 PP
   S: 86   ....rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVt 166
               +l+++++++sf+ +++g +++++ +e+ dpe+yk+ + +i++n   d++e+  +ltf +++ +  +  k++eL+++G++ipVt
   Q: 762  gaykQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKTkVCYILNN---DVSEM--ELTFAEEKYKsGQLEKVVELISSGAQIPVT 843
           9999***********************************99****88...89996..6666644444156667889*********** PP
   S: 167  neNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl 253
           neNk  Y++l+++yrl ++++e+v++f +G+ne++p++ll++F+e+ele+      +i++ +l +  +  + +   s++++wFw v+
   Q: 844  NENKIYYINLLAQYRLANQVREEVDHFLKGLNELVPENLLAIFDENELEVCSVIFFKINIAKLHAV-SPGHAIFFLSKVMKWFWAVV 929
           *************************************************98888889999999994.5667799************* PP
   S: 254  eefsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           + f++ee +++LqF+Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+l+++L +Ai+e+ +gF++
   Q: 930  SCFTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEELHKMLKLAISEGsEGFGM 1011
           ******************************99555555.******************************************97 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MDQCILLTFT LSSCLWEVRW KNLRNLQIKE WLLNHQLLEY RLLFKDVQCL EELADVKIWS 60
KLQEVFPEKL VRRREAQSCL VGELALQEWL CSLRLKHYYP HLKSLGCSIL LDLAQVESHS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACCAAT GTATCCTGTT GACCTTTACC CTCTCTTCCT GTTTGTGGAT AGTAGTATAG 60
GAAGTGAGGT GGAAGAACTT GAGAAACCTT CAGATTAAGG AATGGCTTCT GAACCACCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	77.49	0.00e+00	1267.00
IUUC-Apl-004071	Anas platyrhynchos	76.87	0.00e+00	1211.00
IUUC-Aca-005218	Anolis carolinensis	78.28	0.00e+00	1258.00
IUUC-Ame-011871	Astyanax mexicanus	69.18	0.00e+00	1388.00
IUUC-Bta-012978	Bos taurus	77.04	0.00e+00	1261.00
IUUC-Cja-019081	Callithrix jacchus	76.91	0.00e+00	1260.00
IUUC-Cfa-020736	Canis familiaris	74.57	0.00e+00	1179.00
IUUC-Cpo-021581	Cavia porcellus	76.79	0.00e+00	1257.00
IUUC-Csa-024189	Chlorocebus sabaeus	71.46	0.00e+00	664.00
IUUC-Cho-024751	Choloepus hoffmanni	76.91	0.00e+00	1234.00
IUUC-Cin-025773	Ciona intestinalis	40.94	3.00e-130	459.00
IUUC-Csv-026090	Ciona savignyi	39.75	9.00e-162	563.00
IUUC-Dre-027788	Danio rerio	70.23	0.00e+00	1404.00
IUUC-Dno-030022	Dasypus novemcinctus	76.67	0.00e+00	1259.00
IUUC-Dme-031577	Drosophila melanogaster	41.39	0.00e+00	665.00
IUUC-Ete-032402	Echinops telfairi	76.19	0.00e+00	1217.00
IUUC-Eca-033908	Equus caballus	77.40	0.00e+00	1267.00
IUUC-Eeu-034869	Erinaceus europaeus	76.08	0.00e+00	695.00
IUUC-Fca-036023	Felis catus	77.28	0.00e+00	1264.00
IUUC-Fal-037477	Ficedula albicollis	77.15	0.00e+00	1271.00
IUUC-Gmo-039197	Gadus morhua	75.46	0.00e+00	1235.00
IUUC-Gga-040704	Gallus gallus	77.03	0.00e+00	1260.00
IUUC-Gac-041511	Gasterosteus aculeatus	74.73	0.00e+00	1248.00
IUUC-Ggo-044527	Gorilla gorilla	75.97	0.00e+00	1229.00
IUUC-Hsa-046082	Homo sapiens	76.91	0.00e+00	1260.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	77.28	0.00e+00	1266.00
IUUC-Loc-052541	Lepisosteus oculatus	70.87	0.00e+00	1422.00
IUUC-Laf-053852	Loxodonta africana	76.31	0.00e+00	1244.00
IUUC-Mcc-054759	Macaca mulatta	77.10	4.00e-169	587.00
IUUC-Meu-056247	Macropus eugenii	63.76	0.00e+00	663.00
IUUC-Mga-060161	Meleagris gallopavo	76.33	0.00e+00	1237.00
IUUC-Mmr-061447	Microcebus murinus	76.91	0.00e+00	1261.00
IUUC-Mdo-062110	Monodelphis domestica	77.16	0.00e+00	1235.00
IUUC-Mmu-064349	Mus musculus	77.16	0.00e+00	1264.00
IUUC-Mpu-065824	Mustela putorius furo	77.52	0.00e+00	1266.00
IUUC-Mlu-067729	Myotis lucifugus	77.40	0.00e+00	1262.00
IUUC-Nle-069721	Nomascus leucogenys	77.16	0.00e+00	1260.00
IUUC-Opr-070189	Ochotona princeps	77.11	0.00e+00	1256.00
IUUC-Ont-072122	Oreochromis niloticus	76.06	0.00e+00	1238.00
IUUC-Oan-072700	Ornithorhynchus anatinus	68.86	0.00e+00	968.00
IUUC-Ocu-074057	Oryctolagus cuniculus	77.04	0.00e+00	1264.00
IUUC-Ola-087492	Oryzias latipes	74.12	0.00e+00	1240.00
IUUC-Oga-088084	Otolemur garnettii	77.40	0.00e+00	1263.00
IUUC-Oar-090354	Ovis aries	76.90	0.00e+00	1243.00
IUUC-Ptr-091456	Pan troglodytes	76.79	0.00e+00	1256.00
IUUC-Pan-092596	Papio anubis	75.73	0.00e+00	1231.00
IUUC-Psi-092942	Pelodiscus sinensis	77.89	0.00e+00	1265.00
IUUC-Pma-094662	Petromyzon marinus	57.02	0.00e+00	677.00
IUUC-Pfo-096838	Poecilia formosa	69.54	0.00e+00	1358.00
IUUC-Pab-097849	Pongo abelii	76.79	0.00e+00	1258.00
IUUC-Pca-100498	Procavia capensis	72.14	0.00e+00	671.00
IUUC-Pva-102599	Pteropus vampyrus	76.79	0.00e+00	1259.00
IUUC-Rno-105776	Rattus norvegicus	76.91	0.00e+00	1259.00
IUUC-Sha-106699	Sarcophilus harrisii	76.79	0.00e+00	1232.00
IUUC-Sar-113621	Sorex araneus	75.52	0.00e+00	1219.00
IUUC-Ssc-115742	Sus scrofa	76.91	0.00e+00	1261.00
IUUC-Tgu-116490	Taeniopygia guttata	76.55	0.00e+00	1258.00
IUUC-Tru-117679	Takifugu rubripes	74.85	0.00e+00	1219.00
IUUC-Tsy-119607	Tarsius syrichta	72.11	0.00e+00	831.00
IUUC-Tni-120376	Tetraodon nigroviridis	71.34	0.00e+00	1130.00
IUUC-Tbe-127348	Tupaia belangeri	63.24	1.00e-111	396.00
IUUC-Ttr-128786	Tursiops truncatus	74.00	0.00e+00	1197.00
IUUC-Vpa-130180	Vicugna pacos	76.84	0.00e+00	1012.00
IUUC-Xtr-132631	Xenopus tropicalis	62.59	0.00e+00	1036.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence