iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033843

UUCD1 version

UUC-EqC-00697

Ensembl Protein ID

ENSECAP00000004315.1

UniProt Accession

F7B6P6; F7B6P6_HORSE

Protein Name

Uncharacterized protein

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000004792.1	ENSECAT00000006122.1	ENSECAP00000004315.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-100	337.2	527	850

Active Site

Position(s)	Description	Evidence
819	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G   g+a++++ ++d+
   Q: 527  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGY-WGLAIYNN-CIDV 608
           689******************************************998888876.88888....789*******7.7*****86.68** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gk  ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 609  HFPMVVYRKLMGKG-TFRDLGDSHPVLYQSLKDLLEY-EGNVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVNLYS 694
           *************5.**********************.7799986.99***9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 695  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQ 783
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 784  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 850
           *****************...8888866666**************************************97 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

KRAAAKHLIE RYYHQLTEGC GNEACTNEFC ASCPSFLRMD NNAAAIKALE LYKINAKLCD 60
PHPSKKGASS AYLENSKGAP NNSCSDIKMN KKEGHGARDD FKDVTYLTEE TVYEILELCR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGCGAGCAG CTGCAAAGCA TCTAATAGAA CGCTACTACC ACCAGTTAAC TGAGGGCTGT 60
GGAAATGAGG CCTGCACGAA TGAGTTTTGT GCTTCCTGTC CAAGTTTTCT TCGTATGGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	98.71	0.00e+00	1600.00
IUUC-Atr-003144	Amborella trichopoda	45.35	3.00e-90	325.00
IUUC-Apl-003742	Anas platyrhynchos	94.29	0.00e+00	1542.00
IUUC-Aca-004873	Anolis carolinensis	93.39	0.00e+00	1556.00
IUUC-Ame-011166	Astyanax mexicanus	85.88	0.00e+00	1431.00
IUUC-Bta-013286	Bos taurus	97.66	0.00e+00	1548.00
IUUC-Cja-019707	Callithrix jacchus	97.66	0.00e+00	1579.00
IUUC-Cfa-020154	Canis familiaris	98.48	0.00e+00	1588.00
IUUC-Cpo-021292	Cavia porcellus	96.72	0.00e+00	1572.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	47.17	2.00e-80	292.00
IUUC-Csa-023378	Chlorocebus sabaeus	97.78	0.00e+00	1578.00
IUUC-Cho-025059	Choloepus hoffmanni	93.57	0.00e+00	1489.00
IUUC-Cin-025643	Ciona intestinalis	44.57	0.00e+00	695.00
IUUC-Csv-026282	Ciona savignyi	44.43	0.00e+00	648.00
IUUC-Cme-027151	Cyanidioschyzon merolae	43.79	6.00e-96	345.00
IUUC-Dre-027901	Danio rerio	85.28	0.00e+00	1417.00
IUUC-Dno-029320	Dasypus novemcinctus	97.54	0.00e+00	1574.00
IUUC-Dor-030756	Dipodomys ordii	94.74	0.00e+00	731.00
IUUC-Dme-032035	Drosophila melanogaster	42.96	4.00e-161	561.00
IUUC-Eeu-035109	Erinaceus europaeus	95.67	0.00e+00	1526.00
IUUC-Fca-036344	Felis catus	96.96	0.00e+00	1588.00
IUUC-Fal-036747	Ficedula albicollis	94.29	0.00e+00	1543.00
IUUC-Gmo-038840	Gadus morhua	62.79	0.00e+00	1079.00
IUUC-Gga-040399	Gallus gallus	94.29	0.00e+00	1543.00
IUUC-Gac-041933	Gasterosteus aculeatus	85.16	0.00e+00	1371.00
IUUC-Ggo-044804	Gorilla gorilla	98.01	0.00e+00	1581.00
IUUC-Hsa-045727	Homo sapiens	98.01	0.00e+00	1581.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	93.79	0.00e+00	1488.00
IUUC-Lch-050197	Latimeria chalumnae	90.99	0.00e+00	1502.00
IUUC-Loc-052743	Lepisosteus oculatus	89.16	0.00e+00	1494.00
IUUC-Lma-053245	Leptosphaeria maculans	33.33	6.00e-53	203.00
IUUC-Laf-053615	Loxodonta africana	96.61	0.00e+00	1571.00
IUUC-Mcc-054934	Macaca mulatta	97.78	0.00e+00	1577.00
IUUC-Meu-056061	Macropus eugenii	96.14	0.00e+00	1324.00
IUUC-Mga-059271	Meleagris gallopavo	94.17	0.00e+00	1537.00
IUUC-Mmr-061288	Microcebus murinus	97.54	0.00e+00	1579.00
IUUC-Mdo-062975	Monodelphis domestica	95.68	0.00e+00	1552.00
IUUC-Mmu-063674	Mus musculus	94.73	0.00e+00	1512.00
IUUC-Mpu-066568	Mustela putorius furo	98.83	0.00e+00	1603.00
IUUC-Mlu-067522	Myotis lucifugus	89.30	0.00e+00	1463.00
IUUC-Nle-069505	Nomascus leucogenys	98.01	0.00e+00	1581.00
IUUC-Opr-070570	Ochotona princeps	89.29	0.00e+00	1441.00
IUUC-Ont-071527	Oreochromis niloticus	85.86	0.00e+00	1442.00
IUUC-Oan-073446	Ornithorhynchus anatinus	91.33	0.00e+00	1030.00
IUUC-Ocu-074922	Oryctolagus cuniculus	95.24	0.00e+00	1568.00
IUUC-Ola-086996	Oryzias latipes	85.56	0.00e+00	1445.00
IUUC-Oga-088261	Otolemur garnettii	97.31	0.00e+00	1578.00
IUUC-Oar-090024	Ovis aries	97.66	0.00e+00	1548.00
IUUC-Ptr-090455	Pan troglodytes	98.01	0.00e+00	1581.00
IUUC-Pan-092509	Papio anubis	97.52	0.00e+00	1420.00
IUUC-Psi-092974	Pelodiscus sinensis	93.82	0.00e+00	1513.00
IUUC-Pma-094643	Petromyzon marinus	70.64	0.00e+00	1228.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.32	1.00e-53	205.00
IUUC-Pfo-096905	Poecilia formosa	85.50	0.00e+00	1440.00
IUUC-Pab-097840	Pongo abelii	95.78	0.00e+00	1544.00
IUUC-Pca-100869	Procavia capensis	96.26	0.00e+00	1560.00
IUUC-Pva-103040	Pteropus vampyrus	95.83	0.00e+00	644.00
IUUC-Rno-105453	Rattus norvegicus	94.73	0.00e+00	1513.00
IUUC-Sha-107651	Sarcophilus harrisii	95.68	0.00e+00	1553.00
IUUC-Smo-108858	Selaginella moellendorffii	48.70	4.00e-110	392.00
IUUC-Sar-113293	Sorex araneus	97.31	0.00e+00	1576.00
IUUC-Ssc-115979	Sus scrofa	97.78	0.00e+00	1581.00
IUUC-Tgu-116901	Taeniopygia guttata	94.29	0.00e+00	1541.00
IUUC-Tru-118368	Takifugu rubripes	86.18	0.00e+00	1436.00
IUUC-Tsy-119516	Tarsius syrichta	93.56	0.00e+00	1469.00
IUUC-Tni-120143	Tetraodon nigroviridis	85.50	0.00e+00	1429.00
IUUC-Tbe-127484	Tupaia belangeri	92.13	0.00e+00	1082.00
IUUC-Ttr-129078	Tursiops truncatus	97.66	0.00e+00	1565.00
IUUC-Vpa-130312	Vicugna pacos	90.05	0.00e+00	1345.00
IUUC-Xtr-132881	Xenopus tropicalis	91.70	0.00e+00	1510.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence