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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063153
UUCD1 version UUC-MuM-00048
Ensembl Protein ID ENSMUSP00000099465.3
UniProt Accession Q8R516; A2A9P9; Q52QU8; Q6PEF6; Q8C1N7; Q8VIB4; MIB2_MOUSE
Genbank Protein ID AAX84652.1; BAB79447.1; BAB86856.1; CAM16749.1; EDL15023.1; BAC25227.1
Protein Name E3 ubiquitin-protein ligase MIB2; Dystrophin-like protein; Mind bomb homolog 2; RING-type E3 ubiquitin transferase MIB2; Skeletrophin
Genbank Nucleotide ID AY974090; AB063290; AB072336; AL627405; CH466594; BC058086
Gene Name Mib2; Skd
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029060.17 ENSMUST00000103176.9 ENSMUSP00000099465.3
ENSMUSG00000029060.17 ENSMUST00000141108.1 ENSMUSP00000122269.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDPINAHINTMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19855135; 18824586
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 61.32 0.00e+00 1138.00 IUUC-Dre-028844
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
 E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Protein Sequence
(Fasta)
MDLDPHAGVQ VGMRVVRGMD WKWGQQDGGE GGVGTVVELG RHGSPSTPDR TVVVQWDQGT 60
RTNYRAGYQG AHDLLLYDNA QIGIRHPNII CDCCKKHGLR GMRWKCRVCF DYDLCTQCYM 120
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Protein Fasta Sequence


>IUUC-Mmu-063153|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
TGTGCGGCGC CCCGCGACTG TAGTCGGGGA GCCGTGGTGG GGCTCCCTGG TGGGCTAGCG 60
CAAGAGAGGC GGCCTTGCTA AACACTGTTA GGGGGCGGAG GACGGCGGGC TGCAGCTGGC 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063153|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0967--Endosome
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001370--BIR_rpt
IPR010606--Mib_Herc2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR000433--Znf_ZZ
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS51416--MIB_HERC2
PS50089--ZF_RING_2
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2
Pfam

PF12796--Ank_2
PF06701--MIB_HERC2
PF00569--ZZ
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00184--RING
SM00291--ZnF_ZZ
Gene Ontology

GO:0005769--C:early endosome
GO:0000151--C:ubiquitin ligase complex
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007219--P:Notch signaling pathway
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016567--P:protein ubiquitination
KEGG mmu:76580
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000355 Aegilops tauschii 27.91 1.00e-20 96.70
IUUC-Aml-001839 Ailuropoda melanoleuca 86.15 0.00e+00 1137.00
IUUC-Apl-003333 Anas platyrhynchos 62.27 0.00e+00 1056.00
IUUC-Ame-011227 Astyanax mexicanus 57.85 0.00e+00 1104.00
IUUC-Bta-012993 Bos taurus 83.01 0.00e+00 1510.00
IUUC-Bdi-014301 Brachypodium distachyon 27.81 2.00e-19 92.40
IUUC-Cja-019653 Callithrix jacchus 88.82 0.00e+00 1615.00
IUUC-Cfa-020044 Canis familiaris 88.40 0.00e+00 1543.00
IUUC-Cpo-021836 Cavia porcellus 87.88 0.00e+00 1583.00
IUUC-Csa-023940 Chlorocebus sabaeus 88.40 0.00e+00 1639.00
IUUC-Dre-028844 Danio rerio 61.66 0.00e+00 1175.00
IUUC-Dno-030086 Dasypus novemcinctus 78.97 0.00e+00 957.00
IUUC-Dor-030915 Dipodomys ordii 83.41 0.00e+00 711.00
IUUC-Dme-031821 Drosophila melanogaster 44.85 6.00e-167 581.00
IUUC-Ete-033045 Echinops telfairi 79.71 0.00e+00 984.00
IUUC-Eca-034009 Equus caballus 86.94 0.00e+00 1194.00
IUUC-Eeu-035321 Erinaceus europaeus 86.67 5.00e-138 485.00
IUUC-Fal-036757 Ficedula albicollis 66.11 0.00e+00 1316.00
IUUC-Gmo-039304 Gadus morhua 57.23 0.00e+00 1051.00
IUUC-Gga-040651 Gallus gallus 65.17 0.00e+00 1307.00
IUUC-Gac-042061 Gasterosteus aculeatus 59.83 0.00e+00 1142.00
IUUC-Gma-043595 Glycine max 27.46 1.00e-21 99.00
IUUC-Ggo-045409 Gorilla gorilla 62.11 4.00e-167 581.00
IUUC-Hsa-046523 Homo sapiens 89.13 0.00e+00 1627.00
IUUC-Hvu-047502 Hordeum vulgare 28.07 4.00e-19 90.10
IUUC-Itr-048215 Ictidomys tridecemlineatus 87.79 0.00e+00 1569.00
IUUC-Lch-049427 Latimeria chalumnae 62.46 0.00e+00 1225.00
IUUC-Loc-052166 Lepisosteus oculatus 60.87 0.00e+00 1186.00
IUUC-Laf-054174 Loxodonta africana 78.22 0.00e+00 1015.00
IUUC-Mcc-055748 Macaca mulatta 88.61 0.00e+00 1641.00
IUUC-Meu-056351 Macropus eugenii 65.27 0.00e+00 630.00
IUUC-Mga-059882 Meleagris gallopavo 54.55 0.00e+00 1018.00
IUUC-Mmr-061388 Microcebus murinus 80.40 0.00e+00 1381.00
IUUC-Mdo-061981 Monodelphis domestica 70.19 0.00e+00 1102.00
IUUC-Mpu-066551 Mustela putorius furo 87.00 0.00e+00 1352.00
IUUC-Nle-069881 Nomascus leucogenys 78.57 0.00e+00 1347.00
IUUC-Opr-070624 Ochotona princeps 79.37 0.00e+00 833.00
IUUC-Ont-072414 Oreochromis niloticus 60.08 0.00e+00 1154.00
IUUC-Osa-085300 Oryza sativa 30.64 3.00e-16 80.10
IUUC-Ola-086715 Oryzias latipes 57.28 0.00e+00 1100.00
IUUC-Oga-088898 Otolemur garnettii 87.57 0.00e+00 1551.00
IUUC-Oar-089265 Ovis aries 75.18 0.00e+00 929.00
IUUC-Pan-092360 Papio anubis 88.04 0.00e+00 1246.00
IUUC-Psi-093964 Pelodiscus sinensis 65.73 0.00e+00 1264.00
IUUC-Pma-094121 Petromyzon marinus 39.32 1.00e-146 513.00
IUUC-Pfo-096821 Poecilia formosa 60.50 0.00e+00 1158.00
IUUC-Pab-098440 Pongo abelii 68.64 0.00e+00 1022.00
IUUC-Pop-098784 Populus trichocarpa 27.43 1.00e-21 99.80
IUUC-Pca-100806 Procavia capensis 87.40 0.00e+00 1046.00
IUUC-Ppe-102003 Prunus persica 26.67 1.00e-20 96.70
IUUC-Pva-102667 Pteropus vampyrus 82.83 0.00e+00 960.00
IUUC-Rno-105681 Rattus norvegicus 94.86 0.00e+00 1683.00
IUUC-Sha-106735 Sarcophilus harrisii 65.18 1.00e-158 552.00
IUUC-Sit-109898 Setaria italica 27.30 7.00e-20 94.00
IUUC-Sbi-114492 Sorghum bicolor 27.61 5.00e-20 94.40
IUUC-Ssc-116370 Sus scrofa 87.46 0.00e+00 1532.00
IUUC-Tgu-116853 Taeniopygia guttata 65.56 0.00e+00 1293.00
IUUC-Tru-118714 Takifugu rubripes 59.85 0.00e+00 1147.00
IUUC-Tni-119764 Tetraodon nigroviridis 60.29 0.00e+00 1152.00
IUUC-Tca-121711 Theobroma cacao 24.43 3.00e-18 88.60
IUUC-Tae-124169 Triticum aestivum 27.91 7.00e-21 97.10
IUUC-Ttr-128730 Tursiops truncatus 80.23 0.00e+00 759.00
IUUC-Xtr-132967 Xenopus tropicalis 63.57 0.00e+00 1269.00
IUUC-Xma-133473 Xiphophorus maculatus 59.81 0.00e+00 1013.00
Created Date 25-Jun-2017

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