iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096838

Ensembl Protein ID

ENSPFOP00000014177.2

UniProt Accession

A0A087Y824; A0A087Y824_POEFO

Genbank Protein ID

ENSPFOP00000014177

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AYCK01003420

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000014094.2	ENSPFOT00000014197.2	ENSPFOP00000014177.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-100	336.6	682	1018

Active Site

Position(s)	Description	Evidence
986	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++++lf ++sen++  ++pn d+  +   +lk++ef+Gr++gk+l+++   
   Q: 682  SDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTSNQLFtRFSENNQGLVHPNADRPAH--LRLKMYEFAGRVVGKCLYESalg 766
           7999**************************************888999***********975..9******************9999 PP
   S: 86   ....rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtn 167
               +l+++++++sf+ +++g +++++ +e+ d+e+yk+ + +i++n   d++e++l ++ + + ++ +  k++eL++gG++i Vtn
   Q: 767  gaykQLVRARFTRSFLAQIIGLRMNYKYFETDDQEFYKTkVCFILNN---DVSEMDLVFAEE-KYKSGQLEKVVELISGGAQIAVTN 849
           9999***********************************99****98...999976666655.333566678889************ PP
   S: 168  eNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevl 253
           +Nk  Y +l+++yrl ++++ +ve+f +G+ne++p++ll++F+e+elell+cG+ +i+v+d+k+++    g ++ ++++++wFw v+
   Q: 850  DNKIHYLNLLAQYRLASQVRDEVEHFLKGLNELVPENLLAIFDENELELLMCGTGNINVQDFKAHAvIVGGSWHFREKVMKWFWAVV 936
           ******************************************************************445778999************ PP
   S: 254  eefsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           ++f++ee +++LqF+Tgss+lP+gGf++l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+l+++L +Ai+e+ +gF++
   Q: 937  SSFTQEELARLLQFTTGSSQLPPGGFNTLCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEELHKMLKLAISEGsEGFGM 1018
           ******************************99555555.******************************************97 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

MDRRFFLTLL FCSLSWILFW EVRWKKRKEG QIEEWLQVHS LSQYSHLFED VQTLEELSLS 60
ALSRLEEVVK EQQHWREIAE AHIKLLRDFA FQEWLSSQNL EHYHHILKTL GCINLDDLSR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGTATTTC AACTTGAATG TTAACAGGTT AAGATGAAGT AGGAAGAAGT CGACATTATT 60
TACCATATTT CTGCGTTTCA GGCTTTTAGT CTCTGGAATC AGCTACCTTT CCTCTCCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	81.63	0.00e+00	1360.00
IUUC-Apl-004071	Anas platyrhynchos	79.34	0.00e+00	1285.00
IUUC-Aca-005218	Anolis carolinensis	80.34	0.00e+00	1332.00
IUUC-Ame-011871	Astyanax mexicanus	91.86	0.00e+00	1877.00
IUUC-Bta-012978	Bos taurus	81.41	0.00e+00	1356.00
IUUC-Cja-019081	Callithrix jacchus	81.53	0.00e+00	1355.00
IUUC-Cfa-020736	Canis familiaris	79.34	0.00e+00	1286.00
IUUC-Cpo-021581	Cavia porcellus	81.41	0.00e+00	1358.00
IUUC-Csa-024189	Chlorocebus sabaeus	75.16	0.00e+00	697.00
IUUC-Cho-024751	Choloepus hoffmanni	81.04	0.00e+00	1312.00
IUUC-Cin-025773	Ciona intestinalis	43.22	5.00e-151	528.00
IUUC-Csv-026090	Ciona savignyi	40.54	6.00e-173	601.00
IUUC-Dre-027788	Danio rerio	89.41	0.00e+00	1848.00
IUUC-Dno-030022	Dasypus novemcinctus	81.29	0.00e+00	1352.00
IUUC-Dme-031577	Drosophila melanogaster	48.42	0.00e+00	714.00
IUUC-Ete-032402	Echinops telfairi	79.98	0.00e+00	1293.00
IUUC-Eca-033908	Equus caballus	82.02	0.00e+00	1366.00
IUUC-Eeu-034869	Erinaceus europaeus	86.83	0.00e+00	828.00
IUUC-Fca-036023	Felis catus	81.65	0.00e+00	1359.00
IUUC-Fal-037477	Ficedula albicollis	80.74	0.00e+00	1348.00
IUUC-Gmo-039197	Gadus morhua	94.40	0.00e+00	1549.00
IUUC-Gga-040704	Gallus gallus	78.60	0.00e+00	1338.00
IUUC-Gac-041511	Gasterosteus aculeatus	93.80	0.00e+00	1571.00
IUUC-Ggo-044527	Gorilla gorilla	78.52	0.00e+00	1284.00
IUUC-Hsa-046082	Homo sapiens	81.53	0.00e+00	1355.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	81.77	0.00e+00	1363.00
IUUC-Lch-049772	Latimeria chalumnae	69.37	0.00e+00	1351.00
IUUC-Loc-052541	Lepisosteus oculatus	87.38	0.00e+00	1784.00
IUUC-Laf-053852	Loxodonta africana	81.53	0.00e+00	1350.00
IUUC-Mcc-054759	Macaca mulatta	75.98	0.00e+00	628.00
IUUC-Meu-056247	Macropus eugenii	66.28	0.00e+00	711.00
IUUC-Mga-060161	Meleagris gallopavo	79.13	0.00e+00	1315.00
IUUC-Mmr-061447	Microcebus murinus	81.77	0.00e+00	1359.00
IUUC-Mdo-062110	Monodelphis domestica	79.10	0.00e+00	1312.00
IUUC-Mmu-064349	Mus musculus	81.17	0.00e+00	1355.00
IUUC-Mpu-065824	Mustela putorius furo	82.02	0.00e+00	1358.00
IUUC-Mlu-067729	Myotis lucifugus	81.65	0.00e+00	1337.00
IUUC-Nle-069721	Nomascus leucogenys	81.65	0.00e+00	1345.00
IUUC-Opr-070189	Ochotona princeps	81.40	0.00e+00	1347.00
IUUC-Ont-072122	Oreochromis niloticus	95.86	0.00e+00	1564.00
IUUC-Oan-072700	Ornithorhynchus anatinus	72.23	0.00e+00	1063.00
IUUC-Ocu-074057	Oryctolagus cuniculus	81.77	0.00e+00	1360.00
IUUC-Ola-087492	Oryzias latipes	94.28	0.00e+00	1560.00
IUUC-Oga-088084	Otolemur garnettii	81.77	0.00e+00	1354.00
IUUC-Oar-090354	Ovis aries	81.20	0.00e+00	1338.00
IUUC-Ptr-091456	Pan troglodytes	81.29	0.00e+00	1350.00
IUUC-Pan-092596	Papio anubis	80.46	0.00e+00	1329.00
IUUC-Psi-092942	Pelodiscus sinensis	80.80	0.00e+00	1333.00
IUUC-Pma-094662	Petromyzon marinus	62.13	0.00e+00	761.00
IUUC-Pab-097849	Pongo abelii	81.29	0.00e+00	1352.00
IUUC-Pca-100498	Procavia capensis	76.55	0.00e+00	726.00
IUUC-Pva-102599	Pteropus vampyrus	81.29	0.00e+00	1342.00
IUUC-Rno-105776	Rattus norvegicus	81.53	0.00e+00	1349.00
IUUC-Sha-106699	Sarcophilus harrisii	79.71	0.00e+00	1321.00
IUUC-Sar-113621	Sorex araneus	80.44	0.00e+00	1315.00
IUUC-Ssc-115742	Sus scrofa	81.53	0.00e+00	1360.00
IUUC-Tgu-116490	Taeniopygia guttata	81.17	0.00e+00	1334.00
IUUC-Tru-117679	Takifugu rubripes	95.38	0.00e+00	1561.00
IUUC-Tsy-119607	Tarsius syrichta	78.45	0.00e+00	922.00
IUUC-Tni-120376	Tetraodon nigroviridis	91.01	0.00e+00	1456.00
IUUC-Tbe-127348	Tupaia belangeri	83.78	1.00e-87	317.00
IUUC-Ttr-128786	Tursiops truncatus	78.37	0.00e+00	1295.00
IUUC-Vpa-130180	Vicugna pacos	79.85	0.00e+00	1048.00
IUUC-Xtr-132631	Xenopus tropicalis	66.59	0.00e+00	1105.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence